FR2380300A1 - Steroides-11b-substitues et procede de leur preparation - Google Patents

Steroides-11b-substitues et procede de leur preparation

Info

Publication number
FR2380300A1
FR2380300A1 FR7803781A FR7803781A FR2380300A1 FR 2380300 A1 FR2380300 A1 FR 2380300A1 FR 7803781 A FR7803781 A FR 7803781A FR 7803781 A FR7803781 A FR 7803781A FR 2380300 A1 FR2380300 A1 FR 2380300A1
Authority
FR
France
Prior art keywords
steroids
preparation
substitutes
substituted
novel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7803781A
Other languages
English (en)
Other versions
FR2380300B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Akzo NV
Original Assignee
Akzo NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo NV filed Critical Akzo NV
Publication of FR2380300A1 publication Critical patent/FR2380300A1/fr
Application granted granted Critical
Publication of FR2380300B1 publication Critical patent/FR2380300B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0081—Substituted in position 17 alfa and 17 beta
    • C07J1/0085—Substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being a saturated hydrocarbon group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0059—Estrane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0081—Substituted in position 17 alfa and 17 beta
    • C07J1/0088—Substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being an unsaturated hydrocarbon group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J11/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/008—Ketals at position 17
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J33/00—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J33/005—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton spiro-condensed
    • C07J33/007—Cyclic thioketals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne de nouveaux stéroïdes substitués en position 11 et un procédé de leur préparation. Ces composés sont des stéroïdes de la série de l'oestrane substitués en position 11, répondant à la formule :
FR7803781A 1977-02-10 1978-02-10 Steroides-11b-substitues et procede de leur preparation Granted FR2380300A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL7701384A NL7701384A (nl) 1977-02-10 1977-02-10 Werkwijze voor het bereiden van nieuwe steroiden van de oestraanreeks.

Publications (2)

Publication Number Publication Date
FR2380300A1 true FR2380300A1 (fr) 1978-09-08
FR2380300B1 FR2380300B1 (fr) 1981-05-08

Family

ID=19827952

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7803781A Granted FR2380300A1 (fr) 1977-02-10 1978-02-10 Steroides-11b-substitues et procede de leur preparation

Country Status (16)

Country Link
US (1) US4292251A (fr)
JP (1) JPS53101357A (fr)
AU (1) AU519916B2 (fr)
BE (1) BE863872A (fr)
CA (1) CA1109458A (fr)
DE (1) DE2805490A1 (fr)
DK (1) DK62278A (fr)
ES (2) ES466843A1 (fr)
FI (1) FI780424A (fr)
FR (1) FR2380300A1 (fr)
GB (1) GB1595661A (fr)
IE (1) IE46384B1 (fr)
LU (1) LU79036A1 (fr)
NL (1) NL7701384A (fr)
SE (1) SE7801539L (fr)
ZA (1) ZA78476B (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0305242A1 (fr) * 1987-07-30 1989-03-01 Roussel-Uclaf Nouveaux 17-aryle stéroides, leur procédé et intermédiaires de préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3042136A1 (de) * 1980-11-03 1982-06-09 Schering Ag, 1000 Berlin Und 4619 Bergkamen Verfahren zur herstellung von 3 (beta), 7 (beta) -dihydroxy- (delta) (pfeil hoch)5(pfeil hoch) -steroiden
FR2528434B1 (fr) * 1982-06-11 1985-07-19 Roussel Uclaf Nouveaux 19-nor steroides substitues en 11b et eventuellement en 2, leur procede de preparation et leur application comme medicament
AU572589B2 (en) 1983-12-14 1988-05-12 Upjohn Company, The 11(alpha)-difluoromethyl and (e)-and (z)-11-fluoromethylene steroids
US4567000A (en) * 1984-08-31 1986-01-28 The Upjohn Company 11-Difluoromethylene steroids
DE3702383A1 (de) * 1987-01-23 1988-08-04 Schering Ag 11ss-alkinylestrene und -estradiene, deren herstellung und diese enthaltende pharmazeutische praeparate
US6037339A (en) 1993-02-08 2000-03-14 Akzo Nobel N.V. C-11 substituted steroids for treating menopausal complaints
US5710144A (en) * 1993-02-08 1998-01-20 Akzo Nobel N.V. C-11 substituted steroids for treating menopausal complaints
ZA94715B (en) * 1993-02-08 1994-10-24 Akzo Nv Steroids for treating menopausal complaints
KR20010041698A (ko) * 1998-03-09 2001-05-25 악조 노벨 엔.브이. 신규 피임 키트
US20030083231A1 (en) * 1998-11-24 2003-05-01 Ahlem Clarence N. Blood cell deficiency treatment method
EP1175433B1 (fr) 1999-05-04 2005-08-03 Strakan International Limited Glycosides d'androgenes et activite androgenique desdits glycosides
DE102007027635A1 (de) 2007-06-12 2008-12-18 Bayer Schering Pharma Aktiengesellschaft 17ß-Cyano-19-androst-4-en-Derivat, dessen Verwendung und das Derivat enthaltende Arzneimittel
DE102007027637A1 (de) 2007-06-12 2008-12-18 Bayer Schering Pharma Aktiengesellschaft 17ß-Cyano-19-nor-androst-4-en-Derivat, dessen Verwendung und das Derivat enthaltende Arzneimittel
DE102007027636A1 (de) 2007-06-12 2008-12-18 Bayer Schering Pharma Aktiengesellschaft 17ß-Cyano-18a-homo-19-nor-androst-4-en-Derivat, dessen Verwendung und das Derivat enthaltende Arzneimittel
DE102007063495A1 (de) 2007-12-29 2009-09-17 Bayer Schering Pharma Aktiengesellschaft 19-Nor-Steroidderivate mit einer 15α,16α-Methylengruppe und einem gesättigten 17,17-Spirolactonring, deren Verwendung sowie diese Derivate enthaltende Arzneimittel
DE102007063500A1 (de) 2007-12-29 2009-07-02 Bayer Schering Pharma Aktiengesellschaft 17-(1'-Propenyl)-17-3'-oxidoestra-4-en-3-on-Derivat, dessen Verwendung und das Derivat enthaltende Arzneimittel
DE102007063498A1 (de) 2007-12-29 2009-07-02 Bayer Schering Pharma Aktiengesellschaft 15,16-Methylen-steroid-17,17-Lactol-Derivat, dessen Verwendung und das Derivat enthaltende Arzneimittel
DE102007063499A1 (de) 2007-12-29 2009-07-02 Bayer Schering Pharma Aktiengesellschaft Steroid-17,17-Lactol-Derivat, dessen Verwendung und das Derivat enthaltende Arzneimittel
DE102007063503A1 (de) 2007-12-29 2009-07-02 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-19-nor-21-carbonsäure-Steroid y-Lacton-Derivat, dessen Verwendung und das Derivat enthaltende Arzneimittel
DE102007063496A1 (de) 2007-12-29 2009-07-02 Bayer Schering Pharma Aktiengesellschaft 15,16-Methylen-17-(1'-propenyl)-17-3'-oxidoestra-4-en-3-on-Derivat, dessen Verwendung und das Derivat enthaltende Arzneimittel
DE102007063501A1 (de) 2007-12-29 2009-07-02 Bayer Schering Pharma Aktiengesellschaft 15, 16-Methylen-17-hydroxy-19-nor-21-carbonsäure-Steroid y-Lacton-Derivat, dessen Verwendung und das Derivat enthaltende Arzneimittel

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3377365A (en) * 1966-10-12 1968-04-09 Searle & Co (optionally 17-alkylated) 11beta, 13beta-dialkylgona-1, 3, 5(10)-triene-3, 17beta-diols, ethers and esters thereof
FR2235949A1 (fr) * 1973-06-18 1975-01-31 Roussel Uclaf
FR2377419A1 (fr) * 1977-01-13 1978-08-11 Roussel Uclaf Nouveaux derives steroides 11b-substitues 1,3,5 (10) trieniques, leur procede de preparation et leur application comme medicament

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3299108A (en) * 1965-10-18 1967-01-17 Searle & Co 17alpha-alkynyl/alkenyl-13beta-alkyl-11-alkylgona-1, 3, 5 (10)-triene-3, 17beta-diols, ethers and esters thereof and intermediates thereto
US3465010A (en) * 1966-11-22 1969-09-02 Searle & Co 17 - (unsaturated hydrocarbon - substituted) 11,13beta - dialkylgon -4 - ene - 3,17beta-diols and esters thereof
US3377366A (en) * 1966-12-02 1968-04-09 Searle & Co 17alpha-alkynyl/alkenyl-11, 13beta-dialkylgon-5(10)-en-3-ones and esters thereof
US3755301A (en) * 1972-06-23 1973-08-28 Searle & Co Manufacture of 11-alkyl steroids
FI54128C (fi) * 1972-12-09 1978-10-10 Akzo Nv Foerfarande foer framstaellning av nya 11,11-alkylidensteroider ur oestran- och 19-norpregnanserien med foerbaettrad hormonell verkan
NL7317358A (nl) * 1973-12-19 1975-06-23 Akzo Nv Nieuwe 11(beta)-alkylsteroiden van de oestraanreeks.

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3377365A (en) * 1966-10-12 1968-04-09 Searle & Co (optionally 17-alkylated) 11beta, 13beta-dialkylgona-1, 3, 5(10)-triene-3, 17beta-diols, ethers and esters thereof
FR2235949A1 (fr) * 1973-06-18 1975-01-31 Roussel Uclaf
FR2377419A1 (fr) * 1977-01-13 1978-08-11 Roussel Uclaf Nouveaux derives steroides 11b-substitues 1,3,5 (10) trieniques, leur procede de preparation et leur application comme medicament

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0305242A1 (fr) * 1987-07-30 1989-03-01 Roussel-Uclaf Nouveaux 17-aryle stéroides, leur procédé et intermédiaires de préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant

Also Published As

Publication number Publication date
ES466843A1 (es) 1979-06-01
GB1595661A (en) 1981-08-12
JPS53101357A (en) 1978-09-04
CA1109458A (fr) 1981-09-22
DK62278A (da) 1978-08-11
ZA78476B (en) 1978-12-27
ES475164A1 (es) 1979-06-16
IE780178L (en) 1978-08-10
LU79036A1 (fr) 1978-06-26
AU3310378A (en) 1979-08-16
IE46384B1 (en) 1983-05-18
AU519916B2 (en) 1982-01-07
SE7801539L (sv) 1978-08-11
FI780424A (fi) 1978-07-11
BE863872A (fr) 1978-08-10
FR2380300B1 (fr) 1981-05-08
DE2805490A1 (de) 1978-08-17
NL7701384A (nl) 1978-08-14
US4292251A (en) 1981-09-29

Similar Documents

Publication Publication Date Title
FR2380300A1 (fr) Steroides-11b-substitues et procede de leur preparation
FR2430412A1 (fr) Derives substitues de propanolamine utiles comme medicaments et procede de leur preparation
FR2378747A1 (fr) Nouveaux composes d'addition d'un derive de dipeptide et d'un derive d'amino-acide, et leur procede de preparation et de decomposition
FR2401914A1 (fr) Nouveaux composes heterocycliques, procede pour leur preparation et compositions medicinales contenant lesdits composes
FR2362811A1 (fr) A-halogenocyclobutanones substituees et leur procede de preparation
FR2361359A1 (fr) Nouvelles oximes hydrazones et leur procede de preparation
FR2387971A1 (fr) Nouvelles trimethoxy cinnamoyles piperazines, leur procede de preparation et leur application en therapeutique
FR2384811A1 (fr) Derives de la neocarzinostatine, leur application therapeutique et leur procede de preparation
FR2429797A1 (fr)
FR2422334A1 (fr)
FR2418240A1 (fr) Procede de preparation de composes de glucopyranose-nitrosouree et nouveaux composes ainsi obtenus
FR2397411A1 (fr) Composes tricycliques derives du norbornane, leur utilisation et procede pour leur preparation
FR2376848A1 (fr) Phenylcarbamoyl-pyrazolines, procede pour leur preparation et utilisation de ces composes comme insecticides
FR2401148A1 (fr) Procede de preparation de 1-amino-3-aryloxy-2-propanols
FR2421914A1 (fr) 3-acetoxy-9b-11b-epoxy-pregna-trienes et dienes et procede de preparation de 6a-halogeno-pregna-1,4-diene-3 ones et de 6a halogeno-pregna-4-ene-3-ones correspondants
FR2403336A1 (fr) Derives de 3,4-dihydrocarbostyrile, leur procede de preparation et leur utilisation pour le traitement des troubles cardiaques
FR2374291A1 (fr)
FR2384775A1 (fr) Derives de la morphine, leur procede de preparation et leur application comme medicament
FR2385670A1 (fr) Procede de preparation de 2,2-dimethylolalcanals
FR2397387A1 (fr) 4,4'-bis-formyl-polyhalo-diphenoxyalcanes, procede de preparation et application a la synthese de 4,4'-dicyano-polyhalo-diphenoxyalcanes
FR2383152A1 (fr) Procede de preparation du 2-methyl-3-prenyl-4,5,6-trimethoxyphenol
FR2414513A1 (fr)
FR2358884A1 (fr) Compositions d'amino-alcools et leur procede de preparation et leur application notamment pour le traitement d'affections buccales
FR2405948A1 (fr) Nouvelles 4-phenyl-thieno-(2,3-c)- piperidines, procedes pour leur preparation et compositions pharmaceutiques les renfermant
FR2383933A1 (fr) Procede de preparation de 2,4-dioxo-oxazolidines

Legal Events

Date Code Title Description
ST Notification of lapse