ES481026A1 - Un procedimiento para la preparacion de un derivado de oxazafosforina opticamente activo. - Google Patents
Un procedimiento para la preparacion de un derivado de oxazafosforina opticamente activo.Info
- Publication number
- ES481026A1 ES481026A1 ES481026A ES481026A ES481026A1 ES 481026 A1 ES481026 A1 ES 481026A1 ES 481026 A ES481026 A ES 481026A ES 481026 A ES481026 A ES 481026A ES 481026 A1 ES481026 A1 ES 481026A1
- Authority
- ES
- Spain
- Prior art keywords
- optically active
- general formula
- oxazaphosphorin
- derivatives
- novel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- ZZVDXRCAGGQFAK-UHFFFAOYSA-N 2h-oxazaphosphinine Chemical class N1OC=CC=P1 ZZVDXRCAGGQFAK-UHFFFAOYSA-N 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title 1
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 abstract 2
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical class ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 abstract 1
- 208000017604 Hodgkin disease Diseases 0.000 abstract 1
- 208000010747 Hodgkins lymphoma Diseases 0.000 abstract 1
- 208000005045 Interdigitating dendritic cell sarcoma Diseases 0.000 abstract 1
- 101100313649 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) POT1 gene Proteins 0.000 abstract 1
- 101100161758 Yarrowia lipolytica (strain CLIB 122 / E 150) POX3 gene Proteins 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001414 amino alcohols Chemical class 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000003325 follicular Effects 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 208000032839 leukemia Diseases 0.000 abstract 1
- 208000025036 lymphosarcoma Diseases 0.000 abstract 1
- 229910052698 phosphorus Inorganic materials 0.000 abstract 1
- 239000011574 phosphorus Substances 0.000 abstract 1
- -1 phosphorus compound Chemical class 0.000 abstract 1
- 208000029922 reticulum cell sarcoma Diseases 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
- C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
- C07F9/65842—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring
- C07F9/65846—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring the phosphorus atom being part of a six-membered ring which may be condensed with another ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/22—Amides of acids of phosphorus
- C07F9/26—Amides of acids of phosphorus containing P-halide groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Un procedimiento para la preparación de un derivado de oxazafosforina ópticamente activo, representado por la fórmula general: **(Fórmula 01)** donde R1, R2 y R3 son respectivamente diferentes entre sí y cada uno de ellos representa un átomo de hidrógeno, un grupo alquilo inferior, un grupo aralquilo o un grupo arilo y X es un átomo de halógeno; cuyo procedimiento consiste en hacer reaccionar un amonoalcohol ópticamente activo representado por la fórmula general: **(Fórmula 02)** donde R1, R2 y R3 son los definidos anteriormente, con un compuesto de fósforo representado por la fórmula general: POX3 donde X es un átomo de halógeno.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP6468178A JPS54157580A (en) | 1978-05-29 | 1978-05-29 | Optically active oxazaphosphorine derivative |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES481026A1 true ES481026A1 (es) | 1980-02-01 |
Family
ID=13265139
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES481026A Expired ES481026A1 (es) | 1978-05-29 | 1979-05-29 | Un procedimiento para la preparacion de un derivado de oxazafosforina opticamente activo. |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US4239709A (es) |
| JP (1) | JPS54157580A (es) |
| AU (1) | AU516429B2 (es) |
| BE (1) | BE876578A (es) |
| CA (1) | CA1108175A (es) |
| CH (1) | CH646710A5 (es) |
| DE (1) | DE2921057C3 (es) |
| ES (1) | ES481026A1 (es) |
| FR (1) | FR2427339A1 (es) |
| GB (1) | GB2021591B (es) |
| IT (1) | IT1120976B (es) |
| NL (1) | NL183141C (es) |
| SE (1) | SE446189B (es) |
| SU (1) | SU867314A3 (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3111428A1 (de) * | 1981-03-24 | 1982-10-07 | Asta-Werke Ag, Chemische Fabrik, 4800 Bielefeld | Oxazaphosphorin-4-thio-alkansulfonsaeuren und deren neutrale salze, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen |
| GB8401534D0 (en) * | 1984-01-20 | 1984-02-22 | Royal Free Hosp School Med | Biocompatible surfaces |
| US5229162A (en) * | 1984-01-20 | 1993-07-20 | Biocompatibles Ltd. | Article having biocompatible surface |
| US5380904A (en) * | 1984-01-20 | 1995-01-10 | Biocompatibles Ltd. | Process for rendering a surface biocompatible, and articles containing the same |
| ZA851062B (en) * | 1984-03-01 | 1985-11-27 | Asta Werke Ag Chem Fab | Salts of oxazaphosphorine derivatives and process for their production |
| FR2567129B1 (fr) * | 1984-07-06 | 1986-12-05 | Adir | Nouveaux derives de l'oxaazaphosphorine, leur procede de preparation et les compositions pharmaceutiques les renfermant |
| US5258538A (en) * | 1985-08-26 | 1993-11-02 | Applied Biosystems, Inc. | 2,3-disubstituted-1,3,2-oxazaphosphacycloalkanes as nucleic acid linking agents |
| KR900013763A (ko) * | 1989-02-28 | 1990-09-05 | 안시환 | 모사전송기의 원고 급지장치 |
| DE19739159C1 (de) * | 1997-09-06 | 1999-01-28 | Asta Medica Ag | Verfahren zur Herstellung von Oxazaphosphorin-2-aminen |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1203268B (de) * | 1961-10-26 | 1965-10-21 | Farmochimica Cutolo Calosi S P | Verfahren zur Herstellung von 2-Chlor-3, 4-dimethyl-5-phenyl-1, 3, 2-oxazophospholidin-2-on |
| US3732340A (en) * | 1966-07-11 | 1973-05-08 | Asta Werke Ag Chem Fab | N',o-propylene phosphoric acid ester diamides |
| GB1235022A (en) * | 1969-06-04 | 1971-06-09 | Laeaeke Ag | A new method for the production of cyclophosphamide |
| DE2201675A1 (de) * | 1972-01-14 | 1973-07-19 | Asta Werke Ag Chem Fab | Alkylsulfonsaeureester 1,3,2-oxazaphospha-cyclischer verbindungen, verfahren zu ihrer herstellung und pharmazeutische praeparate |
| PL100390B1 (pl) * | 1975-10-06 | 1978-09-30 | Sposob wytwarzania 2-tlenku-2-/bis/2-chloroetylo/-amino/-1-/okso-3-aza-2-fosfacykloheksanu/cyklofosfamidu/o czynnosci optycznej |
-
1978
- 1978-05-29 JP JP6468178A patent/JPS54157580A/ja active Granted
-
1979
- 1979-05-23 DE DE2921057A patent/DE2921057C3/de not_active Expired
- 1979-05-23 CA CA328,094A patent/CA1108175A/en not_active Expired
- 1979-05-25 SU SU792769753A patent/SU867314A3/ru active
- 1979-05-28 IT IT68144/79A patent/IT1120976B/it active
- 1979-05-28 SE SE7904595A patent/SE446189B/sv not_active IP Right Cessation
- 1979-05-28 BE BE0/195419A patent/BE876578A/xx not_active IP Right Cessation
- 1979-05-28 CH CH494979A patent/CH646710A5/de not_active IP Right Cessation
- 1979-05-28 AU AU47477/79A patent/AU516429B2/en not_active Ceased
- 1979-05-29 ES ES481026A patent/ES481026A1/es not_active Expired
- 1979-05-29 NL NLAANVRAGE7904215,A patent/NL183141C/xx not_active IP Right Cessation
- 1979-05-29 GB GB7918581A patent/GB2021591B/en not_active Expired
- 1979-05-29 FR FR7913639A patent/FR2427339A1/fr active Granted
- 1979-05-29 US US06/043,462 patent/US4239709A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| NL183141B (nl) | 1988-03-01 |
| DE2921057C3 (de) | 1981-11-26 |
| GB2021591B (en) | 1982-09-08 |
| DE2921057B2 (de) | 1981-01-15 |
| AU516429B2 (en) | 1981-06-04 |
| NL183141C (nl) | 1988-08-01 |
| BE876578A (fr) | 1979-11-28 |
| IT1120976B (it) | 1986-03-26 |
| SE446189B (sv) | 1986-08-18 |
| FR2427339A1 (fr) | 1979-12-28 |
| FR2427339B1 (es) | 1984-09-14 |
| CA1108175A (en) | 1981-09-01 |
| JPS54157580A (en) | 1979-12-12 |
| DE2921057A1 (de) | 1979-12-06 |
| US4239709A (en) | 1980-12-16 |
| SE7904595L (sv) | 1979-11-30 |
| JPS5761360B2 (es) | 1982-12-23 |
| CH646710A5 (de) | 1984-12-14 |
| AU4747779A (en) | 1979-12-06 |
| GB2021591A (en) | 1979-12-05 |
| SU867314A3 (ru) | 1981-09-23 |
| NL7904215A (nl) | 1979-12-03 |
| IT7968144A0 (it) | 1979-05-28 |
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