GB1104731A - Conessine derivatives - Google Patents

Conessine derivatives

Info

Publication number
GB1104731A
GB1104731A GB5776/66A GB577666A GB1104731A GB 1104731 A GB1104731 A GB 1104731A GB 5776/66 A GB5776/66 A GB 5776/66A GB 577666 A GB577666 A GB 577666A GB 1104731 A GB1104731 A GB 1104731A
Authority
GB
United Kingdom
Prior art keywords
salts
mono
compounds
conessine
bismetho
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB5776/66A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DSM Delft BV
Original Assignee
Koninklijke Nederlandsche Gist en Spiritusfabriek BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Koninklijke Nederlandsche Gist en Spiritusfabriek BV filed Critical Koninklijke Nederlandsche Gist en Spiritusfabriek BV
Publication of GB1104731A publication Critical patent/GB1104731A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036—Nitrogen-containing hetero ring
    • C07J71/0042—Nitrogen only

Abstract

The invention comprises mono- and bisquaternary ammonium salts, and acid addition salts of mono-quaternary salts, of compounds of formula <FORM:1104731/C2/1> having a double bond in the 5,6-position or in the 4,5- and 6,7-positions, wherein R1, R2 and R5 are C1- 4 alkyl groups and each of R3 and R4 is a hydrogen atom, an a - or b -hydroxy group or an oxo group, with the exception of bismetho-salts of conessine, and their preparation by mono- or bis-quaternization. The compounds of the invention have muscle-relaxing activity and may be used in pharmaceutical compositions in combination with a carrier, for example in forms suitable for parenteral administration.
GB5776/66A 1965-02-26 1966-02-09 Conessine derivatives Expired GB1104731A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL6502483A NL6502483A (en) 1965-02-26 1965-02-26

Publications (1)

Publication Number Publication Date
GB1104731A true GB1104731A (en) 1968-02-28

Family

ID=19792503

Family Applications (1)

Application Number Title Priority Date Filing Date
GB5776/66A Expired GB1104731A (en) 1965-02-26 1966-02-09 Conessine derivatives

Country Status (6)

Country Link
US (1) US3485825A (en)
BE (1) BE676980A (en)
CH (1) CH498823A (en)
FR (1) FR5242M (en)
GB (1) GB1104731A (en)
NL (2) NL6502483A (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL6908367A (en) * 1969-01-16 1970-07-20 Koninklijke Gist Spiritus
US20050245495A1 (en) * 2004-04-07 2005-11-03 Chen Zhao Azacyclosteroid histamine-3 receptor ligands
US7345034B2 (en) * 2004-04-07 2008-03-18 Abbott Laboratories Azacyclosteroid histamine-3 receptor ligands
US20100040568A1 (en) * 2008-04-30 2010-02-18 Skinmedica, Inc. Steroidal compounds as melanogenesis modifiers and uses thereof
CN104688745B (en) 2010-05-20 2019-11-12 爱荷华大学研究基金会 Method for inhibiting amyotrophia
US11090313B2 (en) 2010-05-20 2021-08-17 University Of Iowa Research Foundation Methods for inhibiting muscle atrophy
EP3520793B1 (en) 2011-06-06 2023-03-29 University of Iowa Research Foundation Substances and compostions for use in methods of inhibiting muscle atrophy

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2913455A (en) * 1958-05-22 1959-11-17 Searle & Co 18-dimethylamino steroids and intermediates
US2912432A (en) * 1958-11-28 1959-11-10 Searle & Co 3-oxo and 3-hydroxy derivatives of 18-dimethyl-aminopregn-20-enes and intermediates

Also Published As

Publication number Publication date
BE676980A (en) 1966-08-24
CH498823A (en) 1970-11-15
FR5242M (en) 1967-07-17
NL6502483A (en) 1966-08-29
US3485825A (en) 1969-12-23
NL124636C (en)

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