FR3096579B1 - composition pour la protection et la reparation de la barriere hematoencephalique (BHE) - Google Patents
composition pour la protection et la reparation de la barriere hematoencephalique (BHE) Download PDFInfo
- Publication number
- FR3096579B1 FR3096579B1 FR1905566A FR1905566A FR3096579B1 FR 3096579 B1 FR3096579 B1 FR 3096579B1 FR 1905566 A FR1905566 A FR 1905566A FR 1905566 A FR1905566 A FR 1905566A FR 3096579 B1 FR3096579 B1 FR 3096579B1
- Authority
- FR
- France
- Prior art keywords
- repair
- protection
- composition
- bbb
- hematoencephalic barrier
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 210000001218 blood-brain barrier Anatomy 0.000 title abstract 3
- 230000008499 blood brain barrier function Effects 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/717—Celluloses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/721—Dextrans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La présente invention se rapporte à une composition pharmaceutique pour son application comme médicament, en particulier pour son utilisation pour la protection de la barrière hématoencéphalique et/ou la réparation et/ou la restauration de la barrière hématoencéphalique. La présente invention trouve une application notamment dans les domaines thérapeutique, pharmaceutiques et vétérinaires. Figure abrégé [Fig. 3]
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR1905566A FR3096579B1 (fr) | 2019-05-27 | 2019-05-27 | composition pour la protection et la reparation de la barriere hematoencephalique (BHE) |
CA3141923A CA3141923A1 (fr) | 2019-05-27 | 2020-04-30 | Composition pour la protection et la reparation de la barriere hematoencephalique (bhe) |
AU2020284406A AU2020284406A1 (en) | 2019-05-27 | 2020-04-30 | Composition for the protection and repair of the blood brain barrier |
US17/595,818 US20220152089A1 (en) | 2019-05-27 | 2020-04-30 | Composition for the protection and repair of the blood brain barrier |
KR1020217042420A KR20220042310A (ko) | 2019-05-27 | 2020-04-30 | 혈액-뇌 장벽(bbb)의 보호 및 복구용 조성물 |
CN202080047142.7A CN114206354B (zh) | 2019-05-27 | 2020-04-30 | 用于保护和修复血脑屏障(bbb)的组合物 |
EP20721621.9A EP3976060A1 (fr) | 2019-05-27 | 2020-04-30 | Composition pour la protection et la reparation de la barriere hematoencephalique (bhe) |
BR112021023737A BR112021023737A2 (pt) | 2019-05-27 | 2020-04-30 | Composição farmacêutica e uso |
JP2021570515A JP2022534278A (ja) | 2019-05-27 | 2020-04-30 | 血液脳関門(bbb)の保護及び修復のための組成物 |
PCT/EP2020/062081 WO2020239356A1 (fr) | 2019-05-27 | 2020-04-30 | Composition pour la protection et la reparation de la barriere hematoencephalique (bhe) |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR1905566 | 2019-05-27 | ||
FR1905566A FR3096579B1 (fr) | 2019-05-27 | 2019-05-27 | composition pour la protection et la reparation de la barriere hematoencephalique (BHE) |
Publications (2)
Publication Number | Publication Date |
---|---|
FR3096579A1 FR3096579A1 (fr) | 2020-12-04 |
FR3096579B1 true FR3096579B1 (fr) | 2023-05-05 |
Family
ID=68138337
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR1905566A Active FR3096579B1 (fr) | 2019-05-27 | 2019-05-27 | composition pour la protection et la reparation de la barriere hematoencephalique (BHE) |
Country Status (10)
Country | Link |
---|---|
US (1) | US20220152089A1 (fr) |
EP (1) | EP3976060A1 (fr) |
JP (1) | JP2022534278A (fr) |
KR (1) | KR20220042310A (fr) |
CN (1) | CN114206354B (fr) |
AU (1) | AU2020284406A1 (fr) |
BR (1) | BR112021023737A2 (fr) |
CA (1) | CA3141923A1 (fr) |
FR (1) | FR3096579B1 (fr) |
WO (1) | WO2020239356A1 (fr) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2024119112A1 (fr) * | 2022-12-01 | 2024-06-06 | Stream Biomedical, Inc. | Utilisation de perlécan et de fragments de celle-ci pour traiter une rupture de la barrière hémato-encéphalique |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4021066A1 (de) * | 1990-07-03 | 1992-01-09 | Hoechst Ag | Langzeitprophylaxe gegen erkrankungen, die durch viren oder durch unkonventionelle viren verursacht werden |
US6573251B2 (en) * | 1994-03-30 | 2003-06-03 | Denis Barritault | Drug and pharmaceutical composition for the treatment of lesions of the nervous system and fractions enriched in heparan sulfate |
FR2718025B1 (fr) * | 1994-03-30 | 1996-06-21 | Paris Val Marne Universite | Médicament et composition pharmaceutique pour le traitement des lésions du système nerveux. |
FR2781485B1 (fr) | 1998-07-21 | 2003-08-08 | Denis Barritault | Polymeres biocompatibles leur procede de preparation et les compositions les contenant |
WO2001051003A2 (fr) * | 2000-01-10 | 2001-07-19 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Utilisation de conjugues de lipides dans le traitement de maladies |
FR2832708B1 (fr) | 2001-11-29 | 2004-02-13 | Organes Tissus Regeneration Re | Procede de sulfonation de composes comprenant des groupements hydroxyle (oh) libres ou des amines primaires ou secondaires |
EP2260853B1 (fr) | 2003-10-28 | 2015-10-21 | Organes Tissus Régénération Réparation Remplacement | Polymères biocompatibles pour une composition médicale |
US20090062208A1 (en) | 2007-02-06 | 2009-03-05 | Mochly-Rosen Daria D | Methods for maintaining blood-brain barrier integrity in hypertensive subjects using a delta-PKC inhibitor |
US8343942B2 (en) * | 2008-04-04 | 2013-01-01 | University Of Utah Research Foundation | Methods for treating interstitial cystitis |
CN101632728B (zh) | 2008-07-21 | 2013-08-07 | 河北以岭医药研究院有限公司 | 一种中药组合物在制备保护血脑屏障的药物中的应用 |
EP3097928A1 (fr) * | 2015-05-28 | 2016-11-30 | Organes Tissus Régénération Réparation Remplacement | Composition pour le traitement des lesions cerebrales |
EP3097922A1 (fr) * | 2015-05-28 | 2016-11-30 | Denis Barritault | Composition pour le traitement des lesions tissulaires |
CN105148276B (zh) | 2015-09-22 | 2018-11-20 | 深圳市第二人民医院 | 抑制Claudin-5降解阻止缺血性血脑屏障损伤的保护剂 |
JP7106340B2 (ja) | 2017-05-12 | 2022-07-26 | 花王株式会社 | 血液脳関門保護剤 |
-
2019
- 2019-05-27 FR FR1905566A patent/FR3096579B1/fr active Active
-
2020
- 2020-04-30 AU AU2020284406A patent/AU2020284406A1/en active Pending
- 2020-04-30 WO PCT/EP2020/062081 patent/WO2020239356A1/fr unknown
- 2020-04-30 US US17/595,818 patent/US20220152089A1/en active Pending
- 2020-04-30 BR BR112021023737A patent/BR112021023737A2/pt unknown
- 2020-04-30 EP EP20721621.9A patent/EP3976060A1/fr active Pending
- 2020-04-30 CN CN202080047142.7A patent/CN114206354B/zh active Active
- 2020-04-30 CA CA3141923A patent/CA3141923A1/fr active Pending
- 2020-04-30 JP JP2021570515A patent/JP2022534278A/ja active Pending
- 2020-04-30 KR KR1020217042420A patent/KR20220042310A/ko unknown
Also Published As
Publication number | Publication date |
---|---|
KR20220042310A (ko) | 2022-04-05 |
AU2020284406A1 (en) | 2022-01-06 |
FR3096579A1 (fr) | 2020-12-04 |
US20220152089A1 (en) | 2022-05-19 |
CA3141923A1 (fr) | 2020-12-03 |
EP3976060A1 (fr) | 2022-04-06 |
JP2022534278A (ja) | 2022-07-28 |
WO2020239356A1 (fr) | 2020-12-03 |
CN114206354B (zh) | 2023-12-29 |
BR112021023737A2 (pt) | 2022-02-01 |
CN114206354A (zh) | 2022-03-18 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Gomes et al. | Chlorhexidine in endodontics | |
Mollashahi et al. | Evaluation of cytotoxic effects of various endodontic irrigation solutions on the survival of stem cell of human apical papilla | |
Victorino et al. | The effects of chlorhexidine and ethanol on push-out bond strength of fiber posts | |
ATE486587T1 (de) | Formulierungen zur oralen verabreichung von wirkstoffen | |
MA37809A1 (fr) | Administration de médicament biodégradable pour compositions hydrophobes | |
Sabatini et al. | Matrix metalloproteinase inhibitory properties of benzalkonium chloride stabilizes adhesive interfaces | |
Pithon et al. | Effect of 10% papain gel on enamel deproteinization before bonding procedure | |
NO20042596L (no) | Inbibitorer av 11-beta-hydroksy steroid dehydrogenase type 1 | |
MA29606B1 (fr) | Combinaison pharmaceutique comprenant un antibacterien et une substance active choisie parmi le carveol, le thymol, l'eugenol, le borneol et le carvacrol | |
MA31496B1 (fr) | Inhibiteurs macrocycliques innovants de la replication du virus de l'hepatite c | |
ATE270544T1 (de) | Halbfeste arzneizubereitung enthaltend isotretinoin | |
Shafiei et al. | Effect of carbodiimide on bonding durability of adhesive-cemented fiber posts in root canals | |
BR0207910A (pt) | HidantÈnios e sua utilização no tratamento do diabetes | |
ATE302616T1 (de) | Oral anzuwendende arzneizusammensetzungen mit gesteuerter wirkstoffabgabe | |
MD3830120T2 (ro) | Noi proteine de fuziune specifice pentru CD137 și PD-L1 | |
BR9808427A (pt) | Produto, processo de preparação e utilização do mesmo e composição farmacêutica | |
FR2918571B1 (fr) | Compositions antibiotiques a base d'huiles essentielles prophylaxie et traitement d'infections nosocomiales | |
BR0008509A (pt) | Composição farmacêutica oral estabilizada contendo iodeto e iodato e método | |
BR0111678A (pt) | Composições medicinais contendo derivados de propenona | |
FR3096579B1 (fr) | composition pour la protection et la reparation de la barriere hematoencephalique (BHE) | |
Hadrous et al. | Evaluation of shear bond strength of orthodontic molar tubes bonded using hydrophilic primers: an in vitro study | |
EE05054B1 (et) | 5-HT4 agonisti v?i antagonisti peroraalne ravimkoostis ja selle kasutamine meditsiinis | |
BR0009674A (pt) | Composto, droga, e, uso de composto | |
MA27474A1 (fr) | Vaccin | |
FR2997405B1 (fr) | Utilisation d'une silice precipitee contenant du titane et d'un agent de couplage specifique dans une composition d'elastomere(s) |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PLFP | Fee payment |
Year of fee payment: 2 |
|
PLSC | Publication of the preliminary search report |
Effective date: 20201204 |
|
PLFP | Fee payment |
Year of fee payment: 3 |
|
PLFP | Fee payment |
Year of fee payment: 4 |
|
PLFP | Fee payment |
Year of fee payment: 5 |
|
PLFP | Fee payment |
Year of fee payment: 6 |