GB397249A - Improvements relating to the production of organic salts of bismuth - Google Patents
Improvements relating to the production of organic salts of bismuthInfo
- Publication number
- GB397249A GB397249A GB1197332A GB1197332A GB397249A GB 397249 A GB397249 A GB 397249A GB 1197332 A GB1197332 A GB 1197332A GB 1197332 A GB1197332 A GB 1197332A GB 397249 A GB397249 A GB 397249A
- Authority
- GB
- United Kingdom
- Prior art keywords
- acid
- oil
- acids
- basic bismuth
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229910052797 bismuth Inorganic materials 0.000 title 1
- JCXGWMGPZLAOME-UHFFFAOYSA-N bismuth atom Chemical class [Bi] JCXGWMGPZLAOME-UHFFFAOYSA-N 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
- 239000002253 acid Substances 0.000 abstract 11
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 6
- 150000007513 acids Chemical class 0.000 abstract 6
- 150000001621 bismuth Chemical class 0.000 abstract 6
- 239000000243 solution Substances 0.000 abstract 6
- 239000003921 oil Substances 0.000 abstract 5
- 235000019198 oils Nutrition 0.000 abstract 5
- RHBYWBXANWPTJD-UHFFFAOYSA-N 1-propanoyloxycyclohexane-1-carboxylic acid Chemical compound CCC(=O)OC1(C(O)=O)CCCCC1 RHBYWBXANWPTJD-UHFFFAOYSA-N 0.000 abstract 4
- AJKHBTQKPQUKTP-UHFFFAOYSA-N 1-acetyloxycyclohexane-1-carboxylic acid Chemical compound CC(=O)OC1(C(O)=O)CCCCC1 AJKHBTQKPQUKTP-UHFFFAOYSA-N 0.000 abstract 2
- BPOVRAAUERBWFK-UHFFFAOYSA-N 1-hydroxycyclohexane-1-carboxylic acid Chemical compound OC(=O)C1(O)CCCCC1 BPOVRAAUERBWFK-UHFFFAOYSA-N 0.000 abstract 2
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical class OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 abstract 2
- 229910002651 NO3 Inorganic materials 0.000 abstract 2
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 abstract 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 abstract 2
- 150000001447 alkali salts Chemical class 0.000 abstract 2
- 150000008064 anhydrides Chemical class 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 238000000354 decomposition reaction Methods 0.000 abstract 2
- 238000002347 injection Methods 0.000 abstract 2
- 239000007924 injection Substances 0.000 abstract 2
- 235000008390 olive oil Nutrition 0.000 abstract 2
- 239000004006 olive oil Substances 0.000 abstract 2
- 238000002360 preparation method Methods 0.000 abstract 2
- RZWZRACFZGVKFM-UHFFFAOYSA-N propanoyl chloride Chemical compound CCC(Cl)=O RZWZRACFZGVKFM-UHFFFAOYSA-N 0.000 abstract 2
- 235000011149 sulphuric acid Nutrition 0.000 abstract 2
- 239000001117 sulphuric acid Substances 0.000 abstract 2
- 235000015112 vegetable and seed oil Nutrition 0.000 abstract 2
- 239000008158 vegetable oil Substances 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/94—Bismuth compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
1-Propionyloxyhexahydrobenzoic acid is made by the action of propionyl chloride or anhydride on 1-hydroxyhexahydrobenzoic acid, in the presence of sulphuric acid.ALSO:The basic bismuth salts of a -carbalkyloxycyclohexanylacetic acids, of 1-acyloxyhexahydrobenzoic acids, or of the malonic acid esters of the general formula <FORM:0397249/III/1> where R contains at least seven carbon atoms and has one or more branch chains and R<1> is an alkyl radical, are directly prepared in the form of a solution in oil by effecting a double decomposition between an inorganic basic bismuth salt such as the nitrate and an alkali salt of the acid in the presence of a vegetable oil such as olive oil. The solution in oil is extracted from the aqueous mixture with ether, the ether solution filtered and dried, and the ether then distilled off. The solution in oil may be used medicinally for injection purposes. In examples, the preparation of the basic bismuth salts of the following acids is described: a -carbethoxy-cyclohexanylacetic acid, 1-acetoxyhexahydrobenzoic acid, 1-propionyloxyhexahydrobenzoic acid, and a -carboxyethyl-b -methylnonoic acid. 1-Propionyloxyhexahydrobenzoic acid is made by the action of propionyl chloride or anhydride on 1-hydroxyhexahydrobenzoic acid, in the presence of sulphuric acid.ALSO:Solutions in oil of the basic bismuth salts of a -carbalkyloxycyclohexanylacetic acids, of 1-acyloxyhexahydrobenzoic acids, or of the malonic acid esters of the general formula <FORM:0397249/VI/1> where R contains at least seven carbon atoms and has one or more branch chains and R1 is an alkyl radical, are prepared by effecting a double decomposition between a basic bismuth salt such as the nitrate and an alkali salt of the acid in the presence of a vegetable oil such as olive oil. The solution in oil may be used medicinally for injection purposes. In examples, the preparation of the basic bismuth salts of the following acids is described: a -carbethoxycyclohexanylacetic acid, 1-acetoxyhexahydrobenzoic acid, 1-propionyloxyhexahydrobenzoic acid, and a -carboxyethyl-b -methyl nonoic acid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1197332A GB397249A (en) | 1932-04-26 | 1932-04-26 | Improvements relating to the production of organic salts of bismuth |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1197332A GB397249A (en) | 1932-04-26 | 1932-04-26 | Improvements relating to the production of organic salts of bismuth |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB397249A true GB397249A (en) | 1933-08-24 |
Family
ID=9996059
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1197332A Expired GB397249A (en) | 1932-04-26 | 1932-04-26 | Improvements relating to the production of organic salts of bismuth |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB397249A (en) |
-
1932
- 1932-04-26 GB GB1197332A patent/GB397249A/en not_active Expired
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