FR2387970A1 - Derives de la guanidine et medicament en contenant - Google Patents
Derives de la guanidine et medicament en contenantInfo
- Publication number
- FR2387970A1 FR2387970A1 FR7811536A FR7811536A FR2387970A1 FR 2387970 A1 FR2387970 A1 FR 2387970A1 FR 7811536 A FR7811536 A FR 7811536A FR 7811536 A FR7811536 A FR 7811536A FR 2387970 A1 FR2387970 A1 FR 2387970A1
- Authority
- FR
- France
- Prior art keywords
- guanidine derivatives
- medicinal products
- containing medicinal
- guanidino
- thiazole
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/88—Nitrogen atoms, e.g. allantoin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
L'invention concerne l'industrie pharmaceutique. Elle a pour objet des dérivés de la guanidine qui sont des antagonistes des récepteurs H-2 de l'histamine et qui inhibent la sécrétion d'acide gastrique, de même que le procedé pour les préparer et les compositions pharmaceutiques en contenant. Le procédé est appliqué, de préférence, à la synthèse du 2-guanidino-4-Ø2-(2-cyano-3-éthylguanidino) éthylthiométhylõ thiazole et du 2-guanidino-4-Ø2-(2-cyano-3-méthylguanidino)éthyl-thiométhylõ thiazole.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB1638977 | 1977-04-20 |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2387970A1 true FR2387970A1 (fr) | 1978-11-17 |
FR2387970B1 FR2387970B1 (fr) | 1983-03-25 |
Family
ID=10076448
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7811536A Granted FR2387970A1 (fr) | 1977-04-20 | 1978-04-19 | Derives de la guanidine et medicament en contenant |
FR8210491A Granted FR2519341A1 (fr) | 1977-04-20 | 1982-06-16 | Derives de la guanidine, utiles comme intermediaires chimiques |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR8210491A Granted FR2519341A1 (fr) | 1977-04-20 | 1982-06-16 | Derives de la guanidine, utiles comme intermediaires chimiques |
Country Status (28)
Country | Link |
---|---|
US (4) | US4165377A (fr) |
JP (3) | JPS53147069A (fr) |
AR (1) | AR223315A1 (fr) |
AT (1) | AT363099B (fr) |
AU (1) | AU516297B2 (fr) |
BE (1) | BE866156A (fr) |
CA (1) | CA1097658A (fr) |
CS (2) | CS200545B2 (fr) |
DD (1) | DD135824A5 (fr) |
DK (1) | DK172778A (fr) |
ES (3) | ES468985A1 (fr) |
FI (1) | FI781230A (fr) |
FR (2) | FR2387970A1 (fr) |
GB (1) | GB2060607B (fr) |
GR (1) | GR62452B (fr) |
HU (1) | HU176807B (fr) |
IE (1) | IE47044B1 (fr) |
IL (1) | IL54549A0 (fr) |
IN (1) | IN148903B (fr) |
IT (1) | IT1094469B (fr) |
NL (1) | NL190486C (fr) |
NO (1) | NO781300L (fr) |
NZ (1) | NZ186965A (fr) |
PL (2) | PL113082B1 (fr) |
PT (1) | PT67921B (fr) |
SE (1) | SE7804461L (fr) |
SU (1) | SU730299A3 (fr) |
ZA (1) | ZA782129B (fr) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0003640A2 (fr) * | 1978-01-18 | 1979-08-22 | Imperial Chemical Industries Plc | Dérivés de guanidine à activité antisécrétive de l'acide gastrique, procédés pour leur préparation et compositions pharmaceutiques les contenant |
FR2450827A1 (fr) * | 1979-03-06 | 1980-10-03 | Yamanouchi Pharma Co Ltd | Composes du guanidinothiazole utiles comme inhibiteurs des secretions d'acide gastrique, leurs procedes de preparation et les compositions medicales contenant de tels composes |
FR2462431A1 (fr) * | 1979-08-02 | 1981-02-13 | Yamanouchi Pharma Co Ltd | Nouveau compose du guanidinothiazole, son procede de preparation et des compositions medicales contenant de tels composes |
WO1982000462A1 (fr) * | 1980-08-11 | 1982-02-18 | Rech Syntheses Organ | Imino-alkyle et amino-nitrile cyano-guanidines |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL49528A (en) * | 1975-05-21 | 1980-11-30 | Smith Kline French Lab | Imidazolyl(or thiazolyl)methylthio(or butyl)guanidine or thiourea derivatives,their preparation and pharmaceutical compositions comprising them |
DE2963363D1 (en) * | 1978-05-24 | 1982-09-09 | Ici Plc | Antisecretory thiadiazole derivatives, processes for their manufacture and pharmaceutical compositions containing them |
US4200578A (en) | 1978-12-18 | 1980-04-29 | Bristol-Myers Company | Thiazole derivatives |
EP0014057B1 (fr) * | 1979-01-18 | 1985-01-02 | Imperial Chemical Industries Plc | Dérivés de la guanidine, procédés pour leur préparation et compositions pharmaceutiques les contenant |
US4521418A (en) * | 1979-02-21 | 1985-06-04 | Smith Kline & French Laboratories Limited | Guanidinothiazolyl derivatives |
CH644369A5 (de) * | 1979-05-03 | 1984-07-31 | Sandoz Ag | 2-amino-4-chlorthiazolverbindungen. |
US4242351A (en) * | 1979-05-07 | 1980-12-30 | Imperial Chemical Industries Limited | Antisecretory oxadiazoles and pharmaceutical compositions containing them |
FI76795C (fi) * | 1979-09-04 | 1988-12-12 | Bristol Myers Co | Foerfarande foer framstaellning av nya, terapeutiskt anvaendbara 3,4-disubstituerade 1,2,5-tiadiazol-1-oxider och -1,1-dioxider samt nya mellanprodukter. |
US4359466A (en) * | 1979-10-24 | 1982-11-16 | Smith Kline & French Laboratories Limited | Guanidine compounds |
IL61234A (en) * | 1979-10-24 | 1984-03-30 | Smith Kline French Lab | Guanidino thiazolyl alkylamino(alkylthioalkylamino)nitrotetrahydropyridines,process for preparing them and pharmaceutical compositions containing them |
GR71929B (fr) * | 1979-11-13 | 1983-08-19 | Ici Ltd | |
NZ196923A (en) * | 1980-04-29 | 1983-12-16 | Shionogi & Co | 2-guanidino-4-(-acylaminoalkyl(thio)methyl)thiazoles and analogs |
EP0045155B1 (fr) * | 1980-07-30 | 1985-01-02 | Imperial Chemical Industries Plc | Dérivés de guanidine |
US4760075A (en) * | 1980-10-02 | 1988-07-26 | Eli Lilly And Company | N-thiazolylmethylthioalkyl-N-alkyl-amidines and related compounds |
US4904792A (en) * | 1980-10-02 | 1990-02-27 | Eli Lilly And Company | N-thiazolymethylthioalkyl-N'-alkylamidines and related compounds |
US4374843A (en) * | 1980-10-14 | 1983-02-22 | Pfizer Inc. | 2-Guanidino-4-heteroarylthiazoles |
EP0059597B1 (fr) * | 1981-02-27 | 1986-04-23 | Imperial Chemical Industries Plc | Dérivés heterocycliques guanidino substitués possédant une activité antihistaminique H-2 |
CA1209998A (fr) * | 1981-03-09 | 1986-08-19 | David J. Gilman | Derives amides inhibiteurs des recepteurs h.sub.2 de l'histamine |
CA1233818A (fr) * | 1981-03-09 | 1988-03-08 | David J. Gilman | Derives de la guanidine, inhibiteurs des recepteurs h.sub.2 a l'histamine |
US4460584A (en) * | 1981-03-13 | 1984-07-17 | Imperial Chemical Industries Plc | Nitrogen heterocycles |
IN158869B (fr) * | 1981-03-18 | 1987-02-07 | Ici Plc | |
EP0065823A1 (fr) * | 1981-05-13 | 1982-12-01 | Imperial Chemical Industries Plc | Dérivés hétérocycliques de guanidine, comme antagonistes de histamine H-2 |
EP0067508B1 (fr) * | 1981-05-18 | 1985-10-30 | Imperial Chemical Industries Plc | Dérivés d'amidine |
US4452987A (en) * | 1981-08-20 | 1984-06-05 | Pfizer Inc. | Haloacetyl imidazoles |
US4510313A (en) * | 1981-08-20 | 1985-04-09 | Pfizer Inc. | 2-Guanidino-4-heteroarylthiazoles |
US4590299A (en) * | 1981-08-20 | 1986-05-20 | Pfizer Inc. | 2-guanidino-4-heteroarylthiazoles |
JPS5872571A (ja) * | 1981-10-27 | 1983-04-30 | Shionogi & Co Ltd | 2−グアニジノ−4−〔2−(ホルムアミド)エチルチオメチル〕チアゾ−ルの製法 |
US4647557A (en) * | 1982-12-28 | 1987-03-03 | Gerard Moinet | Novel heterocyclic derivatives bearing an amino radical, processes for their production and the pharmaceutical compositions containing them |
JPS59227870A (ja) * | 1983-06-07 | 1984-12-21 | Yamanouchi Pharmaceut Co Ltd | 新規2−グアニジノチアゾリン誘導体ならびにその製造法 |
JPS60255756A (ja) * | 1984-06-01 | 1985-12-17 | Ikeda Mohandou:Kk | アミノアルキルフエノキシ誘導体 |
JPS6160673A (ja) * | 1984-08-30 | 1986-03-28 | Yamanouchi Pharmaceut Co Ltd | グアニジノチアゾ−ル誘導体の製造法 |
US4814341A (en) * | 1986-08-26 | 1989-03-21 | Reiter Lawrence A | 2-guanidino-4-(2-furyl) thiazoles as antiulcer agents |
US4997981A (en) * | 1986-10-29 | 1991-03-05 | Pfizer Inc. | Processes for 2-(1-pentyl-3-guanidino)-4-(2-methyl-4-imidazolyl) thiazole and analogs |
US5837716A (en) * | 1995-11-13 | 1998-11-17 | Albany Medical College | Analgesic heterocyclic compounds |
WO1998040367A1 (fr) * | 1997-03-11 | 1998-09-17 | Albemarle Corporation | Nouveaux derives de thiazol et leur preparation |
US5731442A (en) * | 1997-03-11 | 1998-03-24 | Albemarle Corporation | Synthesis of thiazole derivatives |
US5856500A (en) * | 1997-03-11 | 1999-01-05 | Albemarle Corporation | Synthesis of thiazole derivatives |
EP3018125B1 (fr) | 2013-07-03 | 2020-08-05 | Shin Nippon Biomedical Laboratories, Ltd. | Nouveau composé, agent de détection du transporteur de cations organiques 3 et inhibiteur de l'activité du transporteur de cations organiques 3 |
US20230349922A1 (en) | 2020-08-11 | 2023-11-02 | Université De Strasbourg | H2 Blockers Targeting Liver Macrophages for the Prevention and Treatment of Liver Disease and Cancer |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3950333A (en) * | 1971-03-09 | 1976-04-13 | Smith Kline & French Laboratories Limited | Pharmacologically active guanidine compounds |
Family Cites Families (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE758145A (fr) | 1969-10-29 | 1971-04-28 | Smith Kline French Lab | Iso-thio-urees et derives |
GB1305548A (fr) | 1969-10-29 | 1973-02-07 | ||
BE758146A (fr) | 1969-10-29 | 1971-04-28 | Smith Kline French Lab | Derives de l'amidine |
GB1305547A (fr) | 1969-10-29 | 1973-02-07 | ||
GB1305549A (fr) | 1969-10-29 | 1973-02-07 | ||
GB1305550A (fr) | 1969-10-29 | 1973-02-07 | ||
GB1341375A (en) | 1969-11-19 | 1973-12-19 | Smith Kline French Lab | Aminoalkylimidazoles and process for their production |
GB1341376A (en) | 1969-11-19 | 1973-12-19 | Smith Kline French Lab | Pharmaceutical compositions comprising 4-methyl-5-2-aminoethyl imidazole |
CA946968A (en) | 1970-05-18 | 1974-05-07 | Xerox Corporation | System for generating laser light of the three primary colors |
GB1307539A (en) | 1970-06-25 | 1973-02-21 | Smith Kline French Lab | Thiourea derivatives |
GB1336061A (en) | 1971-02-03 | 1973-11-07 | Ilford Ltd | Photographic emulsions |
GB1395929A (en) | 1972-08-08 | 1975-05-29 | Smith Kline French Lab | Thioureas |
US3905984A (en) * | 1971-03-09 | 1975-09-16 | Smith Kline French Lab | Pyridyl substituted thioalkyl-and oxyalkyl-thioureas and ureas |
US4018931A (en) * | 1971-03-09 | 1977-04-19 | Smith Kline & French Laboratories Limited | Pharmacologically active thiourea and urea compounds |
US4053473A (en) * | 1971-07-22 | 1977-10-11 | Smith Kline & French Laboratories Limited | Pharmacologically active thiourea and urea compounds |
US3932427A (en) * | 1971-03-09 | 1976-01-13 | Smith Kline & French Laboratories, Inc. | Pyridyl substituted aminoalkyl-thioureas and ureas |
US4018928A (en) * | 1971-03-09 | 1977-04-19 | Smith Kline & French Laboratories Limited | Pyridyl substituted aminoalkyl-thioureas and ureas |
US4049672A (en) * | 1971-03-09 | 1977-09-20 | Smith Kline & French Laboratories Limited | 4-Methyl-5-imidazolylmethylthioethylamine and -S-methylisothiourea |
US3950353A (en) * | 1971-03-09 | 1976-04-13 | Smith Kline & French Laboratories Limited | Pharmacologically active thiourea and urea compounds |
GB1399283A (en) | 1972-04-20 | 1975-07-02 | Smith Kline French Lab | Pharmaceutical compositions |
GB1400319A (en) | 1972-04-20 | 1975-07-16 | Smith Kline French Lab | Pharmaceutical compositions |
GB1397436A (en) * | 1972-09-05 | 1975-06-11 | Smith Kline French Lab | Heterocyclic n-cyanoguinidines |
US3920822A (en) * | 1972-09-05 | 1975-11-18 | Smith Kline French Lab | Inhibition of histamine activity with cyanoguanidines |
US3975530A (en) * | 1972-09-05 | 1976-08-17 | Smith Kline & French Laboratories Limited | N-cyano-N'-heterocyclic-alkyl quanidine inhibitors of H2 histamine receptors |
GB1398426A (en) | 1972-09-05 | 1975-06-18 | Smith Kline French Lab | Heterocyclic substituted guanidines |
GB1421999A (en) | 1973-02-08 | 1976-01-21 | Smith Kline French Lab | Heterocyclic containing sulphoxides |
GB1419994A (en) | 1973-05-03 | 1976-01-07 | Smith Kline French Lab | Heterocyclicalkylaminotheterocyclic compounds methods for their preparation and compositions comprising them |
GB1421792A (en) | 1973-05-17 | 1976-01-21 | Smith Kline French Lab | Heterocyclic substituted-1, 1-diamino-ethylene derivatives methods for their preparation and compositions containing them |
GB1422408A (en) | 1973-06-12 | 1976-01-28 | Smith Kline French Lab | Imidazo 1,2-a pyridines |
GB1431589A (en) | 1973-07-13 | 1976-04-07 | Smith Kline French Lab | Ureas, thioureas and guanidines n,n-disubstituted by heterocyclo- alkylene and/or heterocycloalkylenethioalkylene groups |
GB1565205A (en) * | 1975-07-31 | 1980-04-16 | Smith Kline French Lab | Heterocyclic sulphoxides |
GB1493931A (en) | 1974-02-07 | 1977-11-30 | Smith Kline French Lab | Guanidines isothioureas and thioureas |
GB1496787A (en) | 1974-03-12 | 1978-01-05 | Smith Kline French Lab | Heteroalkylthioalkyl amidine derivatives |
CA1004576A (en) * | 1974-05-24 | 1977-02-01 | Ralph O. Jacobsen | Bale shredder |
GB1497260A (en) | 1974-06-28 | 1978-01-05 | Smith Kline French Lab | Guanidine derivatives |
GB1531231A (en) | 1974-09-02 | 1978-11-08 | Smith Kline French Lab | Process for the production of cyanoguanidine derivatives |
GB1531221A (en) | 1974-09-02 | 1978-11-08 | Smith Kline French Lab | Process for preparing guanidine derivatives |
GB1530895A (en) | 1974-09-02 | 1978-11-01 | Smith Kline French Lab | Electrochemical reduction of 4-imidazole carboxylic acids |
GB1533380A (en) | 1974-09-02 | 1978-11-22 | Smith Kline French Lab | Process for the preparation of heterocyclic substituted thioureas and h-cyanoguanidines |
GB1533378A (en) | 1974-09-02 | 1978-11-22 | Smith Kline French Lab | Process for the preparation of heterocyclic substituted thioureas |
GB1533379A (en) | 1974-09-02 | 1978-11-22 | Smith Kline French Lab | Process for the preparation of heterocyclic substituted ureas |
GB1542840A (en) | 1975-02-03 | 1979-03-28 | Smith Kline French Lab | Heterocyclic dithiocarbamates and isothioureas |
GB1554153A (en) | 1975-05-15 | 1979-10-17 | Smith Kline French Lab | Process for making 2-amino-2-alkylthionitroethylenes |
GB1563090A (en) * | 1975-07-31 | 1980-03-19 | Smith Kline French Lab | Cyclobutene-diones |
FR2317591B1 (fr) | 1975-07-08 | 1979-06-15 | Clarel | Appareil d'eclairage pour lampes fluorescentes |
GB1564502A (en) | 1975-07-31 | 1980-04-10 | Smith Kline French Lab | Guanidines thioureas and 1,1-diamino-2-nitroethylene derivatives |
GB1565647A (en) | 1975-07-31 | 1980-04-23 | Smith Kline French Lab | Pharmacologically active compounds 4-substituted-imidazole-5-methanols |
IN146736B (fr) | 1975-10-02 | 1979-08-25 | Smith Kline French Lab | |
US4099672A (en) * | 1977-02-28 | 1978-07-11 | Ray Albert Sheahan | Shower-head fixture |
US4309435A (en) * | 1978-10-16 | 1982-01-05 | Imperial Chemical Industries Ltd. | Antisecretory guanidine derivatives and pharmaceutical compositions containing them |
JPS6056143B2 (ja) * | 1979-08-02 | 1985-12-09 | 山之内製薬株式会社 | アミジン誘導体ならびにその製造法 |
-
1978
- 1978-04-13 ZA ZA00782129A patent/ZA782129B/xx unknown
- 1978-04-13 IE IE728/78A patent/IE47044B1/en not_active IP Right Cessation
- 1978-04-13 NZ NZ186965A patent/NZ186965A/xx unknown
- 1978-04-13 NO NO781300A patent/NO781300L/no unknown
- 1978-04-13 GR GR55969A patent/GR62452B/el unknown
- 1978-04-14 AU AU35106/78A patent/AU516297B2/en not_active Expired
- 1978-04-15 IN IN274/DEL/78A patent/IN148903B/en unknown
- 1978-04-17 CA CA301,263A patent/CA1097658A/fr not_active Expired
- 1978-04-18 PL PL1978206191A patent/PL113082B1/pl unknown
- 1978-04-18 PL PL1978218009A patent/PL113054B1/pl unknown
- 1978-04-19 BE BE186933A patent/BE866156A/fr not_active IP Right Cessation
- 1978-04-19 PT PT67921A patent/PT67921B/pt unknown
- 1978-04-19 SE SE7804461A patent/SE7804461L/xx unknown
- 1978-04-19 NL NLAANVRAGE7804159,A patent/NL190486C/xx not_active IP Right Cessation
- 1978-04-19 US US05/897,910 patent/US4165377A/en not_active Expired - Lifetime
- 1978-04-19 CS CS782521A patent/CS200545B2/cs unknown
- 1978-04-19 CS CS788113A patent/CS200546B2/cs unknown
- 1978-04-19 FR FR7811536A patent/FR2387970A1/fr active Granted
- 1978-04-19 DD DD78204901A patent/DD135824A5/xx unknown
- 1978-04-19 IL IL54549A patent/IL54549A0/xx not_active IP Right Cessation
- 1978-04-19 AT AT0276978A patent/AT363099B/de not_active IP Right Cessation
- 1978-04-20 AR AR271843A patent/AR223315A1/es active
- 1978-04-20 ES ES468985A patent/ES468985A1/es not_active Expired
- 1978-04-20 IT IT22558/78A patent/IT1094469B/it active
- 1978-04-20 JP JP4713678A patent/JPS53147069A/ja active Granted
- 1978-04-20 FI FI781230A patent/FI781230A/fi not_active Application Discontinuation
- 1978-04-20 DK DK172778A patent/DK172778A/da active IP Right Grant
- 1978-04-20 HU HU78IE834A patent/HU176807B/hu unknown
- 1978-04-20 SU SU782607390A patent/SU730299A3/ru active
- 1978-06-22 GB GB8006269A patent/GB2060607B/en not_active Expired
- 1978-11-08 ES ES474929A patent/ES474929A1/es not_active Expired
-
1979
- 1979-02-01 ES ES477387A patent/ES477387A1/es not_active Expired
- 1979-08-13 US US06/065,801 patent/US4234735A/en not_active Expired - Lifetime
- 1979-08-13 US US06/065,802 patent/US4262126A/en not_active Expired - Lifetime
-
1980
- 1980-07-25 US US06/172,302 patent/US4347370A/en not_active Expired - Lifetime
-
1982
- 1982-06-16 FR FR8210491A patent/FR2519341A1/fr active Granted
-
1983
- 1983-11-18 JP JP58216401A patent/JPS59130276A/ja active Granted
- 1983-11-18 JP JP58216402A patent/JPS59130277A/ja active Granted
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3950333A (en) * | 1971-03-09 | 1976-04-13 | Smith Kline & French Laboratories Limited | Pharmacologically active guanidine compounds |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0003640A2 (fr) * | 1978-01-18 | 1979-08-22 | Imperial Chemical Industries Plc | Dérivés de guanidine à activité antisécrétive de l'acide gastrique, procédés pour leur préparation et compositions pharmaceutiques les contenant |
EP0003640A3 (en) * | 1978-01-18 | 1979-09-05 | Imperial Chemical Industries Limited | Antisecretory guanidine derivatives, processes for their manufacture and pharmaceutical compositions containing them |
FR2450827A1 (fr) * | 1979-03-06 | 1980-10-03 | Yamanouchi Pharma Co Ltd | Composes du guanidinothiazole utiles comme inhibiteurs des secretions d'acide gastrique, leurs procedes de preparation et les compositions medicales contenant de tels composes |
FR2462431A1 (fr) * | 1979-08-02 | 1981-02-13 | Yamanouchi Pharma Co Ltd | Nouveau compose du guanidinothiazole, son procede de preparation et des compositions medicales contenant de tels composes |
WO1982000462A1 (fr) * | 1980-08-11 | 1982-02-18 | Rech Syntheses Organ | Imino-alkyle et amino-nitrile cyano-guanidines |
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