GB1534387A - D-threo-1-phenyl-2-trifluoroacetamido-1,3-propanediol derivatives - Google Patents
D-threo-1-phenyl-2-trifluoroacetamido-1,3-propanediol derivativesInfo
- Publication number
- GB1534387A GB1534387A GB32845/77A GB3284577A GB1534387A GB 1534387 A GB1534387 A GB 1534387A GB 32845/77 A GB32845/77 A GB 32845/77A GB 3284577 A GB3284577 A GB 3284577A GB 1534387 A GB1534387 A GB 1534387A
- Authority
- GB
- United Kingdom
- Prior art keywords
- compound
- ch3o2s
- formula
- stands
- denotes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The compounds of the annexed formula <IMAGE> in which R stands for CH3S- or CH3O2S- and R1 stands for hydrogen or, if R denotes CH3O2S-, for an acyl radical of an aliphatic carboxylic acid having 15-17 C atoms or aminoacetic acid, are prepared by reaction of a compound of the annexed formula <IMAGE> with free trifluoroacetic acid or a functional derivative thereof. The corresponding esters, if R stands for CH3O2S-, are obtained by subsequent esterification to give the corresponding compound in which R1 is an acyl radical. The compound of the formula Ia in which R denotes CH3O2S and R1 denotes hydrogen is also prepared by oxidation of the corresponding methylmercapto compound using a peroxide compound. The esters of aminoacetic acid of the formula Ia can be converted into the corresponding therapeutically utilisable acid addition salts. The compounds obtained show a broad antibiotic spectrum of action and are highly suitable for use in human medicine.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT26042/76A IT1065143B (en) | 1976-08-05 | 1976-08-05 | D-TREO-1-FENYL-2-TRIFLUOROACETAMIDO-1,3-PROPANDIOL DERIVATIVES AND PROCESSES FOR THEIR PREPARATION |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1534387A true GB1534387A (en) | 1978-12-06 |
Family
ID=11218484
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB32845/77A Expired GB1534387A (en) | 1976-08-05 | 1977-08-05 | D-threo-1-phenyl-2-trifluoroacetamido-1,3-propanediol derivatives |
Country Status (16)
| Country | Link |
|---|---|
| JP (1) | JPS5321135A (en) |
| AT (1) | AT351018B (en) |
| AU (1) | AU509278B2 (en) |
| BE (1) | BE857543A (en) |
| CA (1) | CA1087207A (en) |
| CH (1) | CH609338A5 (en) |
| DE (1) | DE2735431A1 (en) |
| ES (1) | ES461093A1 (en) |
| FR (1) | FR2360560A1 (en) |
| GB (1) | GB1534387A (en) |
| HU (1) | HU173169B (en) |
| IE (1) | IE45460B1 (en) |
| IT (1) | IT1065143B (en) |
| NL (1) | NL7708695A (en) |
| PT (1) | PT66889B (en) |
| YU (1) | YU40678B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0677511A2 (en) | 1983-06-02 | 1995-10-18 | ZAMBON GROUP S.p.A. | Intermediates for the preparation of 1-(phenyl)-1-hydroxy-2-amino-3-fluoro propane derivatives |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5977276A (en) * | 1982-10-27 | 1984-05-02 | 松下冷機株式会社 | Ice machine |
| IT1317836B1 (en) * | 2000-02-16 | 2003-07-15 | Zambon Spa | USE OF TIAMFENICOLO FOR THE PREPARATION OF PHARMACEUTICAL COMPOSITIONS USEFUL FOR THE TREATMENT OF STAPHYLOCOCCI INFECTIONS |
-
1976
- 1976-08-05 IT IT26042/76A patent/IT1065143B/en active
-
1977
- 1977-07-18 YU YU1779/77A patent/YU40678B/en unknown
- 1977-07-28 ES ES461093A patent/ES461093A1/en not_active Expired
- 1977-08-04 PT PT66889A patent/PT66889B/en unknown
- 1977-08-04 CH CH959077A patent/CH609338A5/en not_active IP Right Cessation
- 1977-08-05 BE BE179956A patent/BE857543A/en not_active IP Right Cessation
- 1977-08-05 AU AU27655/77A patent/AU509278B2/en not_active Expired
- 1977-08-05 HU HU77CE1140A patent/HU173169B/en unknown
- 1977-08-05 DE DE19772735431 patent/DE2735431A1/en not_active Withdrawn
- 1977-08-05 NL NL7708695A patent/NL7708695A/en not_active Application Discontinuation
- 1977-08-05 AT AT577177A patent/AT351018B/en not_active IP Right Cessation
- 1977-08-05 FR FR7724168A patent/FR2360560A1/en active Granted
- 1977-08-05 CA CA284,228A patent/CA1087207A/en not_active Expired
- 1977-08-05 IE IE1643/77A patent/IE45460B1/en unknown
- 1977-08-05 JP JP9345877A patent/JPS5321135A/en active Pending
- 1977-08-05 GB GB32845/77A patent/GB1534387A/en not_active Expired
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0677511A2 (en) | 1983-06-02 | 1995-10-18 | ZAMBON GROUP S.p.A. | Intermediates for the preparation of 1-(phenyl)-1-hydroxy-2-amino-3-fluoro propane derivatives |
| EP0678506A2 (en) | 1983-06-02 | 1995-10-25 | ZAMBON GROUP S.p.A. | Intermediates for the preparation of 1-(phenyl)-1-hydroxy-2-amino-3-fluoro propane derivatives |
Also Published As
| Publication number | Publication date |
|---|---|
| BE857543A (en) | 1977-12-01 |
| HU173169B (en) | 1979-03-28 |
| YU177977A (en) | 1982-10-31 |
| IE45460L (en) | 1978-02-05 |
| AU509278B2 (en) | 1980-05-01 |
| DE2735431A1 (en) | 1978-02-09 |
| YU40678B (en) | 1986-04-30 |
| AT351018B (en) | 1979-07-10 |
| CA1087207A (en) | 1980-10-07 |
| PT66889A (en) | 1977-09-01 |
| CH609338A5 (en) | 1979-02-28 |
| IT1065143B (en) | 1985-02-25 |
| PT66889B (en) | 1979-01-25 |
| IE45460B1 (en) | 1982-08-25 |
| AU2765577A (en) | 1979-02-08 |
| ES461093A1 (en) | 1978-06-16 |
| JPS5321135A (en) | 1978-02-27 |
| NL7708695A (en) | 1978-02-07 |
| FR2360560A1 (en) | 1978-03-03 |
| ATA577177A (en) | 1978-12-15 |
| FR2360560B1 (en) | 1981-02-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 416 | Proceeding under section 16 patents act 1949 | ||
| PS | Patent sealed | ||
| 732 | Registration of transactions, instruments or events in the register (sect. 32/1977) | ||
| PCNP | Patent ceased through non-payment of renewal fee |