ATA276978A - Verfahren zur herstellung von neuen guanidin- derivaten und von deren saeureadditionssalzen - Google Patents

Verfahren zur herstellung von neuen guanidin- derivaten und von deren saeureadditionssalzen

Info

Publication number
ATA276978A
ATA276978A AT276978A AT276978A ATA276978A AT A276978 A ATA276978 A AT A276978A AT 276978 A AT276978 A AT 276978A AT 276978 A AT276978 A AT 276978A AT A276978 A ATA276978 A AT A276978A
Authority
AT
Austria
Prior art keywords
acid addition
addition salts
producing new
guanidine derivatives
new guanidine
Prior art date
Application number
AT276978A
Other languages
English (en)
Other versions
AT363099B (de
Original Assignee
Ici Ltd
Ici America Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ici Ltd, Ici America Inc filed Critical Ici Ltd
Priority to AT112180A priority Critical patent/AT362386B/de
Publication of ATA276978A publication Critical patent/ATA276978A/de
Application granted granted Critical
Publication of AT363099B publication Critical patent/AT363099B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/88—Nitrogen atoms, e.g. allantoin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT0276978A 1977-04-20 1978-04-19 Verfahren zur herstellung von neuen guanidinderivaten und von deren saeureadditionssalzen AT363099B (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AT112180A AT362386B (de) 1977-04-20 1980-02-28 Verfahren zur herstellung von neuen guanidin- derivaten und von deren saeureadditionssalzen

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1638977 1977-04-20

Publications (2)

Publication Number Publication Date
ATA276978A true ATA276978A (de) 1980-12-15
AT363099B AT363099B (de) 1981-07-10

Family

ID=10076448

Family Applications (1)

Application Number Title Priority Date Filing Date
AT0276978A AT363099B (de) 1977-04-20 1978-04-19 Verfahren zur herstellung von neuen guanidinderivaten und von deren saeureadditionssalzen

Country Status (28)

Country Link
US (4) US4165377A (de)
JP (3) JPS53147069A (de)
AR (1) AR223315A1 (de)
AT (1) AT363099B (de)
AU (1) AU516297B2 (de)
BE (1) BE866156A (de)
CA (1) CA1097658A (de)
CS (2) CS200546B2 (de)
DD (1) DD135824A5 (de)
DK (1) DK172778A (de)
ES (3) ES468985A1 (de)
FI (1) FI781230A (de)
FR (2) FR2387970A1 (de)
GB (1) GB2060607B (de)
GR (1) GR62452B (de)
HU (1) HU176807B (de)
IE (1) IE47044B1 (de)
IL (1) IL54549A0 (de)
IN (1) IN148903B (de)
IT (1) IT1094469B (de)
NL (1) NL190486C (de)
NO (1) NO781300L (de)
NZ (1) NZ186965A (de)
PL (2) PL113082B1 (de)
PT (1) PT67921B (de)
SE (1) SE7804461L (de)
SU (1) SU730299A3 (de)
ZA (1) ZA782129B (de)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL49528A (en) * 1975-05-21 1980-11-30 Smith Kline French Lab Imidazolyl(or thiazolyl)methylthio(or butyl)guanidine or thiourea derivatives,their preparation and pharmaceutical compositions comprising them
US4315009A (en) * 1978-01-18 1982-02-09 Imperial Chemical Industries Limited Antisecretory guanidine derivatives and pharmaceutical compositions containing them
ATE1353T1 (de) * 1978-05-24 1982-08-15 Imperial Chemical Industries Plc Anti-sekretion thiadiazol-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.
US4200578A (en) 1978-12-18 1980-04-29 Bristol-Myers Company Thiazole derivatives
DE3069889D1 (en) * 1979-01-18 1985-02-14 Ici Plc Guanidine derivatives, processes for their manufacture and pharmaceutical compositions containing them
US4521418A (en) * 1979-02-21 1985-06-04 Smith Kline & French Laboratories Limited Guanidinothiazolyl derivatives
JPS6056143B2 (ja) * 1979-08-02 1985-12-09 山之内製薬株式会社 アミジン誘導体ならびにその製造法
PH16099A (en) * 1979-03-06 1983-06-24 Yamanouchi Pharma Co Ltd Guanidinothiazole compounds,process for preparing them and medical composition containing them
CH644369A5 (de) * 1979-05-03 1984-07-31 Sandoz Ag 2-amino-4-chlorthiazolverbindungen.
US4242351A (en) * 1979-05-07 1980-12-30 Imperial Chemical Industries Limited Antisecretory oxadiazoles and pharmaceutical compositions containing them
DK160611C (da) * 1979-09-04 1991-09-16 Bristol Myers Squibb Co Analogifremgangsmaade til fremstilling af 3,4-disubstituerede 1,2,5-thiadiazol-1-oxider og -1,1-dioxider
US4359466A (en) * 1979-10-24 1982-11-16 Smith Kline & French Laboratories Limited Guanidine compounds
IL61234A (en) * 1979-10-24 1984-03-30 Smith Kline French Lab Guanidino thiazolyl alkylamino(alkylthioalkylamino)nitrotetrahydropyridines,process for preparing them and pharmaceutical compositions containing them
GR71929B (de) * 1979-11-13 1983-08-19 Ici Ltd
NZ196923A (en) * 1980-04-29 1983-12-16 Shionogi & Co 2-guanidino-4-(-acylaminoalkyl(thio)methyl)thiazoles and analogs
EP0045155B1 (de) * 1980-07-30 1985-01-02 Imperial Chemical Industries Plc Guanidinderivate
WO1982000462A1 (en) * 1980-08-11 1982-02-18 Rech Syntheses Organ Imino-alkyl and amino-nitrile cyano-guanidines
US4904792A (en) * 1980-10-02 1990-02-27 Eli Lilly And Company N-thiazolymethylthioalkyl-N'-alkylamidines and related compounds
US4760075A (en) * 1980-10-02 1988-07-26 Eli Lilly And Company N-thiazolylmethylthioalkyl-N-alkyl-amidines and related compounds
US4374843A (en) * 1980-10-14 1983-02-22 Pfizer Inc. 2-Guanidino-4-heteroarylthiazoles
EP0059597B1 (de) * 1981-02-27 1986-04-23 Imperial Chemical Industries Plc Guanidin substituierte heterocyclische Derivate mit histamin-H-2-antagonistischer Wirkung
CA1209998A (en) * 1981-03-09 1986-08-19 David J. Gilman Amide derivatives as histamine h-2 receptor antagonists
CA1233818A (en) * 1981-03-09 1988-03-08 David J. Gilman Guanidine derivatives as histamine h-2 receptor antagonists
US4460584A (en) * 1981-03-13 1984-07-17 Imperial Chemical Industries Plc Nitrogen heterocycles
IN158869B (de) * 1981-03-18 1987-02-07 Ici Plc
EP0065823A1 (de) * 1981-05-13 1982-12-01 Imperial Chemical Industries Plc Heterozyklische Guanidinderivate als Histamin-H-2-Antagonisten
EP0067508B1 (de) * 1981-05-18 1985-10-30 Imperial Chemical Industries Plc Amidin-Derivate
US4590299A (en) * 1981-08-20 1986-05-20 Pfizer Inc. 2-guanidino-4-heteroarylthiazoles
US4452987A (en) * 1981-08-20 1984-06-05 Pfizer Inc. Haloacetyl imidazoles
US4510313A (en) * 1981-08-20 1985-04-09 Pfizer Inc. 2-Guanidino-4-heteroarylthiazoles
JPS5872571A (ja) * 1981-10-27 1983-04-30 Shionogi & Co Ltd ２−グアニジノ−４−〔２−（ホルムアミド）エチルチオメチル〕チアゾ−ルの製法
US4647557A (en) * 1982-12-28 1987-03-03 Gerard Moinet Novel heterocyclic derivatives bearing an amino radical, processes for their production and the pharmaceutical compositions containing them
JPS59227870A (ja) * 1983-06-07 1984-12-21 Yamanouchi Pharmaceut Co Ltd 新規２−グアニジノチアゾリン誘導体ならびにその製造法
JPS60255756A (ja) * 1984-06-01 1985-12-17 Ikeda Mohandou:Kk アミノアルキルフエノキシ誘導体
JPS6160673A (ja) * 1984-08-30 1986-03-28 Yamanouchi Pharmaceut Co Ltd グアニジノチアゾ−ル誘導体の製造法
US4814341A (en) * 1986-08-26 1989-03-21 Reiter Lawrence A 2-guanidino-4-(2-furyl) thiazoles as antiulcer agents
US4997981A (en) * 1986-10-29 1991-03-05 Pfizer Inc. Processes for 2-(1-pentyl-3-guanidino)-4-(2-methyl-4-imidazolyl) thiazole and analogs
CA2237384A1 (en) * 1995-11-13 1997-05-22 The Albany Medical College Analgesic compounds and uses thereof
WO1998040367A1 (en) * 1997-03-11 1998-09-17 Albemarle Corporation Novel thiazole derivatives and their preparation
US5856500A (en) * 1997-03-11 1999-01-05 Albemarle Corporation Synthesis of thiazole derivatives
US5731442A (en) * 1997-03-11 1998-03-24 Albemarle Corporation Synthesis of thiazole derivatives
US9745274B2 (en) 2013-07-03 2017-08-29 Shin Nippon Biomedical Laboratories, Ltd. Compound, organic cation transporter 3 detection agent, and organic cation transporter 3 activity inhibitor
EP4196793A1 (de) 2020-08-11 2023-06-21 Université de Strasbourg Auf lebermakrophagen abzielende h2-blocker zur prävention und behandlung von lebererkrankungen und krebs

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BE758145A (fr) 1969-10-29 1971-04-28 Smith Kline French Lab Iso-thio-urees et derives
BE758146A (fr) 1969-10-29 1971-04-28 Smith Kline French Lab Derives de l'amidine
GB1305549A (de) 1969-10-29 1973-02-07
GB1305550A (de) 1969-10-29 1973-02-07
GB1305548A (de) 1969-10-29 1973-02-07
GB1305547A (de) 1969-10-29 1973-02-07
GB1341375A (en) 1969-11-19 1973-12-19 Smith Kline French Lab Aminoalkylimidazoles and process for their production
GB1341376A (en) 1969-11-19 1973-12-19 Smith Kline French Lab Pharmaceutical compositions comprising 4-methyl-5-2-aminoethyl imidazole
CA946968A (en) 1970-05-18 1974-05-07 Xerox Corporation System for generating laser light of the three primary colors
GB1307539A (en) 1970-06-25 1973-02-21 Smith Kline French Lab Thiourea derivatives
GB1336061A (en) 1971-02-03 1973-11-07 Ilford Ltd Photographic emulsions
US4049672A (en) * 1971-03-09 1977-09-20 Smith Kline & French Laboratories Limited 4-Methyl-5-imidazolylmethylthioethylamine and -S-methylisothiourea
US3905984A (en) * 1971-03-09 1975-09-16 Smith Kline French Lab Pyridyl substituted thioalkyl-and oxyalkyl-thioureas and ureas
GB1395929A (en) 1972-08-08 1975-05-29 Smith Kline French Lab Thioureas
US3932427A (en) * 1971-03-09 1976-01-13 Smith Kline & French Laboratories, Inc. Pyridyl substituted aminoalkyl-thioureas and ureas
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US4018928A (en) * 1971-03-09 1977-04-19 Smith Kline & French Laboratories Limited Pyridyl substituted aminoalkyl-thioureas and ureas
US4018931A (en) * 1971-03-09 1977-04-19 Smith Kline & French Laboratories Limited Pharmacologically active thiourea and urea compounds
GB1399283A (en) 1972-04-20 1975-07-02 Smith Kline French Lab Pharmaceutical compositions
GB1400319A (en) 1972-04-20 1975-07-16 Smith Kline French Lab Pharmaceutical compositions
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GB1398426A (en) 1972-09-05 1975-06-18 Smith Kline French Lab Heterocyclic substituted guanidines
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US3975530A (en) * 1972-09-05 1976-08-17 Smith Kline & French Laboratories Limited N-cyano-N'-heterocyclic-alkyl quanidine inhibitors of H2 histamine receptors
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GB1431589A (en) 1973-07-13 1976-04-07 Smith Kline French Lab Ureas, thioureas and guanidines n,n-disubstituted by heterocyclo- alkylene and/or heterocycloalkylenethioalkylene groups
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GB1493931A (en) 1974-02-07 1977-11-30 Smith Kline French Lab Guanidines isothioureas and thioureas
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CA1004576A (en) * 1974-05-24 1977-02-01 Ralph O. Jacobsen Bale shredder
GB1497260A (en) 1974-06-28 1978-01-05 Smith Kline French Lab Guanidine derivatives
GB1533378A (en) 1974-09-02 1978-11-22 Smith Kline French Lab Process for the preparation of heterocyclic substituted thioureas
GB1533379A (en) 1974-09-02 1978-11-22 Smith Kline French Lab Process for the preparation of heterocyclic substituted ureas
GB1533380A (en) 1974-09-02 1978-11-22 Smith Kline French Lab Process for the preparation of heterocyclic substituted thioureas and h-cyanoguanidines
GB1531231A (en) 1974-09-02 1978-11-08 Smith Kline French Lab Process for the production of cyanoguanidine derivatives
GB1530895A (en) 1974-09-02 1978-11-01 Smith Kline French Lab Electrochemical reduction of 4-imidazole carboxylic acids
GB1531221A (en) 1974-09-02 1978-11-08 Smith Kline French Lab Process for preparing guanidine derivatives
GB1542840A (en) 1975-02-03 1979-03-28 Smith Kline French Lab Heterocyclic dithiocarbamates and isothioureas
GB1554153A (en) 1975-05-15 1979-10-17 Smith Kline French Lab Process for making 2-amino-2-alkylthionitroethylenes
GB1563090A (en) * 1975-07-31 1980-03-19 Smith Kline French Lab Cyclobutene-diones
FR2317591B1 (fr) 1975-07-08 1979-06-15 Clarel Appareil d'eclairage pour lampes fluorescentes
GB1565647A (en) 1975-07-31 1980-04-23 Smith Kline French Lab Pharmacologically active compounds 4-substituted-imidazole-5-methanols
GB1564502A (en) 1975-07-31 1980-04-10 Smith Kline French Lab Guanidines thioureas and 1,1-diamino-2-nitroethylene derivatives
IN146736B (de) 1975-10-02 1979-08-25 Smith Kline French Lab
US4099672A (en) * 1977-02-28 1978-07-11 Ray Albert Sheahan Shower-head fixture
US4309435A (en) * 1978-10-16 1982-01-05 Imperial Chemical Industries Ltd. Antisecretory guanidine derivatives and pharmaceutical compositions containing them
JPS6056143B2 (ja) * 1979-08-02 1985-12-09 山之内製薬株式会社 アミジン誘導体ならびにその製造法

Also Published As

Publication number Publication date
GR62452B (en) 1979-04-12
FR2387970B1 (de) 1983-03-25
CS200546B2 (en) 1980-09-15
US4347370A (en) 1982-08-31
AU516297B2 (en) 1981-05-28
FI781230A (fi) 1978-10-21
IE780728L (en) 1978-10-20
JPS53147069A (en) 1978-12-21
FR2519341B1 (de) 1984-05-18
GB2060607A (en) 1981-05-07
NL7804159A (nl) 1978-10-24
IT1094469B (it) 1985-08-02
ZA782129B (en) 1979-03-28
NL190486C (nl) 1994-03-16
HU176807B (en) 1981-05-28
NO781300L (no) 1978-10-23
DD135824A5 (de) 1979-05-30
IN148903B (de) 1981-07-18
US4165377A (en) 1979-08-21
US4234735A (en) 1980-11-18
ES474929A1 (es) 1979-04-16
IT7822558A0 (it) 1978-04-20
FR2519341A1 (fr) 1983-07-08
FR2387970A1 (fr) 1978-11-17
ES477387A1 (es) 1979-10-16
PL113054B1 (en) 1980-11-29
JPS6335629B2 (de) 1988-07-15
JPS59130277A (ja) 1984-07-26
US4262126A (en) 1981-04-14
AR223315A1 (es) 1981-08-14
SE7804461L (sv) 1978-10-21
AU3510678A (en) 1979-10-18
IL54549A0 (en) 1978-07-31
PT67921B (en) 1979-11-14
NL190486B (nl) 1993-10-18
BE866156A (fr) 1978-10-19
NZ186965A (en) 1980-02-21
GB2060607B (en) 1982-03-31
PL206191A1 (pl) 1979-06-04
PT67921A (en) 1978-05-01
CS200545B2 (en) 1980-09-15
AT363099B (de) 1981-07-10
PL113082B1 (en) 1980-11-29
IE47044B1 (en) 1983-12-14
JPS6156231B2 (de) 1986-12-01
ES468985A1 (es) 1979-09-16
CA1097658A (en) 1981-03-17
JPS625907B2 (de) 1987-02-07
DK172778A (da) 1978-10-21
SU730299A3 (ru) 1980-04-25
JPS59130276A (ja) 1984-07-26

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Legal Events

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ELJ Ceased due to non-payment of the annual fee