FR2427339A1 - Nouveaux derives optiquement actifs d'oxazaphosphorine et leur procede de preparation - Google Patents
Nouveaux derives optiquement actifs d'oxazaphosphorine et leur procede de preparationInfo
- Publication number
- FR2427339A1 FR2427339A1 FR7913639A FR7913639A FR2427339A1 FR 2427339 A1 FR2427339 A1 FR 2427339A1 FR 7913639 A FR7913639 A FR 7913639A FR 7913639 A FR7913639 A FR 7913639A FR 2427339 A1 FR2427339 A1 FR 2427339A1
- Authority
- FR
- France
- Prior art keywords
- oxazaphosphorine
- optically active
- preparation process
- active derivatives
- new optically
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- ZZVDXRCAGGQFAK-UHFFFAOYSA-N 2h-oxazaphosphinine Chemical class N1OC=CC=P1 ZZVDXRCAGGQFAK-UHFFFAOYSA-N 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
- C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
- C07F9/65842—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring
- C07F9/65846—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring the phosphorus atom being part of a six-membered ring which may be condensed with another ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/22—Amides of acids of phosphorus
- C07F9/26—Amides of acids of phosphorus containing P-halide groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Nouveau procédé de préparation de dérivés optiquement actifs d'oxazaphosphorine ayant la formule générale :
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6468178A JPS54157580A (en) | 1978-05-29 | 1978-05-29 | Optically active oxazaphosphorine derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2427339A1 true FR2427339A1 (fr) | 1979-12-28 |
FR2427339B1 FR2427339B1 (fr) | 1984-09-14 |
Family
ID=13265139
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7913639A Granted FR2427339A1 (fr) | 1978-05-29 | 1979-05-29 | Nouveaux derives optiquement actifs d'oxazaphosphorine et leur procede de preparation |
Country Status (14)
Country | Link |
---|---|
US (1) | US4239709A (fr) |
JP (1) | JPS54157580A (fr) |
AU (1) | AU516429B2 (fr) |
BE (1) | BE876578A (fr) |
CA (1) | CA1108175A (fr) |
CH (1) | CH646710A5 (fr) |
DE (1) | DE2921057C3 (fr) |
ES (1) | ES481026A1 (fr) |
FR (1) | FR2427339A1 (fr) |
GB (1) | GB2021591B (fr) |
IT (1) | IT1120976B (fr) |
NL (1) | NL183141C (fr) |
SE (1) | SE446189B (fr) |
SU (1) | SU867314A3 (fr) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3111428A1 (de) * | 1981-03-24 | 1982-10-07 | Asta-Werke Ag, Chemische Fabrik, 4800 Bielefeld | Oxazaphosphorin-4-thio-alkansulfonsaeuren und deren neutrale salze, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen |
US5380904A (en) * | 1984-01-20 | 1995-01-10 | Biocompatibles Ltd. | Process for rendering a surface biocompatible, and articles containing the same |
US5229162A (en) * | 1984-01-20 | 1993-07-20 | Biocompatibles Ltd. | Article having biocompatible surface |
GB8401534D0 (en) * | 1984-01-20 | 1984-02-22 | Royal Free Hosp School Med | Biocompatible surfaces |
ZA851062B (en) * | 1984-03-01 | 1985-11-27 | Asta Werke Ag Chem Fab | Salts of oxazaphosphorine derivatives and process for their production |
FR2567129B1 (fr) * | 1984-07-06 | 1986-12-05 | Adir | Nouveaux derives de l'oxaazaphosphorine, leur procede de preparation et les compositions pharmaceutiques les renfermant |
US5258538A (en) * | 1985-08-26 | 1993-11-02 | Applied Biosystems, Inc. | 2,3-disubstituted-1,3,2-oxazaphosphacycloalkanes as nucleic acid linking agents |
KR900013763A (ko) * | 1989-02-28 | 1990-09-05 | 안시환 | 모사전송기의 원고 급지장치 |
DE19739159C1 (de) * | 1997-09-06 | 1999-01-28 | Asta Medica Ag | Verfahren zur Herstellung von Oxazaphosphorin-2-aminen |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1235022A (en) * | 1969-06-04 | 1971-06-09 | Laeaeke Ag | A new method for the production of cyclophosphamide |
DE2644905A1 (de) * | 1975-10-06 | 1977-04-14 | Polska Akad Nauk Centrum | Verfahren zur herstellung von optisch aktivem 2- eckige klammer auf bis-(2-chloraethyl)-amino eckige klammer zu -1-oxa-3-aza-2-phosphacyclohexanoxid-2 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1203268B (de) * | 1961-10-26 | 1965-10-21 | Farmochimica Cutolo Calosi S P | Verfahren zur Herstellung von 2-Chlor-3, 4-dimethyl-5-phenyl-1, 3, 2-oxazophospholidin-2-on |
US3732340A (en) * | 1966-07-11 | 1973-05-08 | Asta Werke Ag Chem Fab | N',o-propylene phosphoric acid ester diamides |
DE2201675A1 (de) * | 1972-01-14 | 1973-07-19 | Asta Werke Ag Chem Fab | Alkylsulfonsaeureester 1,3,2-oxazaphospha-cyclischer verbindungen, verfahren zu ihrer herstellung und pharmazeutische praeparate |
-
1978
- 1978-05-29 JP JP6468178A patent/JPS54157580A/ja active Granted
-
1979
- 1979-05-23 DE DE2921057A patent/DE2921057C3/de not_active Expired
- 1979-05-23 CA CA328,094A patent/CA1108175A/fr not_active Expired
- 1979-05-25 SU SU792769753A patent/SU867314A3/ru active
- 1979-05-28 AU AU47477/79A patent/AU516429B2/en not_active Ceased
- 1979-05-28 BE BE0/195419A patent/BE876578A/fr not_active IP Right Cessation
- 1979-05-28 SE SE7904595A patent/SE446189B/sv not_active IP Right Cessation
- 1979-05-28 IT IT68144/79A patent/IT1120976B/it active
- 1979-05-28 CH CH494979A patent/CH646710A5/de not_active IP Right Cessation
- 1979-05-29 NL NLAANVRAGE7904215,A patent/NL183141C/xx not_active IP Right Cessation
- 1979-05-29 FR FR7913639A patent/FR2427339A1/fr active Granted
- 1979-05-29 ES ES481026A patent/ES481026A1/es not_active Expired
- 1979-05-29 GB GB7918581A patent/GB2021591B/en not_active Expired
- 1979-05-29 US US06/043,462 patent/US4239709A/en not_active Expired - Lifetime
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1235022A (en) * | 1969-06-04 | 1971-06-09 | Laeaeke Ag | A new method for the production of cyclophosphamide |
DE2644905A1 (de) * | 1975-10-06 | 1977-04-14 | Polska Akad Nauk Centrum | Verfahren zur herstellung von optisch aktivem 2- eckige klammer auf bis-(2-chloraethyl)-amino eckige klammer zu -1-oxa-3-aza-2-phosphacyclohexanoxid-2 |
Non-Patent Citations (1)
Title |
---|
EXBK/75 * |
Also Published As
Publication number | Publication date |
---|---|
JPS54157580A (en) | 1979-12-12 |
DE2921057B2 (de) | 1981-01-15 |
SE446189B (sv) | 1986-08-18 |
DE2921057A1 (de) | 1979-12-06 |
SU867314A3 (ru) | 1981-09-23 |
AU516429B2 (en) | 1981-06-04 |
GB2021591A (en) | 1979-12-05 |
IT1120976B (it) | 1986-03-26 |
JPS5761360B2 (fr) | 1982-12-23 |
BE876578A (fr) | 1979-11-28 |
NL183141C (nl) | 1988-08-01 |
GB2021591B (en) | 1982-09-08 |
SE7904595L (sv) | 1979-11-30 |
AU4747779A (en) | 1979-12-06 |
CH646710A5 (de) | 1984-12-14 |
IT7968144A0 (it) | 1979-05-28 |
US4239709A (en) | 1980-12-16 |
ES481026A1 (es) | 1980-02-01 |
NL183141B (nl) | 1988-03-01 |
FR2427339B1 (fr) | 1984-09-14 |
DE2921057C3 (de) | 1981-11-26 |
NL7904215A (nl) | 1979-12-03 |
CA1108175A (fr) | 1981-09-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
FR2364219A1 (fr) | Derives de thiazolidine, leur procede de preparation et leur application en therapeutique | |
FR2427337A1 (fr) | Nouveaux derives acyles de la cephalosporine, leur preparation et leurs utilisations therapeutiques | |
FR2380285A1 (fr) | Nouveaux derives insatures d'acides 7-acylamido-3-cephem-4-carboxyliques, utiles notamment comme agents antibacteriens, et leur procede de preparation | |
FR2355796A1 (fr) | Procede de preparation de fluorures d'acides perfluoro-alcoxy-propioniques | |
FR2368471A1 (fr) | Nouveaux amides d'acides omega-amino-carboxyliques et procedes pour leur preparation | |
FR2427339A1 (fr) | Nouveaux derives optiquement actifs d'oxazaphosphorine et leur procede de preparation | |
FR2421901A1 (fr) | Procede de preparation de derives du lysergol | |
FR2394522A1 (fr) | Nouveaux derives d'acides (s-phenenyl tris(carbonylimino))-5,5',5''tri-benzene-carboxyliques utiles notamment comme inhibiteurs du complement, et leur procede de preparation | |
FR2377367A1 (fr) | Procede de preparation d'alcoxy-cetones | |
FR2384775A1 (fr) | Derives de la morphine, leur procede de preparation et leur application comme medicament | |
FR2362841A1 (fr) | Derives d'acides heterocyclyl-carboxyliques acyles utiles comme medicaments et procede pour leur preparation | |
OA06310A (fr) | Nouveaux dérivés N-substitués de l'acide aziridinyl-2-carboxylique et leur procédé de préparation. | |
FR2383941A1 (fr) | Nouveaux derives pyrimidinyliques et leur procede de preparation | |
FR2388789A1 (fr) | Derives d'acide benzoique, leur procede de preparation et leur application therapeutique | |
FR2435466A1 (fr) | Derives de l'hydroquinone et leur procede de preparation | |
FR2431496A1 (fr) | Procede pour la preparation d'esters d'acide 10-bromo-vincaminique et de composes analogues | |
FR2361341A1 (fr) | Procede de preparation d'esters de l'acide anthranilique | |
FR2398047A1 (fr) | Procede de preparation d'a-cetocarbonamides n-substitues et produits obtenus par ce procede | |
FR2419289A1 (fr) | Derives de glyoxal-2-oxime et leur procede de preparation | |
FR2396001A1 (fr) | Derives a-acetyleniques et a-vinyliques d'amino-acides utiles comme medicaments et leur procede de preparation | |
FR2391204A1 (fr) | Derives de l'anthraquinone, leur procede de preparation et leur application a la teinture de matieres plastiques | |
FR2416214A1 (fr) | Derives d'acide naphtyl-1 acetique, leur procede de preparation et leur application therapeutique | |
FR2355839A1 (fr) | Derives optiquement actifs d'acide benzoxazolyl-propionique, procede pour leur preparation et compositions therapeutiques les contenant | |
FR2367065A1 (fr) | Nouveaux composes du type 1-amino-2-hydroxy-3-heterocyclyloxy-propane utiles en tant que medicaments et leur procede de preparation | |
FR2418234A1 (fr) | Derives d'acide 7-(2,3-dihydrobenzo-5-furannyl)acetamidocephalosporanique utiles notamment comme antibiotiques et leur procede de preparation |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |