FR2360561A1 - Nouveaux dipeptides utiles comme inhibiteurs de l'elastase - Google Patents

Nouveaux dipeptides utiles comme inhibiteurs de l'elastase

Info

Publication number
FR2360561A1
FR2360561A1 FR7719277A FR7719277A FR2360561A1 FR 2360561 A1 FR2360561 A1 FR 2360561A1 FR 7719277 A FR7719277 A FR 7719277A FR 7719277 A FR7719277 A FR 7719277A FR 2360561 A1 FR2360561 A1 FR 2360561A1
Authority
FR
France
Prior art keywords
dipeptides
elastase inhibitors
new useful
useful
new
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7719277A
Other languages
English (en)
Other versions
FR2360561B1 (fr
Inventor
Cedric Herbert Hassall
William Henry Johnson
Noel Allan Roberts
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB26662/76A external-priority patent/GB1564317A/en
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of FR2360561A1 publication Critical patent/FR2360561A1/fr
Application granted granted Critical
Publication of FR2360561B1 publication Critical patent/FR2360561B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Rheumatology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

L'invention concerne de nouveaux composés chimiques utiles comme médicaments, un procédé pour leur préparation, ainsi que leur utilisation. Les nouveaux composés sont des dérivés dipeptidiques de formule générale :
FR7719277A 1976-06-25 1977-06-23 Nouveaux dipeptides utiles comme inhibiteurs de l'elastase Granted FR2360561A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB26662/76A GB1564317A (en) 1976-06-25 1976-06-25 Dipeptide derivatives
GB3284776 1976-08-06
GB1065777 1977-03-14

Publications (2)

Publication Number Publication Date
FR2360561A1 true FR2360561A1 (fr) 1978-03-03
FR2360561B1 FR2360561B1 (fr) 1980-04-25

Family

ID=27256556

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7719277A Granted FR2360561A1 (fr) 1976-06-25 1977-06-23 Nouveaux dipeptides utiles comme inhibiteurs de l'elastase

Country Status (17)

Country Link
US (1) US4187216A (fr)
JP (1) JPS532417A (fr)
AT (4) AT355742B (fr)
AU (1) AU510722B2 (fr)
CA (1) CA1092097A (fr)
CH (1) CH627735A5 (fr)
DE (1) DE2728593A1 (fr)
DK (1) DK283177A (fr)
FR (1) FR2360561A1 (fr)
IE (1) IE45517B1 (fr)
IL (1) IL52337A (fr)
IT (1) IT1080679B (fr)
LU (1) LU77603A1 (fr)
NL (1) NL7706967A (fr)
NZ (1) NZ184428A (fr)
PH (1) PH14141A (fr)
SE (1) SE7707339L (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2329646A1 (fr) * 1975-10-30 1977-05-27 Ajinomoto Kk Nouveaux derives dipeptidiques, sels correspondants et procede de mesure d'une activite enzymatique les utilisant

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4309342A (en) * 1980-07-03 1982-01-05 Abbott Laboratories Antibacterial peptides
US4462943A (en) * 1980-11-24 1984-07-31 E. R. Squibb & Sons, Inc. Carboxyalkyl amino acid derivatives of various substituted prolines
US4610816A (en) * 1980-12-18 1986-09-09 Schering Corporation Substituted dipeptides as inhibitors of enkephalinases
US4906615A (en) * 1980-12-18 1990-03-06 Schering Corporation Substituted dipeptides as inhibitors of enkephalinases
US4820729A (en) * 1981-03-30 1989-04-11 Rorer Pharmaceutical Corporation N-substituted-amido-amino acids
CS226907B1 (en) * 1981-08-07 1984-04-16 Kasafirek Evzen Alkylamides of carboxyalkanoylpeptides
CS231228B1 (en) * 1982-10-01 1984-10-15 Evzen Kasafirek Biologically effective tri and tetrapeptide alkylamide derivatives and their processing method
NZ214543A (en) * 1984-12-14 1990-03-27 Australian Commercial Research Amino acid and peptide derivatives that inhibit human leucocytic elastase enzyme (hle)
EP0190852A3 (fr) * 1985-01-31 1988-11-02 Ajinomoto Co., Inc. Dérivés dipeptides et les médicaments antihypertensifs les contenant
FR2646847B1 (fr) * 1989-05-12 1991-07-12 Rhone Poulenc Sante N-phenyl amides, leurs procedes de preparation et les medicaments les contenant
JPH05345754A (ja) * 1992-06-15 1993-12-27 Suntory Ltd ジペプチド誘導体およびそれを有効成分とする骨疾患の予防または治療剤
FR2733995B1 (fr) * 1995-05-09 1997-07-25 Inst Nat Sante Rech Med Inhibiteurs de l'inactivation de neuropeptides endogenes notamment la cholecystokinine, leurs procedes de preparation leur utilisation comme medicaments et procede de criblage de medicaments
US7855181B2 (en) * 1999-08-13 2010-12-21 University Of Florida Research Foundation, Inc. Dipeptides for prevention of muscle breakdown and microbial infection
EP2922835B1 (fr) * 2012-11-21 2017-08-09 Boehringer Ingelheim International GmbH Procédé de fabrication de n-sulfinyl alpha-amino amides

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5255593A (en) * 1975-10-30 1977-05-07 Ajinomoto Kk Measuring method of enzyme activity

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2329646A1 (fr) * 1975-10-30 1977-05-27 Ajinomoto Kk Nouveaux derives dipeptidiques, sels correspondants et procede de mesure d'une activite enzymatique les utilisant

Also Published As

Publication number Publication date
ATA300579A (de) 1980-12-15
NL7706967A (nl) 1977-12-28
AT363205B (de) 1981-07-27
ATA300479A (de) 1981-01-15
LU77603A1 (fr) 1978-07-11
CH627735A5 (de) 1982-01-29
PH14141A (en) 1981-03-05
IE45517B1 (en) 1982-09-22
DK283177A (da) 1977-12-26
ATA300379A (de) 1980-12-15
AU510722B2 (en) 1980-07-10
IL52337A0 (en) 1977-08-31
FR2360561B1 (fr) 1980-04-25
IE45517L (en) 1977-12-25
IL52337A (en) 1980-11-30
AT355742B (de) 1980-03-25
AU2624377A (en) 1979-01-04
JPS532417A (en) 1978-01-11
CA1092097A (fr) 1980-12-23
AT363626B (de) 1981-08-25
DE2728593A1 (de) 1978-01-05
AT363206B (de) 1981-07-27
NZ184428A (en) 1980-08-26
SE7707339L (sv) 1977-12-26
IT1080679B (it) 1985-05-16
US4187216A (en) 1980-02-05
ATA448177A (de) 1979-08-15

Similar Documents

Publication Publication Date Title
FR2442839A1 (fr) Derives substitues de morpholine utiles comme medicaments et procede de leur preparation
FR2401914A1 (fr) Nouveaux composes heterocycliques, procede pour leur preparation et compositions medicinales contenant lesdits composes
FR2360561A1 (fr) Nouveaux dipeptides utiles comme inhibiteurs de l'elastase
FR2375187A1 (fr) Cyclopentane-1-amines, procede pour leur preparation et produits contenant ces composes
FR2365567A1 (fr) Nouvelles piperazinylpyridines utiles comme medicaments
FR2361346A1 (fr) Dipeptides utiles comme medicaments
FR2363559A1 (fr) Nouveaux derives de perhydro-aza-heterocycles utiles comme medicaments et procede pour leur preparation
FR2358415A1 (fr) Derives peptidiques, leur preparation et leur application en tant que medicaments
FR2383183A1 (fr) Derives de benzodiazepine
FR2368488A1 (fr) Procede pour la preparation de methoxypsoralene
FR2391179A1 (fr) Nouveaux composes utiles comme intermediaires de synthese de la vitamine e
FR2392958A1 (fr) Nouveaux amino-acides fluores utiles comme medicament
FR2436150A1 (fr) Derives de 3'',4''-diacyltylosine utiles comme medicaments
FR2400008A1 (fr) Agents anti-hypertensifs
FR2365566A1 (fr) Nouveaux derives du thiophene utiles comme medicaments
FR2374291A1 (fr)
FR2359154A1 (fr) Derives peptidiques utiles comme medicaments et procede pour leur preparation
FR2383931A1 (fr) Derives d'oxadiazolopyrimidine
FR2387983A1 (fr) Nouveaux derives de benzodiazepine utiles comme medicaments
FR2355011A1 (fr) 2-imino-3-aminothiazolidines utiles comme medicaments
FR2398751A1 (fr) Nouveaux derives de cyclohexane utiles comme substances odoriferantes et/ou aromatisantes
FR2384771A1 (fr) Derives de quinazoline utiles comme medicament
FR2402644A1 (fr) Nouveaux nitroethylcyclopentanes utiles comme intermediaires pour la synthese des prostaglandines, et leur procede de preparation
FR2354317A1 (fr) Benzyl-cyanoacetals, leur preparation et leur utilisation pour des syntheses chimiques
FR2385686A1 (fr) Nouveaux anilides utiles comme agents microbicides

Legal Events

Date Code Title Description
ST Notification of lapse