GB610538A - Enteric gelatin capsule shell or envelope - Google Patents
Enteric gelatin capsule shell or envelopeInfo
- Publication number
- GB610538A GB610538A GB2939445A GB2939445A GB610538A GB 610538 A GB610538 A GB 610538A GB 2939445 A GB2939445 A GB 2939445A GB 2939445 A GB2939445 A GB 2939445A GB 610538 A GB610538 A GB 610538A
- Authority
- GB
- United Kingdom
- Prior art keywords
- per cent
- phthalate
- salts
- cellulose acetate
- gelatin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
Abstract
Cellulose acetate hydrogen phthalate containing 5-25 per cent weight of free carboxyl is prepared by dissolving phthalic anhydride in pyridine, adding cellulose acetate containing 33 per cent acetyl and heating on a steam bath for 14-18 hours. The reaction mixture is diluted with acetone, poured into 5 per cent hydrochloric acid and the resultant precipitate washed and dried. In the form of its water-soluble salts it may be incorporated in gelatin capsules which, after subsequent tanning in 1 per cent aqueous formaldehyde, to render them resistant to dissolution in the stomach, are thereby capable of rapid disintegration in the intestinal secretions. The sodium, potassium, ammonium and lithium salts and salts of organic amines such as diethanolamine, ethylene diamine, diethylene triamine and triethylene tetramine are specified.ALSO:A medicinal capsule shell consists of a tanned gelatin envelope which contains in dispersed admixture with the gelatin, particles of a material resistant to dissolution in the stomach but capable of dissolving in the intestinal secretions. Such materials are the water-soluble salts of cellulose acetate hydrogen phthalate containing 5-25 per cent free carboxyl and they may be used in the proportion of 5-10 per cent wt. of the shell. Examples are the sodium, potassium, ammonium and lithium salts, and the salts of organic amides such as diethanolamine, ethylene diamine, diethylene triamine and triethylene tetramine. In an example finely ground cellulose acetate hydrogen phthalate is mixed with sufficient sodium bicarbonate to neutralize the phthalate and the mixture dissolved in water Gelatin is soaked in aqueous glycerin, the phthalate mixture added and the product maintained at 600 DEG C. The phthalate should dissolve and the pH of the solution should not exceed 7-7.5. This solution is suitable for preparing capsules which are subsequently tanned as, for example, by immersion in 1 per cent aqueous formaldehyde solution followed by washing and drying.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB2939445A GB610538A (en) | 1945-11-05 | 1945-11-05 | Enteric gelatin capsule shell or envelope |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB2939445A GB610538A (en) | 1945-11-05 | 1945-11-05 | Enteric gelatin capsule shell or envelope |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB610538A true GB610538A (en) | 1948-10-18 |
Family
ID=10290880
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2939445A Expired GB610538A (en) | 1945-11-05 | 1945-11-05 | Enteric gelatin capsule shell or envelope |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB610538A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6258380B1 (en) | 1999-03-05 | 2001-07-10 | Banner Pharmacaps, Inc. | Chewable soft capsule |
| US8097279B2 (en) | 2002-04-25 | 2012-01-17 | Banner Pharmacaps Inc. | Chewable soft capsule |
-
1945
- 1945-11-05 GB GB2939445A patent/GB610538A/en not_active Expired
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6258380B1 (en) | 1999-03-05 | 2001-07-10 | Banner Pharmacaps, Inc. | Chewable soft capsule |
| US8097279B2 (en) | 2002-04-25 | 2012-01-17 | Banner Pharmacaps Inc. | Chewable soft capsule |
| US8241665B2 (en) | 2002-04-25 | 2012-08-14 | Banner Pharmacaps, Inc. | Chewable soft capsule |
| US8414916B2 (en) | 2002-04-25 | 2013-04-09 | Banner Pharma Caps, Inc. | Chewable soft capsule |
| US8765174B2 (en) | 2002-04-25 | 2014-07-01 | Banner Pharmacaps Inc. | Chewable soft capsule |
| US9072677B2 (en) | 2002-04-25 | 2015-07-07 | Banner Life Sciences Llc | Chewable soft capsules |
| US9668976B2 (en) | 2002-04-25 | 2017-06-06 | Banner Life Sciences, LLC | Chewable soft capsules |
| US9861586B2 (en) | 2002-04-25 | 2018-01-09 | Patheon Softgels, LLC | Chewable soft capsules |
| US10342763B2 (en) | 2002-04-25 | 2019-07-09 | Patheon Softgels, Inc. | Chewable soft capsules |
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