FR2571724B1 - Complexes metalliques de derives du bis-indole et compositions pharmaceutiques aqueuses les contenant - Google Patents

Complexes metalliques de derives du bis-indole et compositions pharmaceutiques aqueuses les contenant

Info

Publication number: FR2571724B1
Authority: FR; France
Prior art keywords: bis; pharmaceutical compositions; compositions containing; metal complexes; aqueous pharmaceutical
Prior art date: 1984-10-16
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

FR8515254A

Other languages

English (en)

Other versions

FR2571724A1 (fr

Inventor

Geza Takacsi Nagy

Gabor Szepesi

Maria Gazdag

Zsofia Pap

Nee Sziklay

Kalman Burger

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Richter Gedeon Nyrt

Richter Gedeon Vegyeszeti Gyar Nyrt

Original Assignee

Richter Gedeon Nyrt

Richter Gedeon Vegyeszeti Gyar RT

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-10-16

Filing date

1985-10-15

Publication date

1988-08-26

1985-10-15 Application filed by Richter Gedeon Nyrt, Richter Gedeon Vegyeszeti Gyar RT filed Critical Richter Gedeon Nyrt

1986-04-18 Publication of FR2571724A1 publication Critical patent/FR2571724A1/fr

1988-08-26 Application granted granted Critical

1988-08-26 Publication of FR2571724B1 publication Critical patent/FR2571724B1/fr

Status Expired legal-status Critical Current

Links

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Dermatology (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Oil, Petroleum & Natural Gas (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicinal Preparation (AREA)

FR8515254A 1984-10-16 1985-10-15 Complexes metalliques de derives du bis-indole et compositions pharmaceutiques aqueuses les contenant Expired FR2571724B1 (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
HU843861A HU195513B (en)	1984-10-16	1984-10-16	Process for producing stable solutions of alkaloides with bis-indole skeleton

Publications (2)

Publication Number	Publication Date
FR2571724A1 FR2571724A1 (fr)	1986-04-18
FR2571724B1 true FR2571724B1 (fr)	1988-08-26

Family

ID=10965811

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FR8515254A Expired FR2571724B1 (fr)	1984-10-16	1985-10-15	Complexes metalliques de derives du bis-indole et compositions pharmaceutiques aqueuses les contenant

Country Status (29)

Country	Link
US (1)	US4684638A (fr)
JP (1)	JPS61106584A (fr)
CN (1)	CN1007958B (fr)
AT (1)	AT389996B (fr)
AU (1)	AU580342B2 (fr)
BE (1)	BE903447A (fr)
CA (1)	CA1272192A (fr)
CH (1)	CH667459A5 (fr)
CS (1)	CS251798B2 (fr)
DD (1)	DD239207A5 (fr)
DE (1)	DE3536745A1 (fr)
DK (1)	DK169972B1 (fr)
ES (1)	ES8701185A1 (fr)
FI (1)	FI84134C (fr)
FR (1)	FR2571724B1 (fr)
GB (1)	GB2165540B (fr)
GR (1)	GR852510B (fr)
HU (1)	HU195513B (fr)
IE (1)	IE58467B1 (fr)
IL (1)	IL76719A (fr)
IN (1)	IN162910B (fr)
IT (1)	IT1186776B (fr)
LT (1)	LT2203B (fr)
LU (1)	LU86115A1 (fr)
LV (1)	LV5175A3 (fr)
NL (1)	NL192779C (fr)
SE (1)	SE466017B (fr)
SU (1)	SU1706372A3 (fr)
ZA (1)	ZA857905B (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1341262C (fr) *	1987-08-06	2001-06-26	Camille A. Boulet	Nouveau procede de synthese de 3',4'-anhydrovinblastine de la vinblastine et de la vincristine
US5170515A (en) *	1987-09-16	1992-12-15	Toto Ltd.	Water closet
FR2623089B1 (fr) *	1987-11-13	1990-04-27	Pf Medicament	Composition pharmaceutique pour l'administration parenterale de navelbine
HU204995B (en) *	1989-11-07	1992-03-30	Richter Gedeon Vegyeszet	Process for producing pharmaceutical composition comprising alkaloid with bis-indole skeleton, with antitumour activity and suitable fr parenteral purposes
US20110015221A1 (en) *	2003-12-23	2011-01-20	Pierre Fabre Medicament	Pharmaceutical composition of vinflunine which is intended for parenteral administration preparation method thereof and use of same
FR2863891B1 (fr) *	2003-12-23	2006-03-24	Pf Medicament	Composition pharmaceutique de vinflunine destinee a une administration parentale, procede de preparation et utilisation
WO2007047951A2 (fr) *	2005-10-20	2007-04-26	University Of South Florida	Libération moléculaire au niveau de cellules en utilisant des composés dérivés de l'aspirine

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE595570C (de) *	1932-10-07	1934-04-16	I G Farbenindustrie Akt Ges	Verfahren zur Darstellung waesseriger Loesungen von Schwermetallverbindungen der aromatischen Halogenylsulfamide
US3426024A (en) *	1967-11-17	1969-02-04	Vanderbilt Co R T	Amine complexes of zinc salts of chlorinated thiobisphenols
DE2502932C2 (de) *	1975-01-24	1985-04-18	Bayer Ag, 5090 Leverkusen	Metallkomplexe von N-Trityl-azolen, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Fungizide
FR2349335A1 (fr) *	1976-04-28	1977-11-25	Inst Int Pathologie Cellulaire	Complexes d'alcaloides bis-indoliques du type vinblastine avec la tubuline, leur procede d'obtention et leur utilisation
EP0004770B1 (fr) *	1978-04-11	1984-06-13	Efamol Limited	Composition pharmaceutique et diététique comprenant des acides gamma-linoléniques
DE3261761D1 (en) *	1981-07-14	1985-02-14	Efamol Ltd	Pharmaceutical and dietary composition when used for enhancement of 1-series pg production
IT1170152B (it) *	1982-07-19	1987-06-03	Lilly Co Eli	Miglioramenti a o riguardanti formulazioni di vinca-alcaloidi

1984
- 1984-10-16 HU HU843861A patent/HU195513B/hu unknown
1985
- 1985-08-15 FI FI853123A patent/FI84134C/fi not_active IP Right Cessation
- 1985-09-13 JP JP60201957A patent/JPS61106584A/ja active Granted
- 1985-09-26 CN CN85107053A patent/CN1007958B/zh not_active Expired
- 1985-09-27 CH CH4203/85A patent/CH667459A5/de not_active IP Right Cessation
- 1985-10-01 US US06/782,492 patent/US4684638A/en not_active Expired - Fee Related
- 1985-10-14 IE IE253185A patent/IE58467B1/en not_active IP Right Cessation
- 1985-10-15 DE DE19853536745 patent/DE3536745A1/de active Granted
- 1985-10-15 IL IL76719A patent/IL76719A/xx not_active IP Right Cessation
- 1985-10-15 CA CA000492974A patent/CA1272192A/fr not_active Expired - Fee Related
- 1985-10-15 DD DD85281749A patent/DD239207A5/de not_active IP Right Cessation
- 1985-10-15 NL NL8502821A patent/NL192779C/nl not_active IP Right Cessation
- 1985-10-15 AT AT0297985A patent/AT389996B/de not_active IP Right Cessation
- 1985-10-15 AU AU48714/85A patent/AU580342B2/en not_active Ceased
- 1985-10-15 FR FR8515254A patent/FR2571724B1/fr not_active Expired
- 1985-10-15 DK DK472085A patent/DK169972B1/da not_active IP Right Cessation
- 1985-10-15 SU SU853963551A patent/SU1706372A3/ru active
- 1985-10-15 GB GB08525360A patent/GB2165540B/en not_active Expired
- 1985-10-15 IT IT22482/85A patent/IT1186776B/it active
- 1985-10-15 ZA ZA857905A patent/ZA857905B/xx unknown
- 1985-10-15 ES ES547862A patent/ES8701185A1/es not_active Expired
- 1985-10-15 BE BE0/215727A patent/BE903447A/fr not_active IP Right Cessation
- 1985-10-15 SE SE8504786A patent/SE466017B/sv not_active IP Right Cessation
- 1985-10-15 IN IN730/CAL/85A patent/IN162910B/en unknown
- 1985-10-15 LU LU86115A patent/LU86115A1/de unknown
- 1985-10-16 GR GR852510A patent/GR852510B/el unknown
- 1985-10-16 CS CS857387A patent/CS251798B2/cs unknown
1993
- 1993-01-18 LV LV930046A patent/LV5175A3/xx unknown
- 1993-08-13 LT LTRP858A patent/LT2203B/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
CA1272192A (fr)	1990-07-31
FR2571724A1 (fr)	1986-04-18
FI853123A0 (fi)	1985-08-15
SE8504786D0 (sv)	1985-10-15
AU4871485A (en)	1986-04-24
NL192779B (nl)	1997-10-01
SU1706372A3 (ru)	1992-01-15
AT389996B (de)	1990-02-26
IL76719A0 (en)	1986-02-28
DE3536745A1 (de)	1986-04-17
FI84134B (fi)	1991-07-15
SE8504786L (sv)	1986-04-17
IL76719A (en)	1989-10-31
CS251798B2 (en)	1987-08-13
IT1186776B (it)	1987-12-16
DE3536745C2 (fr)	1992-01-23
ZA857905B (en)	1986-06-25
GR852510B (fr)	1986-02-18
GB2165540A (en)	1986-04-16
DK472085A (da)	1986-04-17
SE466017B (sv)	1991-12-02
NL8502821A (nl)	1986-05-16
JPS61106584A (ja)	1986-05-24
IN162910B (fr)	1988-07-23
LT2203B (lt)	1993-10-15
AU580342B2 (en)	1989-01-12
IE852531L (en)	1986-04-16
DD239207A5 (de)	1986-09-17
US4684638A (en)	1987-08-04
IE58467B1 (en)	1993-09-22
CN85107053A (zh)	1986-06-10
GB8525360D0 (en)	1985-11-20
ES8701185A1 (es)	1986-11-16
FI84134C (fi)	1991-10-25
JPH0339489B2 (fr)	1991-06-14
DK169972B1 (da)	1995-04-18
CN1007958B (zh)	1990-05-16
DK472085D0 (da)	1985-10-15
BE903447A (fr)	1986-04-15
ES547862A0 (es)	1986-11-16
GB2165540B (en)	1988-04-27
HU195513B (en)	1988-05-30
CH667459A5 (de)	1988-10-14
IT8522482A0 (it)	1985-10-15
ATA297985A (de)	1989-08-15
FI853123L (fi)	1986-04-17
LV5175A3 (lv)	1993-10-10
LU86115A1 (de)	1986-03-24
NL192779C (nl)	1998-02-03

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Legal Events

Date	Code	Title	Description
1996-09-06	ST	Notification of lapse