FR2407211A1 - Nouveaux derives de 3-(1-pyrazolyl)-pyridazine, leurs procedes de preparation et medicaments contenant ces nouveaux derives - Google Patents

Nouveaux derives de 3-(1-pyrazolyl)-pyridazine, leurs procedes de preparation et medicaments contenant ces nouveaux derives

Info

Publication number
FR2407211A1
FR2407211A1 FR7820938A FR7820938A FR2407211A1 FR 2407211 A1 FR2407211 A1 FR 2407211A1 FR 7820938 A FR7820938 A FR 7820938A FR 7820938 A FR7820938 A FR 7820938A FR 2407211 A1 FR2407211 A1 FR 2407211A1
Authority
FR
France
Prior art keywords
new derivatives
pyrazolyl
pyridazine
preparation
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7820938A
Other languages
English (en)
Other versions
FR2407211B1 (fr
Inventor
Geza Szilagyi
Szilagyi Endre Kasztreiner Laszlo Tardos Edit Kosa Laszlo Jaszlits Gyorgy Cseh Ilona Kovacs Nee Geza
Endre Kasztreiner
Laszlo Tardos
Edit Kosa
Laszlo Jaszlits
Gyorgy Cseh
Ilona Kovacs
Nee Szaro
Pal Tolnay
Sandor Elek
Istvan Elek
Istvan Elekes
Istvan Polgari
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richter Gedeon Vegyeszeti Gyar Nyrt
Original Assignee
Richter Gedeon Vegyeszeti Gyar RT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszeti Gyar RT filed Critical Richter Gedeon Vegyeszeti Gyar RT
Publication of FR2407211A1 publication Critical patent/FR2407211A1/fr
Application granted granted Critical
Publication of FR2407211B1 publication Critical patent/FR2407211B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

LA PRESENTE INVENTION A POUR OBJET DE NOUVEAUX DERIVES DE 3-(1-PYRAZOLYL)-PYRIDAZINE QUI REPONDENT A LA FORMULE GENERALE I CI-DESSOUS DANS LAQUELLE R, R, R ET R ONT LES SIGNIFICATIONS DEFINIES DANS LE BREVET, AINSI QUE LES SELS COMPATIBLES DU POINT DE VUE PHARMACEUTIQUE DE CES COMPOSES. L'INVENTION A EGALEMENT POUR OBJET DES PROCEDES DE PREPARATION DE CES NOUVEAUX DERIVES. APPLICATION DES NOUVEAUX DERIVES DE 3-(1-PYRAZOLYL)-PYRIDAZINE CONFORMES A L'INVENTION: EN TANT QUE MEDICAMENTS HYPOTENSEURS, QUI SONT EN OUTRE CAPABLES D'INHIBER DE FACON APPRECIABLE LES ENZYMES QUI REGULENT LE CATABOLISME DES PROSTAGLANDINES. (CF DESSIN DANS BOPI)
FR7820938A 1977-10-25 1978-07-13 Nouveaux derives de 3-(1-pyrazolyl)-pyridazine, leurs procedes de preparation et medicaments contenant ces nouveaux derives Granted FR2407211A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU77GO1381A HU176100B (en) 1977-10-25 1977-10-25 Process for preparing new 3-/1-pyrazolyl/-pyridazine derivatives

Publications (2)

Publication Number Publication Date
FR2407211A1 true FR2407211A1 (fr) 1979-05-25
FR2407211B1 FR2407211B1 (fr) 1982-09-03

Family

ID=10996838

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7820938A Granted FR2407211A1 (fr) 1977-10-25 1978-07-13 Nouveaux derives de 3-(1-pyrazolyl)-pyridazine, leurs procedes de preparation et medicaments contenant ces nouveaux derives

Country Status (24)

Country Link
US (1) US4224325A (fr)
JP (1) JPS5461187A (fr)
AT (1) AT359076B (fr)
AU (1) AU525814B2 (fr)
BE (1) BE868987A (fr)
CA (1) CA1090337A (fr)
CH (1) CH637951A5 (fr)
CS (1) CS217964B2 (fr)
DD (1) DD139848A5 (fr)
DE (1) DE2831072A1 (fr)
DK (1) DK317678A (fr)
ES (1) ES471779A1 (fr)
FI (1) FI63397C (fr)
FR (1) FR2407211A1 (fr)
GB (1) GB2007644B (fr)
HU (1) HU176100B (fr)
IL (1) IL55120A (fr)
IT (1) IT1097156B (fr)
NL (1) NL7807572A (fr)
NO (1) NO149354C (fr)
PL (2) PL115063B1 (fr)
SE (1) SE437988B (fr)
SU (3) SU847920A3 (fr)
YU (1) YU169878A (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2471380A1 (fr) * 1979-12-13 1981-06-19 Sterling Drug Inc 6-(pyridinyl)-pyridazines, leur preparation et leur utilisation therapeutique

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4302456A (en) * 1977-04-13 1981-11-24 The Upjohn Company Process for therapeutic treatment
US4302457A (en) * 1977-04-13 1981-11-24 The Upjohn Company Process for therapeutic treatment
DE2935359A1 (de) * 1979-09-01 1981-03-26 Basf Ag, 67063 Ludwigshafen 6-imidazolyl-3-hydrazino-pyridazine
US4503056A (en) * 1982-03-02 1985-03-05 Abbott Laboratories 1-(Pyridazinyl)pyrazoline derivatives
US5001125A (en) * 1984-03-26 1991-03-19 Janssen Pharmaceutica N.V. Anti-virally active pyridazinamines

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5231083A (en) * 1975-09-05 1977-03-09 Chugai Pharmaceut Co Ltd Preparation of pyrazolylpyridazine derivatives
FR2394542A1 (fr) * 1977-06-13 1979-01-12 Richter Gedeon Vegyeszet Derives de 3-(1-pyrazolyl)-pyridazine et leur procede de preparation et nouveaux medicaments les contenant

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1220428B (de) 1960-03-25 1966-07-07 Takeda Pharmaceutical Verfahren zur Herstellung von 2-Pyrazolyl-(1')-pyrimidinderivaten und deren Salzen

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5231083A (en) * 1975-09-05 1977-03-09 Chugai Pharmaceut Co Ltd Preparation of pyrazolylpyridazine derivatives
FR2394542A1 (fr) * 1977-06-13 1979-01-12 Richter Gedeon Vegyeszet Derives de 3-(1-pyrazolyl)-pyridazine et leur procede de preparation et nouveaux medicaments les contenant

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CA1974 *
CA1977 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2471380A1 (fr) * 1979-12-13 1981-06-19 Sterling Drug Inc 6-(pyridinyl)-pyridazines, leur preparation et leur utilisation therapeutique

Also Published As

Publication number Publication date
AU3799778A (en) 1980-01-17
GB2007644B (en) 1982-03-10
SU856385A3 (ru) 1981-08-15
DD139848A5 (de) 1980-01-23
IT1097156B (it) 1985-08-26
FR2407211B1 (fr) 1982-09-03
SU845786A3 (ru) 1981-07-07
FI63397C (fi) 1983-06-10
CS217964B2 (en) 1983-02-25
NO149354B (no) 1983-12-27
FI63397B (fi) 1983-02-28
CA1090337A (fr) 1980-11-25
ES471779A1 (es) 1979-10-01
NO149354C (no) 1984-04-04
ATA509278A (de) 1980-03-15
PL208409A1 (fr) 1980-02-25
HU176100B (en) 1980-12-28
SE7807822L (sv) 1979-04-26
IL55120A0 (en) 1978-09-29
BE868987A (fr) 1979-01-15
US4224325A (en) 1980-09-23
IL55120A (en) 1982-05-31
CH637951A5 (de) 1983-08-31
PL118799B1 (en) 1981-10-31
SE437988B (sv) 1985-03-25
NO782446L (no) 1979-04-26
NL7807572A (nl) 1979-04-27
AT359076B (de) 1980-10-27
JPS5527063B2 (fr) 1980-07-17
GB2007644A (en) 1979-05-23
JPS5461187A (en) 1979-05-17
AU525814B2 (en) 1982-12-02
YU169878A (en) 1983-01-21
DE2831072A1 (de) 1979-05-10
DK317678A (da) 1979-04-26
FI782237A (fi) 1979-04-26
IT7825681A0 (it) 1978-07-14
SU847920A3 (ru) 1981-07-15
PL218031A1 (fr) 1980-07-14
PL115063B1 (en) 1981-03-31

Similar Documents

Publication Publication Date Title
FR2416012A1 (fr) Derives de l'imidazole et medicament contenant ces substances
FR2414039A1 (fr) Derives de prostacycline, leur procede de preparation et leurs applications en therapeutique
FR2392971A1 (fr) Derives de l'acide prostanoique, leur preparation et medicament contenant ces substances
FR2439189A1 (fr) Nouveaux derives de la 5h-2,3-benzodiazepine et procede pour la preparation de ces derives et compositions pharmaceutiques les contenant
FR2439182A1 (fr) Nouveaux derives cyclopeptidiques, leur preparation et leur application comme medicaments
FR2421899A1 (fr) Nouveaux derives du tetrahydropyridinyl-indole et leurs sels, le procede de preparation et l'application a titre de medicaments de ces nouveaux produits
FR2425433A1 (fr) Nouveaux acides lactame-n-acetiques et leurs amides, leurs procedes de preparation et compositions therapeutiques
FR2394546A1 (fr) Nouveaux derives de 1,2,3,4,6,7-hexahydro-11bah-benzo(a)-quinolizine, leur preparation et leur application en tant que medicaments
FR2448531A1 (fr) Nouveaux derives de 4-(naphtylmethyl)piperidine, utiles notamment comme agents antipsychotiques et leur procede de preparation
FR2407211A1 (fr) Nouveaux derives de 3-(1-pyrazolyl)-pyridazine, leurs procedes de preparation et medicaments contenant ces nouveaux derives
FR2453866A1 (fr) Derives peptidiques, procede pour leur preparation et leur application dans des preparations pharmaceutiques
FR2407212A1 (fr) Isochromanes, isothiochromanes, 2-benzoxepines et 2-benzothiepines et medicament en contenant
FR2450820A1 (fr) Nouveaux derives d'acides 1- (o-mercaptoacyl) -4,5-dihydropyrazole-5-carboxyliques, utiles notamment comme agents hypotenseurs, et leur procede de preparation
FR2417502A1 (fr) Nouvelles 2-phenylimino-imidazolidines substituees, leurs sels d'addition avec des acides, medicaments les renfermant et procedes pour leur preparation
FR2447721A1 (fr) Compositions pour le traitement du glaucome, contenant un derive de carbostyrile comme constituant actif
FR2407928A1 (fr) Derives de quinazoline utiles comme medicaments antihypertenseurs et procede de leur preparation
FR2422405A1 (fr) Nouveaux medicaments constitues de derives de l'acide p-aminobenzoique
FR2361371A1 (fr) Nouvelles 2-phenylamino imidazolines-(2) substituees, leurs sels d'addition avec des acides, les medicaments les renfermant et procedes pour leur preparation
FR2390424A1 (fr) Nouveaux derives d'amides de l'acide phenylacetique substitues, leur application en tant que medicament et leur application
FR2441617A1 (fr) Nouveaux derives de s-triazine, leur procede de preparation et compositions pharmaceutiques les contenant
FR2410649A1 (fr) 1-phenyl-2-pyrrolidin-2-yl-ethanols substitues, leur procede de preparation, leurs applications et medicaments les contenant
FR2390954A1 (fr) Nouvelles guanylhydrazones, leurs procedes de preparation et medicaments les contenant
FR2413383A1 (fr) Derives de type 5,6-dihydro-prostacycline, leurs procedes de preparation et leurs applications therapeutiques
FI793552A (fi) Aminopropanolderivat av 6-hydroxi-2,3,4,5-tetrahydro-1h-1-bensazepin-2-on foerfarande foer framstaellning av dem och farmaceutiska preparat innehaollande dessa
FR2456744A1 (fr) Derives de la pyrazolo (1,5-c)quinazoline, procede de preparation de ces derives et medicaments contenant ces derniers

Legal Events

Date Code Title Description
ST Notification of lapse