GB885439A - Improvements in steroids and the synthesis thereof - Google Patents

Improvements in steroids and the synthesis thereof

Info

Publication number
GB885439A
GB885439A GB1739/60A GB173960A GB885439A GB 885439 A GB885439 A GB 885439A GB 1739/60 A GB1739/60 A GB 1739/60A GB 173960 A GB173960 A GB 173960A GB 885439 A GB885439 A GB 885439A
Authority
GB
United Kingdom
Prior art keywords
diester
general formula
carboxylic acid
dihydroxyprogesterone
monoester
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1739/60A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Olin Corp
Original Assignee
Olin Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Olin Corp filed Critical Olin Corp
Publication of GB885439A publication Critical patent/GB885439A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

The invention comprises cyclopentanophenanthrene compounds of the general formula <FORM:0885439/IV (b)/1> wherein R represents the acyl radical of a hydrocarbon carboxylic acid of less than 13 carbon atoms and R1 represents hydrogen or the acyl radical of a hydrocarbon carboxylic acid containing less than 13 carbon atoms, and the preparation thereof by reacting 16a ,17a -dihydroxyprogesterone with an acid anhydride or an acid halide of the required carboxylic acid to form the required 16a ,17a -diester of the above general formula, and when required, treating the diester with a dilute basic reagent such as a dilute solution of an alkali metal hydroxide or carbonate in a lower alcohol, to form the 17-monoester of the above general formula. The 17-monoester may be subsequently acylated at the 16-position to form a 16,17-diester having different ester groups. The ester groups may be derived from alkanoic, aromatic, aralkanoic, cycloalkane carboxylic, alkenoic and cycloalkene carboxylic acids. In the examples the 16, 17 - dicaproate, 17 - monocaproate, 16 - acetate 17-caproate, 16,17-diacetate, 17-monoacetate and 16-benzoate 17-acetate of 16a ,17a -dihydroxyprogesterone are prepared.
GB1739/60A 1959-01-20 1960-01-18 Improvements in steroids and the synthesis thereof Expired GB885439A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US885439XA 1959-01-20 1959-01-20

Publications (1)

Publication Number Publication Date
GB885439A true GB885439A (en) 1961-12-28

Family

ID=22211975

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1739/60A Expired GB885439A (en) 1959-01-20 1960-01-18 Improvements in steroids and the synthesis thereof

Country Status (1)

Country Link
GB (1) GB885439A (en)

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