FR2455572A1 - Derives de phenylethylamine, leur preparation et utilisation dans le traitement des affections cardiovasculaires, et compositions les contenant - Google Patents

Derives de phenylethylamine, leur preparation et utilisation dans le traitement des affections cardiovasculaires, et compositions les contenant

Info

Publication number
FR2455572A1
FR2455572A1 FR8009846A FR8009846A FR2455572A1 FR 2455572 A1 FR2455572 A1 FR 2455572A1 FR 8009846 A FR8009846 A FR 8009846A FR 8009846 A FR8009846 A FR 8009846A FR 2455572 A1 FR2455572 A1 FR 2455572A1
Authority
FR
France
Prior art keywords
preparation
treatment
compositions containing
derivatives
cardiovascular conditions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR8009846A
Other languages
English (en)
Other versions
FR2455572B1 (fr
Inventor
Claude Gillet
Joseph Roba
Alexis Cordi
William Van Dorsser
Georges Lambelin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Continental Pharma Inc
Original Assignee
Continental Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Continental Pharma Inc filed Critical Continental Pharma Inc
Publication of FR2455572A1 publication Critical patent/FR2455572A1/fr
Application granted granted Critical
Publication of FR2455572B1 publication Critical patent/FR2455572B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/58—Radicals substituted by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)

Abstract

LA PRESENTE INVENTION EST RELATIVE A DES DERIVES DE PHENYLETHYLAMINES. LES DERIVES REPONDENT A LA FORMULE: (CF DESSIN DANS BOPI) DANS LAQUELLE LES SUBSTITUANTS R A R ET X PEUVENT AVOIR DIFFERENTES SIGNIFICATIONS. CES DERIVES POSSEDENT D'INTERESSANTES ACTIVITES SUR LE SYSTEME CARDIOVASCULAIRE ET LE SYSTEME NERVEUX CENTRAL.
FR8009846A 1979-05-04 1980-04-30 Derives de phenylethylamine, leur preparation et utilisation dans le traitement des affections cardiovasculaires, et compositions les contenant Expired FR2455572B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
LU81225 1979-05-04

Publications (2)

Publication Number Publication Date
FR2455572A1 true FR2455572A1 (fr) 1980-11-28
FR2455572B1 FR2455572B1 (fr) 1986-07-25

Family

ID=19729148

Family Applications (2)

Application Number Title Priority Date Filing Date
FR8009847A Granted FR2455587A1 (fr) 1979-05-04 1980-04-30 Derives de benzimidazole, leur preparation et utilisation dans le traitement des affections cardiovasculaires et compositions les contenant
FR8009846A Expired FR2455572B1 (fr) 1979-05-04 1980-04-30 Derives de phenylethylamine, leur preparation et utilisation dans le traitement des affections cardiovasculaires, et compositions les contenant

Family Applications Before (1)

Application Number Title Priority Date Filing Date
FR8009847A Granted FR2455587A1 (fr) 1979-05-04 1980-04-30 Derives de benzimidazole, leur preparation et utilisation dans le traitement des affections cardiovasculaires et compositions les contenant

Country Status (22)

Country Link
US (1) US4338330A (fr)
JP (2) JPS565465A (fr)
AT (2) AT376210B (fr)
AU (2) AU537573B2 (fr)
BE (2) BE883069A (fr)
CA (1) CA1146563A (fr)
CH (2) CH645090A5 (fr)
DE (2) DE3016827A1 (fr)
DK (2) DK187880A (fr)
ES (2) ES8104245A1 (fr)
FI (2) FI801428A (fr)
FR (2) FR2455587A1 (fr)
GB (2) GB2055360B (fr)
GR (2) GR68536B (fr)
IE (1) IE50218B1 (fr)
IL (2) IL59973A (fr)
IT (2) IT1159060B (fr)
NL (2) NL8002567A (fr)
NO (2) NO801286L (fr)
PT (2) PT71175A (fr)
SE (2) SE8003278L (fr)
ZA (2) ZA802695B (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1984004091A1 (fr) * 1983-04-19 1984-10-25 Beecham Group Plc Derives de 2-phenylethylamine pharmaceutiquement actifs

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1156661A (fr) * 1980-02-25 1983-11-08 Hoffmann-La Roche Limited Derives de phenoxy-aminopropanol
JPS582343A (ja) * 1981-06-30 1983-01-07 Osaka Soda Co Ltd 耐窒素酸化物性に優れた加硫性ゴム組成物
US4550119A (en) * 1983-05-23 1985-10-29 Warner-Lambert Company 2,4-Dihydro-5-[(substituted)phenyl]-4,4-disubstituted-3H-pyrazol-3-ones
US5104892A (en) * 1989-12-11 1992-04-14 American Home Products Corporation Substituted benzimidazole derivatives possessing Class III antiarrhythmic activity
US5541204A (en) * 1994-12-02 1996-07-30 Bristol-Myers Squibb Company Aryloxypropanolamine β 3 adrenergic agonists
WO2003080545A2 (fr) * 2002-03-20 2003-10-02 Metabolex, Inc. Acides phenylacetiques substitues
US7351719B2 (en) 2002-10-31 2008-04-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Amide compounds having MCH-antagonistic activity and medicaments comprising these compounds
US7199259B2 (en) * 2003-06-20 2007-04-03 Metabolex, Inc. Resolution of α-(phenoxy)phenylacetic acid derivatives
CA2567437A1 (fr) * 2004-05-25 2005-12-08 Metabolex, Inc. Triazoles substitues comme modulateurs de ppar et methodes de preparation
JP2008500358A (ja) * 2004-05-25 2008-01-10 メタボレックス インコーポレーティッド Ｐｐａｒのモジュレーターとしての、二環式の置換されたトリアゾール、およびこれらの調製方法
US7714131B2 (en) * 2005-09-23 2010-05-11 Metabolex, Inc. Process for the stereoselective preparation of (−)-halofenate and derivatives thereof
EP2727911B1 (fr) * 2012-10-31 2016-12-21 Medizinische Hochschule Hannover Nouveaux moyens et procédés de traitement du paludisme et autres troubles parasitaires

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2062055A1 (de) * 1969-12-17 1971-06-24 Pfizer Corp , Colon (Panama) Propanolamin Derivate

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1157556A (en) * 1966-06-09 1969-07-09 Egyt Gyogyszervegyeszeti Gyar Novel Benzazole Derivatives and the Preparation thereof
FR1570892A (fr) * 1968-06-18 1969-06-13
US3574218A (en) * 1969-08-11 1971-04-06 Egyt Gyogyszervegyeszeti Gyar 2-aryl- or aralkyl-substituted benzazole derivatives
CH624395A5 (fr) 1976-01-08 1981-07-31 Ciba Geigy Ag
DE2609645A1 (de) 1976-03-09 1977-09-15 Boehringer Sohn Ingelheim Aminoalkylheterocyclen
DE2640730C2 (de) * 1976-09-10 1983-08-25 Hoechst Ag, 6230 Frankfurt Benzoxazolyloxy- und Benzothiazolyloxy-phenoxy-Verbindungen und diese enthaltende herbizide Mittel
DE2644833A1 (de) * 1976-10-05 1978-04-20 Boehringer Sohn Ingelheim Neue 1-aryloxy-2-hydroxy-3-alkylenaminopropane und verfahren zu ihrer herstellung
DE2737630A1 (de) 1977-08-20 1979-03-01 Boehringer Mannheim Gmbh Neue aminopropanolderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE2801953A1 (de) 1978-01-18 1979-07-19 Boehringer Mannheim Gmbh 4-hydroxy-2-benzimidazolinon-derivate, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel
DE2801980A1 (de) 1978-01-18 1979-07-19 Boehringer Mannheim Gmbh 4-hydroxy-2-benzimidazolin-thion- derivate, verfahren zu ihrer herstellung sowie diese verbindungen enthaltende arzneimittel
EP0003758A1 (fr) 1978-02-09 1979-09-05 Ciba-Geigy Ag Hydroxy-benzodihétérocycles éthérifiés et leurs sels d'addition acides, procédé pour leur préparation et compositions pharmaceutiques les contenant
DE2905877A1 (de) 1979-02-16 1980-08-28 Boehringer Mannheim Gmbh Neue aminopropanolderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE2905876A1 (de) 1979-02-16 1980-08-28 Boehringer Mannheim Gmbh Neue piperidinopropylderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2062055A1 (de) * 1969-12-17 1971-06-24 Pfizer Corp , Colon (Panama) Propanolamin Derivate

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1984004091A1 (fr) * 1983-04-19 1984-10-25 Beecham Group Plc Derives de 2-phenylethylamine pharmaceutiquement actifs

Also Published As

Publication number Publication date
FI801429A (fi) 1980-11-05
GB2055360A (en) 1981-03-04
IL59973A (en) 1985-03-31
ES8103729A1 (es) 1981-03-16
IT8021779A0 (it) 1980-05-02
NO801286L (no) 1980-11-05
GR68535B (fr) 1982-01-18
IT8021780A1 (it) 1981-11-02
CA1146563A (fr) 1983-05-17
JPS565465A (en) 1981-01-20
FR2455587B1 (fr) 1983-06-24
CH644599A5 (fr) 1984-08-15
FR2455572B1 (fr) 1986-07-25
SE8003277L (sv) 1980-11-05
CH645090A5 (fr) 1984-09-14
GB2055091A (en) 1981-02-25
ES491143A0 (es) 1981-04-16
FI801428A (fi) 1980-11-05
JPS5663946A (en) 1981-05-30
PT71174A (fr) 1980-05-01
IT8021779A1 (it) 1981-11-02
GR68536B (fr) 1982-01-18
AU5809580A (en) 1980-11-06
ES8104245A1 (es) 1981-04-16
AU5809680A (en) 1980-11-06
NO150916B (no) 1984-10-01
ATA238780A (de) 1984-03-15
AT376210B (de) 1984-10-25
ATA238680A (de) 1984-04-15
IT1159060B (it) 1987-02-25
BE883069A (fr) 1980-08-18
SE8003278L (sv) 1980-11-05
IE800918L (en) 1980-11-04
ZA802695B (en) 1981-08-26
GB2055091B (en) 1983-11-09
JPS6033424B2 (ja) 1985-08-02
IL59973A0 (en) 1980-07-31
NL8002568A (nl) 1980-11-06
IT8021780A0 (it) 1980-05-02
DE3016828A1 (de) 1980-11-13
PT71175A (fr) 1980-05-01
AT376418B (de) 1984-11-26
DK187980A (da) 1980-11-05
NO801285L (no) 1980-11-05
DK187880A (da) 1980-11-05
IT1150018B (it) 1986-12-10
ZA802694B (en) 1981-08-26
AU537573B2 (en) 1984-07-05
NL8002567A (nl) 1980-11-06
BE883068A (fr) 1980-08-18
IL59974A0 (en) 1980-07-31
GB2055360B (en) 1983-07-06
ES491142A0 (es) 1981-03-16
AU542596B2 (en) 1985-02-28
US4338330A (en) 1982-07-06
NO150916C (no) 1985-01-16
IE50218B1 (en) 1986-03-05
FR2455587A1 (fr) 1980-11-28
DE3016827A1 (de) 1980-11-20

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