GB1276909A - Benzodiazepine derivatives preparation - Google Patents
Benzodiazepine derivatives preparationInfo
- Publication number
- GB1276909A GB1276909A GB52353/69A GB5235369A GB1276909A GB 1276909 A GB1276909 A GB 1276909A GB 52353/69 A GB52353/69 A GB 52353/69A GB 5235369 A GB5235369 A GB 5235369A GB 1276909 A GB1276909 A GB 1276909A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- formula
- benzodiazepine derivatives
- oct
- reacting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Furnace Details (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
1276909 Benzodiazepine derivatives. SANKYO CO Ltd 24 Oct 1969 [24 Oct 1968 (2) 17 April 1969] 52353/69 Heading C2C Compounds of the general formula (R 1-3 =H, C 1-5 alkyl, alkoxy, alkylamino, alkylthio, alkylsulphinyl or alkylsulphonyl, halogen, OH, NO 2 , CN, CF 3 , NH 2 , acyl, acylamino, di- (C 1-5 alkyl)amino, acyloxy, COOH, alkoxycarbonyl, NH 2 CO, C 2-6 alkylcarbamoyl, di- (C 1-5 alkyl)carbamoyl; R 4 =H, C 1-5 alkyl, cycloalkyl, aryl, aralkyl, phenacyl; R 5 = H, C 1-5 alkyl; A= alkylene; X = O, S) are prepared by reacting a compound of the formula with a reactive derivative of HOOCCHR 5 Q (Q=acid radical of reactive ester). Quaternary ammonium salts of the formula may be obtained as by-products, and converted to the required compounds by heating. The starting materials may be prepared by reacting a compound of the formula with HXANH 2 . Reference has been directed by the Comptroller to Specification 1,056,423.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP43077500A JPS4834752B1 (en) | 1968-10-24 | 1968-10-24 | |
| JP43077504A JPS4834756B1 (en) | 1968-10-24 | 1968-10-24 | |
| JP44029908A JPS4925276B1 (en) | 1969-04-17 | 1969-04-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1276909A true GB1276909A (en) | 1972-06-07 |
Family
ID=27286759
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB52353/69A Expired GB1276909A (en) | 1968-10-24 | 1969-10-24 | Benzodiazepine derivatives preparation |
Country Status (17)
| Country | Link |
|---|---|
| AR (1) | AR207426A1 (en) |
| BE (1) | BE740587A (en) |
| BG (2) | BG20109A3 (en) |
| CH (1) | CH533130A (en) |
| DE (1) | DE1954065C3 (en) |
| DK (1) | DK153152C (en) |
| FI (1) | FI49621C (en) |
| FR (1) | FR2021469B1 (en) |
| GB (1) | GB1276909A (en) |
| IE (1) | IE33825B1 (en) |
| IL (1) | IL33190A (en) |
| NL (1) | NL166262C (en) |
| NO (1) | NO128109B (en) |
| OA (1) | OA03155A (en) |
| PL (1) | PL82688B1 (en) |
| RO (2) | RO55843A (en) |
| SE (2) | SE384857B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH565180A5 (en) * | 1970-12-23 | 1975-08-15 | Hoffmann La Roche |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3914215A (en) * | 1967-11-27 | 1975-10-21 | Sankyo Co | Benzodiazepine derivatives and process for preparing the same |
| GB1222294A (en) * | 1968-09-19 | 1971-02-10 | Upjohn Co | Oxazinobenzodiazepine derivatives |
-
1969
- 1969-10-15 IL IL33190A patent/IL33190A/en unknown
- 1969-10-21 BE BE740587D patent/BE740587A/xx not_active IP Right Cessation
- 1969-10-23 IE IE1447/69A patent/IE33825B1/en unknown
- 1969-10-23 BG BG13231A patent/BG20109A3/xx unknown
- 1969-10-23 DK DK561869A patent/DK153152C/en not_active IP Right Cessation
- 1969-10-23 FR FR696936338A patent/FR2021469B1/fr not_active Expired
- 1969-10-23 DE DE1954065A patent/DE1954065C3/en not_active Expired
- 1969-10-23 BG BG20368A patent/BG19175A3/xx unknown
- 1969-10-23 NL NL6915994.A patent/NL166262C/en not_active IP Right Cessation
- 1969-10-23 NO NO04212/69A patent/NO128109B/no unknown
- 1969-10-23 PL PL1969136465A patent/PL82688B1/en unknown
- 1969-10-23 OA OA53762A patent/OA03155A/en unknown
- 1969-10-24 SE SE7215303A patent/SE384857B/en unknown
- 1969-10-24 GB GB52353/69A patent/GB1276909A/en not_active Expired
- 1969-10-24 FI FI693070A patent/FI49621C/en active
- 1969-10-24 CH CH1592069A patent/CH533130A/en not_active IP Right Cessation
- 1969-10-24 SE SE14615/69A patent/SE366314B/xx unknown
- 1969-10-24 RO RO61341A patent/RO55843A/ro unknown
- 1969-10-24 RO RO69346A patent/RO57031A/ro unknown
-
1971
- 1971-01-01 AR AR236342A patent/AR207426A1/en active
Also Published As
| Publication number | Publication date |
|---|---|
| NL166262B (en) | 1981-02-16 |
| OA03155A (en) | 1970-12-15 |
| BG20109A3 (en) | 1975-10-30 |
| FR2021469A1 (en) | 1970-07-24 |
| FR2021469B1 (en) | 1973-04-06 |
| DE1954065A1 (en) | 1970-08-27 |
| NO128109B (en) | 1973-10-01 |
| DE1954065C3 (en) | 1979-09-13 |
| CH533130A (en) | 1973-01-31 |
| FI49621C (en) | 1975-08-11 |
| SE366314B (en) | 1974-04-22 |
| PL82688B1 (en) | 1975-10-31 |
| DK153152B (en) | 1988-06-20 |
| BG19175A3 (en) | 1975-04-30 |
| IE33825L (en) | 1970-04-24 |
| DE1954065B2 (en) | 1979-01-11 |
| IL33190A0 (en) | 1969-12-31 |
| DK153152C (en) | 1988-12-05 |
| RO55843A (en) | 1974-02-01 |
| RO57031A (en) | 1974-12-15 |
| IE33825B1 (en) | 1974-11-13 |
| NL166262C (en) | 1981-07-15 |
| SE384857B (en) | 1976-05-24 |
| FI49621B (en) | 1975-04-30 |
| NL6915994A (en) | 1970-04-28 |
| BE740587A (en) | 1970-04-21 |
| AR207426A1 (en) | 1976-10-08 |
| IL33190A (en) | 1972-11-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PE20 | Patent expired after termination of 20 years |