GB1492528A - Pyrazinyl piperazine derivatives - Google Patents

Pyrazinyl piperazine derivatives

Info

Publication number
GB1492528A
GB1492528A GB15644/76A GB1564476A GB1492528A GB 1492528 A GB1492528 A GB 1492528A GB 15644/76 A GB15644/76 A GB 15644/76A GB 1564476 A GB1564476 A GB 1564476A GB 1492528 A GB1492528 A GB 1492528A
Authority
GB
United Kingdom
Prior art keywords
pyrazinyl
compounds
piperazine derivatives
prepared
appropriate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB15644/76A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of GB1492528A publication Critical patent/GB1492528A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/20—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Novel piperazinylpyrazines of the formula <IMAGE> in which the substituents are defined in Claim 1, and their N-oxides are prepared. These compounds are obtained by reacting an appropriate pyrazine or its N-oxide, which contains an easily removable group in the 2-position, which is defined in Claim 1, with an appropriate piperazine. The compounds III are also prepared as acid addition salts. The compounds obtained can be used in pharmaceutical compositions having anorexic action.
GB15644/76A 1975-04-21 1976-04-15 Pyrazinyl piperazine derivatives Expired GB1492528A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US57005275A 1975-04-21 1975-04-21

Publications (1)

Publication Number Publication Date
GB1492528A true GB1492528A (en) 1977-11-23

Family

ID=24277994

Family Applications (1)

Application Number Title Priority Date Filing Date
GB15644/76A Expired GB1492528A (en) 1975-04-21 1976-04-15 Pyrazinyl piperazine derivatives

Country Status (36)

Country Link
JP (1) JPS51136688A (en)
AR (1) AR210349A1 (en)
AT (1) AT353795B (en)
AU (1) AU496854B2 (en)
BE (1) BE840904A (en)
BG (1) BG34185A3 (en)
CA (1) CA1059128A (en)
CH (1) CH619462A5 (en)
CS (1) CS195726B2 (en)
CY (1) CY1090A (en)
DD (1) DD124599A5 (en)
DE (1) DE2617205C3 (en)
DK (1) DK143899C (en)
EG (1) EG12387A (en)
ES (4) ES447150A1 (en)
FI (1) FI62666C (en)
FR (1) FR2308367A1 (en)
GB (1) GB1492528A (en)
GR (1) GR59900B (en)
HK (1) HK60380A (en)
HU (1) HU172684B (en)
IE (1) IE42979B1 (en)
IL (1) IL49391A (en)
KE (1) KE3088A (en)
LU (1) LU74795A1 (en)
MY (1) MY8100225A (en)
NL (1) NL167692C (en)
NO (1) NO146599C (en)
PH (1) PH12274A (en)
PL (1) PL99664B1 (en)
PT (1) PT65027B (en)
RO (1) RO73278A (en)
SE (1) SE421695B (en)
SU (1) SU638260A3 (en)
YU (1) YU100676A (en)
ZA (1) ZA762320B (en)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4252816A (en) * 1979-12-03 1981-02-24 Merck & Co., Inc. Tetrahydro-1H-1,4-diazepino(1,7-a)benzimidazoles useful as analgesic agents
US4339579A (en) 1980-12-29 1982-07-13 American Home Products Corporation 2,6-Bis-(pyrrolopyrazinyl)pyrazines
EP0094498A2 (en) * 1982-05-06 1983-11-23 American Cyanamid Company Antiatherosclerotic 1-piperazine derivatives
US4788290A (en) * 1987-12-11 1988-11-29 American Home Products Corporation Serotonergic pyrazine derivatives
WO1999021834A1 (en) * 1997-10-27 1999-05-06 Neurosearch A/S Heteroaryl diazacycloalkanes as cholinergic ligands at nicotinic acetylcholine receptors
WO2000064885A1 (en) * 1999-04-26 2000-11-02 Neurosearch A/S Heteroaryl diazacycloalkanes, their preparation and use
WO2003000666A1 (en) * 2001-06-21 2003-01-03 Pfizer Products Inc. 5-ht receptor ligands and uses thereof
WO2004009586A1 (en) * 2002-07-19 2004-01-29 Biovitrum Ab Novel piperazinyl-pyrazinone derivatives for the treatment of 5-ht2a receptor-related disorders
EA007539B1 (en) * 2002-07-19 2006-10-27 Биовитрум Аб Novel pyrazinone derivatives for the treatment of 5-htreceptor-related disorders

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4091098A (en) * 1977-04-25 1978-05-23 Merck & Co., Inc. 3-(1-PIPERAZINYL)-1,2,4-BENZOTRIAZINES AND N-oxides
US4163849A (en) 1978-03-17 1979-08-07 Merck & Co., Inc. Piperazinylpyrazines
US4547505A (en) * 1983-03-25 1985-10-15 Degussa Aktiengesellschaft N-Phenyl-N-'-cycloalkylalkanoylpiperazine useful as analgetics and process for its production
EP0580465A1 (en) * 1992-06-25 1994-01-26 Sanofi New therapeutic use of heterocyclic piperazines as 5-HT3 agonists and new derivatives
EE200200453A (en) * 2000-02-16 2003-12-15 Neurogen Corporation Substituted arylpyrazines

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2606906A (en) * 1948-10-14 1952-08-12 American Cyanamid Co 1-(2-pyridyl) piperazine and process of preparing same

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4252816A (en) * 1979-12-03 1981-02-24 Merck & Co., Inc. Tetrahydro-1H-1,4-diazepino(1,7-a)benzimidazoles useful as analgesic agents
US4339579A (en) 1980-12-29 1982-07-13 American Home Products Corporation 2,6-Bis-(pyrrolopyrazinyl)pyrazines
EP0094498A2 (en) * 1982-05-06 1983-11-23 American Cyanamid Company Antiatherosclerotic 1-piperazine derivatives
EP0094498A3 (en) * 1982-05-06 1985-04-03 American Cyanamid Company Antiatherosclerotic 1-piperazine derivatives
US4788290A (en) * 1987-12-11 1988-11-29 American Home Products Corporation Serotonergic pyrazine derivatives
EP1491532A1 (en) * 1997-10-27 2004-12-29 Neurosearch A/S Heteroaryl diazacycloalkanes as cholinergic ligands at nicotinic acetyloholine receptors
WO1999021834A1 (en) * 1997-10-27 1999-05-06 Neurosearch A/S Heteroaryl diazacycloalkanes as cholinergic ligands at nicotinic acetylcholine receptors
CZ299499B6 (en) * 1997-10-27 2008-08-13 Neurosearch A/S Homopiperazine derivative, pharmaceutical composition in which the derivative is comprised and its use
US6897219B2 (en) 1997-10-27 2005-05-24 Neurosearch A/S Heteroaryl diazacycloalkanes, their preparation and use
US6825189B1 (en) 1997-10-27 2004-11-30 Neurosearch A/S Certain heteroaryl diazacycloalkanes as cholinergic ligands at nicotinic acetylcholine receptors
US7064118B2 (en) 1999-04-26 2006-06-20 Neurosearch A/S Heteroaryl diazacycloalkanes, their preparation and use
US7282494B2 (en) 1999-04-26 2007-10-16 Neurosearch A/S Heteroaryl diazacycloalkanes, their preparation and use
WO2000064885A1 (en) * 1999-04-26 2000-11-02 Neurosearch A/S Heteroaryl diazacycloalkanes, their preparation and use
WO2003000666A1 (en) * 2001-06-21 2003-01-03 Pfizer Products Inc. 5-ht receptor ligands and uses thereof
WO2004009586A1 (en) * 2002-07-19 2004-01-29 Biovitrum Ab Novel piperazinyl-pyrazinone derivatives for the treatment of 5-ht2a receptor-related disorders
EA007539B1 (en) * 2002-07-19 2006-10-27 Биовитрум Аб Novel pyrazinone derivatives for the treatment of 5-htreceptor-related disorders
US7244722B2 (en) 2002-07-19 2007-07-17 Biovitrum Ab Amino-substituted 1H-pyrazin-2-ones and 1H-quinoxalin-2-ones

Also Published As

Publication number Publication date
ES459405A1 (en) 1978-08-16
DE2617205A1 (en) 1976-10-28
NL167692B (en) 1981-08-17
SE421695B (en) 1982-01-25
NL167692C (en) 1982-01-18
PT65027B (en) 1978-04-03
PH12274A (en) 1978-12-12
ATA288376A (en) 1979-05-15
YU100676A (en) 1982-08-31
ZA762320B (en) 1977-11-30
NO146599C (en) 1982-11-03
ES459406A1 (en) 1978-08-16
RO73278A (en) 1982-09-09
FR2308367B1 (en) 1979-09-21
BE840904A (en) 1976-08-16
AR210349A1 (en) 1977-07-29
IL49391A (en) 1979-09-30
IL49391A0 (en) 1976-06-30
BG34185A3 (en) 1983-07-15
FR2308367A1 (en) 1976-11-19
PT65027A (en) 1976-05-01
HK60380A (en) 1980-11-07
ES447150A1 (en) 1977-09-16
ES459407A1 (en) 1978-08-16
SE7604093L (en) 1976-10-22
FI760978A (en) 1976-10-22
GR59900B (en) 1978-03-16
AU496854B2 (en) 1978-11-02
EG12387A (en) 1978-12-31
PL99664B1 (en) 1978-07-31
HU172684B (en) 1978-11-28
DD124599A5 (en) 1977-03-02
AT353795B (en) 1979-12-10
DE2617205C3 (en) 1981-01-29
CH619462A5 (en) 1980-09-30
JPS5522475B2 (en) 1980-06-17
DK143899C (en) 1982-04-13
NO146599B (en) 1982-07-26
IE42979L (en) 1976-10-21
MY8100225A (en) 1981-12-31
AU1296676A (en) 1977-10-20
CS195726B2 (en) 1980-02-29
NL7603800A (en) 1976-10-25
NO761207L (en) 1976-10-22
DK143899B (en) 1981-10-26
KE3088A (en) 1980-11-07
FI62666B (en) 1982-10-29
FI62666C (en) 1983-02-10
CA1059128A (en) 1979-07-24
CY1090A (en) 1980-12-27
DK164476A (en) 1976-10-22
JPS51136688A (en) 1976-11-26
DE2617205B2 (en) 1980-05-08
LU74795A1 (en) 1977-02-07
SU638260A3 (en) 1978-12-15
IE42979B1 (en) 1980-11-19

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee

Effective date: 19930415