GB689281A - Improvements in or relating to the production of sulphanilamido-thiadiazoles - Google Patents
Improvements in or relating to the production of sulphanilamido-thiadiazolesInfo
- Publication number
- GB689281A GB689281A GB3957/51A GB395751A GB689281A GB 689281 A GB689281 A GB 689281A GB 3957/51 A GB3957/51 A GB 3957/51A GB 395751 A GB395751 A GB 395751A GB 689281 A GB689281 A GB 689281A
- Authority
- GB
- United Kingdom
- Prior art keywords
- phthalylsulphanilamido
- thiadiazole
- sulphanilamido
- thiadiazoles
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
The invention comprises 2-(N4-phthalylsulphanilamido) - 1,3,4 - thiadiazoles substituted in the 5-position by a lower alkyl or mononuclear aryl radical, and their preparation by reacting the correspondingly substituted 2-sulphanilamido-1,3,4-thiadiazole with phthalic acid or a functional derivative thereof. An inert solvent such as glacial acetic acid may be present during the reaction. Examples are given of the preparation of (1) 2-(N4-phthalylsulphanilamido) - 5 - methyl - 1,3,4 - thiadiazole by heating 2-sulphanilamido-5-methyl-1,3,4-thiadiazole with phthalic anhydride in the presence of glacial acetic acid; and (2) 2-(N4-phthalylsulphanilamido) - 5 - ethyl - 1,3,4 - thiadiazole; and (3) 2-(N4-phthalylsulphanilamido)-5-phenyl-1,3,4-thiadiazole by similar methods.ALSO:2-(N4-phthalylsulphanilamido)-1,3,4-thiadiazoles substituted in the 5-position by a lower alkyl or mononuclear aryl radical (see Group IV (b)), which are easily soluble at the pH value prevailing in the intestinal canal, are formed into tablets with potato starch, gelatine and talcum.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK689281X | 1950-02-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB689281A true GB689281A (en) | 1953-03-25 |
Family
ID=8152266
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3957/51A Expired GB689281A (en) | 1950-02-18 | 1951-02-19 | Improvements in or relating to the production of sulphanilamido-thiadiazoles |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB689281A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11492346B2 (en) | 2019-06-18 | 2022-11-08 | Pfizer Inc. | Benzisoxazole sulfonamide derivatives |
| US11911372B2 (en) | 2018-06-28 | 2024-02-27 | Ctxt Pty Ltd | Compounds |
-
1951
- 1951-02-19 GB GB3957/51A patent/GB689281A/en not_active Expired
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11911372B2 (en) | 2018-06-28 | 2024-02-27 | Ctxt Pty Ltd | Compounds |
| US11492346B2 (en) | 2019-06-18 | 2022-11-08 | Pfizer Inc. | Benzisoxazole sulfonamide derivatives |
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