GB876721A - New steroid compounds - Google Patents
New steroid compoundsInfo
- Publication number
- GB876721A GB876721A GB6753/59A GB675359A GB876721A GB 876721 A GB876721 A GB 876721A GB 6753/59 A GB6753/59 A GB 6753/59A GB 675359 A GB675359 A GB 675359A GB 876721 A GB876721 A GB 876721A
- Authority
- GB
- United Kingdom
- Prior art keywords
- cyclic
- methyl
- carboxylic acid
- androsten
- methyltestosterone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/407—Liver; Hepatocytes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cell Biology (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Nutrition Science (AREA)
- Developmental Biology & Embryology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Physiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Steroid Compounds (AREA)
Abstract
The invention comprises steroid compounds of the general formula <FORM:0876721/IV (b)/1> wherein R represents hydrogen or an acyl group derived from an aliphatic, cyclic or partly cyclic carboxylic acid containing not more than 9 carbon atoms, and the preparation of 4,11b -dihydroxy-17a -methyltestosterone by dehydrating 4,5,11b ,17b -tetrahydroxy-17a -methyl-4-androsten-3-one in alkaline solution, e.g. by means of a methanolic solution of potassium hydroxide, and if necessary, neutralising the alkaline solution, e.g. with acetic acid and, when required, esterifying the 4-hydroxy compound with the required carboxylic acid chloride or acid anhydride, e.g. in the presence of a tertiary amine such as pyridine. Esters mentioned are the benzoate, b -phenylpropionate, b -cyclopentylpropionate, acetate, and propionate. In an example 11b -hydroxy-17a -methyltestosterone is treated with osmium tetroxide and the resulting 4,5,11b ,17b -tetrahydroxy-17a -methyl-4-androsten-3-one is dehydrated as above to form 4,11b -dihydroxy17a -methyl-testosterone which is then esterified to form the particular esters referred to above.ALSO:A therapeutic composition comprises at least one steroid of the general formula <FORM:0876721/VI/1> wherein R represents hydrogen or an acyl group derived from an aliphatic, cyclic or party cyclic carboxylic acid containing not more than 9 carbon atoms, and a pharmaceutically acceptable carrier therefor.
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB6753/59A GB876721A (en) | 1959-02-26 | 1959-02-26 | New steroid compounds |
| BR116361/60A BR6016361D0 (en) | 1959-02-26 | 1960-01-21 | PROCESS TO PREPARE 4-REPLACED-11-BETA-HYDROXY-17-ALPHA-METHYLTESTOSTERONE |
| CH198560A CH385202A (en) | 1959-02-26 | 1960-02-22 | Process for the preparation of the new 4,11B-dihydroxy-17a-methyltestosterone |
| BE588006A BE588006A (en) | 1959-02-26 | 1960-02-25 | New steroid compounds and their preparation process. |
| FR836387A FR260M (en) | 1959-02-26 | 1960-08-22 | A synthetic steroid, 4,11beta-dihydroxy-17alpha-methyl-testosterone. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB6753/59A GB876721A (en) | 1959-02-26 | 1959-02-26 | New steroid compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB876721A true GB876721A (en) | 1961-09-06 |
Family
ID=9820153
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB6753/59A Expired GB876721A (en) | 1959-02-26 | 1959-02-26 | New steroid compounds |
Country Status (5)
| Country | Link |
|---|---|
| BE (1) | BE588006A (en) |
| BR (1) | BR6016361D0 (en) |
| CH (1) | CH385202A (en) |
| FR (1) | FR260M (en) |
| GB (1) | GB876721A (en) |
-
1959
- 1959-02-26 GB GB6753/59A patent/GB876721A/en not_active Expired
-
1960
- 1960-01-21 BR BR116361/60A patent/BR6016361D0/en unknown
- 1960-02-22 CH CH198560A patent/CH385202A/en unknown
- 1960-02-25 BE BE588006A patent/BE588006A/en unknown
- 1960-08-22 FR FR836387A patent/FR260M/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| FR260M (en) | 1961-03-06 |
| CH385202A (en) | 1964-12-15 |
| BR6016361D0 (en) | 1973-05-24 |
| BE588006A (en) | 1960-08-25 |
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