GB885439A - Improvements in steroids and the synthesis thereof - Google Patents
Improvements in steroids and the synthesis thereofInfo
- Publication number
- GB885439A GB885439A GB1739/60A GB173960A GB885439A GB 885439 A GB885439 A GB 885439A GB 1739/60 A GB1739/60 A GB 1739/60A GB 173960 A GB173960 A GB 173960A GB 885439 A GB885439 A GB 885439A
- Authority
- GB
- United Kingdom
- Prior art keywords
- diester
- general formula
- carboxylic acid
- dihydroxyprogesterone
- monoester
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
The invention comprises cyclopentanophenanthrene compounds of the general formula <FORM:0885439/IV (b)/1> wherein R represents the acyl radical of a hydrocarbon carboxylic acid of less than 13 carbon atoms and R1 represents hydrogen or the acyl radical of a hydrocarbon carboxylic acid containing less than 13 carbon atoms, and the preparation thereof by reacting 16a ,17a -dihydroxyprogesterone with an acid anhydride or an acid halide of the required carboxylic acid to form the required 16a ,17a -diester of the above general formula, and when required, treating the diester with a dilute basic reagent such as a dilute solution of an alkali metal hydroxide or carbonate in a lower alcohol, to form the 17-monoester of the above general formula. The 17-monoester may be subsequently acylated at the 16-position to form a 16,17-diester having different ester groups. The ester groups may be derived from alkanoic, aromatic, aralkanoic, cycloalkane carboxylic, alkenoic and cycloalkene carboxylic acids. In the examples the 16, 17 - dicaproate, 17 - monocaproate, 16 - acetate 17-caproate, 16,17-diacetate, 17-monoacetate and 16-benzoate 17-acetate of 16a ,17a -dihydroxyprogesterone are prepared.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US885439XA | 1959-01-20 | 1959-01-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB885439A true GB885439A (en) | 1961-12-28 |
Family
ID=22211975
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB1739/60A Expired GB885439A (en) | 1959-01-20 | 1960-01-18 | Improvements in steroids and the synthesis thereof |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB885439A (en) |
-
1960
- 1960-01-18 GB GB1739/60A patent/GB885439A/en not_active Expired
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