GB868484A - Naphthalene derivatives, intermediates in the synthesis of reserpine - Google Patents

Naphthalene derivatives, intermediates in the synthesis of reserpine

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Publication number
GB868484A
GB868484A GB13237/59A GB1323759A GB868484A GB 868484 A GB868484 A GB 868484A GB 13237/59 A GB13237/59 A GB 13237/59A GB 1323759 A GB1323759 A GB 1323759A GB 868484 A GB868484 A GB 868484A
Authority
GB
United Kingdom
Prior art keywords
lactone
carboxylic acid
epoxy
bromo
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB13237/59A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratoires Francais de Chimiotherapie SA
Original Assignee
Laboratoires Francais de Chimiotherapie SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoires Francais de Chimiotherapie SA filed Critical Laboratoires Francais de Chimiotherapie SA
Publication of GB868484A publication Critical patent/GB868484A/en
Expired legal-status Critical Current

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Abstract

The invention comprises (a) the dextro rotatory lactone of 8b -hydroxy-2a -bromo-3b , 5b - epoxy- 1,2,3,4,4aa ,5,8, 8aa - octahydronaphthalene-1b -carboxylic acid, (b) the laevorotatory 1,8-lactone of 6a -bromo-7b ,8b -dihydroxy- 2a - methoxy- 3b ,5b - epoxy- 4aa , 8aa -decahydronaphthalene-1b -carboxylic acid and (c) the laevorotatory lactone of the 6a -bromo-8b - hydroxy-2a - methoxy-7-oxo-3b ,5b -epoxy- 4aa , 8aa - decahydronaphthalene- 1b -carboxylic acid, together with processes for their preparation; that of (a) by reaction in an inert solvent of the laevo-rotatory lactone of 5b ,8b - dihydroxy- 1,4,4aa ,5,8, 8aa - hexahydronaphthalene-1b -carboxylic acid with the theoretical quantity of N-bromosuccinimide; (b) by bromination in 6a -position of the dextro-rotatory lactone of 8b -hydroxy-2a -3b , 5b - epoxy- 1,2,3,4,4aa ,5,8, 8aa - octahydronaphthalene-1b -carboxylic acid with N-bromosuccinimide in dilute sulphuric acid, and (c) by oxidation of (b) with chromic acid in acetic acid. Detailed examples are given. Specification 868,483 also is referred to.
GB13237/59A 1956-12-06 1957-10-30 Naphthalene derivatives, intermediates in the synthesis of reserpine Expired GB868484A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR868484X 1956-12-06

Publications (1)

Publication Number Publication Date
GB868484A true GB868484A (en) 1961-05-17

Family

ID=9346159

Family Applications (1)

Application Number Title Priority Date Filing Date
GB13237/59A Expired GB868484A (en) 1956-12-06 1957-10-30 Naphthalene derivatives, intermediates in the synthesis of reserpine

Country Status (1)

Country Link
GB (1) GB868484A (en)

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