FR2413373A1 - Procede d'alkylation de 4(5)-mercaptomethylimidazoles avec des derives d'aziridine - Google Patents
Procede d'alkylation de 4(5)-mercaptomethylimidazoles avec des derives d'aziridineInfo
- Publication number
- FR2413373A1 FR2413373A1 FR7836922A FR7836922A FR2413373A1 FR 2413373 A1 FR2413373 A1 FR 2413373A1 FR 7836922 A FR7836922 A FR 7836922A FR 7836922 A FR7836922 A FR 7836922A FR 2413373 A1 FR2413373 A1 FR 2413373A1
- Authority
- FR
- France
- Prior art keywords
- bopi
- mercaptomethylimidazoles
- alkylation process
- aziridine derivatives
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
L'INVENTION CONCERNE UN PROCEDE POUR LA PREPARATION DE N-CYANO-N-2-(4- OU 5-METHYL-1H-IMIDAZOLE-5 OU -4-YL)-METHYLTHIOETHYL-GUANIDINES DE FORMULES GENERALES: (CF DESSIN DANS BOPI) (CF DESSIN DANS BOPI) DANS LESQUELLES R REPRESENTE UN GROUPE ALKYLE JUSQU'EN C. ON FAIT REAGIR DES 5(4)-METHYL-4(5)-MERCAPTOMETHYL-IMIDAZOLES DE FORMULES GENERALES: (CF DESSIN DANS BOPI) SOUS FORME DE BASE LIBRE OU D'UN SEL AVEC UN DERIVE D'AZIRIDINE DE FORMULE GENERALE: (CF DESSIN DANS BOPI) DANS LAQUELLE R EST TEL QUE DEFINI CI-DESSUS. LE PROCEDE EST PLUS ECONOMIQUE EN RAISON DE SON RENDEMENT ELEVE, DE L'ECONOMIE D'UNE ETAPE REACTIONNELLE ET DE L'UTILISATION DE PRODUITS DE DEPART PEU COUTEUX.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH1634077A CH631971A5 (en) | 1977-12-30 | 1977-12-30 | Process for preparing imidazole derivatives |
CH1069578 | 1978-10-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
FR2413373A1 true FR2413373A1 (fr) | 1979-07-27 |
Family
ID=25707086
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7836922A Pending FR2413373A1 (fr) | 1977-12-30 | 1978-12-29 | Procede d'alkylation de 4(5)-mercaptomethylimidazoles avec des derives d'aziridine |
Country Status (16)
Country | Link |
---|---|
JP (1) | JPS55500026A (fr) |
CS (1) | CS207750B2 (fr) |
DE (1) | DE2857324D2 (fr) |
DK (1) | DK319679A (fr) |
FI (1) | FI784018A (fr) |
FR (1) | FR2413373A1 (fr) |
GB (1) | GB2036003B (fr) |
GR (1) | GR65283B (fr) |
IT (1) | IT1102765B (fr) |
NL (1) | NL171054C (fr) |
NO (1) | NO784350L (fr) |
PL (1) | PL113033B1 (fr) |
SE (1) | SE7907148L (fr) |
SU (1) | SU950188A3 (fr) |
WO (1) | WO1979000466A1 (fr) |
YU (1) | YU313178A (fr) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2425429A1 (fr) * | 1978-05-12 | 1979-12-07 | Crc Ricerca Chim | N-cyano-azomethines utilisables pour la preparation d'antihistaminiques et leur preparation |
FR2425434A1 (fr) * | 1978-05-12 | 1979-12-07 | Crc Ricerca Chim | Thiols derives de l'imidazole utilisables pour la preparation d'antihistaminiques et leur preparation |
FR2473044A1 (fr) * | 1980-01-08 | 1981-07-10 | Glaxo Group Ltd | Procede de preparation de la n-(2-((5-((dimethylamino)-methyl)-2-furannylmethyl)-thio)ethyl)-n'-methyl-2-nitro-1,1-ethene-diamine, et produits intermediaires de cette preparation |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1981000255A1 (fr) * | 1979-07-16 | 1981-02-05 | Rech Syntheses Organ | Imino-alkyle et amino-nitrile cyano-guanidines |
JPS56501008A (fr) * | 1979-07-30 | 1981-07-23 | ||
CA1181084A (fr) * | 1980-01-08 | 1985-01-15 | Glaxo Group Limited | Preparation d'un derive de furane |
EP0058286A1 (fr) * | 1981-02-12 | 1982-08-25 | Société de Recherches et de Synthèses Organiques SA | Isomères géométriques de cyano-guanidines et leurs procédés de préparation |
GB8502446D0 (en) * | 1985-01-31 | 1985-03-06 | Smith Kline French Lab | Preparing aziridine derivative |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1531231A (en) * | 1974-09-02 | 1978-11-08 | Smith Kline French Lab | Process for the production of cyanoguanidine derivatives |
GB1533380A (en) * | 1974-09-02 | 1978-11-22 | Smith Kline French Lab | Process for the preparation of heterocyclic substituted thioureas and h-cyanoguanidines |
IL56265A (en) * | 1977-12-28 | 1982-08-31 | Om Lab Sa | Process for preparing imidazolyl methylthio guanidine derivatives and a novel intermediate therefor |
-
1978
- 1978-12-22 NO NO784350A patent/NO784350L/no unknown
- 1978-12-22 GR GR57973A patent/GR65283B/el unknown
- 1978-12-28 WO PCT/CH1978/000058 patent/WO1979000466A1/fr unknown
- 1978-12-28 GB GB7928551A patent/GB2036003B/en not_active Expired
- 1978-12-28 IT IT31352/78A patent/IT1102765B/it active
- 1978-12-28 FI FI784018A patent/FI784018A/fi unknown
- 1978-12-28 DE DE78CH7800058T patent/DE2857324D2/de not_active Expired
- 1978-12-28 JP JP50020578A patent/JPS55500026A/ja active Pending
- 1978-12-29 CS CS789198A patent/CS207750B2/cs unknown
- 1978-12-29 YU YU03131/78A patent/YU313178A/xx unknown
- 1978-12-29 FR FR7836922A patent/FR2413373A1/fr active Pending
- 1978-12-29 NL NLAANVRAGE7812662,A patent/NL171054C/xx not_active IP Right Cessation
- 1978-12-30 PL PL1978212389A patent/PL113033B1/pl unknown
-
1979
- 1979-07-30 DK DK319679A patent/DK319679A/da not_active Application Discontinuation
- 1979-08-21 SU SU792802997A patent/SU950188A3/ru active
- 1979-08-28 SE SE7907148A patent/SE7907148L/xx not_active Application Discontinuation
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2425429A1 (fr) * | 1978-05-12 | 1979-12-07 | Crc Ricerca Chim | N-cyano-azomethines utilisables pour la preparation d'antihistaminiques et leur preparation |
FR2425434A1 (fr) * | 1978-05-12 | 1979-12-07 | Crc Ricerca Chim | Thiols derives de l'imidazole utilisables pour la preparation d'antihistaminiques et leur preparation |
FR2473044A1 (fr) * | 1980-01-08 | 1981-07-10 | Glaxo Group Ltd | Procede de preparation de la n-(2-((5-((dimethylamino)-methyl)-2-furannylmethyl)-thio)ethyl)-n'-methyl-2-nitro-1,1-ethene-diamine, et produits intermediaires de cette preparation |
Also Published As
Publication number | Publication date |
---|---|
IT1102765B (it) | 1985-10-07 |
WO1979000466A1 (fr) | 1979-07-26 |
GB2036003A (en) | 1980-06-25 |
DK319679A (da) | 1979-08-30 |
CS207750B2 (en) | 1981-08-31 |
GR65283B (en) | 1980-08-01 |
DE2857324D2 (en) | 1980-11-20 |
JPS55500026A (fr) | 1980-01-24 |
SU950188A3 (ru) | 1982-08-07 |
NO784350L (no) | 1979-07-03 |
FI784018A (fi) | 1979-07-01 |
SE7907148L (sv) | 1979-08-28 |
YU313178A (en) | 1982-10-31 |
PL212389A1 (pl) | 1979-08-13 |
NL7812662A (nl) | 1979-07-03 |
NL171054B (nl) | 1982-09-01 |
PL113033B1 (en) | 1980-11-29 |
NL171054C (nl) | 1983-02-01 |
GB2036003B (en) | 1982-08-18 |
IT7831352A0 (it) | 1978-12-28 |
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