GB649358A - Improved chemotherapeutic compounds - Google Patents
Improved chemotherapeutic compoundsInfo
- Publication number
- GB649358A GB649358A GB1543448A GB1543448A GB649358A GB 649358 A GB649358 A GB 649358A GB 1543448 A GB1543448 A GB 1543448A GB 1543448 A GB1543448 A GB 1543448A GB 649358 A GB649358 A GB 649358A
- Authority
- GB
- United Kingdom
- Prior art keywords
- ethyl
- methyl
- compounds
- butyl
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Halogenated compounds of the general formula <FORM:0649358/IV (b)/1> (in which Hal is halogen, n is 1 or 2 and R is an alkyl radical containing from 1 to 8 carbon atoms) or their salts are prepared by heating until condensation is effected a halogenated hydroxybenzaldehyde with an alkyl carboxylic acid containing from 2 to 9 carbon atoms in the alkyl group or an alkali metal salt thereof. The condensation may take place in the presence of the anhydride corresponding to the acid used in the reaction and a catalyst such as potassium acetate or triethylamine. Examples are given of the preparation of a -methyl-3,5-diiodo-4-hydroxycinnamic acid and the corresponding a -ethyl-, a -n-butyl-, a -n-amyl- and a -n-octylcompounds; a -methyl-3,5-dichloro-4-hydroxycinnamic acid and the corresponding a -ethyl- and a -n-butylcompounds; a -methyl-3,5-dibromo-4-hydroxycinnamic acid and the corresponding a -ethyl- and a -n-butyl compounds; a -methyl-3-chloro-4-hydroxycinnamic acid and the corresponding a -ethyl- and a -n-butyl-compounds; a -methyl-3-bromo-4-hydroxy-cinnamic acid and the corresponding a -ethyl- and a -n-butyl-compounds; and a -n-hexyl - 3,5 - diiodo - 4 - hydroxycinnamic acid. The preparation of analogous compounds is referred to in which 3,5-diiodo-2-hydroxybenzaldehyde is substituted for the 4-hydroxy isomer.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB1543448A GB649358A (en) | 1948-06-08 | 1948-06-08 | Improved chemotherapeutic compounds |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB1543448A GB649358A (en) | 1948-06-08 | 1948-06-08 | Improved chemotherapeutic compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
GB649358A true GB649358A (en) | 1951-01-24 |
Family
ID=10059055
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB1543448A Expired GB649358A (en) | 1948-06-08 | 1948-06-08 | Improved chemotherapeutic compounds |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB649358A (en) |
-
1948
- 1948-06-08 GB GB1543448A patent/GB649358A/en not_active Expired
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