FR2407921A1 - Nouveaux 7-oxa-bicycloheptanes et -bicycloheptenes, utiles notamment comme agents cardiovasculaires, et leur procede de preparation - Google Patents

Nouveaux 7-oxa-bicycloheptanes et -bicycloheptenes, utiles notamment comme agents cardiovasculaires, et leur procede de preparation

Info

Publication number
FR2407921A1
FR2407921A1 FR7831200A FR7831200A FR2407921A1 FR 2407921 A1 FR2407921 A1 FR 2407921A1 FR 7831200 A FR7831200 A FR 7831200A FR 7831200 A FR7831200 A FR 7831200A FR 2407921 A1 FR2407921 A1 FR 2407921A1
Authority
FR
France
Prior art keywords
cardiovascular agents
bicycloheptenes
bicycloheptanes
oxa
useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7831200A
Other languages
English (en)
Other versions
FR2407921B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Publication of FR2407921A1 publication Critical patent/FR2407921A1/fr
Application granted granted Critical
Publication of FR2407921B1 publication Critical patent/FR2407921B1/fr
Expired legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

LES MEDICAMENTS SELON L'INVENTION REPONDENT AUX FORMULES GENERALES: (CF DESSIN DANS BOPI) DANS LEQUELLES R EST UN ATOME D'HYDROGENE OU UN GROUPE ALKYLE; R EST UN GROUPE -CHO, -CHOH OU -CHCH-R-(ALKYLENE INFERIEUR)-CH; R EST UN GROUPE CETO OU HYDROXYMETHYLE; ET LA LIGNE EN TRAIT INTERROMPU EST UNE LIAISON SUPPLEMENTAIRE FACULTATIVE, ET X EST EGAL A 0 OU A 1. APPLICATION COMME AGENTS CARDIOVASCULAIRES, NOTAMMENT COMME INHIBITEURS DE L'AGGLOMERATION DES PLAQUETTES SANGUINES A DES DOSES JOURNALIERES D'ENVIRON 1 A 100MG PAR KG, NOTAMMENT EN TABLETTES, CAPSULES, SOLUTIONS OU SUSPENSIONS CONTENANT ENVIRON 5 A 500MG D'INGREDIENT ACTIF PAR UNITE DE DOSAGE.
FR787831200A 1977-11-04 1978-11-03 Nouveaux 7-oxa-bicycloheptanes et -bicycloheptenes, utiles notamment comme agents cardiovasculaires, et leur procede de preparation Expired FR2407921B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/848,543 US4143054A (en) 1977-11-04 1977-11-04 7-oxabicycloheptane- and 7-oxabicycloheptene compounds

Publications (2)

Publication Number Publication Date
FR2407921A1 true FR2407921A1 (fr) 1979-06-01
FR2407921B1 FR2407921B1 (fr) 1985-07-26

Family

ID=25303579

Family Applications (2)

Application Number Title Priority Date Filing Date
FR787831200A Expired FR2407921B1 (fr) 1977-11-04 1978-11-03 Nouveaux 7-oxa-bicycloheptanes et -bicycloheptenes, utiles notamment comme agents cardiovasculaires, et leur procede de preparation
FR818121586A Expired FR2497203B1 (fr) 1977-11-04 1981-11-18 Nouveaux 7-oxa-bicycloheptanes et -bicycloheptenes utiles notamment comme agents cardiovasculaires, et leur procede de preparation

Family Applications After (1)

Application Number Title Priority Date Filing Date
FR818121586A Expired FR2497203B1 (fr) 1977-11-04 1981-11-18 Nouveaux 7-oxa-bicycloheptanes et -bicycloheptenes utiles notamment comme agents cardiovasculaires, et leur procede de preparation

Country Status (7)

Country Link
US (1) US4143054A (fr)
JP (1) JPS5473791A (fr)
CA (1) CA1128538A (fr)
DE (1) DE2847832A1 (fr)
FR (2) FR2407921B1 (fr)
GB (3) GB2086887B (fr)
IT (1) IT1100921B (fr)

Cited By (1)

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Publication number Priority date Publication date Assignee Title
US5383287A (en) * 1992-06-03 1995-01-24 Valmet Paper Machinery Inc. Method and wire group in a dryer section provided with a single-wire draw

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ZA829068B (en) * 1980-07-01 1983-02-23 Nat Res Dev Prostaglandins
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US4537981A (en) * 1981-11-09 1985-08-27 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane and 7-oxabicycloheptene compounds
ZA827529B (en) * 1981-11-09 1983-09-28 Squibb & Sons Inc 7-oxabicycloheptane and 7-oxabicycloheptene compounds
JPS58502148A (ja) * 1981-12-23 1983-12-15 ナシヨナル　リサ−チ　デイベロツプメント　コ−ポレイシヨン プロスタグランジン
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US4556675A (en) * 1982-05-17 1985-12-03 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane and 7-oxabicycloheptene compounds
US4416896A (en) * 1982-05-17 1983-11-22 E. R. Squibb & Sons, Inc. 7-Oxabicyclopheptane substituted amino prostaglandin analogs useful in the treatment of thrombolytic disease
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US4614825A (en) * 1982-05-17 1986-09-30 E. R. Squibb & Sons, Inc. 7-oxabicycloheptane and 7-oxabicycloheptene compounds
US4463015A (en) * 1982-08-18 1984-07-31 E. R. Squibb & Sons, Inc. Aryl substituted 7-oxabicycloheptane compounds, useful in inhibiting platelet aggregation
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CA1254577A (fr) * 1983-05-13 1989-05-23 Peter W. Sprague Produits intermediaires de 7-oxabicycloheptane prostaglandine et methode de preparation
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US4525479A (en) * 1983-08-29 1985-06-25 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane substituted thiocarbamate prostaglandin analogs useful as cardiovascular agents
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US4522949A (en) * 1983-10-20 1985-06-11 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane substituted prostaglandin interphenylene analogs useful as cardiovascular agents
US4513103A (en) * 1983-10-21 1985-04-23 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane ethers useful in the treatment of thrombolytic disease
US4524151A (en) 1983-11-14 1985-06-18 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane thio ethers useful as cardiovascular agents
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US4526900A (en) * 1984-01-26 1985-07-02 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane substituted oxa prostaglandin analogs and their use in the treatment of thrombolytic disease
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IT1100921B (it) 1985-09-28
GB2086381B (en) 1982-11-10
FR2497203A1 (fr) 1982-07-02
GB2086887B (en) 1982-12-08
IT7829433A0 (it) 1978-11-03
GB2086887A (en) 1982-05-19
GB2008107A (en) 1979-05-31
FR2497203B1 (fr) 1985-07-26
US4143054A (en) 1979-03-06
FR2407921B1 (fr) 1985-07-26
GB2086381A (en) 1982-05-12
JPS5473791A (en) 1979-06-13
CA1128538A (fr) 1982-07-27
GB2008107B (en) 1982-12-01
DE2847832A1 (de) 1979-05-10

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