ES341322A1 - Process for the preparation o Pyrazinoyl-and Pyrazinamido-Guanidines - Google Patents

Process for the preparation o Pyrazinoyl-and Pyrazinamido-Guanidines

Info

Publication number
ES341322A1
ES341322A1 ES341322A ES341322A ES341322A1 ES 341322 A1 ES341322 A1 ES 341322A1 ES 341322 A ES341322 A ES 341322A ES 341322 A ES341322 A ES 341322A ES 341322 A1 ES341322 A1 ES 341322A1
Authority
ES
Spain
Prior art keywords
alkyl
hydrogen
phenyl
pyrazinamido
pyrazinoyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES341322A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of ES341322A1 publication Critical patent/ES341322A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms

Abstract

(3,5 - Diamino - 6 - halo - pyrazinoyl and -pyrazinamido)-guanidines of the general formula wherein R is chlorine or bromine R1 and R2 are each hydrogen, C 1-5 alkyl, C 3-5 alkenyl or C 4-8 (cycloalkyl-alkyl) R3 is hydrogen, C 1-5 alkyl, hydroxy-C 1-5 alkyl, phenyl-C 1-5 alkyl, (halophenyl) - C 1-5 alkyl, (C 1-5 alkyl-phenyl) - C 1-5 alkyl, (C 1-5 alkoxyphenyl)-C 1-5 alkyl or pyridyl- C 1-5 alkyl R4 is hydrogen, C 1-5 alkyl or phenyl- C 1-5 alkyl or when R3 and R4 are each C 1-5 alkyl they can be linked together to form a cyclic structure with the nitrogen atom to which they are attached, thereby forming a group of the structure where x is 4, 5, 6 or 7 R5 is hydrogen or C 1-5 alkyl or when R4 and R5 are each C 1-5 alkyl they can be linked together with the nitrogen atoms to which they are attached to form a cyclic structure wherein y is 2 or 3 and n is 0 or 1 and acid addition salts thereof are prepared by reaction under anhydrous conditions in the presence of a solvent having a boiling-point of at least 100 C. of a 3,5-diamino-6-halopyrazinoic acid and a guanidine or aminoguanidine of the respective formul[mu] followed optionally by salification.
ES341322A 1966-08-25 1967-06-02 Process for the preparation o Pyrazinoyl-and Pyrazinamido-Guanidines Expired ES341322A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US57491066A 1966-08-25 1966-08-25

Publications (1)

Publication Number Publication Date
ES341322A1 true ES341322A1 (en) 1968-10-01

Family

ID=24298148

Family Applications (1)

Application Number Title Priority Date Filing Date
ES341322A Expired ES341322A1 (en) 1966-08-25 1967-06-02 Process for the preparation o Pyrazinoyl-and Pyrazinamido-Guanidines

Country Status (6)

Country Link
BE (1) BE699436A (en)
CH (1) CH487167A (en)
DK (1) DK115846B (en)
ES (1) ES341322A1 (en)
GB (1) GB1158399A (en)
NL (1) NL6707564A (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4224447A (en) * 1979-03-27 1980-09-23 Merck & Co., Inc. Novel pyrazinecarboxamides and processes for preparing same
US4246406A (en) * 1979-03-27 1981-01-20 Merck & Co., Inc. Heterocyclic substituted pyrazinoylguanidines
US6858615B2 (en) 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenyl guanidine sodium channel blockers
CL2008003651A1 (en) 2007-12-10 2009-06-19 Novartis Ag Substituted 3,5-diamino-6-chloropyrazinamide derivative compounds; pharmaceutical composition; pharmaceutical combination; and use in the treatment of an inflammatory or allergic condition, in particular an inflammatory or obstructive disease of the airways.
AR086745A1 (en) 2011-06-27 2014-01-22 Parion Sciences Inc 3,5-DIAMINO-6-CHLORINE-N- (N- (4- (4- (2- (HEXIL (2,3,4,5,6-PENTAHYDROXIHEXIL)) AMINO) ETOXI) PHENYL) BUTIL) CARBAMIMIDOIL) PIRAZINA -2-CARBOXAMIDE
US9029382B2 (en) 2012-12-17 2015-05-12 Parion Sciences, Inc. 3,5-diamino-6-chloro-N-(N-(4-phenylbutyl)carbamimidoyl) pyrazine-2-carboxamide compounds
HUE032891T2 (en) 2012-12-17 2017-11-28 Parion Sciences Inc Chloro-pyrazine carboxamide derivatives useful for the treatment of diseases favoured by insufficient mucosal hydration
US9102633B2 (en) 2013-12-13 2015-08-11 Parion Sciences, Inc. Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds

Also Published As

Publication number Publication date
BE699436A (en) 1967-12-04
DK115846B (en) 1969-11-17
GB1158399A (en) 1969-07-16
CH487167A (en) 1970-03-15
NL6707564A (en) 1968-02-26

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