JPS5665894A - Purification of 7-aminocephalosporanic acid derivative - Google Patents

Purification of 7-aminocephalosporanic acid derivative

Info

Publication number
JPS5665894A
JPS5665894A JP13987879A JP13987879A JPS5665894A JP S5665894 A JPS5665894 A JP S5665894A JP 13987879 A JP13987879 A JP 13987879A JP 13987879 A JP13987879 A JP 13987879A JP S5665894 A JPS5665894 A JP S5665894A
Authority
JP
Japan
Prior art keywords
crosslinked polymer
adsorbent resin
acid derivative
aminocephalosporanic acid
nonpolar
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP13987879A
Other languages
Japanese (ja)
Other versions
JPH0124795B2 (en
Inventor
Yoshihiro Murai
Shuji Yamamoto
Katsuaki Tsuzuki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asahi Chemical Industry Co Ltd
Original Assignee
Asahi Chemical Industry Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asahi Chemical Industry Co Ltd filed Critical Asahi Chemical Industry Co Ltd
Priority to JP13987879A priority Critical patent/JPS5665894A/en
Publication of JPS5665894A publication Critical patent/JPS5665894A/en
Publication of JPH0124795B2 publication Critical patent/JPH0124795B2/ja
Granted legal-status Critical Current

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  • Cephalosporin Compounds (AREA)

Abstract

PURPOSE: To purify the titled compound useful as a raw material for the production of antibacterial agent, etc., economically, in an industrial scale, by adsorbing an aqueous solution containing a specific 7-aminocephalosporanic acid derivative selectively with a particular synthetic adsorbent resin composed of a nonpolar loosely crosslinked polymer, and eluting the adsorbed compound.
CONSTITUTION: An aqueous solution containing (A) a 7-aminocephalosporanic acid derivative of formula (X is H, hydroxyl group, acetate group, or nucleophilic residue) is treated with (B) a synthetic adsorbent resin composed of a nonpolar loosely crosslinked polymer selected from a styrenedivinylbenzene crosslinked polymer and an acrylic ester crosslinked polymer. The component (A) adsorbed selectively to the adsorbent resin (B) is eluted with an eluent such as a basic buffer solution, etc. at pH7.0W13.0. Preferably, the adsorbent resin has the mode pore size of 50W1,000Å, a specific surface area of 100W800m2/g, and the pore volume of 0.6W1.2cm3/g. The adsorption treatment is pref. carried out at pH2.0W6.0.
COPYRIGHT: (C)1981,JPO&Japio
JP13987879A 1979-10-31 1979-10-31 Purification of 7-aminocephalosporanic acid derivative Granted JPS5665894A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP13987879A JPS5665894A (en) 1979-10-31 1979-10-31 Purification of 7-aminocephalosporanic acid derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP13987879A JPS5665894A (en) 1979-10-31 1979-10-31 Purification of 7-aminocephalosporanic acid derivative

Publications (2)

Publication Number Publication Date
JPS5665894A true JPS5665894A (en) 1981-06-03
JPH0124795B2 JPH0124795B2 (en) 1989-05-15

Family

ID=15255665

Family Applications (1)

Application Number Title Priority Date Filing Date
JP13987879A Granted JPS5665894A (en) 1979-10-31 1979-10-31 Purification of 7-aminocephalosporanic acid derivative

Country Status (1)

Country Link
JP (1) JPS5665894A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014157091A (en) * 2013-02-15 2014-08-28 Central Research Institute Of Electric Power Industry Device and method for measuring age of groundwater

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS50106996A (en) * 1974-01-23 1975-08-22
JPS5276486A (en) * 1975-12-18 1977-06-27 Meiji Seika Kaisha Ltd Purification of cephalosporin c
JPS52128294A (en) * 1976-04-20 1977-10-27 Fujisawa Pharmaceut Co Ltd Separation and purification of cephalosporins

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS50106996A (en) * 1974-01-23 1975-08-22
JPS5276486A (en) * 1975-12-18 1977-06-27 Meiji Seika Kaisha Ltd Purification of cephalosporin c
JPS52128294A (en) * 1976-04-20 1977-10-27 Fujisawa Pharmaceut Co Ltd Separation and purification of cephalosporins

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014157091A (en) * 2013-02-15 2014-08-28 Central Research Institute Of Electric Power Industry Device and method for measuring age of groundwater

Also Published As

Publication number Publication date
JPH0124795B2 (en) 1989-05-15

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