FR2452485A1 - Nouveaux acides et esters 4-amino-3-quinoleinecarboxyliques, utiles notamment comme agents antisecretoires et anti-ulcere - Google Patents
Nouveaux acides et esters 4-amino-3-quinoleinecarboxyliques, utiles notamment comme agents antisecretoires et anti-ulcereInfo
- Publication number
- FR2452485A1 FR2452485A1 FR8006516A FR8006516A FR2452485A1 FR 2452485 A1 FR2452485 A1 FR 2452485A1 FR 8006516 A FR8006516 A FR 8006516A FR 8006516 A FR8006516 A FR 8006516A FR 2452485 A1 FR2452485 A1 FR 2452485A1
- Authority
- FR
- France
- Prior art keywords
- acids
- alkyl
- esters
- amino
- quinoleinecarboxylic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
LES MEDICAMENTS SELON L'INVENTION SONT DES ACIDES ET ESTERS 4-AMINO-3-QUINOLEINECARBOXYLIQUES DE FORMULE GENERALE: (CF DESSIN DANS BOPI) DANS LAQUELLE R REPRESENTE UN ATOME D'HALOGENE OU UN GROUPE ALKYLE INFERIEUR, PHENYLE, ALCOXY INFERIEUR, ALKYLTHIO INFERIEUR, TRIFLUOROMETHYLE, CYANO OU DIALKYLAMINO, R REPRESENTE UN GROUPE ALKYLE INFERIEUR, PHENYLE, PHENYLALKYLE INFERIEUR OU PHENYLE SUBSTITUE PAR 1 A 3 RADICAUX CHOISIS PARMI LES HALOGENES ET LES GROUPES ALKYLE INFERIEUR, ALCOXY INFERIEUR, ALKYLTHIO INFERIEUR, CYANO, HYDROXY, CARBAMOYLE, CARBOXY, ACETYLE, TRIFLUOROMETHYLE ET NITRO ET R EST UN ATOME D'HYDROGENE OU UN GROUPE ALKYLE INFERIEUR, DIMETHYLAMINOALKYLE INFERIEUR, (ALKYL INFERIEUR)ALCOXY INFERIEUR OU ALLYLE, ET LEURS SELS D'ADDITION D'ACIDES NON TOXIQUES ACCEPTABLES EN PHARMACIE. APPLICATION: COMME AGENTS ANTISECRETOIRES ET POUR LE TRAITEMENT DES ULCERES PEPTIQUES, A DES DOSES JOURNALIERES DE 100 A 1000MG CHEZ L'HUMAIN ADULTE.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2398179A | 1979-03-26 | 1979-03-26 | |
US06/127,153 US4343804A (en) | 1979-03-26 | 1980-03-04 | 4-Amino-3-quinolinecarboxylic acids and esters-antisecretory anti-ulcer compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2452485A1 true FR2452485A1 (fr) | 1980-10-24 |
FR2452485B1 FR2452485B1 (fr) | 1986-09-12 |
Family
ID=26697875
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR8006516A Expired FR2452485B1 (fr) | 1979-03-26 | 1980-03-24 | Nouveaux acides et esters 4-amino-3-quinoleinecarboxyliques, utiles notamment comme agents antisecretoires et anti-ulcere |
Country Status (31)
Country | Link |
---|---|
US (1) | US4343804A (fr) |
JP (1) | JPH02117663A (fr) |
AR (1) | AR230268A1 (fr) |
AT (1) | AT372373B (fr) |
AU (1) | AU528388B2 (fr) |
BR (1) | BR8001779A (fr) |
CA (1) | CA1147338A (fr) |
CH (1) | CH644105A5 (fr) |
DE (1) | DE3011490A1 (fr) |
DK (1) | DK156056C (fr) |
EG (1) | EG15009A (fr) |
ES (1) | ES8103048A1 (fr) |
FI (1) | FI77452C (fr) |
FR (1) | FR2452485B1 (fr) |
GB (1) | GB2047244B (fr) |
GR (1) | GR68006B (fr) |
HK (1) | HK67983A (fr) |
IE (1) | IE49577B1 (fr) |
IL (1) | IL59628A (fr) |
IN (1) | IN151446B (fr) |
IT (1) | IT1133079B (fr) |
MX (1) | MX6264E (fr) |
NL (1) | NL8001752A (fr) |
NO (1) | NO153927C (fr) |
NZ (1) | NZ193252A (fr) |
PH (1) | PH16416A (fr) |
PL (1) | PL125030B1 (fr) |
PT (1) | PT71008B (fr) |
SE (1) | SE435837B (fr) |
SG (1) | SG33683G (fr) |
YU (1) | YU41702B (fr) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8610981D0 (en) * | 1986-05-06 | 1986-06-11 | Ici America Inc | Quinoline amides |
GB8621425D0 (en) * | 1986-09-05 | 1986-10-15 | Smith Kline French Lab | Compounds |
GB8804447D0 (en) * | 1988-02-25 | 1988-03-23 | Smithkline Beckman Intercredit | Compounds |
GB8804443D0 (en) * | 1988-02-25 | 1988-03-23 | Smithkline Beckman Intercredit | Compounds |
GB8804445D0 (en) * | 1988-02-25 | 1988-03-23 | Smithkline Beckman Intercredit | Compounds |
GB8804444D0 (en) * | 1988-02-25 | 1988-03-23 | Smithkline Beckman Intercredit | Compounds |
GB8804446D0 (en) * | 1988-02-25 | 1988-03-23 | Smithkline Beckman Intercredit | Compounds |
GB8804448D0 (en) * | 1988-02-25 | 1988-03-23 | Smithkline Beckman Intercredit | Compounds |
US5432182A (en) * | 1989-02-23 | 1995-07-11 | Smithkline Beecham Intercredit B.V. | Compounds substituted quinoline derivatives |
CA2011086A1 (fr) * | 1989-03-17 | 1990-09-17 | Karl-Heinz Geiss | 2-alkyl-4-arylmethylaminoquinolines, leur utilisation et medicaments les contenant |
DE3917233A1 (de) * | 1989-05-26 | 1990-11-29 | Basf Ag | 8-substituierte 4-(heterocyclylmethylamino)-chinoline, ihre verwendung und daraus hergestellte arzneimittel |
GB8918265D0 (en) * | 1989-08-10 | 1989-09-20 | Smithkline Beckman Intercredit | Compounds |
US5362743A (en) * | 1993-03-09 | 1994-11-08 | Pfizer Inc. | Aminoquinoline derivatives |
US5556863A (en) * | 1993-06-11 | 1996-09-17 | Astra Aktiebolag | Compound for gastric acid secretion inhibition |
IS4164A (is) * | 1993-06-11 | 1994-12-12 | Ab Astra | Efnasambönd sem hindra flæði magasýru |
EP0720601B1 (fr) * | 1993-08-10 | 2000-10-25 | James Black Foundation Limited | Ligands de recepteur de cck et de gastrine |
US5650415A (en) * | 1995-06-07 | 1997-07-22 | Sugen, Inc. | Quinoline compounds |
KR0169813B1 (ko) * | 1995-07-12 | 1999-01-15 | 김종인 | 4-아미노-3-아실나프티리딘 유도체 |
US5760041A (en) * | 1996-02-05 | 1998-06-02 | American Cyanamid Company | 4-aminoquinazoline EGFR Inhibitors |
US6875769B2 (en) * | 1996-05-23 | 2005-04-05 | Pfizer Inc. | Substituted6,6-hetero-bicyclicderivatives |
US5929080A (en) * | 1997-05-06 | 1999-07-27 | American Cyanamid Company | Method of treating polycystic kidney disease |
US6251912B1 (en) | 1997-08-01 | 2001-06-26 | American Cyanamid Company | Substituted quinazoline derivatives |
US6323209B1 (en) | 1997-11-06 | 2001-11-27 | American Cyanamid Company | Method of treating or inhibiting colonic polyps |
ES2457396T3 (es) | 1998-09-29 | 2014-04-25 | Wyeth Holdings Llc | 3-Cianoquinolinas sustituidas como inhibidores de las proteínas tirosina quinasas |
HUP0203973A3 (en) * | 1999-12-28 | 2004-07-28 | Eisai Co Ltd | Heterocyclic compounds having sulfonamide groups, pharmaceutical compositions containing them and their use |
US6521618B2 (en) | 2000-03-28 | 2003-02-18 | Wyeth | 3-cyanoquinolines, 3-cyano-1,6-naphthyridines, and 3-cyano-1,7-naphthyridines as protein kinase inhibitors |
US6576644B2 (en) * | 2000-09-06 | 2003-06-10 | Bristol-Myers Squibb Co. | Quinoline inhibitors of cGMP phosphodiesterase |
UA80393C2 (uk) | 2000-12-07 | 2007-09-25 | Алтана Фарма Аг | Фармацевтична композиція, яка містить інгібітор фде 4, диспергований в матриці |
MY140561A (en) * | 2002-02-20 | 2009-12-31 | Nycomed Gmbh | Dosage form containing pde 4 inhibitor as active ingredient |
GEP20084540B (en) | 2003-01-14 | 2008-11-25 | Arena Pharm Inc | 1,2,3-trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prpphylaxis and treatment of disorders related thereto such as diabetes and hyperglycemia |
ME00524B (me) | 2003-03-10 | 2011-10-10 | Astrazeneca Ab | Novi postupak za dobijanje roflumilasta |
TWI335328B (en) * | 2003-07-14 | 2011-01-01 | Arena Pharm Inc | Fused-aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related hereto |
WO2006097456A1 (fr) * | 2005-03-16 | 2006-09-21 | Nycomed Gmbh | Forme posologique a gout masque |
WO2011022216A1 (fr) * | 2009-08-17 | 2011-02-24 | High Point Pharmaceuticals, Llc | Dérivés de pyridine substitués, compositions pharmaceutiques et procédés d'utilisation pour traiter le stress oxydatif |
CN103221391B (zh) | 2010-01-27 | 2018-07-06 | 艾尼纳制药公司 | (R)-2-(7-(4-环戊基-3-(三氟甲基)苄基氧基)-1,2,3,4-四氢环戊二烯并[b]吲哚-3-基)乙酸及其盐的制备方法 |
CA2812061A1 (fr) | 2010-09-22 | 2012-03-29 | Arena Pharmaceuticals, Inc. | Modulateurs du recepteur gpr119 et traitement des troubles qui lui sont lies |
AU2016205361C1 (en) | 2015-01-06 | 2021-04-08 | Arena Pharmaceuticals, Inc. | Methods of treating conditions related to the S1P1 receptor |
KR102603199B1 (ko) | 2015-06-22 | 2023-11-16 | 아레나 파마슈티칼스, 인크. | S1p1 수용체-관련 장애에서의 사용을 위한 (r)-2-(7-(4-시클로펜틸-3-(트리플루오로메틸)벤질옥시)-1,2,3,4-테트라히드로시클로-펜타[b]인돌-3-일)아세트산 (화합물 1)의 결정성 l-아르기닌 염 |
UA126119C2 (uk) * | 2016-11-11 | 2022-08-17 | Баєр Енімал Хелс Гмбх | Протигельмінтні похідні хінолін-3-карбоксаміду |
MX2019009841A (es) | 2017-02-16 | 2020-01-30 | Arena Pharm Inc | Compuestos y metodos para el tratamiento de la colangitis biliar primaria. |
US20210177827A1 (en) * | 2017-10-25 | 2021-06-17 | Children`S Medical Center Corporation | Papd5 inhibitors and methods of use thereof |
SG11202010024UA (en) | 2018-05-09 | 2020-11-27 | Bayer Animal Health Gmbh | New quinoline derivatives |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3470186A (en) * | 1967-06-02 | 1969-09-30 | American Cyanamid Co | Substituted 4-anilino-3-quinolinecarboxylic acids and esters |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS4838712A (fr) * | 1971-09-18 | 1973-06-07 |
-
1980
- 1980-03-04 US US06/127,153 patent/US4343804A/en not_active Expired - Lifetime
- 1980-03-14 IL IL59628A patent/IL59628A/xx unknown
- 1980-03-22 GR GR61513A patent/GR68006B/el unknown
- 1980-03-24 FI FI800910A patent/FI77452C/fi not_active IP Right Cessation
- 1980-03-24 AT AT0156480A patent/AT372373B/de not_active IP Right Cessation
- 1980-03-24 IE IE605/80A patent/IE49577B1/en unknown
- 1980-03-24 FR FR8006516A patent/FR2452485B1/fr not_active Expired
- 1980-03-24 MX MX808722U patent/MX6264E/es unknown
- 1980-03-25 PL PL1980222993A patent/PL125030B1/pl unknown
- 1980-03-25 DE DE19803011490 patent/DE3011490A1/de active Granted
- 1980-03-25 IN IN345/CAL/80A patent/IN151446B/en unknown
- 1980-03-25 EG EG80174A patent/EG15009A/xx active
- 1980-03-25 NZ NZ193252A patent/NZ193252A/en unknown
- 1980-03-25 CH CH234080A patent/CH644105A5/fr not_active IP Right Cessation
- 1980-03-25 ES ES489887A patent/ES8103048A1/es not_active Expired
- 1980-03-25 PT PT71008A patent/PT71008B/pt unknown
- 1980-03-25 SE SE8002292A patent/SE435837B/sv not_active IP Right Cessation
- 1980-03-25 GB GB8009991A patent/GB2047244B/en not_active Expired
- 1980-03-25 DK DK128380A patent/DK156056C/da not_active IP Right Cessation
- 1980-03-25 BR BR8001779A patent/BR8001779A/pt unknown
- 1980-03-25 NO NO800858A patent/NO153927C/no unknown
- 1980-03-25 PH PH23804A patent/PH16416A/en unknown
- 1980-03-25 NL NL8001752A patent/NL8001752A/nl not_active Application Discontinuation
- 1980-03-26 CA CA000348417A patent/CA1147338A/fr not_active Expired
- 1980-03-26 AR AR280455A patent/AR230268A1/es active
- 1980-03-26 IT IT67465/80A patent/IT1133079B/it active
- 1980-03-26 YU YU844/80A patent/YU41702B/xx unknown
- 1980-03-26 AU AU56848/80A patent/AU528388B2/en not_active Ceased
-
1983
- 1983-06-13 SG SG336/83A patent/SG33683G/en unknown
- 1983-12-15 HK HK679/83A patent/HK67983A/xx unknown
-
1989
- 1989-09-26 JP JP1250369A patent/JPH02117663A/ja active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3470186A (en) * | 1967-06-02 | 1969-09-30 | American Cyanamid Co | Substituted 4-anilino-3-quinolinecarboxylic acids and esters |
Non-Patent Citations (6)
Title |
---|
CA1958 * |
CA1962 * |
CA1970 * |
EXBK/46 * |
EXBK/51 * |
EXBK/69 * |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
FR2452485A1 (fr) | Nouveaux acides et esters 4-amino-3-quinoleinecarboxyliques, utiles notamment comme agents antisecretoires et anti-ulcere | |
FR2416012A1 (fr) | Derives de l'imidazole et medicament contenant ces substances | |
FR2360587A1 (fr) | Nouveaux derives d'amino-alcoyl-furannes utiles comme medicaments | |
NO152130C (no) | Analogifremgangsmaate for fremstilling av bronchospasmolytisk virksomme forbindelser | |
NO843836L (no) | Terapeutisk aktive sulfamatderivater | |
FR2371437A1 (fr) | Nouveaux derives de pipepidine ou de morpholine utiles comme medicaments et comme fongicides | |
FR2422634A1 (fr) | Isosteres de type 9-desoxy-9a-methylene de pgi2, utiles comme medicaments, et leur procede de preparation | |
FR2456733A1 (fr) | Nouveaux acides 2-(mercapto-1-oxo(alkyl inferieur))-1,2,3,4-tetrahydroisoquinoleine-3-carboxyliques, utiles notamment comme inhibiteurs de l'enzyme de conversion de l'angiotensine i | |
ES8707947A1 (es) | Un procedimiento para la preparacion de acidos 3-hidroxifenoxialquilenheterociclilcarboxilicos. | |
FR2391723A1 (fr) | Composition therapeutique a base de cetone aliphatique pour le traitement des ulceres peptiques | |
FR2360561A1 (fr) | Nouveaux dipeptides utiles comme inhibiteurs de l'elastase | |
FR2361346A1 (fr) | Dipeptides utiles comme medicaments | |
BR8806558A (pt) | Processos para preparacao de compostos | |
ATE62908T1 (de) | Neue derivate von 4,5-dihydro-oxazolen, verfahren zu ihrer herstellung und ihre verwendung. | |
ES2037077T3 (es) | Metodo para preparar quinona-amidas. | |
ATE24911T1 (de) | Pyrido(3',4':4,5)furo(3,2-g)coumarine oder pyrido(3,4-h)psoralene, herstellung, verwendung in der kosmetologie und als arzneimittel und diese enthaltende zubereitungen. | |
ATE110568T1 (de) | Pharmazeutisches präparat zur behandlung des katarakts. | |
FR2355011A1 (fr) | 2-imino-3-aminothiazolidines utiles comme medicaments | |
ES8300096A1 (es) | "un procedimiento para preparar derivados de halofenil-piridil-alilamina". | |
FR2359154A1 (fr) | Derives peptidiques utiles comme medicaments et procede pour leur preparation | |
ES552782A0 (es) | Un procedimiento para preparar un compuesto de n-fenil-trans-4-guanidincometilciclohexanocarboxamida. | |
FR2377382A1 (fr) | Nouveaux phenylazacycloalcanes utiles comme medicaments | |
FR2388810A1 (fr) | 3-(1-piperazinyl)-1,2,4-benzotriazines et n-oxydes utiles comme medicaments | |
WO1987003287A3 (fr) | PROCEDE POUR LA PREPARATION DE COMPOSES alpha-HYDROXY CARBONYLES | |
FR2420975A1 (fr) | Medicaments anticomplementaires en partie antinephretiques, de type soyasapogenol b et leur procede de preparation |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |