FR2592048A1 - Inhibiteurs d'ureido-renine, a action therapeutique - Google Patents
Inhibiteurs d'ureido-renine, a action therapeutiqueInfo
- Publication number
- FR2592048A1 FR2592048A1 FR8616673A FR8616673A FR2592048A1 FR 2592048 A1 FR2592048 A1 FR 2592048A1 FR 8616673 A FR8616673 A FR 8616673A FR 8616673 A FR8616673 A FR 8616673A FR 2592048 A1 FR2592048 A1 FR 2592048A1
- Authority
- FR
- France
- Prior art keywords
- bopi
- ureido
- therapeutic action
- renin inhibitors
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
- C07C275/06—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton
- C07C275/14—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Composés de formule (CF DESSIN DANS BOPI) dans laquelle, de préférence : X est (CF DESSIN DANS BOPI) R1 est (CF DESSIN DANS BOPI) ou -CH-(CH3)2 ; R2 est un atome d'hydrogène ou un groupement -CH2-CH-(CH3)2, ou -CH-(CH3)2 ; R5 est (CF DESSIN DANS BOPI) R4 est (CF DESSIN DANS BOPI) R3 est -CH2-CH-(CH3)2 ; R9 est (CF DESSIN DANS BOPI) ou (CF DESSIN DANS BOPI) R10 est -0-CH3 ; q est égal à un. Ces composés interviennent dans la transformation de l'angiotensinogène en angiotensine II en inhibant la rénine, et ils sont donc utiles comme agents antihypertenseurs.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US81256185A | 1985-12-23 | 1985-12-23 |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2592048A1 true FR2592048A1 (fr) | 1987-06-26 |
FR2592048B1 FR2592048B1 (fr) | 1995-07-07 |
Family
ID=25209973
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR8616673A Expired - Fee Related FR2592048B1 (fr) | 1985-12-23 | 1986-11-28 | Inhibiteurs d'ureido-renine, a action therapeutique |
Country Status (6)
Country | Link |
---|---|
JP (1) | JPS62164658A (fr) |
CA (1) | CA1297631C (fr) |
DE (1) | DE3643977A1 (fr) |
FR (1) | FR2592048B1 (fr) |
GB (1) | GB2184730B (fr) |
IT (1) | IT1213574B (fr) |
Families Citing this family (57)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4599198A (en) * | 1985-08-02 | 1986-07-08 | Pfizer Inc. | Intermediates in polypeptide synthesis |
US5049548A (en) * | 1989-03-03 | 1991-09-17 | Merck & Co., Inc. | Renin-inhibitory di-, tri-, and tetrapeptides |
US5614522A (en) * | 1990-11-19 | 1997-03-25 | G.D. Searle & Co. | Retroviral protease inhibitors |
CA2096408C (fr) * | 1990-11-19 | 2005-02-08 | Gary Anthony Decrescenzo | Inhibiteurs de la protease des retrovirus |
US5482947A (en) * | 1990-11-19 | 1996-01-09 | Talley; John J. | Retroviral protease inhibitors |
US5475013A (en) * | 1990-11-19 | 1995-12-12 | Monsanto Company | Retroviral protease inhibitors |
US5648511A (en) * | 1990-11-19 | 1997-07-15 | G.D. Searle & Co. | Method for making intermediates useful in the synthesis of retroviral protease inhibitors |
EP0558603B1 (fr) * | 1990-11-19 | 1998-08-26 | Monsanto Company | Inhibiteurs de proteases retrovirales |
US5708004A (en) * | 1990-11-19 | 1998-01-13 | Monsanto Company | Retroviral protease inhibitors |
US5475027A (en) * | 1990-11-19 | 1995-12-12 | G.D. Searle & Co. | Retroviral protease inhibitors |
DE69132423T2 (de) | 1990-11-19 | 2001-04-26 | Monsanto Co | Inhibitoren retroviraler Proteasen |
US5583238A (en) * | 1990-11-19 | 1996-12-10 | G. D. Searle & Co. | Method for making intermediates useful in synthesis of retroviral protease inhibitors |
ATE141265T1 (de) * | 1992-05-20 | 1996-08-15 | Searle & Co | Verfahren zur herstellung von intermediaten in der synthese von retroviralen protease inhibitoren |
EP0641325B1 (fr) * | 1992-05-21 | 2001-03-07 | Monsanto Company | Inhibiteurs de protease retrovirale |
US6743929B1 (en) | 1992-08-25 | 2004-06-01 | G. D. Searle & Co. | Sulfonylalkanoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors |
US5760076A (en) * | 1992-08-25 | 1998-06-02 | G.D Searle & Co. | Succinoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors |
DE69311810T2 (de) * | 1992-08-25 | 1997-11-27 | Searle & Co | N-(alkanoylamino-2-hydroxypropyl)-sulfonamide verwendbar als retrovirale proteaseninhibitoren |
US6022994A (en) * | 1992-08-25 | 2000-02-08 | G. D. Searle &. Co. | Succinoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors |
CA2140928C (fr) * | 1992-08-25 | 2008-01-29 | Michael L. Vazquez | Sulfonylalcanoylaminohydroxyethylaminosulfonamides utiles comme inhibiteurs de la protease retrovirale |
US7141609B2 (en) | 1992-08-25 | 2006-11-28 | G.D. Searle & Co. | α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors |
US6046190A (en) * | 1992-08-25 | 2000-04-04 | G.D. Searle & Co. | Hydroxyethylamino sulphonamides useful as retroviral protease inhibitors |
US5968942A (en) | 1992-08-25 | 1999-10-19 | G. D. Searle & Co. | α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors |
US5843946A (en) | 1992-08-25 | 1998-12-01 | G.D. Searle & Co. | α-and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors |
US5830897A (en) * | 1992-08-27 | 1998-11-03 | G. D. Searle & Co. | α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors |
US6337398B1 (en) | 1992-10-30 | 2002-01-08 | G.D. Searle & Co. | Succinoylamino hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors |
ES2196436T3 (es) * | 1992-10-30 | 2003-12-16 | Searle & Co | Acidos sulfonilalcanoilamino-hidroxietilamino-sulfamicos utiles como inhibidores de proteasas retrovirales. |
US5578606A (en) * | 1992-10-30 | 1996-11-26 | G. D. Searle & Co. | α- and β-amino acid hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors |
US5756498A (en) * | 1992-10-30 | 1998-05-26 | G.D. Searle & Co. | Sulfonylalkanoylamino hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors |
ATE211462T1 (de) | 1992-10-30 | 2002-01-15 | Searle & Co | N-substituierte hydroxyethylaminosulfamidsäure- derivate verwendbar als inhibitoren retroviraler proteasen |
US5514801A (en) * | 1992-12-29 | 1996-05-07 | Monsanto Company | Cyclic sulfone containing retroviral protease inhibitors |
US5830888A (en) * | 1993-04-16 | 1998-11-03 | Monsanto Company | Macrocyclic retroviral protease inhibitors |
US5750648A (en) * | 1993-08-20 | 1998-05-12 | G.D. Searle & Co. | Retroviral protease inhibitors and combinations thereof |
US5602119A (en) * | 1993-10-29 | 1997-02-11 | Vazquez; Michael L. | Succinoylamino hydroxyethylamino sulfamic acid derivatives useful as retroviral protease inhibitors |
US6133444A (en) * | 1993-12-22 | 2000-10-17 | Perseptive Biosystems, Inc. | Synthons for the synthesis and deprotection of peptide nucleic acids under mild conditions |
DE69515465T2 (de) * | 1994-11-04 | 2000-08-03 | Santen Pharmaceutical Co Ltd | Neue hydroxy-substituierte 1,3-dialkyl-harnstoffderivate |
US5831117A (en) | 1995-01-20 | 1998-11-03 | G. D. Searle & Co. | Method of preparing retroviral protease inhibitor intermediates |
EP1586558A3 (fr) | 1995-01-20 | 2005-10-26 | G.D. Searle LLC. | Inhibiteurs hydroxyethylamino contenant des bis-sulfinamides utilises pour inhiber des proteases retrovirales |
US6140505A (en) | 1995-03-10 | 2000-10-31 | G. D. Searle & Co. | Synthesis of benzo fused heterocyclic sulfonyl chlorides |
US5756533A (en) * | 1995-03-10 | 1998-05-26 | G.D. Searle & Co. | Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors |
US5776971A (en) * | 1995-03-10 | 1998-07-07 | G.D. Searle & Co. | Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors |
US6667307B2 (en) | 1997-12-19 | 2003-12-23 | G.D. Searle & Co. | Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors |
US6407134B1 (en) | 1995-03-10 | 2002-06-18 | G. D. Searle & Co. | Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors |
US6861539B1 (en) | 1995-03-10 | 2005-03-01 | G. D. Searle & Co. | Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors |
EP1188766A1 (fr) | 1995-03-10 | 2002-03-20 | G.D. Searle & Co. | Hydroxyethylamino sulfonamide de bis-aminoacide comme inhibiteurs de proteases de retrovirus |
US7339078B2 (en) | 1995-03-10 | 2008-03-04 | G.D. Searle Llc | Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors |
US5985870A (en) * | 1995-03-10 | 1999-11-16 | G.D. Searle & Co. | Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors |
US6150556A (en) | 1995-03-10 | 2000-11-21 | G. D. Dearle & Co. | Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors |
US6169085B1 (en) | 1995-03-10 | 2001-01-02 | G. D. Searle & Company | Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors |
US5705500A (en) * | 1995-03-10 | 1998-01-06 | G.D. Searle & Co. | Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors |
RU2174519C2 (ru) | 1995-03-10 | 2001-10-10 | Джи. Ди. Сирл Энд Ко. | Гидроксиэтиламино сульфонамиды гетероциклокарбонил аминокислоты, ингибирующие ретровирусную протеазу |
WO1997018205A1 (fr) * | 1995-11-15 | 1997-05-22 | G.D. Searle & Co. | Inhibiteurs de proteases retrovirales a base de sulfonylalcanoylamino hydroxyethylamino sulfonamides substitues |
BR9815469A (pt) * | 1997-05-08 | 2001-03-06 | Smithkline Beecham Corp | Inibidores de protease |
WO2000002862A1 (fr) | 1998-07-08 | 2000-01-20 | G.D. Searle & Co. | Inhibiteurs de la protease retrovirale |
WO2002014264A2 (fr) * | 2000-08-11 | 2002-02-21 | The Brigham And Women's Hospital, Inc. | (hydroxyethyl)urees utilisees en tant qu'inhibiteurs de la production de beta-amyloide de la maladie d'alhzeimer |
KR100750102B1 (ko) | 2001-06-14 | 2007-08-17 | 삼성전자주식회사 | 디스크 카트리지 |
GEP20074221B (en) | 2001-07-11 | 2007-10-25 | Elan Pharm Inc | N-(3-amino-2-hydroxy-propyl) substituted alkylamide compounds |
US7351738B2 (en) * | 2002-11-27 | 2008-04-01 | Elan Pharmaceuticals, Inc. | Substituted ureas and carbamates |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0104041A1 (fr) * | 1982-09-15 | 1984-03-28 | Aktiebolaget Hässle | Inhibiteurs d'enzyme |
WO1984003044A1 (fr) * | 1983-02-07 | 1984-08-16 | Ferring Ab | Inhibiteurs enzymatiques |
EP0159156A1 (fr) * | 1984-03-30 | 1985-10-23 | E.R. Squibb & Sons, Inc. | Uréidoamino- et -imino-acides hydroxy substitués |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4599198A (en) * | 1985-08-02 | 1986-07-08 | Pfizer Inc. | Intermediates in polypeptide synthesis |
-
1986
- 1986-11-19 CA CA000523367A patent/CA1297631C/fr not_active Expired - Lifetime
- 1986-11-28 FR FR8616673A patent/FR2592048B1/fr not_active Expired - Fee Related
- 1986-12-16 GB GB8630006A patent/GB2184730B/en not_active Expired - Fee Related
- 1986-12-22 DE DE19863643977 patent/DE3643977A1/de not_active Withdrawn
- 1986-12-22 IT IT8622804A patent/IT1213574B/it active
- 1986-12-23 JP JP61316118A patent/JPS62164658A/ja active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0104041A1 (fr) * | 1982-09-15 | 1984-03-28 | Aktiebolaget Hässle | Inhibiteurs d'enzyme |
WO1984003044A1 (fr) * | 1983-02-07 | 1984-08-16 | Ferring Ab | Inhibiteurs enzymatiques |
EP0159156A1 (fr) * | 1984-03-30 | 1985-10-23 | E.R. Squibb & Sons, Inc. | Uréidoamino- et -imino-acides hydroxy substitués |
Also Published As
Publication number | Publication date |
---|---|
GB8630006D0 (en) | 1987-01-28 |
GB2184730A (en) | 1987-07-01 |
IT8622804A0 (it) | 1986-12-22 |
CA1297631C (fr) | 1992-03-17 |
FR2592048B1 (fr) | 1995-07-07 |
GB2184730B (en) | 1990-02-07 |
DE3643977A1 (de) | 1987-07-02 |
JPS62164658A (ja) | 1987-07-21 |
IT1213574B (it) | 1989-12-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
FR2592048A1 (fr) | Inhibiteurs d'ureido-renine, a action therapeutique | |
EP0202577A3 (fr) | N-(acyldipeptidyl)-aminoglycols | |
KR880009910A (ko) | 리폭시게네이즈 억제 화합물 | |
FR2456733A1 (fr) | Nouveaux acides 2-(mercapto-1-oxo(alkyl inferieur))-1,2,3,4-tetrahydroisoquinoleine-3-carboxyliques, utiles notamment comme inhibiteurs de l'enzyme de conversion de l'angiotensine i | |
NO924929L (no) | Farmasoeytisk aktive benzoquinazolinforbindelser | |
NO860852L (no) | Tilling derav. | |
PT1044186E (pt) | Composto 2-benzilamino-2-fenil-acetamida substituidos | |
ATE51618T1 (de) | Imidazolderivate, verfahren zu deren herstellung, deren anwendung und pharmazeutische zusammenstellungen. | |
DE69808099T2 (de) | Substituierte 6-alkylphenanthridine | |
ES539123A0 (es) | Un compuesto de 3-indolcarboxamida | |
NO163957C (no) | Analogifremgangsmaate til fremstilling av terapeutisk aktive karbapenemforbindelser. | |
ATE50773T1 (de) | Alkylresorcinolphosphite. | |
ES2038710T3 (es) | Un procedimiento de preparacion de un derivado de benzoxazina y su utilizacion. | |
FR2631827B1 (fr) | Nouveaux derives d'(hetero)aryl-5 tetrazole, leur procede de preparation et leur application en therapeutique | |
ATE71092T1 (de) | Hydroxybutenolid-derivate, ihre herstellung und ihre verwendung. | |
FR2447383A1 (fr) | Acides mercaptoacylpyrrolidine- et mercaptoacylpiperidine-phosphoniques, a action antihypertensive | |
ES2041679T3 (es) | Compuestos analgesicos de octohidroindolizinas 5-substituidas y productos intermedios 7-ceto. | |
ATE55907T1 (de) | Oktahydroindolizine brauchbar als analgetika. | |
FI861947A (fi) | Hexensyror. | |
TNSN91055A1 (fr) | Nouvelles tetrahydroimidazo (1,4) benzodiazepine -2-(thi) ones | |
ATE151987T1 (de) | Verwendung von 3-pyridazinone zur verringerung der blutplätchenzahl | |
FR2450835A2 (fr) | Derives de la tetrahydroalstonine et leur application en therapeutique | |
FR2453138A1 (fr) | Tetradecapeptides lineaires, intermediaires de synthese d'homologues de somatostatine | |
FR2450824A1 (fr) | Nouveaux derives d'acides 1-(o-mercaptoacyl)-5-pyrazolidinone-3-carboxyliques, utiles notamment comme agents hypotenseurs | |
MX9702941A (es) | Compuestos de di-ter - butilfenol que tiene una porcion heterociclica, utiles como agentes anti-inflamatorios. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |