GB1083724A - N-substituted azabicyclononanes - Google Patents

N-substituted azabicyclononanes

Info

Publication number
GB1083724A
GB1083724A GB2004165A GB2004165A GB1083724A GB 1083724 A GB1083724 A GB 1083724A GB 2004165 A GB2004165 A GB 2004165A GB 2004165 A GB2004165 A GB 2004165A GB 1083724 A GB1083724 A GB 1083724A
Authority
GB
United Kingdom
Prior art keywords
formula
reaction
prepared
general formula
halide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2004165A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GD Searle LLC filed Critical GD Searle LLC
Priority claimed from US502289A external-priority patent/US3299044A/en
Publication of GB1083724A publication Critical patent/GB1083724A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Novel compounds of general formula <FORM:1083724/C2/1> wherein Ar is phenyl or pyridyl, Y is H, Cl, F, Br or I, Z is NH2, dimethylamino or pyrrolidino and n is 2 or 3, and acid addition salts thereof, are prepared either by hydration of a nitrile of general formula <FORM:1083724/C2/2> to give compounds where Z is NH2 or by condensing the alkali metallo derivative of a compound of general formula <FORM:1083724/C2/3> with a compound of formula <FORM:1083724/C2/4> or by reaction of 3-azabicyclo-[3.2.2]-nonane with a halide of formula <FORM:1083724/C2/5> (Z1 is dimethylamino or pyrrolidino), optionally followed in appropriate cases by salt formation. Nitriles of the second general formula above are prepared either by reaction of 3-azabicyclo-[3.2.2]-nonane with a halide of formula <FORM:1083724/C2/6> or by condensing a halide of Formula IV above with an alkali metallo derivative of an acetonitrile of formula <FORM:1083724/C2/7> which may be prepared in situ by reaction of an appropriate benzyl cyanide, sodamide, and a halopyridine. 5 - Chloro -2,2 - diphenylvaleric acid pyrrolidide is prepared by reaction of trimethylenechlorobromide and the sodium derivative of N-diphenylacetylpyrrolidine.
GB2004165A 1964-05-13 1965-05-12 N-substituted azabicyclononanes Expired GB1083724A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36722764A 1964-05-13 1964-05-13
US502289A US3299044A (en) 1964-05-13 1965-10-22 Complex n-substituted azabicycloalkanes

Publications (1)

Publication Number Publication Date
GB1083724A true GB1083724A (en) 1967-09-20

Family

ID=33302709

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2004165A Expired GB1083724A (en) 1964-05-13 1965-05-12 N-substituted azabicyclononanes

Country Status (3)

Country Link
BE (1) BE663869A (en)
FR (1) FR4401M (en)
GB (1) GB1083724A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4134890A (en) * 1977-03-11 1979-01-16 G. D. Searle & Co. 2-Aryl-2-[ω-(diisopropylamino)alkyl]-ω-(azabicycloalkyl)alkanamides

Also Published As

Publication number Publication date
BE663869A (en) 1965-11-16
FR4401M (en) 1966-09-05

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