FR2414039A1 - Derives de prostacycline, leur procede de preparation et leurs applications en therapeutique - Google Patents

Derives de prostacycline, leur procede de preparation et leurs applications en therapeutique

Info

Publication number
FR2414039A1
FR2414039A1 FR7900343A FR7900343A FR2414039A1 FR 2414039 A1 FR2414039 A1 FR 2414039A1 FR 7900343 A FR7900343 A FR 7900343A FR 7900343 A FR7900343 A FR 7900343A FR 2414039 A1 FR2414039 A1 FR 2414039A1
Authority
FR
France
Prior art keywords
preparation process
therapeutic applications
prostacycline
derivatives
prostacycline derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7900343A
Other languages
English (en)
Other versions
FR2414039B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Publication of FR2414039A1 publication Critical patent/FR2414039A1/fr
Application granted granted Critical
Publication of FR2414039B1 publication Critical patent/FR2414039B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/147—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of carboxylic acids or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/005—Analogues or derivatives having the five membered ring replaced by other rings
    • C07C405/0075—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system
    • C07C405/0083—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system which is only ortho or peri condensed, e.g. carbacyclins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/613—Unsaturated compounds containing a keto groups being part of a ring polycyclic
    • C07C49/617—Unsaturated compounds containing a keto groups being part of a ring polycyclic a keto group being part of a condensed ring system
    • C07C49/623—Unsaturated compounds containing a keto groups being part of a ring polycyclic a keto group being part of a condensed ring system having two rings
    • C07C49/633—Unsaturated compounds containing a keto groups being part of a ring polycyclic a keto group being part of a condensed ring system having two rings the condensed ring system containing eight or nine carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/743—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups having unsaturation outside the rings, e.g. humulones, lupulones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/30—Unsaturated compounds
    • C07C62/38—Unsaturated compounds containing keto groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

L'INVENTION A POUR OBJET: (CF DESSIN DANS BOPI) DANS LAQUELLE R REPRESENTE UN ATOME D'HYDROGENE OU UN GROUPE ALKYLE AYANT DE 1 A 15 ATOMES DE CARBONE; R REPRESENTE UN GROUPE ALKYLE OU ALCENYLE; ET N REPRESENTE UN ENTIER DE 1 A 8, ET LEURS SELS PHARMACEUTIQUEMENT ACCEPTABLES. CES COMPOSES ONT UNE ACTIVITE INHIBITRICE DE L'AGREGATION PLAQUETTAIRE.
FR7900343A 1978-01-06 1979-01-08 Derives de prostacycline, leur procede de preparation et leurs applications en therapeutique Granted FR2414039A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP46278A JPS5495552A (en) 1978-01-06 1978-01-06 Prostacyline derivative and its preparation

Publications (2)

Publication Number Publication Date
FR2414039A1 true FR2414039A1 (fr) 1979-08-03
FR2414039B1 FR2414039B1 (fr) 1981-11-27

Family

ID=11474452

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7900343A Granted FR2414039A1 (fr) 1978-01-06 1979-01-08 Derives de prostacycline, leur procede de preparation et leurs applications en therapeutique

Country Status (7)

Country Link
US (1) US4322435A (fr)
JP (1) JPS5495552A (fr)
CH (2) CH639359A5 (fr)
DE (2) DE2954373C2 (fr)
FR (1) FR2414039A1 (fr)
GB (1) GB2012265B (fr)
IT (1) IT1192762B (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2419271A1 (fr) * 1978-03-09 1979-10-05 Sumitomo Chemical Co Nouveaux derives bicyclo-octaniques, leur preparation et leur utilisation comme medicaments
FR2466446A1 (fr) * 1978-01-26 1981-04-10 Erba Farmitalia Bicyclo-alcanones, intermediaires de la preparation d'isosteres de type 9-desoxy-9a-methylene de pgi2

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4732914A (en) * 1978-02-13 1988-03-22 The Upjohn Company Prostacyclin analogs
DE2845770A1 (de) * 1978-10-19 1980-04-30 Schering Ag Neue prostacyclin-derivate und verfahren zu ihrer herstellung
CA1201712A (fr) * 1980-02-28 1986-03-11 Paul A. Aristoff Analogues de la carbacycline
US4525586A (en) * 1980-02-28 1985-06-25 The Upjohn Company Composition and process
DE3048906A1 (de) * 1980-12-19 1982-07-15 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3121155A1 (de) * 1981-05-22 1982-12-09 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3201764A1 (de) * 1982-01-21 1983-09-08 Merck Patent Gmbh, 6100 Darmstadt 13-thia-prostacycline, diese enthaltende pharmazeutische zubereitungen und verfahren zu ihrer herstellung
US4590297A (en) * 1982-02-16 1986-05-20 The Upjohn Company Novel 9-substituted carbacyclin analogs
US4533749A (en) * 1982-02-16 1985-08-06 The Upjohn Company 9-Substituted carbacyclin analogs
US4487961A (en) * 1982-02-16 1984-12-11 The Upjohn Company 9-Substituted carbacyclin analogs
US4588823A (en) * 1982-02-16 1986-05-13 The Upjohn Company 9-substituted carbacyclin analogs
US4486598A (en) * 1982-02-22 1984-12-04 The Upjohn Company Carbacyclin analogs
US4585886A (en) * 1982-03-19 1986-04-29 The Upjohn Company 9-Substituted carbacyclin analogs
US4490555A (en) * 1982-03-19 1984-12-25 The Upjohn Company 9-Substituted carbacyclin analogs
US4487960A (en) * 1982-04-19 1984-12-11 The Upjohn Company 9-Substituted carbacyclin analogs
WO1983004019A1 (fr) * 1982-05-06 1983-11-24 Cbd Corporation Composes cycloaliphatiques pharmaceutiques
US4689349A (en) * 1982-05-06 1987-08-25 Cbd Corporation Anti-tumor halo bicyclo alkanones
US4689345A (en) * 1982-05-06 1987-08-25 Cbd Corporation Oxygenated alkyl substituted bicyclo alkanes
DE3225287A1 (de) * 1982-07-02 1984-01-05 Schering AG, 1000 Berlin und 4709 Bergkamen Neue carbacyclinamide, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US4552898A (en) * 1982-07-14 1985-11-12 Syntex (U.S.A.) Inc. [3.2.0]Bicycloheptanone oxime ethers with valuable therapeutic properties
JPS5978179A (ja) * 1982-10-26 1984-05-04 Sankyo Co Ltd エポキシカルバサイクリン誘導体およびその製造法
JPS59141536A (ja) * 1983-02-01 1984-08-14 Sumitomo Chem Co Ltd 新規ビシクロオクタン誘導体
US4561604A (en) * 1983-07-18 1985-12-31 Shimano Industrial Company Limited Spinning reel
EP0162894A4 (fr) * 1983-11-08 1987-01-22 Cbd Corp Halo-bicyclo-alcanones.
US4668814A (en) * 1984-03-08 1987-05-26 The Upjohn Company Interphenylene carbacyclin derivatives
US4683330A (en) * 1984-03-08 1987-07-28 The Upjohn Company Interphenylene carbacyclin derivatives
US4757087A (en) * 1985-03-19 1988-07-12 Sankyo Company Limited Carbacyclin derivatives
JPH075494B2 (ja) 1985-04-30 1995-01-25 三共株式会社 プロスタグランジン類
JPS61280294A (ja) * 1985-06-04 1986-12-10 Nisshin Flour Milling Co Ltd 光学活性カルバサイクリン中間体の製造方法
DE3874440T2 (de) * 1987-07-14 1993-01-28 Sankyo Co Zusammensetzung zur herstellung von antithrombotischen medizinischen erzeugnissen.
DE3835162A1 (de) * 1988-10-13 1990-04-19 Schering Ag (1s,2s,3r,5r)-2-((3s)-2-halogen-3-hydroxy-1-alken(inyl))-3-trialkylsilyloxy-7,7-(2,2-dimethyl-trimethylendioxy)-bicyclo-(3.3.0)-octan-verbindungen und verfahren zu deren herstellung
EP1245556B1 (fr) * 2001-03-29 2004-09-15 DSM Fine Chemicals Austria Nfg GmbH & Co KG Procédé de préparation d'acides carboxyliques par oxydation d'aldéhyde et en présence de periodate, dichromate et d'acide dans l'eau
EP2305628B1 (fr) * 2009-09-23 2019-07-03 International Flavors & Fragrances Inc. Procédé d'oxydation allylique pour la préparation d'arôme utilisant des composés organiques métalliques et catalyseur d'or
CN102655866B (zh) 2009-11-13 2013-11-13 东丽株式会社 糖尿病的治疗或预防药

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4064351A (en) * 1974-09-19 1977-12-20 Sankyo Company Limited 9-OXO-15 ξ-HYDROXY-20-ALKYLIDENEPROST-13(TRANS)-ENOIC ACID DERIVATIVES
IT1113341B (it) 1978-03-31 1986-01-20 Ono Pharmaceutical Co Analoghi della 6,9-metano-pgi2
DE2845770A1 (de) * 1978-10-19 1980-04-30 Schering Ag Neue prostacyclin-derivate und verfahren zu ihrer herstellung

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
EXBK/78 *
EXBK/79 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2466446A1 (fr) * 1978-01-26 1981-04-10 Erba Farmitalia Bicyclo-alcanones, intermediaires de la preparation d'isosteres de type 9-desoxy-9a-methylene de pgi2
FR2419271A1 (fr) * 1978-03-09 1979-10-05 Sumitomo Chemical Co Nouveaux derives bicyclo-octaniques, leur preparation et leur utilisation comme medicaments

Also Published As

Publication number Publication date
IT1192762B (it) 1988-05-04
DE2900352A1 (de) 1979-07-19
GB2012265B (en) 1982-07-21
CH651292A5 (de) 1985-09-13
US4322435A (en) 1982-03-30
DE2900352C2 (fr) 1987-04-16
IT7967023A0 (it) 1979-01-05
JPS5495552A (en) 1979-07-28
JPS6121216B2 (fr) 1986-05-26
FR2414039B1 (fr) 1981-11-27
DE2954373A1 (fr) 1985-03-21
GB2012265A (en) 1979-07-25
CH639359A5 (de) 1983-11-15
DE2954373C2 (fr) 1989-03-23

Similar Documents

Publication Publication Date Title
FR2414039A1 (fr) Derives de prostacycline, leur procede de preparation et leurs applications en therapeutique
FR2385722A1 (fr) Nouveaux derives de cephalosporine, leur procede de preparation et leur application en therapeutique
FR2370731A1 (fr) Nouveaux derives de la piperidine polysubstitues, leurs procedes de preparation et leur application pharmaceutique
FR2453155A1 (fr) Derives de cyanoguanidine, leur procede de preparation et leurs applications en therapeutique
FR2411829A1 (fr) Derives de tetrapeptides, leurs procedes d'obtention et compositions pharmaceutiques les contenant
BE900842A (fr) Nouveaux complexes de platine et leur application en therapeutique.
FR2408584A1 (fr) Composes guanidinobenzoiques et possedant une activite antifibrinolysine et antitrypsine et leur procede de preparation
FR2405246A1 (fr) Nouveaux derives de pyrrole, leur procede de preparation et leurs applications en therapeutique
FR2409989A1 (fr) Pyrazoles substitues en position 4, leur preparation et leur utilisation therapeutique
FR2506306A1 (fr) Nouveaux derives de l'amidinopiperidine, leur procede de preparation et leur application en therapeutique
FR2384811A1 (fr) Derives de la neocarzinostatine, leur application therapeutique et leur procede de preparation
FR2417502A1 (fr) Nouvelles 2-phenylimino-imidazolidines substituees, leurs sels d'addition avec des acides, medicaments les renfermant et procedes pour leur preparation
FR2439774A1 (fr) Nouveaux derives de crysteine utiles notamment comme medicaments pour la suppression des troubles hepatiques et procedes pour leur preparation
FR2361371A1 (fr) Nouvelles 2-phenylamino imidazolines-(2) substituees, leurs sels d'addition avec des acides, les medicaments les renfermant et procedes pour leur preparation
FR2372836A1 (fr) Derives de l'acide propionique, leurs procedes de preparation et leur application en therapeutique
FR2417503A1 (fr) Nouvelles 2-phenylimino-imidazolidines substituees, leurs sels d'addition avec des acides, medicaments les renfermant et procedes pour leur preparation
FR2408608A1 (fr) Nouvel antibiotique denomme ps-5 et ses derives doues d'activite inhibitrice de la b-lactamase et leur procede de preparation
FR2447375A1 (fr) Analogues de la prostaglandine e1 et compositions pharmaceutiques les contenant
FR2456097A1 (fr) Nouveaux derives de la 5 h-furanone-2 et de la 3 h-dihydrofuranone-2, leur procede de preparation et leur application en therapeutique
FR2416886A1 (fr) Nouveaux derives de la 3-phenyl-tetrahydropyridine et leurs sels, procedes de preparation et application a titre de medicaments
FR2355831A1 (fr) Derives de benzazocine, leur procede de preparation et leur application therapeutique
FR2436134A1 (fr) Derives d'acide hydroxamique, leur procede de preparation et medicament les contenant
FR2449689A1 (fr) Nouveaux derives condenses de pyrrolidine ou de piperidine, leur procede de preparation et leurs applications en therapeutique
FR2390954A1 (fr) Nouvelles guanylhydrazones, leurs procedes de preparation et medicaments les contenant
FR2410640A1 (fr) Derives de phenoxyalcanolamines, leur preparation et leurs utilisations therapeutiques

Legal Events

Date Code Title Description
ST Notification of lapse