GB855022A - Improvements in and relating to carbostyril derivatives - Google Patents

Improvements in and relating to carbostyril derivatives

Info

Publication number
GB855022A
GB855022A GB24487/58A GB2448758A GB855022A GB 855022 A GB855022 A GB 855022A GB 24487/58 A GB24487/58 A GB 24487/58A GB 2448758 A GB2448758 A GB 2448758A GB 855022 A GB855022 A GB 855022A
Authority
GB
United Kingdom
Prior art keywords
general formula
compound
alkyl
alkali metal
metal salts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB24487/58A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
National Starch and Chemical Investment Holding Corp
Original Assignee
JR Geigy AG
National Starch and Chemical Investment Holding Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by JR Geigy AG, National Starch and Chemical Investment Holding Corp filed Critical JR Geigy AG
Publication of GB855022A publication Critical patent/GB855022A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Abstract

The invention comprises compounds of the general formula: <FORM:0855022/IV(b)/1> and their alkali metal salts (wherein R1 is a hydrocarbon radical in which any aromatic ring present can be substituted by halogen atoms or C1-3 alkyl or alkoxy groups, or a pyridylalkyl, thienylalkyl or furylalkyl radical; and R2 and R3 are hydrogen atoms or like or unlike C1-4 alkyl or alkoxy groups or halogen atoms), and the preparation thereof by: (1) heating a compound of the general formula: <FORM:0855022/IV(b)/2> (wherein X is a hydrocarbon radical) with a compound of the general formula: <FORM:0855022/IV(b)/3> until at least two moles of the alcohol XOH have been liberated; or (2) treating a compound of the general formula: <FORM:0855022/IV(b)/4> with an alkaline condensing agent. Compounds of formula IV above may be made by N-acylating and esterifying the corresponding N-aryl-anthranilic acids, which may be obtained by reacting alkali metal salts of o-halogen benzoic acids with suitably substituted anilines.
GB24487/58A 1957-08-06 1958-07-30 Improvements in and relating to carbostyril derivatives Expired GB855022A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH855022X 1957-08-06

Publications (1)

Publication Number Publication Date
GB855022A true GB855022A (en) 1960-11-30

Family

ID=4542604

Family Applications (1)

Application Number Title Priority Date Filing Date
GB24487/58A Expired GB855022A (en) 1957-08-06 1958-07-30 Improvements in and relating to carbostyril derivatives

Country Status (1)

Country Link
GB (1) GB855022A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0127135A2 (en) * 1983-05-31 1984-12-05 Schering Corporation Fused tricyclic derivatives of naphthyridinone and pyridone and the corresponding thiones
EP0144996A2 (en) * 1983-12-14 1985-06-19 Schering Corporation Substituted spiro pyridine derivatives, pharmaceutical compositions containing them and processes for the preparation of such compounds and compositions
US4632923A (en) * 1984-08-15 1986-12-30 Schering Corporation Substituted hetero spiro pyridine derivatives as anti-allergy and anti-inflammatory agents

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0127135A2 (en) * 1983-05-31 1984-12-05 Schering Corporation Fused tricyclic derivatives of naphthyridinone and pyridone and the corresponding thiones
EP0127135A3 (en) * 1983-05-31 1985-08-21 Schering Corporation Fused tricyclic derivatives of naphthyridinone, pyridone and quinolone and the corresponding thiones
US4680298A (en) * 1983-05-31 1987-07-14 Schering Corporation Tricyclic anti-allergy and use as anti-inflammatory agents
EP0144996A2 (en) * 1983-12-14 1985-06-19 Schering Corporation Substituted spiro pyridine derivatives, pharmaceutical compositions containing them and processes for the preparation of such compounds and compositions
EP0144996A3 (en) * 1983-12-14 1986-06-11 Schering Corporation Substituted spiro pyridine derivatives, pharmaceutical compositions containing them and processes for the preparation of such compounds and compositions
US4632923A (en) * 1984-08-15 1986-12-30 Schering Corporation Substituted hetero spiro pyridine derivatives as anti-allergy and anti-inflammatory agents

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