GB1472966A - Cephalosporin purification process - Google Patents

Cephalosporin purification process

Info

Publication number
GB1472966A
GB1472966A GB238275A GB238275A GB1472966A GB 1472966 A GB1472966 A GB 1472966A GB 238275 A GB238275 A GB 238275A GB 238275 A GB238275 A GB 238275A GB 1472966 A GB1472966 A GB 1472966A
Authority
GB
United Kingdom
Prior art keywords
carboxylic acid
salt
adsorbent
aqueous solution
cephalosporin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB238275A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GlaxoSmithKline LLC
Original Assignee
SmithKline Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Corp filed Critical SmithKline Corp
Publication of GB1472966A publication Critical patent/GB1472966A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02—Preparation
    • C07D501/12—Separation; Purification

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Peptides Or Proteins (AREA)
GB238275A 1974-01-23 1975-01-20 Cephalosporin purification process Expired GB1472966A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US43591174A 1974-01-23 1974-01-23

Publications (1)

Publication Number Publication Date
GB1472966A true GB1472966A (en) 1977-05-11

Family

ID=23730331

Family Applications (1)

Application Number Title Priority Date Filing Date
GB238275A Expired GB1472966A (en) 1974-01-23 1975-01-20 Cephalosporin purification process

Country Status (9)

Country Link
JP (1) JPS50106996A (fr)
BE (1) BE824028A (fr)
CH (1) CH613971A5 (fr)
DE (1) DE2502097A1 (fr)
ES (1) ES433995A1 (fr)
FR (1) FR2258388B1 (fr)
GB (1) GB1472966A (fr)
IE (1) IE40481B1 (fr)
NL (1) NL7500805A (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT386206B (de) * 1984-03-09 1988-07-25 Glaxo Group Ltd Verfahren zur wiedergewinnung von (6r, 7r)7-( (z)-2-(2-aminothiazol-4-yl)-2-2(2-carboxyprop-2 oxyimino)-acetamido)-3-(1-pyridiniummethyl)ceph-3-em-4-carboxylat (ceftazidim) aus einer dieses enthaltenden waessrigen loesung
EP0697396A1 (fr) * 1994-08-17 1996-02-21 General Electric Company Procédé de récupération d'amines ou de leurs sels de saumures aqueuses par adsorption
ES2129006A1 (es) * 1996-10-02 1999-05-16 Otsuka Kagaku Kk Procedimiento para producir cefazolina.
CN104610282A (zh) * 2015-02-14 2015-05-13 石药集团中诺药业（石家庄）有限公司 一种头孢唑啉酸的提纯方法

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5398989A (en) * 1977-02-09 1978-08-29 Fujisawa Pharmaceut Co Ltd Purification of cephalosporin compounds
US4115644A (en) * 1977-09-19 1978-09-19 Eli Lilly And Company Process for preparing pure cefamandole from alkali metal and ammonium salts thereof
JPS5665894A (en) * 1979-10-31 1981-06-03 Asahi Chem Ind Co Ltd Purification of 7-aminocephalosporanic acid derivative
JPS60161990A (ja) * 1984-02-02 1985-08-23 Shionogi & Co Ltd オキサセフアロスポリンの精製法
BR9809916A (pt) * 1997-06-04 2000-10-03 Biochemie Gmbh Processo de precipitação melhorada de ácido 7-aminocefalosporânico (7-aca)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT386206B (de) * 1984-03-09 1988-07-25 Glaxo Group Ltd Verfahren zur wiedergewinnung von (6r, 7r)7-( (z)-2-(2-aminothiazol-4-yl)-2-2(2-carboxyprop-2 oxyimino)-acetamido)-3-(1-pyridiniummethyl)ceph-3-em-4-carboxylat (ceftazidim) aus einer dieses enthaltenden waessrigen loesung
US4769450A (en) * 1984-03-09 1988-09-06 Glaxo Group Limited Process for recovering ceftazidime
EP0697396A1 (fr) * 1994-08-17 1996-02-21 General Electric Company Procédé de récupération d'amines ou de leurs sels de saumures aqueuses par adsorption
ES2129006A1 (es) * 1996-10-02 1999-05-16 Otsuka Kagaku Kk Procedimiento para producir cefazolina.
CN104610282A (zh) * 2015-02-14 2015-05-13 石药集团中诺药业（石家庄）有限公司 一种头孢唑啉酸的提纯方法

Also Published As

Publication number Publication date
IE40481L (en) 1975-07-23
IE40481B1 (en) 1979-06-06
FR2258388B1 (fr) 1978-07-07
FR2258388A1 (fr) 1975-08-18
NL7500805A (nl) 1975-07-25
BE824028A (fr) 1975-06-30
JPS50106996A (fr) 1975-08-22
DE2502097A1 (de) 1975-07-24
CH613971A5 (en) 1979-10-31
ES433995A1 (es) 1976-11-16

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee