GB842925A - Orally-effective antidiabetic compounds - Google Patents
Orally-effective antidiabetic compoundsInfo
- Publication number
- GB842925A GB842925A GB22079/58A GB2207958A GB842925A GB 842925 A GB842925 A GB 842925A GB 22079/58 A GB22079/58 A GB 22079/58A GB 2207958 A GB2207958 A GB 2207958A GB 842925 A GB842925 A GB 842925A
- Authority
- GB
- United Kingdom
- Prior art keywords
- butyl
- biguanide
- urea
- sulphonyl
- salts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
- C07C279/24—Y being a hetero atom
- C07C279/26—X and Y being nitrogen atoms, i.e. biguanides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Abstract
The invention comprises anti-diabetic salts of blood-sugar lowering sulphonyl ureas with biguanides of the formula: <FORM:0842925/IV(b)/1> wherein R is hydrogen or methyl, and their preparation by treating the sulphonyl urea with the biguanide, preferably in an aqueous or alcoholic medium. The biguanide is suitably reacted in the form of its hydrochloride, in which case the reaction is carried out in the presence of an alkali-metal hydroxide, e.g. sodium hydroxide, or the sulphonyl urea is used in the form of an alkali-metal or alkaline earth metal salt. Specified salts include the N1-dimethyl-biguanide salts of N1-sulphanilyl-N2-butyl-, N1-p-toluenesulphonyl-N2-butyl-, N1-(4-methyl -3-amino-benzenesulphonyl)-N2-butyl (and N2-cyclohexyl) and N1-p-chlorobenzenesulphonyl-N2-3-methoxypropyl-, urea. Specifications 792,776 794,552, 795,606, 797,474, 819,447 and 831,043 are referred to.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE842925X | 1957-07-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB842925A true GB842925A (en) | 1960-07-27 |
Family
ID=6771400
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB22079/58A Expired GB842925A (en) | 1957-07-11 | 1958-07-09 | Orally-effective antidiabetic compounds |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB842925A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110128305A (en) * | 2019-05-10 | 2019-08-16 | 天津大学 | The new salt form of melbine-orinase, preparation method and medical usage |
| CN110804017A (en) * | 2019-10-31 | 2020-02-18 | 天津大学 | Salt forming of sulfonylurea compound and metformin, preparation method and application |
-
1958
- 1958-07-09 GB GB22079/58A patent/GB842925A/en not_active Expired
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110128305A (en) * | 2019-05-10 | 2019-08-16 | 天津大学 | The new salt form of melbine-orinase, preparation method and medical usage |
| CN110804017A (en) * | 2019-10-31 | 2020-02-18 | 天津大学 | Salt forming of sulfonylurea compound and metformin, preparation method and application |
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