GB887682A - Improvements in or relating to medicinal coating compositions - Google Patents

Improvements in or relating to medicinal coating compositions

Info

Publication number
GB887682A
GB887682A GB30807/59A GB3080759A GB887682A GB 887682 A GB887682 A GB 887682A GB 30807/59 A GB30807/59 A GB 30807/59A GB 3080759 A GB3080759 A GB 3080759A GB 887682 A GB887682 A GB 887682A
Authority
GB
United Kingdom
Prior art keywords
composition
weight
concentration
added
shellac
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB30807/59A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of GB887682A publication Critical patent/GB887682A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/282—Organic compounds, e.g. fats

Abstract

A coating composition for pills and tablets comprises particles of purified arsenic-free shellac suspended in an aqueous alcoholic solution of methyl cellulose, hydroxyethyl cellulose or sodium carboxymethylcellulose. The shellac may be present in a concentration of 40-100% by weight of the cellulose derivative, and the latter may be present in a concentration of from 5-10% by weight of the composition when of low viscosity (less than 100 cps.), 3-5% when of medium viscosity and 2-3% when of high viscosity (over 1,500 cps.). The alcohol may be ethanol, but other alcohols may be used, e.g. methanol or isopropanol. A plasticizer, e.g. propylene glycol, glycerin, or polyethylene glycol of molecular weight 200-600, may be added in an amount of 1-3 g. per 100 g. of composition. Other specified plasticizers include cotton seed oil and corn oil. Conventional colouring, sweetening, flavouring and opacifying agents may be added.ALSO:A coating composition for pills and tablets comprises particles of purified arsenic-free shellac suspended in an aqueous alcoholic solution of methyl cellulose, hydroxyethyl cellulose or sodium carboxymethylcellulose. The shellac may be present in a concentration of 40-100% by weight of the cellulose derivative, and the latter may be present in a concentration of from 5-10% by weight of the composition when of low viscosity (less than 100 c.p.s.), 3-5% when of medium viscosity and 2-3% when of high viscosity (over 1500 c.p.s.). The alcohol may be ethanol, but other alcohols may be used, e.g. methanol or isopropanol. A plasticizer, e.g. propylene glycol, glycerine, or polyethylene glycol of molecular weight 200-600, may be added in an amount of 1-3 g. per 100 g. of composition. Other specified plasticizers include cottonseed oil and corn oil. Conventional colouring, sweetening, flavouring and opacifying agents may be added.
GB30807/59A 1958-10-22 1959-09-09 Improvements in or relating to medicinal coating compositions Expired GB887682A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US887682XA 1958-10-22 1958-10-22

Publications (1)

Publication Number Publication Date
GB887682A true GB887682A (en) 1962-01-24

Family

ID=22213337

Family Applications (1)

Application Number Title Priority Date Filing Date
GB30807/59A Expired GB887682A (en) 1958-10-22 1959-09-09 Improvements in or relating to medicinal coating compositions

Country Status (1)

Country Link
GB (1) GB887682A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2237620A1 (en) * 1973-07-17 1975-02-14 Byk Gulden Lomberg Chem Fab
WO1995002339A1 (en) * 1993-07-14 1995-01-26 Opta Food Ingredients, Inc. Shellac dispersions and coatings, and method of making
US5436011A (en) * 1993-04-16 1995-07-25 Bristol-Myers Squibb Company Solid pharmaceutical dosage form and a method for reducing abrasion

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2237620A1 (en) * 1973-07-17 1975-02-14 Byk Gulden Lomberg Chem Fab
US5436011A (en) * 1993-04-16 1995-07-25 Bristol-Myers Squibb Company Solid pharmaceutical dosage form and a method for reducing abrasion
WO1995002339A1 (en) * 1993-07-14 1995-01-26 Opta Food Ingredients, Inc. Shellac dispersions and coatings, and method of making
US5567438A (en) * 1993-07-14 1996-10-22 Opta Food Ingredients, Inc. Shellac dispersions and coatings, and method of forming aqueous-based shellac dispersions and coatings

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