GB1542514A - 1-(benzazolylalkyl)piperidine derivatives - Google Patents

1-(benzazolylalkyl)piperidine derivatives

Info

Publication number
GB1542514A
GB1542514A GB7627242A GB2724276A GB1542514A GB 1542514 A GB1542514 A GB 1542514A GB 7627242 A GB7627242 A GB 7627242A GB 2724276 A GB2724276 A GB 2724276A GB 1542514 A GB1542514 A GB 1542514A
Authority
GB
United Kingdom
Prior art keywords
benzazolylalkyl
formula
piperidine derivatives
salts
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB7627242A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/687,139 external-priority patent/US4066772A/en
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Publication of GB1542514A publication Critical patent/GB1542514A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/26—Oxygen atoms

Abstract

1-(Benzazolylalkyl)piperidine derivatives of formula I <IMAGE> and their salts are prepared by subjecting an amine of formula <IMAGE> to N-alkylation to introduce the corresponding substituted alkyl radical. In the compounds of formula I, the substituents have the meanings given in Patent Claim 1. These compounds and their salts have a spasmolytic action and they are in particular used in agents to prevent vomiting.
GB7627242A 1975-07-21 1976-06-30 1-(benzazolylalkyl)piperidine derivatives Expired GB1542514A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US59779375A 1975-07-21 1975-07-21
US05/687,139 US4066772A (en) 1975-07-21 1976-05-17 1,3-Dihydro-1-[3-(1-piperidinyl)propyl]-2H-benzimidazol-2-ones and related compounds
KR7601697A KR810000334B1 (en) 1975-07-21 1976-07-12 Process for preparation 1-(benzazolylalkyl)-piperidine derivatives

Publications (1)

Publication Number Publication Date
GB1542514A true GB1542514A (en) 1979-03-21

Family

ID=27348142

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7627242A Expired GB1542514A (en) 1975-07-21 1976-06-30 1-(benzazolylalkyl)piperidine derivatives

Country Status (25)

Country Link
JP (1) JPS5217475A (en)
AT (1) AT364358B (en)
AU (1) AU511027B2 (en)
BG (1) BG26526A3 (en)
CA (1) CA1085852A (en)
CH (1) CH623820A5 (en)
CS (1) CS202550B2 (en)
DE (1) DE2632870A1 (en)
DK (1) DK154950C (en)
ES (3) ES449740A1 (en)
FI (1) FI62667C (en)
GB (1) GB1542514A (en)
HK (1) HK14180A (en)
IE (1) IE43496B1 (en)
IT (1) IT1062614B (en)
KE (1) KE3215A (en)
LU (1) LU75354A1 (en)
MY (1) MY8100017A (en)
NL (1) NL187442C (en)
NZ (1) NZ181256A (en)
PH (1) PH13710A (en)
PT (1) PT65387B (en)
RO (1) RO70566A (en)
SE (2) SE426490B (en)
YU (1) YU39969B (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4501749A (en) * 1983-10-31 1985-02-26 Merck & Co., Inc. Peripherally selective dopamine antagonists in the treatment of ocular hypertension
WO2004105765A1 (en) * 2003-05-27 2004-12-09 Janssen Pharmaceutica N.V. Macrocyclic quinazoline derivatives as antiproliferative agents
US8318731B2 (en) 2007-07-27 2012-11-27 Janssen Pharmaceutica Nv Pyrrolopyrimidines
US8492377B2 (en) 2006-07-13 2013-07-23 Janssen Pharmaceutica Nv MTKI quinazoline derivatives
US8772272B2 (en) 2003-12-18 2014-07-08 Janssen Pharmaceutica Nv Pyrido-and pyrimidopyrimidine derivatives as anti-proliferative agents
US8846929B2 (en) 2007-08-31 2014-09-30 Purdue Pharma L.P. Substituted-quinoxaline-type piperidine compounds and the uses thereof
US9688691B2 (en) 2004-12-08 2017-06-27 Janssen Pharmaceutica Nv Macrocyclic quinazole derivatives and their use as MTKI

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6248684A (en) * 1985-08-26 1987-03-03 Sumitomo Chem Co Ltd Novel iodobutyrophenone derivative and production thereof
JPS62251313A (en) * 1986-04-25 1987-11-02 信越ポリマー株式会社 Bundling device
US6355659B1 (en) 1994-07-29 2002-03-12 Laboratorios Del Dr. Esteve, S.A. 4-(4-Chlorophenyl)-1236-tetrahydro-1(1H-124-triazol-1-yl)butty)pyrideine and salts thereof; pharmaceutical compositions and method of treating psychoses utilizing same
FR2723091B1 (en) * 1994-07-29 1996-11-08 Esteve Labor Dr TETRAHYDROPYRIDINE- (6,4-HYDROXYPIPERIDINE) ALKYLAZOLES
EP1997805A1 (en) * 2007-06-01 2008-12-03 Commissariat à l'Energie Atomique Compounds with antiparasitic activity, applications thereof to the treatment of infectious diseases caused by apicomplexans
US9090618B2 (en) 2012-12-27 2015-07-28 Purdue Pharma L.P. Substituted benzimidazole-type piperidine compounds and uses thereof
CN108697700B (en) * 2016-02-04 2021-08-17 辛多美制药有限公司 Deuterated domperidone composition and method for treating disorders
US11364226B2 (en) 2017-06-30 2022-06-21 Cinrx Pharma, Llc Deuterated domperidone compositions, methods, and preparation

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE633495A (en) * 1962-06-13
BE633914A (en) * 1962-06-22
US3629267A (en) * 1968-10-28 1971-12-21 Smith Kline French Lab Benzoheterocyclicalkyl derivatives of 4-(2-keto -1-benzimidazolinyl)-piperidine 4-(2-keto - 1 - benzimidazolinyl) -1 2 3 6 tetrahydropyridine 1 - phenyl - 1 3 8-triazaspiro(4 5)decan - 4 - one and 2 4 9-triazaspiro(5 5)undecan-1 3 5-trione
AU4698672A (en) * 1972-09-22 1972-11-09 Ciba-Geigy Ag Azacycloaliphatic compounds, process for their manufacture and compositions containing them
FR2218100A1 (en) * 1973-02-20 1974-09-13 Janssen Pharmaceutica Nv Neuroleptic tricyclic derivs. - of benzimidazolinones and triazaspiro-4,5-decan-4-ones
US3989707A (en) * 1974-06-21 1976-11-02 Janssen Pharmaceutica N.V. Benzimidazolinone derivatives

Cited By (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4501749A (en) * 1983-10-31 1985-02-26 Merck & Co., Inc. Peripherally selective dopamine antagonists in the treatment of ocular hypertension
EP0140789A2 (en) * 1983-10-31 1985-05-08 Merck & Co. Inc. Use of peripherally selective dopamine antagonists for the preparation of a medicament for the topical treatment of ocular hypertension
EP0140789A3 (en) * 1983-10-31 1987-12-02 Merck & Co. Inc. Ophthalmic composition containing a peripherally selective dopamine antagonist, for the treatment of ocular hypertension
US8394786B2 (en) 2003-05-27 2013-03-12 Janssen Pharmaceutica N.V. Quinazoline derivatives
EA009064B1 (en) * 2003-05-27 2007-10-26 Янссен Фармацевтика Н. В. Macrocyclic quinazoline derivatives as antiproliferative agents
AU2004243487B2 (en) * 2003-05-27 2009-12-03 Janssen Pharmaceutica N.V. Macrocyclic quinazoline derivatives as antiproliferative agents
US7648975B2 (en) 2003-05-27 2010-01-19 Janssen Pharmaceutica N.V. Macrocyclic quinazoline derivatives as antiproliferative agents
EP2305687A1 (en) * 2003-05-27 2011-04-06 Janssen Pharmaceutica NV Quinazoline derivatives
KR101143878B1 (en) * 2003-05-27 2012-05-24 얀센 파마슈티카 엔.브이. Macrocyclic quinazoline derivatives as antiproliferative agents
US9273013B2 (en) 2003-05-27 2016-03-01 Janssen Pharmaceutica Nv Quinazoline derivatives
WO2004105765A1 (en) * 2003-05-27 2004-12-09 Janssen Pharmaceutica N.V. Macrocyclic quinazoline derivatives as antiproliferative agents
US8772272B2 (en) 2003-12-18 2014-07-08 Janssen Pharmaceutica Nv Pyrido-and pyrimidopyrimidine derivatives as anti-proliferative agents
US8933067B2 (en) 2003-12-18 2015-01-13 Janssen Pharmaceutica Nv Pyrido and pyrimidopyrimidine derivatives as anti-profilerative agents
US9688691B2 (en) 2004-12-08 2017-06-27 Janssen Pharmaceutica Nv Macrocyclic quinazole derivatives and their use as MTKI
US10208062B2 (en) 2004-12-08 2019-02-19 Janssen Pharmaceutica Nv Macrocyclic quinazole derivatives and their use as MTKI
US8492377B2 (en) 2006-07-13 2013-07-23 Janssen Pharmaceutica Nv MTKI quinazoline derivatives
US8318731B2 (en) 2007-07-27 2012-11-27 Janssen Pharmaceutica Nv Pyrrolopyrimidines
US8846929B2 (en) 2007-08-31 2014-09-30 Purdue Pharma L.P. Substituted-quinoxaline-type piperidine compounds and the uses thereof
US9278967B2 (en) 2007-08-31 2016-03-08 Purdue Pharma L.P. Substituted-quinoxaline-type piperidine compounds and the uses thereof
US9527840B2 (en) 2007-08-31 2016-12-27 Purdue Pharma L.P. Substituted-quinoxaline-type piperidine compounds and the uses thereof

Also Published As

Publication number Publication date
ES461630A1 (en) 1978-06-16
ES449740A1 (en) 1978-02-16
MY8100017A (en) 1981-12-31
KE3215A (en) 1982-07-09
SE7608265L (en) 1977-01-22
NL187442B (en) 1991-05-01
LU75354A1 (en) 1977-02-28
AT364358B (en) 1981-10-12
JPS5217475A (en) 1977-02-09
JPS6131109B2 (en) 1986-07-17
SE8008713L (en) 1980-12-11
CA1085852A (en) 1980-09-16
FI62667C (en) 1983-02-10
BG26526A3 (en) 1979-04-12
IE43496L (en) 1977-01-21
AU1596476A (en) 1978-01-19
ATA534776A (en) 1981-03-15
DK327576A (en) 1977-01-22
DK154950C (en) 1989-05-29
SE426490B (en) 1983-01-24
PT65387A (en) 1976-08-01
FI62667B (en) 1982-10-29
PT65387B (en) 1978-06-09
YU179476A (en) 1983-01-21
CS202550B2 (en) 1981-01-30
NL7608023A (en) 1977-01-25
PH13710A (en) 1980-09-09
SE435621B (en) 1984-10-08
YU39969B (en) 1985-06-30
FI762086A (en) 1977-01-22
DE2632870C2 (en) 1989-02-16
CH623820A5 (en) 1981-06-30
NL187442C (en) 1991-10-01
RO70566A (en) 1982-10-11
HK14180A (en) 1980-03-28
DE2632870A1 (en) 1977-02-10
NZ181256A (en) 1978-04-28
ES461631A1 (en) 1978-12-01
IE43496B1 (en) 1981-03-11
IT1062614B (en) 1984-10-20
DK154950B (en) 1989-01-09
AU511027B2 (en) 1980-07-24

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Legal Events

Date Code Title Description
PS Patent sealed
704A Declaration that licence is not available as of right for an excepted use (par. 4a/1977)
PE20 Patent expired after termination of 20 years

Effective date: 19960629