GB928552A - New heterocyclic hydrazine compounds and process for their manufacture - Google Patents

New heterocyclic hydrazine compounds and process for their manufacture

Info

Publication number
GB928552A
GB928552A GB3608861A GB3608861A GB928552A GB 928552 A GB928552 A GB 928552A GB 3608861 A GB3608861 A GB 3608861A GB 3608861 A GB3608861 A GB 3608861A GB 928552 A GB928552 A GB 928552A
Authority
GB
United Kingdom
Prior art keywords
acid
acid addition
trifluoromethyl
alkoxy
halogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3608861A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF Schweiz AG
Original Assignee
Ciba AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH1129360A external-priority patent/CH393340A/en
Application filed by Ciba AG filed Critical Ciba AG
Publication of GB928552A publication Critical patent/GB928552A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/15—Six-membered rings
    • C07D285/16—Thiadiazines; Hydrogenated thiadiazines
    • C—CHEMISTRY; METALLURGY
    • C06—EXPLOSIVES; MATCHES
    • C06B—EXPLOSIVES OR THERMIC COMPOSITIONS; MANUFACTURE THEREOF; USE OF SINGLE SUBSTANCES AS EXPLOSIVES
    • C06B47/00—Compositions in which the components are separately stored until the moment of burning or explosion, e.g. "Sprengel"-type explosives; Suspensions of solid component in a normally non-explosive liquid phase, including a thickened aqueous phase
    • C06B47/02—Compositions in which the components are separately stored until the moment of burning or explosion, e.g. "Sprengel"-type explosives; Suspensions of solid component in a normally non-explosive liquid phase, including a thickened aqueous phase the components comprising a binary propellant
    • C06B47/08—Compositions in which the components are separately stored until the moment of burning or explosion, e.g. "Sprengel"-type explosives; Suspensions of solid component in a normally non-explosive liquid phase, including a thickened aqueous phase the components comprising a binary propellant a component containing hydrazine or a hydrazine derivative
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/15—Six-membered rings
    • C07D285/16—Thiadiazines; Hydrogenated thiadiazines
    • C07D285/18—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines
    • C07D285/20—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems
    • C07D285/22—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D285/24—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with oxygen atoms directly attached to the ring sulfur atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)

Abstract

The invention comprises 4-hydrazino-2-H-1,2,3-benzothiadiazine-1 : 1-dioxides which are substituted in one or more of the 6-, 7- and 8-positions by alkyl, alkoxy, halogen or trifluoromethyl; their acid addition salts (including salts with methionine, tryptophan, lysine and arginine); the preparation thereof by reacting a 2 cyanobenzene-sulphonic acid chloride substituted in at least one of the 4-, 5- and 6-positions by alkyl, alkoxy, halogen or trifluoromethyl, with hydrazine hydrate, then subjecting the 2-sulphone-hydrazido-benzoic acid hydrazidine so produced to ring closure, if necessary in acid medium and, if desired, converting the resulting acid addition salt into the base or the resulting fue base into acid addition salts; and pharmaceutical compositions containing the heterocyclic hydrazines. The intermediate hydrazine may be isolated before ring closure. Pharmaceutical compositions comprise the compounds of the invention in admixture or in conjunction with a suitable pharmaceutical carrier and may be formulated as tablets, dragees, solutions, suspensions or emulsions and may contain other thereapeutically valuable substances. The compounds exhibit a sustained hyposensitive effect in addition to diuretic, adrenolytic and fungistatic effects.
GB3608861A 1960-10-07 1961-10-06 New heterocyclic hydrazine compounds and process for their manufacture Expired GB928552A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH1129360A CH393340A (en) 1960-10-07 1960-10-07 Process for the preparation of new 4-hydrazino-2H-1,2,3-benzothiadiazine-1,1-dioxydes
CH884061 1961-07-27

Publications (1)

Publication Number Publication Date
GB928552A true GB928552A (en) 1963-06-12

Family

ID=25703840

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3608861A Expired GB928552A (en) 1960-10-07 1961-10-06 New heterocyclic hydrazine compounds and process for their manufacture

Country Status (1)

Country Link
GB (1) GB928552A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3407197A (en) * 1966-08-10 1968-10-22 Upjohn Co 2h-1, 2, 3-benzothiadiazine-1, 1-dioxides and process for their production
US3407198A (en) * 1966-08-10 1968-10-22 Upjohn Co 2h-1, 2, 3-benzothiadiazine-1, 1-dioxides

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3407197A (en) * 1966-08-10 1968-10-22 Upjohn Co 2h-1, 2, 3-benzothiadiazine-1, 1-dioxides and process for their production
US3407198A (en) * 1966-08-10 1968-10-22 Upjohn Co 2h-1, 2, 3-benzothiadiazine-1, 1-dioxides

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