DE69515465T2 - Neue hydroxy-substituierte 1,3-dialkyl-harnstoffderivate - Google Patents

Neue hydroxy-substituierte 1,3-dialkyl-harnstoffderivate

Info

Publication number
DE69515465T2
DE69515465T2 DE69515465T DE69515465T DE69515465T2 DE 69515465 T2 DE69515465 T2 DE 69515465T2 DE 69515465 T DE69515465 T DE 69515465T DE 69515465 T DE69515465 T DE 69515465T DE 69515465 T2 DE69515465 T2 DE 69515465T2
Authority
DE
Germany
Prior art keywords
alkyl group
lower alkyl
substituted
group
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69515465T
Other languages
English (en)
Other versions
DE69515465D1 (de
Inventor
Yoichi Kawashima
Ken-Ichi Fujimura
Hiroshi Suhara
Nobuaki Miyawaki
Yuko Fujita
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Santen Pharmaceutical Co Ltd
Original Assignee
Santen Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Santen Pharmaceutical Co Ltd filed Critical Santen Pharmaceutical Co Ltd
Application granted granted Critical
Publication of DE69515465D1 publication Critical patent/DE69515465D1/de
Publication of DE69515465T2 publication Critical patent/DE69515465T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
    • C07C275/06—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton
    • C07C275/10—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
    • C07C275/20—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
    • C07C275/24—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Detergent Compositions (AREA)
DE69515465T 1994-11-04 1995-11-01 Neue hydroxy-substituierte 1,3-dialkyl-harnstoffderivate Expired - Fee Related DE69515465T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP27095794 1994-11-04
PCT/JP1995/002236 WO1996014293A1 (fr) 1994-11-04 1995-11-01 Nouveau derive de 1,3-dialkyluree ayant un groupe hydroxyle

Publications (2)

Publication Number Publication Date
DE69515465D1 DE69515465D1 (de) 2000-04-13
DE69515465T2 true DE69515465T2 (de) 2000-08-03

Family

ID=17493383

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69515465T Expired - Fee Related DE69515465T2 (de) 1994-11-04 1995-11-01 Neue hydroxy-substituierte 1,3-dialkyl-harnstoffderivate

Country Status (11)

Country Link
US (1) US5891912A (de)
EP (1) EP0738711B1 (de)
KR (1) KR100376150B1 (de)
CN (1) CN1055681C (de)
AT (1) ATE190304T1 (de)
CA (1) CA2180021A1 (de)
DE (1) DE69515465T2 (de)
ES (1) ES2145929T3 (de)
FI (1) FI962751A0 (de)
NO (1) NO306944B1 (de)
WO (1) WO1996014293A1 (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10252650A1 (de) * 2002-11-11 2004-05-27 Grünenthal GmbH Cyclohexyl-Harnstoff-Derivate

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US7091311B2 (en) 1996-06-07 2006-08-15 Smithkline Beecham Corporation Peptides and compounds that bind to a receptor
US5985968A (en) * 1997-11-17 1999-11-16 Air Products And Chemicals, Inc. Surface tension reduction with N,N-dialkyl ureas
US6156784A (en) * 1997-12-18 2000-12-05 Boehringer Ingelheim Pharmaceuticals, Inc. Compounds useful as phosphotyrosine mimics
US6420396B1 (en) 1998-12-16 2002-07-16 Beiersdorf Ag Biphenyl and biphenyl-analogous compounds as integrin antagonists
US6677360B2 (en) 1998-12-16 2004-01-13 Bayer Aktiengesellschaft Biphenyl and biphenyl-analogous compounds as integrin antagonists
FR2820136A1 (fr) * 2001-01-26 2002-08-02 Aventis Pharma Sa Nouveaux derives de l'uree, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation
US6842358B2 (en) * 2002-08-01 2005-01-11 Netlogic Microsystems, Inc. Content addressable memory with cascaded array
KR20050093759A (ko) 2002-09-18 2005-09-23 오르토-맥네일 파마슈티칼, 인코퍼레이티드 혈소판 및 조혈 줄기세포의 생산을 증가시키는 방법
US7045653B2 (en) 2002-12-23 2006-05-16 Pfizer, Inc. Pharmaceuticals
TW200505418A (en) * 2003-04-21 2005-02-16 Elan Pharm Inc Phenacyl 2-hydroxy-3-diaminoalkanes
JP4848277B2 (ja) * 2003-08-28 2011-12-28 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド 受容体に結合するペプチドおよび化合物
WO2005063699A1 (en) * 2003-12-31 2005-07-14 Council Of Scientific & Industrial Research N-aryloxypropanolyl-n’-phenethyl-urea
US6962945B2 (en) 2004-03-26 2005-11-08 Council Of Scientific And Industrial Research N-aryloxypropanolyl-N′-phenethyl-urea
FR2885129B1 (fr) * 2005-04-29 2007-06-15 Proskelia Sas Nouveaux derives de l'ureee substituee parun thiazole ou benzothiazole, leur procede de preparation, leur application a titre de medicaments, les compositions pharmaceutiques les renfermant et utilisation.
US7875609B2 (en) * 2005-11-25 2011-01-25 Galapagos Sasu Urea derivatives, processes for their preparation, their use as medicaments, and pharmaceutical compositions containing them
GB0613674D0 (en) * 2006-07-10 2006-08-16 Proskelia Sas Derivatives of urea and related diamines, methods for their manufacture, and uses therefor
US9468637B2 (en) 2009-05-13 2016-10-18 Intra-Cellular Therapies, Inc. Organic compounds
MA33364B1 (fr) 2009-05-28 2012-06-01 Novartis Ag Dérivés aminobutyriques substitués en tant qu'inhibiteurs de néprilysine
PE20120330A1 (es) 2009-05-28 2012-04-17 Novartis Ag Derivados amino-propionicos sustituidos como inhibidores de neprilisina
JO2967B1 (en) 2009-11-20 2016-03-15 نوفارتس ايه جي Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors
CN102971288B (zh) * 2010-04-30 2015-01-21 日产化学工业株式会社 二氨基苯基烷基脲的新制造方法
ES2675216T3 (es) 2013-02-14 2018-07-09 Novartis Ag Derivados de ácido bisfenil-butanoico fosfónico sustituido como inhibidores de NEP (endopeptidasa neutra)
WO2014126972A1 (en) 2013-02-14 2014-08-21 Novartis Ag Substituted bisphenyl butanoic acid derivatives as nep inhibitors with improved in vivo efficacy
EP2956141A4 (de) 2013-02-17 2016-10-26 Intra Cellular Therapies Inc Neuartige verwendungen
EP3177627B1 (de) 2014-08-07 2019-07-24 Intra-Cellular Therapies, Inc. Imidazo[1,2-a]-pyrazolo[4,3-e]-pyrimidin-4-on derivate mit pde1 hemmender wirkung
US10682354B2 (en) 2016-03-28 2020-06-16 Intra-Cellular Therapies, Inc. Compositions and methods
EP3746081A4 (de) 2018-01-31 2021-10-27 Intra-Cellular Therapies, Inc. Neuartige verwendungen

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE53315B1 (en) * 1980-12-18 1988-10-12 Schering Corp Substituted dipeptides,processes for their preparation and pharmaceutical compositions containing them and their use in the inhibition of enkephalinase
CY1406A (en) * 1980-12-18 1988-04-22 Schering Corp Substituted dipeptides, processes for their preparation and pharmaceutical compositions containing them and their use in the inhibition of enkephalinase
DE3134933A1 (de) * 1981-09-03 1983-03-31 Hoechst Ag, 6230 Frankfurt "harnstoffderivate, verfahren zu ihrer herstellung und diese enthaltende medikamente sowie deren verwendung"
JPS5823851A (ja) * 1982-07-29 1983-02-12 Mitsubishi Gas Chem Co Inc 耐熱性樹脂組成物
US4599198A (en) * 1985-08-02 1986-07-08 Pfizer Inc. Intermediates in polypeptide synthesis
US4668769A (en) * 1985-08-02 1987-05-26 Hoover Dennis J Oxa- and azahomocyclostatine polypeptides
US4757050A (en) * 1985-12-23 1988-07-12 E. R. Squibb Sons, Inc. Ureido renin inhibitors
CA1297631C (en) * 1985-12-23 1992-03-17 Sesha I. Natarajan Ureido renin inhibitors
DE3619508A1 (de) * 1986-06-10 1987-12-17 Merck Patent Gmbh Aminosaeurederivate
JP2775690B2 (ja) * 1989-08-22 1998-07-16 昭和シェル石油株式会社 スリップ・レイヤー・シート
US5475027A (en) * 1990-11-19 1995-12-12 G.D. Searle & Co. Retroviral protease inhibitors
EP0554400B1 (de) * 1990-11-19 1997-07-23 Monsanto Company Retrovirale protease-inhibitoren
JPH0672985A (ja) * 1992-08-28 1994-03-15 Ono Pharmaceut Co Ltd （チオ）ウレア誘導体
JP3118738B2 (ja) * 1992-12-22 2000-12-18 小野薬品工業株式会社 （チオ）ウレア誘導体

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10252650A1 (de) * 2002-11-11 2004-05-27 Grünenthal GmbH Cyclohexyl-Harnstoff-Derivate
US7348354B2 (en) 2002-11-11 2008-03-25 Gruenenthal Gmbh Cyclohexylurea compounds

Also Published As

Publication number Publication date
CN1055681C (zh) 2000-08-23
NO962810L (no) 1996-07-03
KR970702846A (ko) 1997-06-10
KR100376150B1 (ko) 2003-11-01
FI962751A (fi) 1996-07-04
WO1996014293A1 (fr) 1996-05-17
NO962810D0 (no) 1996-07-03
NO306944B1 (no) 2000-01-17
CN1138321A (zh) 1996-12-18
CA2180021A1 (en) 1996-05-17
ES2145929T3 (es) 2000-07-16
FI962751A0 (fi) 1996-07-04
ATE190304T1 (de) 2000-03-15
EP0738711B1 (de) 2000-03-08
US5891912A (en) 1999-04-06
EP0738711A4 (de) 1998-09-30
EP0738711A1 (de) 1996-10-23
DE69515465D1 (de) 2000-04-13

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Legal Events

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8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee