GB2079755B - Androstene 17 -carbonate 17 -carboxylates (and carbothioates) - Google Patents

Androstene 17 -carbonate 17 -carboxylates (and carbothioates)

Info

Publication number
GB2079755B
GB2079755B GB8120864A GB8120864A GB2079755B GB 2079755 B GB2079755 B GB 2079755B GB 8120864 A GB8120864 A GB 8120864A GB 8120864 A GB8120864 A GB 8120864A GB 2079755 B GB2079755 B GB 2079755B
Authority
GB
United Kingdom
Prior art keywords
carbothioates
androstene
carboxylates
carbonate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB8120864A
Other versions
GB2079755A (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Publication of GB2079755A publication Critical patent/GB2079755A/en
Application granted granted Critical
Publication of GB2079755B publication Critical patent/GB2079755B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J33/00—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J33/002—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
GB8120864A 1980-07-10 1981-07-06 Androstene 17 -carbonate 17 -carboxylates (and carbothioates) Expired GB2079755B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16845380A 1980-07-10 1980-07-10
US26578581A 1981-05-21 1981-05-21

Publications (2)

Publication Number Publication Date
GB2079755A GB2079755A (en) 1982-01-27
GB2079755B true GB2079755B (en) 1985-01-30

Family

ID=26864131

Family Applications (1)

Application Number Title Priority Date Filing Date
GB8120864A Expired GB2079755B (en) 1980-07-10 1981-07-06 Androstene 17 -carbonate 17 -carboxylates (and carbothioates)

Country Status (17)

Country Link
KR (2) KR860000266B1 (en)
AT (1) AT379816B (en)
AU (1) AU540898B2 (en)
CA (1) CA1174667A (en)
CH (1) CH648856A5 (en)
DE (1) DE3126732A1 (en)
DK (1) DK165837C (en)
ES (2) ES8300785A1 (en)
FI (1) FI71748C (en)
FR (1) FR2486529A1 (en)
GB (1) GB2079755B (en)
IT (1) IT1205446B (en)
NL (1) NL192343C (en)
NO (1) NO163285C (en)
PH (1) PH25874A (en)
PT (1) PT73348B (en)
SE (1) SE449106B (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009513533A (en) * 2003-07-11 2009-04-02 グラクソ グループ リミテッド Certain glucocorticosteroid compounds with anti-inflammatory activity
US8163723B2 (en) 2002-06-14 2012-04-24 Cipla Limited Combination of azelastine and steroids

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2137206B (en) * 1980-02-15 1985-04-03 Glaxo Group Ltd Androstane 17-carbothioc acid derivatives
JPS6041607A (en) * 1983-08-12 1985-03-05 Otsuka Pharmaceut Co Ltd Ointment base
IL78144A0 (en) * 1985-04-04 1986-07-31 Draco Ab Novel androstane-17beta-carboxylic acid esters
SE8501693D0 (en) * 1985-04-04 1985-04-04 Draco Ab NOVEL 16,17-ACETALSUBSTITUTED ANDROSTANE-17BETA-CARBOXYLIC ACID ESTERS
EP0334853B1 (en) * 1987-10-13 1993-06-09 BODOR, Nicholas S. Soft steroids having anti-inflammatory activity
DE4025342A1 (en) * 1990-08-10 1992-02-13 Hoechst Ag CORTICOID-17-ALKYLCARBONATE SUBSTITUTED IN 17-POSITION, METHOD FOR THE PRODUCTION THEREOF, AND MEDICINAL PRODUCTS CONTAINING THE SAME
JP2000513380A (en) * 1997-06-30 2000-10-10 グラクソ、グループ、リミテッド Compound
US6777399B2 (en) 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6759398B2 (en) 2000-08-05 2004-07-06 Smithkline Beecham Corporation Anti-inflammatory androstane derivative
US6777400B2 (en) 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6858593B2 (en) 2000-08-05 2005-02-22 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6750210B2 (en) 2000-08-05 2004-06-15 Smithkline Beecham Corporation Formulation containing novel anti-inflammatory androstane derivative
BRPI0113042B8 (en) 2000-08-05 2021-05-25 Glaxo Group Ltd compound of the formula or a physiologically acceptable solvate thereof, use thereof, pharmaceutical composition, pharmaceutical formulation, method of treating a human or animal subject with an inflammatory and/or allergic condition, and, process for preparing a compound or a solvate thereof
US6787532B2 (en) 2000-08-05 2004-09-07 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivatives
US6858596B2 (en) 2000-08-05 2005-02-22 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivative
GB0019172D0 (en) 2000-08-05 2000-09-27 Glaxo Group Ltd Novel compounds
UA77656C2 (en) 2001-04-07 2007-01-15 Glaxo Group Ltd S-fluoromethyl ester of 6-alpha, 9-alpha-difluoro-17-alpha-[(2-furanylcarbonyl)oxy]-11-beta-hydroxy-16- alpha-methyl-3-oxoandrosta-1,4-dien-17-beta-carbothioacid as anti-inflammatory agent
UA82323C2 (en) * 2002-08-09 2008-04-10 Меда Фарма Гмбх & Ко. Кг Novel combination of a glucocorticoid and pde-inhibitor for the treatment of respiratory diseases, allergic diseases, asthma and chronic obstructive pulmonary diseases
JP5281291B2 (en) 2005-01-10 2013-09-04 グラクソ グループ リミテッド New compounds
TWI374147B (en) * 2006-01-27 2012-10-11 Sun Pharma Advance Res Company Ltd Novel 11β-hydroxyandrosta-4-ene-3-ones
US7687484B2 (en) * 2006-05-25 2010-03-30 Bodor Nicholas S Transporter enhanced corticosteroid activity
US7691811B2 (en) * 2006-05-25 2010-04-06 Bodor Nicholas S Transporter-enhanced corticosteroid activity and methods and compositions for treating dry eye
CN101942001B (en) * 2010-08-24 2013-02-06 山东省医药工业研究所 Purification method of loteprednol etabonate
CN103183714A (en) * 2011-12-29 2013-07-03 山东方明药业集团股份有限公司 Synthetic method for loteprednol

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1384372A (en) * 1971-01-20 1975-02-19 Glaxo Lab Ltd Dereivatives of 17alpha-hydroxyandrost-4-ene-17beta-carboxylic acids
GB1438940A (en) * 1972-07-19 1976-06-09 Glaxo Lab Ltd 17beta-haloalkoxycarbonyl-17alpha-oxysteroids
GB1514476A (en) * 1974-08-30 1978-06-14 Glaxo Lab Ltd Alkyl and haloalkyl androst-4-ene and androsta-1,4-diene-17beta-carboxylates
DE2735110A1 (en) * 1977-08-04 1979-02-15 Hoechst Ag CORTICOID-17-ALKYLCARBONATE AND METHOD FOR THE PRODUCTION THEREOF
IT1114534B (en) * 1978-02-08 1986-01-27 Glaxo Group Ltd ANTI-INFLAMMATORY STEROID OF THE ANDROSTANE SERIES COMPOSITIONS THAT CONTAIN IT AND PROCEDURE TO PRODUCE IT
US4188385A (en) * 1978-04-05 1980-02-12 Syntex (U.S.A.) Inc. Thioetianic acid derivatives
DE2817988A1 (en) * 1978-04-25 1979-11-08 Hoechst Ag CORTICOID 17-ALKYLCARBONATE AND METHOD FOR THE PRODUCTION THEREOF

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8163723B2 (en) 2002-06-14 2012-04-24 Cipla Limited Combination of azelastine and steroids
US8168620B2 (en) 2002-06-14 2012-05-01 Cipla Limited Combination of azelastine and steroids
US8304405B2 (en) 2002-06-14 2012-11-06 Cipla Limited Combination of azelastine and ciclesonide for nasal administration
US8318709B2 (en) 2002-06-14 2012-11-27 Cipla Limited Combination of azelastine and mometasone for nasal administration
JP2009513533A (en) * 2003-07-11 2009-04-02 グラクソ グループ リミテッド Certain glucocorticosteroid compounds with anti-inflammatory activity
JP2009514781A (en) * 2003-07-11 2009-04-09 グラクソ グループ リミテッド Certain glucocorticosteroid compounds with anti-inflammatory activity
JP4709751B2 (en) * 2003-07-11 2011-06-22 グラクソ グループ リミテッド Certain glucocorticosteroid compounds with anti-inflammatory activity
JP4709752B2 (en) * 2003-07-11 2011-06-22 グラクソ グループ リミテッド Certain glucocorticosteroid compounds with anti-inflammatory activity

Also Published As

Publication number Publication date
KR850002759A (en) 1985-05-15
ES504340A0 (en) 1982-12-01
DE3126732C2 (en) 1987-04-30
NO812344L (en) 1982-01-11
NL8103315A (en) 1982-02-01
NO163285B (en) 1990-01-22
IT8105186A0 (en) 1981-07-09
DK165837B (en) 1993-01-25
FI71748B (en) 1986-10-31
NO163285C (en) 1990-05-02
ES8300785A1 (en) 1982-12-01
AU7259181A (en) 1982-01-14
NL192343C (en) 1997-06-04
FI812175L (en) 1982-01-11
ATA307081A (en) 1985-07-15
DK302181A (en) 1982-01-11
ES8306767A1 (en) 1983-06-16
ES514633A0 (en) 1983-06-16
NL192343B (en) 1997-02-03
SE449106B (en) 1987-04-06
KR860000266B1 (en) 1986-03-22
AT379816B (en) 1986-03-10
AU540898B2 (en) 1984-12-06
GB2079755A (en) 1982-01-27
KR830006327A (en) 1983-09-24
CA1174667A (en) 1984-09-18
KR860000452B1 (en) 1986-04-26
PH25874A (en) 1991-12-02
FI71748C (en) 1987-02-09
FR2486529A1 (en) 1982-01-15
SE8104132L (en) 1982-01-11
FR2486529B1 (en) 1985-01-04
CH648856A5 (en) 1985-04-15
PT73348B (en) 1982-09-23
PT73348A (en) 1981-08-01
IT1205446B (en) 1989-03-23
DK165837C (en) 1993-06-21
DE3126732A1 (en) 1982-03-25

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Legal Events

Date Code Title Description
732 Registration of transactions, instruments or events in the register (sect. 32/1977)
732 Registration of transactions, instruments or events in the register (sect. 32/1977)
PE20 Patent expired after termination of 20 years

Effective date: 20010705