GB1305502A - - Google Patents
Info
- Publication number
- GB1305502A GB1305502A GB1252771A GB1252771A GB1305502A GB 1305502 A GB1305502 A GB 1305502A GB 1252771 A GB1252771 A GB 1252771A GB 1252771 A GB1252771 A GB 1252771A GB 1305502 A GB1305502 A GB 1305502A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- hydrogen
- formula
- aldehyde
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/04—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D263/06—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by oxygen atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
1305502 N-secondary alkyl alkane diamines and derivatives thereof PFIZER Inc 30 April 1971 [16 Dec 1970] 12527/71 Heading C2C [Also in Division A5] Novel compounds of the Formula II or III and acid addition salts thereof wherein Y is (CH 2 ) n , where n is 2 to 5; R 1 is C 4-13 alkyl; R 4 is hydrogen, C 1-20 alkyl, C 3-7 cycloalkyl or phenyl optionally substituted by halogen, C 1-4 alkyl or alkoxy, cyano or trifluoromethyl; R 5 is R 4 or thienyl, furyl or pyridyl; or R 4 and R 5 together with the carbon atom to which they are attached are C 3-7 cycloalkyl may be prepared (a) in the case of II by reacting a compound of the Formula I wherein one of R 2 and R 3 is CH 2 CH 2 OH and the other is hydrogen with an aldehyde or ketone R 4 R 5 C = O; (b) in the case III reacting a compound of the Formula I wherein R 2 is hydrogen and R 3 is C 1-20 alkyl with an aldehyde or ketone R 4 R 5 C = O.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US9886070A | 1970-12-16 | 1970-12-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1305502A true GB1305502A (en) | 1973-02-07 |
Family
ID=22271290
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB1252771A Expired GB1305502A (en) | 1970-12-16 | 1971-04-30 |
Country Status (2)
Country | Link |
---|---|
US (1) | US3729564A (en) |
GB (1) | GB1305502A (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4033748A (en) | 1976-07-02 | 1977-07-05 | Merck & Co., Inc. | Dibicyclo[3.1.1] and [2.2.1] heptyl and dibicyclo [3.1.1] and [2.2.1] heptenyl polyamines having a piperidine moiety |
US4100193A (en) * | 1976-06-10 | 1978-07-11 | Merck & Co., Inc. | Novel dibicyclo [2.2.2] octyl and dibicyclo [2.2.2] octenyl polyamines and methods for their preparation |
GB2153831A (en) * | 1984-01-14 | 1985-08-29 | Claude Hepburn | The use of cationic surfactants as crosslinking agents |
WO1994025426A1 (en) * | 1993-04-28 | 1994-11-10 | Alcon Laboratories, Inc. | Diamines as antimicrobial agents and use thereof in ophthalmic composition |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4049417A (en) * | 1975-04-28 | 1977-09-20 | Merck & Co., Inc. | Alicyclic alkylene polyamine microorganism and algae growth inhibitors |
US7445771B2 (en) * | 2003-12-09 | 2008-11-04 | Alcon, Inc. | Use of bis-amines to enhance the antimicrobial activity of aqueous compositions |
EP2788006A1 (en) | 2011-12-07 | 2014-10-15 | Alnylam Pharmaceuticals, Inc. | Biodegradable lipids for the delivery of active agents |
CN106795096B (en) | 2014-06-25 | 2020-05-29 | 爱康泰生治疗公司 | Novel lipid and lipid nanoparticle formulations for delivery of nucleic acids |
JP7072386B2 (en) | 2015-06-29 | 2022-05-20 | アクイタス セラピューティクス インコーポレイテッド | Lipid and Lipid Nanoparticle Formulations for Nucleic Acid Delivery |
RS63986B1 (en) | 2015-10-28 | 2023-03-31 | Acuitas Therapeutics Inc | Novel lipids and lipid nanoparticle formulations for delivery of nucleic acids |
US11357856B2 (en) | 2017-04-13 | 2022-06-14 | Acuitas Therapeutics, Inc. | Lipids for delivery of active agents |
WO2018200943A1 (en) | 2017-04-28 | 2018-11-01 | Acuitas Therapeutics, Inc. | Novel carbonyl lipids and lipid nanoparticle formulations for delivery of nucleic acids |
WO2019036008A1 (en) | 2017-08-16 | 2019-02-21 | Acuitas Therapeutics, Inc. | Lipids for use in lipid nanoparticle formulations |
US11542225B2 (en) | 2017-08-17 | 2023-01-03 | Acuitas Therapeutics, Inc. | Lipids for use in lipid nanoparticle formulations |
WO2019036030A1 (en) | 2017-08-17 | 2019-02-21 | Acuitas Therapeutics, Inc. | Lipids for use in lipid nanoparticle formulations |
CN111491914B (en) * | 2017-12-20 | 2024-04-26 | 罗地亚经营管理公司 | Novel cationic quaternary ammonium compound, composition comprising the same and process for producing the same |
BR112021013654A2 (en) | 2019-01-11 | 2021-09-14 | Acuitas Therapeutics, Inc. | LIPIDS FOR RELEASE OF LIPID NANOPARTICLES FROM ACTIVE AGENTS |
IL299787A (en) | 2020-07-16 | 2023-03-01 | Acuitas Therapeutics Inc | Cationic lipids for use in lipid nanoparticles |
-
1970
- 1970-12-16 US US00098860A patent/US3729564A/en not_active Expired - Lifetime
-
1971
- 1971-04-30 GB GB1252771A patent/GB1305502A/en not_active Expired
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4100193A (en) * | 1976-06-10 | 1978-07-11 | Merck & Co., Inc. | Novel dibicyclo [2.2.2] octyl and dibicyclo [2.2.2] octenyl polyamines and methods for their preparation |
US4033748A (en) | 1976-07-02 | 1977-07-05 | Merck & Co., Inc. | Dibicyclo[3.1.1] and [2.2.1] heptyl and dibicyclo [3.1.1] and [2.2.1] heptenyl polyamines having a piperidine moiety |
GB2153831A (en) * | 1984-01-14 | 1985-08-29 | Claude Hepburn | The use of cationic surfactants as crosslinking agents |
WO1994025426A1 (en) * | 1993-04-28 | 1994-11-10 | Alcon Laboratories, Inc. | Diamines as antimicrobial agents and use thereof in ophthalmic composition |
US5900213A (en) * | 1993-04-28 | 1999-05-04 | Alcon Laboratories, Inc. | Use of diamines to disinfect and clean contact lenses and preserve ophthalmic compositions |
Also Published As
Publication number | Publication date |
---|---|
US3729564A (en) | 1973-04-24 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
GB1305502A (en) | ||
ES403503A1 (en) | Procedure for the preparation of piperidine derivatives and their use as stabilizers (Machine-translation by Google Translate, not legally binding) | |
ES457993A1 (en) | Isothiazolo-pyridines | |
GB1059995A (en) | Preparation of alkyl 3-chloro-3-arylimino-propionates and tautomers thereof | |
ES409192A1 (en) | Amino citric acid derivatives | |
GB1343163A (en) | Cyclopropane carboxylates processes for producing them and compo sitions containing them | |
ES419739A1 (en) | 2-aryl-amino-imidazoline-2 compounds | |
GB1208195A (en) | Process for producing benzodiazepine derivatives | |
GB1329680A (en) | Process for the preparation of carbanilic acid propargyl esters | |
ES394727A1 (en) | Derivatives of thiazolino-pyrimidin-5-ones their preparation and applications | |
ES405645A1 (en) | Procedure for the preparation of new acids 4- (4 bifenilil) -4-hydroxy-butirrics, its esteres or lactonas. (Machine-translation by Google Translate, not legally binding) | |
ES393107A1 (en) | Fungicidal-2-alkoxy-5-halogeno-benzene diazonium cyanides | |
GB1237658A (en) | Substituted 1-oxy-1-thiono-3-halogen- or -3-alkyl phospholines | |
ES303109A1 (en) | Procedure for the preparation of imidazo quinazolinas and pirimido quinazolinas. (Machine-translation by Google Translate, not legally binding) | |
GB1193347A (en) | Production of Alkylenealdehyde-Substituted Hexahydropyrimidin-2-Ones and -Thiones | |
ES381429A1 (en) | Penicillins | |
ES419656A1 (en) | A procedure for the production of a compound of a alkylaminoalcanolic ester. (Machine-translation by Google Translate, not legally binding) | |
GB1197138A (en) | Method for Producing Benzodiazephine Derivatives | |
ES402551A1 (en) | A procedure for the preparation of piperazine derivatives. (Machine-translation by Google Translate, not legally binding) | |
ES391118A1 (en) | Novel glucuronic acid derivatives and process for the preparation thereof | |
ES320141A1 (en) | A procedure for the preparation of penicillins. (Machine-translation by Google Translate, not legally binding) | |
ES292923A1 (en) | Procedure for the obtaining of new derivatives of 6-amino-penicilanic acid (Machine-translation by Google Translate, not legally binding) | |
ES393339A1 (en) | Naphthoquinone derivatives | |
GB1499193A (en) | Indolino-spiropyran compounds useful as colour formers | |
ES417729A1 (en) | Procedure for the preparation of new aminoethanols. (Machine-translation by Google Translate, not legally binding) |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed [section 19, patents act 1949] | ||
PCNP | Patent ceased through non-payment of renewal fee |