JPS5665894A - Purification of 7-aminocephalosporanic acid derivative - Google Patents
Purification of 7-aminocephalosporanic acid derivativeInfo
- Publication number
- JPS5665894A JPS5665894A JP13987879A JP13987879A JPS5665894A JP S5665894 A JPS5665894 A JP S5665894A JP 13987879 A JP13987879 A JP 13987879A JP 13987879 A JP13987879 A JP 13987879A JP S5665894 A JPS5665894 A JP S5665894A
- Authority
- JP
- Japan
- Prior art keywords
- crosslinked polymer
- adsorbent resin
- acid derivative
- aminocephalosporanic acid
- nonpolar
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Cephalosporin Compounds (AREA)
Abstract
PURPOSE: To purify the titled compound useful as a raw material for the production of antibacterial agent, etc., economically, in an industrial scale, by adsorbing an aqueous solution containing a specific 7-aminocephalosporanic acid derivative selectively with a particular synthetic adsorbent resin composed of a nonpolar loosely crosslinked polymer, and eluting the adsorbed compound.
CONSTITUTION: An aqueous solution containing (A) a 7-aminocephalosporanic acid derivative of formula (X is H, hydroxyl group, acetate group, or nucleophilic residue) is treated with (B) a synthetic adsorbent resin composed of a nonpolar loosely crosslinked polymer selected from a styrenedivinylbenzene crosslinked polymer and an acrylic ester crosslinked polymer. The component (A) adsorbed selectively to the adsorbent resin (B) is eluted with an eluent such as a basic buffer solution, etc. at pH7.0W13.0. Preferably, the adsorbent resin has the mode pore size of 50W1,000Å, a specific surface area of 100W800m2/g, and the pore volume of 0.6W1.2cm3/g. The adsorption treatment is pref. carried out at pH2.0W6.0.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP13987879A JPS5665894A (en) | 1979-10-31 | 1979-10-31 | Purification of 7-aminocephalosporanic acid derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP13987879A JPS5665894A (en) | 1979-10-31 | 1979-10-31 | Purification of 7-aminocephalosporanic acid derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5665894A true JPS5665894A (en) | 1981-06-03 |
JPH0124795B2 JPH0124795B2 (en) | 1989-05-15 |
Family
ID=15255665
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP13987879A Granted JPS5665894A (en) | 1979-10-31 | 1979-10-31 | Purification of 7-aminocephalosporanic acid derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5665894A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2014157091A (en) * | 2013-02-15 | 2014-08-28 | Central Research Institute Of Electric Power Industry | Device and method for measuring age of groundwater |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS50106996A (en) * | 1974-01-23 | 1975-08-22 | ||
JPS5276486A (en) * | 1975-12-18 | 1977-06-27 | Meiji Seika Kaisha Ltd | Purification of cephalosporin c |
JPS52128294A (en) * | 1976-04-20 | 1977-10-27 | Fujisawa Pharmaceut Co Ltd | Separation and purification of cephalosporins |
-
1979
- 1979-10-31 JP JP13987879A patent/JPS5665894A/en active Granted
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS50106996A (en) * | 1974-01-23 | 1975-08-22 | ||
JPS5276486A (en) * | 1975-12-18 | 1977-06-27 | Meiji Seika Kaisha Ltd | Purification of cephalosporin c |
JPS52128294A (en) * | 1976-04-20 | 1977-10-27 | Fujisawa Pharmaceut Co Ltd | Separation and purification of cephalosporins |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2014157091A (en) * | 2013-02-15 | 2014-08-28 | Central Research Institute Of Electric Power Industry | Device and method for measuring age of groundwater |
Also Published As
Publication number | Publication date |
---|---|
JPH0124795B2 (en) | 1989-05-15 |
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