GB1539473A - N-aryl-n-(1-l-4-piperidinyl)-arylacetamides - Google Patents
N-aryl-n-(1-l-4-piperidinyl)-arylacetamidesInfo
- Publication number
- GB1539473A GB1539473A GB39099/76A GB3909976A GB1539473A GB 1539473 A GB1539473 A GB 1539473A GB 39099/76 A GB39099/76 A GB 39099/76A GB 3909976 A GB3909976 A GB 3909976A GB 1539473 A GB1539473 A GB 1539473A
- Authority
- GB
- United Kingdom
- Prior art keywords
- arylacetamides
- piperidinyl
- aryl
- formula
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
- C07D211/66—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having a hetero atom as the second substituent in position 4
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
N-Aryl-N-(4-piperidinyl)arylacetamides of the formula <IMAGE> and their salts with acids, the substituents in the formula being defined in Claim 1, are prepared. These compounds are obtained by acylating corresponding piperidine derivatives with an arylacetyl halide. The resulting compounds can be used for the drug therapy of cardiac arrhythmias.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61513175A | 1975-09-23 | 1975-09-23 | |
| US71375676A | 1976-08-12 | 1976-08-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1539473A true GB1539473A (en) | 1979-01-31 |
Family
ID=27087421
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB39099/76A Expired GB1539473A (en) | 1975-09-23 | 1976-09-21 | N-aryl-n-(1-l-4-piperidinyl)-arylacetamides |
Country Status (29)
| Country | Link |
|---|---|
| JP (1) | JPS6016417B2 (en) |
| AT (1) | AT363935B (en) |
| AU (1) | AU510029B2 (en) |
| BG (1) | BG27543A3 (en) |
| CA (1) | CA1068271A (en) |
| CH (1) | CH628623A5 (en) |
| CS (1) | CS222663B2 (en) |
| DE (1) | DE2642856A1 (en) |
| DK (1) | DK150478C (en) |
| ES (1) | ES451768A1 (en) |
| FI (1) | FI61482C (en) |
| FR (1) | FR2325377A1 (en) |
| GB (1) | GB1539473A (en) |
| GR (1) | GR58469B (en) |
| HU (1) | HU172964B (en) |
| IE (1) | IE43802B1 (en) |
| IL (1) | IL50522A (en) |
| IT (1) | IT1073893B (en) |
| LU (1) | LU75837A1 (en) |
| NL (1) | NL187267C (en) |
| NO (1) | NO147672C (en) |
| NZ (1) | NZ181972A (en) |
| PH (1) | PH12497A (en) |
| PL (2) | PL117323B1 (en) |
| PT (1) | PT65631B (en) |
| RO (1) | RO70079A (en) |
| SE (1) | SE427839B (en) |
| SU (1) | SU747424A3 (en) |
| YU (1) | YU39973B (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8791120B2 (en) | 2007-02-13 | 2014-07-29 | Janssen Pharmaceutica Nv | Fast-dissociating dopamine 2 receptor antagonists |
| US8895562B2 (en) | 2008-07-31 | 2014-11-25 | Janssen Pharmaceutica Nv | Piperazin-1-yl-trifluoromethyl-substituted-pyridines as fast dissociating dopamine 2 receptor antagonists |
| US8906921B2 (en) | 2007-04-23 | 2014-12-09 | Janssen Pharmaceutica Nv | 4-alkoxypyridazine derivatives as fast dissociating dopamine 2 receptor antagonists |
| US8933101B2 (en) | 2007-04-23 | 2015-01-13 | Janssen Pharmaceutica Nv | Thia(dia)zoles as fast dissociating dopamine 2 receptor antagonists |
| US8940743B2 (en) | 2005-10-26 | 2015-01-27 | Janssen Pharmaceutica Nv | Piperidin-4-yl-pyridazin-3-ylamine derivatives as fast dissociating dopamine 2 receptor antagonists |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA765684B (en) * | 1975-09-23 | 1978-04-26 | Janssen Pharmaceutica Nv | Novel n-aryl-n-(1-l-4-piperidinyl)-arylacetamides |
| JPS62260786A (en) * | 1986-05-08 | 1987-11-13 | 株式会社ヘキトク | Line system for manufacturing smoked roof tile |
| JO2642B1 (en) | 2006-12-08 | 2012-06-17 | جانسين فارماسوتيكا ان. في | Fast Dissociating Dopamine 2 Receptor Antagonists |
| EP2148872A1 (en) * | 2007-04-23 | 2010-02-03 | Janssen Pharmaceutica, N.V. | Pyridine derivatives as fast dissociating dopamine 2 receptor antagonists |
| CN102159554B (en) | 2008-07-03 | 2014-09-24 | 詹森药业有限公司 | Substituted 6- (1-piperazinyl) -pyridazines as 5-ht6 receptor antagonists |
-
1976
- 1976-09-06 NO NO763054A patent/NO147672C/en unknown
- 1976-09-08 NZ NZ181972A patent/NZ181972A/en unknown
- 1976-09-16 FR FR7627870A patent/FR2325377A1/en active Granted
- 1976-09-17 AU AU17878/76A patent/AU510029B2/en not_active Expired
- 1976-09-20 RO RO7687590A patent/RO70079A/en unknown
- 1976-09-20 LU LU75837A patent/LU75837A1/xx unknown
- 1976-09-20 CA CA261,551A patent/CA1068271A/en not_active Expired
- 1976-09-21 GB GB39099/76A patent/GB1539473A/en not_active Expired
- 1976-09-21 JP JP51112527A patent/JPS6016417B2/en not_active Expired
- 1976-09-21 IT IT51370/76A patent/IT1073893B/en active
- 1976-09-21 GR GR51742A patent/GR58469B/en unknown
- 1976-09-21 IL IL50522A patent/IL50522A/en unknown
- 1976-09-21 CH CH1194876A patent/CH628623A5/en not_active IP Right Cessation
- 1976-09-22 SE SE7610501A patent/SE427839B/en not_active IP Right Cessation
- 1976-09-22 PL PL1976216213A patent/PL117323B1/en unknown
- 1976-09-22 YU YU2336/76A patent/YU39973B/en unknown
- 1976-09-22 HU HU76JA00000767A patent/HU172964B/en not_active IP Right Cessation
- 1976-09-22 ES ES451768A patent/ES451768A1/en not_active Expired
- 1976-09-22 FI FI762698A patent/FI61482C/en not_active IP Right Cessation
- 1976-09-22 IE IE2095/76A patent/IE43802B1/en unknown
- 1976-09-22 PL PL19257876A patent/PL192578A1/en not_active IP Right Cessation
- 1976-09-22 AT AT0702976A patent/AT363935B/en not_active IP Right Cessation
- 1976-09-22 DK DK427876A patent/DK150478C/en active
- 1976-09-22 PH PH18928A patent/PH12497A/en unknown
- 1976-09-22 CS CS766139A patent/CS222663B2/en unknown
- 1976-09-22 PT PT65631A patent/PT65631B/en unknown
- 1976-09-22 NL NLAANVRAGE7610513,A patent/NL187267C/en not_active IP Right Cessation
- 1976-09-23 DE DE19762642856 patent/DE2642856A1/en active Granted
- 1976-09-23 SU SU762405548A patent/SU747424A3/en active
- 1976-09-23 BG BG7634265A patent/BG27543A3/en unknown
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8940743B2 (en) | 2005-10-26 | 2015-01-27 | Janssen Pharmaceutica Nv | Piperidin-4-yl-pyridazin-3-ylamine derivatives as fast dissociating dopamine 2 receptor antagonists |
| US9468640B2 (en) | 2005-10-26 | 2016-10-18 | Janssen Pharmaceutica Nv | Piperidin-4-yl-pyridazin-3-ylamine derivatives as fast dissociating dopamine 2 receptor antagonists |
| US9751860B2 (en) | 2005-10-26 | 2017-09-05 | Janssen Pharmaceutica Nv | Piperidin-4YL-pyridazin-3-ylamine derivatives as fast dissociating dopamine 2 receptor antagonists |
| US8791120B2 (en) | 2007-02-13 | 2014-07-29 | Janssen Pharmaceutica Nv | Fast-dissociating dopamine 2 receptor antagonists |
| US9422296B2 (en) | 2007-02-13 | 2016-08-23 | Janssen Pharmaceutica Nv | Fast-dissociating dopamine 2 receptor antagonists |
| US8906921B2 (en) | 2007-04-23 | 2014-12-09 | Janssen Pharmaceutica Nv | 4-alkoxypyridazine derivatives as fast dissociating dopamine 2 receptor antagonists |
| US8933101B2 (en) | 2007-04-23 | 2015-01-13 | Janssen Pharmaceutica Nv | Thia(dia)zoles as fast dissociating dopamine 2 receptor antagonists |
| US8895562B2 (en) | 2008-07-31 | 2014-11-25 | Janssen Pharmaceutica Nv | Piperazin-1-yl-trifluoromethyl-substituted-pyridines as fast dissociating dopamine 2 receptor antagonists |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| 704A | Declaration that licence is not available as of right for an excepted use (par. 4a/1977) | ||
| PCNP | Patent ceased through non-payment of renewal fee |