GB1083724A - N-substituted azabicyclononanes - Google Patents
N-substituted azabicyclononanesInfo
- Publication number
- GB1083724A GB1083724A GB2004165A GB2004165A GB1083724A GB 1083724 A GB1083724 A GB 1083724A GB 2004165 A GB2004165 A GB 2004165A GB 2004165 A GB2004165 A GB 2004165A GB 1083724 A GB1083724 A GB 1083724A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- reaction
- prepared
- general formula
- halide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Novel compounds of general formula <FORM:1083724/C2/1> wherein Ar is phenyl or pyridyl, Y is H, Cl, F, Br or I, Z is NH2, dimethylamino or pyrrolidino and n is 2 or 3, and acid addition salts thereof, are prepared either by hydration of a nitrile of general formula <FORM:1083724/C2/2> to give compounds where Z is NH2 or by condensing the alkali metallo derivative of a compound of general formula <FORM:1083724/C2/3> with a compound of formula <FORM:1083724/C2/4> or by reaction of 3-azabicyclo-[3.2.2]-nonane with a halide of formula <FORM:1083724/C2/5> (Z1 is dimethylamino or pyrrolidino), optionally followed in appropriate cases by salt formation. Nitriles of the second general formula above are prepared either by reaction of 3-azabicyclo-[3.2.2]-nonane with a halide of formula <FORM:1083724/C2/6> or by condensing a halide of Formula IV above with an alkali metallo derivative of an acetonitrile of formula <FORM:1083724/C2/7> which may be prepared in situ by reaction of an appropriate benzyl cyanide, sodamide, and a halopyridine. 5 - Chloro -2,2 - diphenylvaleric acid pyrrolidide is prepared by reaction of trimethylenechlorobromide and the sodium derivative of N-diphenylacetylpyrrolidine.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US36722764A | 1964-05-13 | 1964-05-13 | |
US502289A US3299044A (en) | 1964-05-13 | 1965-10-22 | Complex n-substituted azabicycloalkanes |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1083724A true GB1083724A (en) | 1967-09-20 |
Family
ID=33302709
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB2004165A Expired GB1083724A (en) | 1964-05-13 | 1965-05-12 | N-substituted azabicyclononanes |
Country Status (3)
Country | Link |
---|---|
BE (1) | BE663869A (en) |
FR (1) | FR4401M (en) |
GB (1) | GB1083724A (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4134890A (en) * | 1977-03-11 | 1979-01-16 | G. D. Searle & Co. | 2-Aryl-2-[ω-(diisopropylamino)alkyl]-ω-(azabicycloalkyl)alkanamides |
-
1965
- 1965-05-12 FR FR16736A patent/FR4401M/en not_active Expired
- 1965-05-12 GB GB2004165A patent/GB1083724A/en not_active Expired
- 1965-05-13 BE BE663869D patent/BE663869A/xx unknown
Also Published As
Publication number | Publication date |
---|---|
BE663869A (en) | 1965-11-16 |
FR4401M (en) | 1966-09-05 |
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