FR2701027B1 - Procede de synthese ameliore du 9-(beta-d-arabinofuranosyl)adenine 5'-phosphate. - Google Patents

Procede de synthese ameliore du 9-(beta-d-arabinofuranosyl)adenine 5'-phosphate.

Info

Publication number
FR2701027B1
FR2701027B1 FR9400750A FR9400750A FR2701027B1 FR 2701027 B1 FR2701027 B1 FR 2701027B1 FR 9400750 A FR9400750 A FR 9400750A FR 9400750 A FR9400750 A FR 9400750A FR 2701027 B1 FR2701027 B1 FR 2701027B1
Authority
FR
France
Prior art keywords
arabinofuranosyl
adenine
beta
phosphate
synthesis process
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR9400750A
Other languages
English (en)
Other versions
FR2701027A1 (fr
Inventor
Donald Eugene Butler
Alan Millar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21753417&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FR2701027(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Publication of FR2701027A1 publication Critical patent/FR2701027A1/fr
Application granted granted Critical
Publication of FR2701027B1 publication Critical patent/FR2701027B1/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
FR9400750A 1993-02-01 1994-01-25 Procede de synthese ameliore du 9-(beta-d-arabinofuranosyl)adenine 5'-phosphate. Expired - Fee Related FR2701027B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US1210693A 1993-02-01 1993-02-01

Publications (2)

Publication Number Publication Date
FR2701027A1 FR2701027A1 (fr) 1994-08-05
FR2701027B1 true FR2701027B1 (fr) 1997-07-18

Family

ID=21753417

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9400750A Expired - Fee Related FR2701027B1 (fr) 1993-02-01 1994-01-25 Procede de synthese ameliore du 9-(beta-d-arabinofuranosyl)adenine 5'-phosphate.

Country Status (2)

Country Link
US (1) US5506352A (fr)
FR (1) FR2701027B1 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999029710A2 (fr) * 1997-12-11 1999-06-17 Schering Aktiengesellschaft Procede de purification utilise pour preparer du phosphate de fludarabine
DE10164510A1 (de) * 2001-12-20 2003-07-10 Schering Ag Orale Fludara reinst Formulierung mit schneller Freisetzung des Wirkstoffes
US20070167353A1 (en) * 2003-10-24 2007-07-19 John Hilfinger Prodrug composition
CN102079766A (zh) * 2009-11-29 2011-06-01 海南中化联合制药工业股份有限公司 一种单磷酸阿糖腺苷的制备方法
EP2683367A4 (fr) * 2011-03-11 2014-08-13 Corn Products Dev Inc Matrice d'encapsulation sans sucre/non cariogène
CN103204890B (zh) * 2013-02-22 2016-03-09 广东先强药业有限公司 一种磷酸化法制备单磷酸阿糖腺苷的方法
CN106866763B (zh) * 2017-04-17 2019-07-23 上海应用技术大学 一种单磷酸阿糖腺苷的合成工艺
CN107793458B (zh) * 2017-09-22 2020-04-21 海南葫芦娃药业集团股份有限公司 一种单磷酸阿糖腺苷的制备方法
CN110407892A (zh) * 2019-08-21 2019-11-05 甘肃泰升化工科技有限公司 一种单磷酸阿糖腺苷的制备方法
CN113173957B (zh) * 2021-04-28 2023-10-27 海南锦瑞制药有限公司 单磷酸阿糖腺苷的合成方法及应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1645896C3 (de) * 1965-03-17 1975-01-02 Ajinomoto Co., Inc., Tokio Verfahren zur Herstellung von 5'-Ribonucleotiden nd S'-Desoxyribonucleotiden
BE756704A (fr) * 1969-09-26 1971-03-01 Parke Davis & Co Procede de production du 5'-phosphate de 9-(beta-d- arabinofuranosyl) adenine et de ses sels
US3943000A (en) * 1974-06-07 1976-03-09 Ferrara Peter J Alkylene oxide modified cereal flours and process of preparing the same
US4061861A (en) * 1976-06-21 1977-12-06 Eli Lilly And Company 7-[α-(2,3-DIHYDRO-2-OXO-1H-benzimidazol-1-ylcarbonyl-amino)arylacetamido]cephalosporins
US4123609A (en) * 1976-11-03 1978-10-31 Warner-Lambert Company Process for the production of 9-(β-D-arabinofuranosyl)adenine, 5'-phosphate
US4518531A (en) * 1979-04-30 1985-05-21 Eli Lilly And Company Allylic chlorination process and compounds prepared thereby
US4814407A (en) * 1985-05-08 1989-03-21 Pcr, Inc. Composition for waterproofing silica-ceramic insulation bodies
US4767873A (en) * 1985-09-13 1988-08-30 The Trustees Of Columbia University In The City Of New York Helical metallocene oligomers and a method for their preparation

Also Published As

Publication number Publication date
US5506352A (en) 1996-04-09
FR2701027A1 (fr) 1994-08-05

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Legal Events

Date Code Title Description
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Effective date: 20060929