FR2439402A1 - Procede de detection de reactions immunologiques utilisant une technique de mesure de battements de tension - Google Patents

Procede de detection de reactions immunologiques utilisant une technique de mesure de battements de tension

Info

Publication number
FR2439402A1
FR2439402A1 FR7829482A FR7829482A FR2439402A1 FR 2439402 A1 FR2439402 A1 FR 2439402A1 FR 7829482 A FR7829482 A FR 7829482A FR 7829482 A FR7829482 A FR 7829482A FR 2439402 A1 FR2439402 A1 FR 2439402A1
Authority
FR
France
Prior art keywords
measurement technique
immunological reactions
particles
beat measurement
detecting immunological
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7829482A
Other languages
English (en)
Other versions
FR2439402B1 (fr
Inventor
Egidijus Edward Uzgiris
Ralph Walter Deblois
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
General Electric Co
Original Assignee
General Electric Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by General Electric Co filed Critical General Electric Co
Publication of FR2439402A1 publication Critical patent/FR2439402A1/fr
Application granted granted Critical
Publication of FR2439402B1 publication Critical patent/FR2439402B1/fr
Granted legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/1031—Investigating individual particles by measuring electrical or magnetic effects
    • G01N15/12—Investigating individual particles by measuring electrical or magnetic effects by observing changes in resistance or impedance across apertures when traversed by individual particles, e.g. by using the Coulter principle
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/806—Electrical property or magnetic property
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Dispersion Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

DES PARTICULES REVETUES D'ANTICORPS AC S'AGGLOMERENT EN PRESENCE DE L'ANTIGENE AG CORRESPONDANT. POUR EVITER QUE LA MESURE SOIT FAUSSEE PAR UNE AGGLOMERATION DES PARTICULES ENTRE ELLES, EN L'ABSENCE D'AG, ON UTILISE DEUX TYPES DE PARTICULES P ET P, REVETUES DU MEME AC, MAIS DE TAILLE DIFFERENTE. EN L'ABSENCE D'AG, IL PEUT Y AVOIR DES AGGLOMERATS PP ET PP, MAIS NON PP. PP N'EST POSSIBLE QU'EN PRESENCE D'AG. ON CHOISIT UN RAPPORT DE TAILLE TEL ENTRE P ET P QUE PP NE PUISSE ETRE CONFONDU AVEC PP OU PP. LA DETECTION DE PP SE FAIT EN MESURANT LES BATTEMENTS DE TENSION PROVOQUES DANS UN CIRCUIT ELECTRIQUE, PAR LE PASSAGE DES AGGLOMERATS DANS UNE ZONE DETERMINEE.
FR7829482A 1977-10-17 1978-10-17 Procede de detection de reactions immunologiques utilisant une technique de mesure de battements de tension Granted FR2439402A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/842,952 US4191739A (en) 1977-10-17 1977-10-17 Antigen-antibody reaction assay employing particle aggregation and resistive pulse analysis

Publications (2)

Publication Number Publication Date
FR2439402A1 true FR2439402A1 (fr) 1980-05-16
FR2439402B1 FR2439402B1 (fr) 1983-10-28

Family

ID=25288666

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7829482A Granted FR2439402A1 (fr) 1977-10-17 1978-10-17 Procede de detection de reactions immunologiques utilisant une technique de mesure de battements de tension

Country Status (7)

Country Link
US (1) US4191739A (fr)
JP (1) JPS5480411A (fr)
DE (1) DE2844879A1 (fr)
FR (1) FR2439402A1 (fr)
GB (1) GB2009410B (fr)
NL (1) NL7810199A (fr)
SE (1) SE445076B (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994020853A1 (fr) * 1993-03-11 1994-09-15 Hoechst Japan Limited Procede de dosage immunologique utilisant un potentiel zeta, et trousse pour dosage immunologique

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2918342A1 (de) * 1979-05-07 1980-11-20 Behringwerke Ag Latex-reagenz
NL185309C (nl) * 1980-07-28 1990-03-01 Akzo Nv Methode voor het bepalen van antigenen met behulp van twee of meer monoklonale antilichamen alsmede immuunreagens.
US4459361A (en) * 1982-06-04 1984-07-10 Angenics, Inc. Ligand assay with one or two particulate reagents and filter
US4521521A (en) * 1983-03-11 1985-06-04 E. I. Du Pont De Nemours And Company Particle reagent size distribution measurements for immunoassay
WO1985004426A1 (fr) * 1984-03-26 1985-10-10 International Health Services Procede de determination du temps de coagulation du sang et reactifs particulaires utilises
US4713347A (en) * 1985-01-14 1987-12-15 Sensor Diagnostics, Inc. Measurement of ligand/anti-ligand interactions using bulk conductance
US6060237A (en) * 1985-02-26 2000-05-09 Biostar, Inc. Devices and methods for optical detection of nucleic acid hybridization
JPS61225656A (ja) * 1985-03-29 1986-10-07 Toshiba Corp 検体検査装置
US4721681A (en) * 1985-05-14 1988-01-26 Fisher Scientific Company Immunoassay in centrifugal field with complementary particles of differing specific gravities
US5236826A (en) * 1985-12-10 1993-08-17 Murex Corporation Immunoassay for the detection or quantitation of an analyte
US5501949A (en) * 1985-12-10 1996-03-26 Murex Diagnostics Corporation Particle bound binding component immunoassay
US4794089A (en) * 1986-03-25 1988-12-27 Midwest Research Microscopy, Inc. Method for electronic detection of a binding reaction
US5858648A (en) * 1996-11-04 1999-01-12 Sienna Biotech, Inc. Assays using reference microparticles
US20040091940A1 (en) * 2001-03-30 2004-05-13 Tokio Sawai Reagent and method for immunoanalysis of elastase 1 and method of detecting pancreatic disease
JP4331073B2 (ja) * 2004-08-31 2009-09-16 デンカ生研株式会社 抗原の測定方法及びそのための試薬
US20070202495A1 (en) * 2006-02-06 2007-08-30 Michael Mayer Use of resistive-pulse sensing with submicrometer pores or nanopores for the detection of the assembly of submicrometer or nanometer sized objects
GB2477287B (en) * 2010-01-27 2012-02-15 Izon Science Ltd Control of particle flow in an aperture
JP5944118B2 (ja) * 2011-07-06 2016-07-05 シャープ株式会社 粒子測定装置
US9804116B2 (en) 2014-12-26 2017-10-31 Kabushiki Kaisha Toshiba Method and device for detecting sample
WO2017033296A1 (fr) * 2015-08-26 2017-03-02 株式会社日立製作所 Dispositif de mesure immunologique et procédé de mesure immunologique
CN113508285A (zh) * 2019-03-12 2021-10-15 国立大学法人东北大学 内毒素检测装置、及内毒素的检测方法
CN111239404B (zh) * 2019-03-31 2020-11-27 武汉生之源生物科技股份有限公司 一种可以同时检测尿样本和血清样本中的视黄醇结合蛋白的检测试剂盒
CN111398137B (zh) * 2020-04-02 2022-07-05 武汉生之源生物科技股份有限公司 一种基于电阻微米孔颗粒计数器的检测方法及其应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3658982A (en) * 1966-06-17 1972-04-25 Ortho Pharma Corp Stable latex reagent for the detection of rheumatoid arthritis
FR2370972A1 (fr) * 1976-11-10 1978-06-09 Hoffmann La Roche Procede de dosage immunologique
FR2392387A1 (fr) * 1976-12-10 1978-12-22 Technicon Instr Procede pour la mise en evidence d'un antigene ou d'un anticorps particuliers dans un liquide

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3815024A (en) * 1970-02-20 1974-06-04 Gen Electric Particle analyzer
BE793185A (fr) * 1971-12-23 1973-04-16 Atomic Energy Commission Appareil pour analyser et trier rapidement des particules telles que des cellules biologiques
US3925018A (en) * 1973-06-08 1975-12-09 Technicon Instr Method and apparatus for quantitative analysis utilizing particulate reagent material
US3984533A (en) * 1975-11-13 1976-10-05 General Electric Company Electrophoretic method of detecting antigen-antibody reaction

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3658982A (en) * 1966-06-17 1972-04-25 Ortho Pharma Corp Stable latex reagent for the detection of rheumatoid arthritis
FR2370972A1 (fr) * 1976-11-10 1978-06-09 Hoffmann La Roche Procede de dosage immunologique
FR2392387A1 (fr) * 1976-12-10 1978-12-22 Technicon Instr Procede pour la mise en evidence d'un antigene ou d'un anticorps particuliers dans un liquide

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994020853A1 (fr) * 1993-03-11 1994-09-15 Hoechst Japan Limited Procede de dosage immunologique utilisant un potentiel zeta, et trousse pour dosage immunologique
US5686252A (en) * 1993-03-11 1997-11-11 Hoechst Japan Limited Immunoassay method utilizing zeta potential and immunoassay kit

Also Published As

Publication number Publication date
JPS5480411A (en) 1979-06-27
DE2844879A1 (de) 1979-04-19
NL7810199A (nl) 1979-04-19
FR2439402B1 (fr) 1983-10-28
US4191739A (en) 1980-03-04
GB2009410A (en) 1979-06-13
GB2009410B (en) 1982-09-02
SE7810773L (sv) 1979-04-18
SE445076B (sv) 1986-05-26

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