FR2432710A1 - Dispositif d'eclairement et de captation sur fond obscur et methode d'utilisation - Google Patents

Dispositif d'eclairement et de captation sur fond obscur et methode d'utilisation

Info

Publication number
FR2432710A1
FR2432710A1 FR7919460A FR7919460A FR2432710A1 FR 2432710 A1 FR2432710 A1 FR 2432710A1 FR 7919460 A FR7919460 A FR 7919460A FR 7919460 A FR7919460 A FR 7919460A FR 2432710 A1 FR2432710 A1 FR 2432710A1
Authority
FR
France
Prior art keywords
illumination
particles
fluorescent light
focal point
radiation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7919460A
Other languages
English (en)
Other versions
FR2432710B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Coulter Electronics Inc
Original Assignee
Coulter Electronics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Coulter Electronics Inc filed Critical Coulter Electronics Inc
Publication of FR2432710A1 publication Critical patent/FR2432710A1/fr
Application granted granted Critical
Publication of FR2432710B1 publication Critical patent/FR2432710B1/fr
Granted legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N2021/6463—Optics
    • G01N2021/6469—Cavity, e.g. ellipsoid

Landscapes

  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)

Abstract

La présente invention concerne un dispositif d'éclairement et de captation ainsi qu'une méthode pour l'analyse de fluorescence, où l'éclairement d'un courant de particules produit de la lumière fluorescente. Selon l'invention, un réflecteur 12, ayant une surface concave 14 avec un premier foyer 16 disposé dans le courant des particules, réfléchit un rayonnement d'éclairement organisé, ce rayonnement convergeant sur le premier foyer 16 pour stimuler les particules pour qu'elles produisent la lumière fluorescente; la lumière fluorescente émane du premier foyer 16, dont une partie est réfléchie par la surface 14; cette lumière fluorescente qui est focalisée sur le second foyer 18 ne contient pas de rayonnement d'éclairement et est recueillie pour une détection et un traitement subséquents. L'invention s'applique notamment à la détection des particules.
FR7919460A 1978-07-31 1979-07-27 Dispositif d'eclairement et de captation sur fond obscur et methode d'utilisation Granted FR2432710A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/929,267 US4199686A (en) 1978-07-31 1978-07-31 Dark field illuminator and collector apparatus and method

Publications (2)

Publication Number Publication Date
FR2432710A1 true FR2432710A1 (fr) 1980-02-29
FR2432710B1 FR2432710B1 (fr) 1983-02-18

Family

ID=25457577

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7919460A Granted FR2432710A1 (fr) 1978-07-31 1979-07-27 Dispositif d'eclairement et de captation sur fond obscur et methode d'utilisation

Country Status (6)

Country Link
US (1) US4199686A (fr)
JP (1) JPS5522189A (fr)
CA (1) CA1113763A (fr)
DE (1) DE2930593A1 (fr)
FR (1) FR2432710A1 (fr)
GB (1) GB2027193B (fr)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8102772L (sv) * 1981-05-04 1982-11-05 Sven Staffan Folestad Forfarande for laserinducerad fluoriscensdetektering och anordning for genomforande av forfarandet
US4592726A (en) * 1983-01-03 1986-06-03 Herbert Brilliant Diagnostic mirror and light filter
ATE58017T1 (de) * 1983-12-24 1990-11-15 Inotech Ag Vorrichtung zum fuehren und sammeln von licht in der fotometrie od. dgl.
DE3922153A1 (de) * 1989-07-06 1991-01-17 Hella Kg Hueck & Co Optischer sensor
US5018866A (en) * 1989-09-12 1991-05-28 Packard Instrument Company Method and apparatus for performing high sensitivity fluorescence measurements
US5203339A (en) * 1991-06-28 1993-04-20 The Government Of The United States Of America As Represented By The Secretary Of The Department Health And Human Services Method and apparatus for imaging a physical parameter in turbid media using diffuse waves
US5484571A (en) * 1991-10-08 1996-01-16 Beckman Instruments, Inc. Enhanced fluorescence detection of samples in capillary column
US5430541A (en) * 1993-01-12 1995-07-04 Applied Biosystems Inc. High efficiency fluorescence flow cell for capillary liquid chromatography or capillary electrophoresis
EP1017987B1 (fr) * 1997-01-31 2005-06-15 The Horticulture And Food Research Institute Of New Zealand Limited Appareil et methode optiques
DE19735119C2 (de) * 1997-08-13 2000-05-18 Deutsches Krebsforsch Verfahren zur Fluoreszenzkorrelationsspektroskopie, insbesbesondere zur Mehrfarben-Fluoreszenzkorrelationsspektroskopie und Vorrichtung zur Durchführung des Verfahrens
US7198939B2 (en) * 2000-01-28 2007-04-03 Agilent Technologies, Inc. Apparatus for interrogating an addressable array
US7300798B2 (en) * 2001-10-18 2007-11-27 Agilent Technologies, Inc. Chemical arrays
WO2003062824A1 (fr) * 2002-01-23 2003-07-31 Boditech Inc. Procede et bande de dosage quantitatif en flux lateral, et dispositif associe de detection de fluorescence induite par laser
US20070059760A1 (en) * 2002-02-21 2007-03-15 Dorsel Andreas N Multi-featured arrays with reflective coating
KR100483706B1 (ko) * 2002-04-04 2005-04-18 바디텍메드 주식회사 레이저 유발 표면형광 검출 장치
US6791690B2 (en) * 2002-04-30 2004-09-14 Agilent Technologies, Inc. Reading dry chemical arrays
JP2004343082A (ja) * 2003-04-17 2004-12-02 Asml Netherlands Bv 凹面および凸面を含む集光器を備えたリトグラフ投影装置
GB2438332B (en) * 2003-10-24 2008-04-09 Biotrace Ltd Bioluminescence monitor
GB0324784D0 (en) 2003-10-24 2003-11-26 Biotrace Ltd Bioluminescence monitor
FR2873438B1 (fr) * 2004-07-23 2006-11-17 Tda Armements Sas Soc Par Acti Procede et systeme d'activation de la charge d'une munition, munition equipee d'un dispositif d'activation a grande precision et systeme de neutralisation d'une cible
US7616311B2 (en) 2005-05-02 2009-11-10 Jmar Llc Systems and methods for a multiple angle light scattering (MALS) instrument having two-dimensional detector array
WO2006130296A2 (fr) * 2005-05-02 2006-12-07 Jmar Research, Inc. Systemes et procedes destines a un instrument a angle de capture eleve et a diffusion de lumiere a angles multiples (mals)
JP2007071794A (ja) * 2005-09-09 2007-03-22 Rion Co Ltd 粒子検出器
US7551279B2 (en) * 2005-09-19 2009-06-23 Jmar Technologies, Inc. Systems and methods for detecting normal levels of bacteria in water using a multiple angle light scattering (MALS) instrument
WO2008021834A2 (fr) * 2006-08-11 2008-02-21 The Regents Of The University Of California Microscope à haute résolution utilisant une amplification optique
JP4857253B2 (ja) * 2007-12-07 2012-01-18 株式会社日立製作所 画像表示装置
CN102004089B (zh) * 2010-11-19 2012-11-21 山东省医药生物技术研究中心 一种检测中药药性的装置和方法
WO2019178090A1 (fr) 2018-03-12 2019-09-19 The University Of North Carolina At Chapel Hill Microscopie à disque optique pour microscopes à fluorescence
US11262570B2 (en) * 2018-03-12 2022-03-01 The University Of North Carolina At Chapel Hill Mirror image microscopy for increased collection

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3248551A (en) * 1962-10-22 1966-04-26 Joseph C Frommer Optical arrangement for sensing very small particles
US3457407A (en) * 1966-07-27 1969-07-22 Us Navy Apparatus for quantitatively detecting foreign particles present in atmospheric air
US3989381A (en) * 1975-05-05 1976-11-02 Coulter Electronics, Inc. Optical chamber with spherical reflective portion and apparatus employing same
US4099872A (en) * 1975-12-11 1978-07-11 White John U Fluorescence spectrophotometer

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2661658A (en) * 1948-07-19 1953-12-08 Ass Elect Ind Optical system for increasing the working distances of microscope objectives
US3622796A (en) * 1969-11-13 1971-11-23 Te Co The Selective collector for the wide-angle portion of a radiation beam
CA962084A (en) * 1971-01-29 1975-02-04 Coulter Electronics Optical aerosol counter
US3946239A (en) * 1975-01-24 1976-03-23 The United States Of America As Represented By The United Energy Research And Development Administration Ellipsoidal cell flow system
CA1029981A (fr) * 1975-07-24 1978-04-25 Parr A. Tate Detecteur de petites taches de substance fluorescente

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3248551A (en) * 1962-10-22 1966-04-26 Joseph C Frommer Optical arrangement for sensing very small particles
US3457407A (en) * 1966-07-27 1969-07-22 Us Navy Apparatus for quantitatively detecting foreign particles present in atmospheric air
US3989381A (en) * 1975-05-05 1976-11-02 Coulter Electronics, Inc. Optical chamber with spherical reflective portion and apparatus employing same
US4099872A (en) * 1975-12-11 1978-07-11 White John U Fluorescence spectrophotometer

Also Published As

Publication number Publication date
CA1113763A (fr) 1981-12-08
GB2027193A (en) 1980-02-13
GB2027193B (en) 1983-03-23
JPS5522189A (en) 1980-02-16
DE2930593A1 (de) 1980-02-28
US4199686A (en) 1980-04-22
FR2432710B1 (fr) 1983-02-18

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