FR2430950A1 - Oxazino-(1,4)(4,3-a) benzimidazole derivs. and related cpds. - have cardiovascular esp. antiarrhythmic and diuretic activity and CNS activity esp. antidepressant - Google Patents

Oxazino-(1,4)(4,3-a) benzimidazole derivs. and related cpds. - have cardiovascular esp. antiarrhythmic and diuretic activity and CNS activity esp. antidepressant

Info

Publication number
FR2430950A1
FR2430950A1 FR7820521A FR7820521A FR2430950A1 FR 2430950 A1 FR2430950 A1 FR 2430950A1 FR 7820521 A FR7820521 A FR 7820521A FR 7820521 A FR7820521 A FR 7820521A FR 2430950 A1 FR2430950 A1 FR 2430950A1
Authority
FR
France
Prior art keywords
esp
activity
phenyl
oxazino
cardiovascular
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
FR7820521A
Other languages
French (fr)
Inventor
J F Ancher
P Dostert
P Guerret
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Delalande SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Delalande SA filed Critical Delalande SA
Priority to FR7820521A priority Critical patent/FR2430950A1/en
Publication of FR2430950A1 publication Critical patent/FR2430950A1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/16—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Oxazino(1,4)(4,3-a)benzimidazole and related cpds. of formula (I) are new. In (I) -NR1R2 = mono-1-4C alkylamino, 3-6C cycloalkylamino, benzylamino, allylamino, dimethylproparglyamino, di(1-3C alkyl)amino, pyrrolidino, piperidino, morpholino, 4-methyl-piperazino,4-(2-hydroxyethel)-piperazino or 4-phenyl-piperazino and R3, X, Y, m is one of the combinations(a)H, CH2,0,1, CH3,0,1,1, CH3, 0,S, 1 or phenyl, 0,0,1 with n = 2 or 3, (b) phenyl, 0,0,2, phenyl, 5,5,1 or phenyl, 0,5,1 with n = 3 or (c) phenyl, 0, CH2, 1 with n = 1 or 2. (I) have cardiovascular activity, esp. as antiarrhythmics and diuretics, and CNS activity, esp. as antidepressants. They may be administered orally (10-300 mg doses 2-6 times daily) or parenterally (2-100 mg doses 1-4 times daily).
FR7820521A 1978-07-10 1978-07-10 Oxazino-(1,4)(4,3-a) benzimidazole derivs. and related cpds. - have cardiovascular esp. antiarrhythmic and diuretic activity and CNS activity esp. antidepressant Pending FR2430950A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7820521A FR2430950A1 (en) 1978-07-10 1978-07-10 Oxazino-(1,4)(4,3-a) benzimidazole derivs. and related cpds. - have cardiovascular esp. antiarrhythmic and diuretic activity and CNS activity esp. antidepressant

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7820521A FR2430950A1 (en) 1978-07-10 1978-07-10 Oxazino-(1,4)(4,3-a) benzimidazole derivs. and related cpds. - have cardiovascular esp. antiarrhythmic and diuretic activity and CNS activity esp. antidepressant

Publications (1)

Publication Number Publication Date
FR2430950A1 true FR2430950A1 (en) 1980-02-08

Family

ID=9210542

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7820521A Pending FR2430950A1 (en) 1978-07-10 1978-07-10 Oxazino-(1,4)(4,3-a) benzimidazole derivs. and related cpds. - have cardiovascular esp. antiarrhythmic and diuretic activity and CNS activity esp. antidepressant

Country Status (1)

Country Link
FR (1) FR2430950A1 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001053291A1 (en) * 2000-01-17 2001-07-26 Teijin Limited Benzimidazole derivatives
US7176320B2 (en) 2000-01-17 2007-02-13 Teijin Limited Benzimidazole derivative
US7268145B2 (en) 1998-07-15 2007-09-11 Teijin Pharma Limited Thiobenzimidazole derivatives

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1545833A1 (en) * 1965-07-16 1969-12-11 Hoechst Ag Process for the preparation of pyridobenzimidazole carboxylic acids

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1545833A1 (en) * 1965-07-16 1969-12-11 Hoechst Ag Process for the preparation of pyridobenzimidazole carboxylic acids

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7268145B2 (en) 1998-07-15 2007-09-11 Teijin Pharma Limited Thiobenzimidazole derivatives
WO2001053291A1 (en) * 2000-01-17 2001-07-26 Teijin Limited Benzimidazole derivatives
US7176320B2 (en) 2000-01-17 2007-02-13 Teijin Limited Benzimidazole derivative
CZ301504B6 (en) * 2000-01-17 2010-03-24 Teijin Limited Benzimidazole derivatives

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