CA1341262C - Nouveau procede de synthese de 3',4'-anhydrovinblastine de la vinblastine et de la vincristine - Google Patents

Nouveau procede de synthese de 3',4'-anhydrovinblastine de la vinblastine et de la vincristine Download PDF

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Publication number
CA1341262C
CA1341262C CA000543832A CA543832A CA1341262C CA 1341262 C CA1341262 C CA 1341262C CA 000543832 A CA000543832 A CA 000543832A CA 543832 A CA543832 A CA 543832A CA 1341262 C CA1341262 C CA 1341262C
Authority
CA
Canada
Prior art keywords
formula
alkyl
process according
enamine
represented
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA000543832A
Other languages
English (en)
Inventor
Camille A. Boulet
James P. Kutney
Michael Mchugh
Hiroki Tsukamoto
Jun Nakano
Lewis S.L. Choi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of British Columbia
Original Assignee
University of British Columbia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of British Columbia filed Critical University of British Columbia
Priority to CA000543832A priority Critical patent/CA1341262C/fr
Priority to US07/228,821 priority patent/US5047528A/en
Priority to DE3826412A priority patent/DE3826412A1/de
Priority to SE8802813A priority patent/SE467875B/sv
Priority to IL8734788A priority patent/IL87347A/en
Priority to AU20512/88A priority patent/AU617342B2/en
Priority to FR888810637A priority patent/FR2622888B1/fr
Priority to NL8801966A priority patent/NL8801966A/nl
Priority to IT8821678A priority patent/IT1227155B/it
Priority to ZA885765A priority patent/ZA885765B/xx
Priority to BE8800908A priority patent/BE1003228A4/fr
Priority to CH2974/88A priority patent/CH676711A5/de
Priority to CN 88104941 priority patent/CN1027266C/zh
Priority to JP63196999A priority patent/JPH0613532B2/ja
Priority to GB8818765A priority patent/GB2215331B/en
Priority to HU884126A priority patent/HU208829B/hu
Application granted granted Critical
Publication of CA1341262C publication Critical patent/CA1341262C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CA000543832A 1987-01-22 1987-08-06 Nouveau procede de synthese de 3',4'-anhydrovinblastine de la vinblastine et de la vincristine Expired - Fee Related CA1341262C (fr)

Priority Applications (16)

Application Number Priority Date Filing Date Title
CA000543832A CA1341262C (fr) 1987-08-06 1987-08-06 Nouveau procede de synthese de 3',4'-anhydrovinblastine de la vinblastine et de la vincristine
US07/228,821 US5047528A (en) 1987-01-22 1988-08-02 Process of synthesis of vinblastine and vincristine
DE3826412A DE3826412A1 (de) 1987-08-06 1988-08-03 Verfahren fuer die synthese von vinblastin und vincristin
SE8802813A SE467875B (sv) 1987-08-06 1988-08-03 Foerfarande foer framstaellning av vinblastin och vinkristin.
IL8734788A IL87347A (en) 1987-08-06 1988-08-04 Process for the synthesis of vinblastine and vincristine
IT8821678A IT1227155B (it) 1987-08-06 1988-08-05 Procedimento di sintesi di vinblastina e vincristina.
FR888810637A FR2622888B1 (fr) 1987-01-22 1988-08-05 Procede perfectionne de synthese de la vinblastine et de la vincristine
NL8801966A NL8801966A (nl) 1987-08-06 1988-08-05 Werkwijze voor de bereiding van vinblastine en vincristine.
AU20512/88A AU617342B2 (en) 1987-01-22 1988-08-05 Process for the synthesis of dimer alkaloid compounds
ZA885765A ZA885765B (en) 1987-08-06 1988-08-05 Process for the synthesis of vinblastine and vincristine
BE8800908A BE1003228A4 (fr) 1987-08-06 1988-08-05 Procede de synthese de la vinblastine et de la vincristine
CH2974/88A CH676711A5 (fr) 1987-08-06 1988-08-05
JP63196999A JPH0613532B2 (ja) 1987-08-06 1988-08-06 二量体の生成方法
CN 88104941 CN1027266C (zh) 1987-08-06 1988-08-06 生物碱化合物类二聚物的合成方法
GB8818765A GB2215331B (en) 1987-08-06 1988-08-08 Improvements in or relating to the synthesis of vinblastine and vincristine and related compounds
HU884126A HU208829B (en) 1987-08-06 1988-08-08 Process for synthetizing dimeric alkaloid compounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CA000543832A CA1341262C (fr) 1987-08-06 1987-08-06 Nouveau procede de synthese de 3',4'-anhydrovinblastine de la vinblastine et de la vincristine

Publications (1)

Publication Number Publication Date
CA1341262C true CA1341262C (fr) 2001-06-26

Family

ID=4136214

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000543832A Expired - Fee Related CA1341262C (fr) 1987-01-22 1987-08-06 Nouveau procede de synthese de 3',4'-anhydrovinblastine de la vinblastine et de la vincristine

Country Status (12)

Country Link
JP (1) JPH0613532B2 (fr)
AU (1) AU617342B2 (fr)
BE (1) BE1003228A4 (fr)
CA (1) CA1341262C (fr)
CH (1) CH676711A5 (fr)
DE (1) DE3826412A1 (fr)
GB (1) GB2215331B (fr)
HU (1) HU208829B (fr)
IT (1) IT1227155B (fr)
NL (1) NL8801966A (fr)
SE (1) SE467875B (fr)
ZA (1) ZA885765B (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5047528A (en) * 1987-01-22 1991-09-10 University Of Bristish Columbia Process of synthesis of vinblastine and vincristine
USRE37449E1 (en) 1987-02-06 2001-11-13 University Of British Columbia Process of synthesis of 3′,4′-anhydrovinblastine, vinblastine and vincristine
US5432279A (en) * 1989-03-04 1995-07-11 Mitsui Petrochemical Industries, Inc. Process for the preparation of binary indole alkaloids
ES2135384T3 (es) * 1990-11-30 1999-11-01 Fujirebio Kk Derivados de 1,4-dihidropiridina opticamente activos y procedimientos para producirlos.
JP3010151U (ja) * 1994-04-26 1995-04-25 スミ子 片山 切込みのついた筒形食器収納ケース。
FR2779146B1 (fr) * 1998-06-02 2002-01-18 Roowin Nouveaux derives de vinca-alcaloides et procedes de preparation

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4279817A (en) * 1975-05-30 1981-07-21 The United States Of America As Represented By The Department Of Health & Human Services Method for producing dimer alkaloids
HU195513B (en) * 1984-10-16 1988-05-30 Richter Gedeon Vegyeszet Process for producing stable solutions of alkaloides with bis-indole skeleton
EP0215058A1 (fr) * 1985-03-12 1987-03-25 The University Of Vermont And State Agricultural College Synthese de composes du type vinblastine et vincristine
CA1341261C (fr) * 1987-01-22 2001-06-26 James P. Kutney Procede pour la synthese de 3',4'-anhydrovinblastine, de la vinblastine et de la vincristine

Also Published As

Publication number Publication date
SE8802813D0 (sv) 1988-08-03
AU2051288A (en) 1989-02-09
HU208829B (en) 1994-01-28
HUT50351A (en) 1990-01-29
SE8802813L (sv) 1989-02-07
AU617342B2 (en) 1991-11-28
NL8801966A (nl) 1989-03-01
GB8818765D0 (en) 1988-09-07
BE1003228A4 (fr) 1992-02-04
JPH01151590A (ja) 1989-06-14
CH676711A5 (fr) 1991-02-28
JPH0613532B2 (ja) 1994-02-23
IT1227155B (it) 1991-03-19
SE467875B (sv) 1992-09-28
ZA885765B (en) 1989-09-27
DE3826412A1 (de) 1989-02-16
GB2215331A (en) 1989-09-20
IT8821678A0 (it) 1988-08-05
GB2215331B (en) 1992-01-02

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