GB900115A - Improvements in or relating to trypsin solutions - Google Patents

Improvements in or relating to trypsin solutions

Info

Publication number
GB900115A
GB900115A GB21001/60A GB2100160A GB900115A GB 900115 A GB900115 A GB 900115A GB 21001/60 A GB21001/60 A GB 21001/60A GB 2100160 A GB2100160 A GB 2100160A GB 900115 A GB900115 A GB 900115A
Authority
GB
United Kingdom
Prior art keywords
amino acid
calcium salt
trypsin
proline
relating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB21001/60A
Inventor
Charles William Frank Damaskus
Paul Ellis Bradford
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Armour and Co
Original Assignee
Armour and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Armour and Co filed Critical Armour and Co
Priority to GB21001/60A priority Critical patent/GB900115A/en
Publication of GB900115A publication Critical patent/GB900115A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

A substantially stable aqueous trypsin solution contains an amino acid and a calcium salt. The amino acid may be l-glutamine, glutamic acid, glycine, l-arginine, cysteine, dl-alamine, dl-isoleucine, l-lysine, dl-methionine, dl-phenylalanine, l-proline, hydroxy-l-proline, dl-serine, dl-threonine or dl-valine, and the calcium salt may be the acetate, citrate, chloride, glycerophosphate, glucoheptanate, gluconate, lactate, lactobionate, lactophosphate, pantothenate or levulinate.ALSO:A pharmaceutical preparation suitable for topical or parenteral use comprises an aqueous solution of trypsin stabilized by the addition of an amino acid and a calcium salt (see Group IV (b)).
GB21001/60A 1960-06-15 1960-06-15 Improvements in or relating to trypsin solutions Expired GB900115A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB21001/60A GB900115A (en) 1960-06-15 1960-06-15 Improvements in or relating to trypsin solutions

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB21001/60A GB900115A (en) 1960-06-15 1960-06-15 Improvements in or relating to trypsin solutions

Publications (1)

Publication Number Publication Date
GB900115A true GB900115A (en) 1962-07-04

Family

ID=10155496

Family Applications (1)

Application Number Title Priority Date Filing Date
GB21001/60A Expired GB900115A (en) 1960-06-15 1960-06-15 Improvements in or relating to trypsin solutions

Country Status (1)

Country Link
GB (1) GB900115A (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3186908A (en) * 1962-08-16 1965-06-01 Parke Davis & Co Calcium lactobionate stabilization of labile antigenic virus vaccine materials
FR2522681A1 (en) * 1981-09-21 1983-09-09 Novo Industri As STABILIZED SOLUTION WITH METHIONINE
US4496537A (en) * 1981-12-23 1985-01-29 Schering Corporation Biologically stable alpha-interferon formulations
WO2008141268A2 (en) * 2007-05-10 2008-11-20 Smith & Nephew, Inc. Enhancement of the calcium sensing receptor
EP2380593A1 (en) * 2010-04-23 2011-10-26 Arkray, Inc. Stabilizing labeled antibody using amino acids
US20120129135A1 (en) * 2010-11-22 2012-05-24 Taipei Medical University Novel type of anion-containing calcium phosphate compound for dental remineralization

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3186908A (en) * 1962-08-16 1965-06-01 Parke Davis & Co Calcium lactobionate stabilization of labile antigenic virus vaccine materials
FR2522681A1 (en) * 1981-09-21 1983-09-09 Novo Industri As STABILIZED SOLUTION WITH METHIONINE
US4496537A (en) * 1981-12-23 1985-01-29 Schering Corporation Biologically stable alpha-interferon formulations
WO2008141268A2 (en) * 2007-05-10 2008-11-20 Smith & Nephew, Inc. Enhancement of the calcium sensing receptor
WO2008141268A3 (en) * 2007-05-10 2009-07-02 Smith & Nephew Inc Enhancement of the calcium sensing receptor
EP2380593A1 (en) * 2010-04-23 2011-10-26 Arkray, Inc. Stabilizing labeled antibody using amino acids
US20120129135A1 (en) * 2010-11-22 2012-05-24 Taipei Medical University Novel type of anion-containing calcium phosphate compound for dental remineralization
US9539445B2 (en) * 2010-11-22 2017-01-10 Taipei Medical University Type of anion-containing calcium phosphate compound for dental remineralization

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