FR2378779A1 - Derives de 5-fluoro-uracile et leur application en therapeutique - Google Patents

Derives de 5-fluoro-uracile et leur application en therapeutique

Info

Publication number
FR2378779A1
FR2378779A1 FR7738495A FR7738495A FR2378779A1 FR 2378779 A1 FR2378779 A1 FR 2378779A1 FR 7738495 A FR7738495 A FR 7738495A FR 7738495 A FR7738495 A FR 7738495A FR 2378779 A1 FR2378779 A1 FR 2378779A1
Authority
FR
France
Prior art keywords
derivatives
uracil
therapeutics
fluoro
application
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7738495A
Other languages
English (en)
Other versions
FR2378779B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai Co Ltd
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Publication of FR2378779A1 publication Critical patent/FR2378779A1/fr
Application granted granted Critical
Publication of FR2378779B1 publication Critical patent/FR2378779B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

L'invention a pour objet des dérivés nouveaux du 5-fluorouracile et des nouvelles compositions anti-tumeurs contenant ces dérivés. Ces dérivés répondent à la formule générale :
FR7738495A 1976-12-24 1977-12-20 Derives de 5-fluoro-uracile et leur application en therapeutique Granted FR2378779A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP51154941A JPS6052708B2 (ja) 1976-12-24 1976-12-24 ５−フルオロウラシル系化合物およびそれを含有する抗腫瘍剤

Publications (2)

Publication Number Publication Date
FR2378779A1 true FR2378779A1 (fr) 1978-08-25
FR2378779B1 FR2378779B1 (fr) 1980-08-22

Family

ID=15595270

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7738495A Granted FR2378779A1 (fr) 1976-12-24 1977-12-20 Derives de 5-fluoro-uracile et leur application en therapeutique

Country Status (14)

Country Link
US (1) US4130648A (fr)
JP (1) JPS6052708B2 (fr)
AU (1) AU519524B2 (fr)
BE (1) BE862213A (fr)
CA (1) CA1077483A (fr)
CH (1) CH636874A5 (fr)
DE (1) DE2757431A1 (fr)
ES (1) ES465406A1 (fr)
FR (1) FR2378779A1 (fr)
GB (1) GB1594840A (fr)
NL (1) NL7714205A (fr)
PH (1) PH12700A (fr)
SE (1) SE436208B (fr)
SU (2) SU827489A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1235864A1 (ru) * 1983-03-11 1986-06-07 Отделение ордена Ленина института химической физики АН СССР Нитроксильные производные 5-фторурацила,обладающие противоопухолевой активностью
US4727077A (en) * 1985-02-20 1988-02-23 Ishihara Sangyo Kaisha Ltd. Benzoyl urea compounds, process for their production, and antitumorous compositions containing them
DK197486A (da) * 1986-04-30 1987-10-31 Ferring Farma Lab 5-fluoruracilprodug
WO2018129533A1 (fr) 2017-01-09 2018-07-12 Shuttle Pharmaceuticals, Llc Inhibiteurs sélectifs d'histone déacétylase pour le traitement d'une maladie humaine
US11584733B2 (en) 2017-01-09 2023-02-21 Shuttle Pharmaceuticals, Inc. Selective histone deacetylase inhibitors for the treatment of human disease
WO2019139921A1 (fr) 2018-01-09 2019-07-18 Shuttle Pharmaceuticals, Inc. Inhibiteurs sélectifs d'histone déacétylase pour le traitement d'une maladie humaine

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5324951B2 (fr) * 1973-11-28 1978-07-24

Also Published As

Publication number Publication date
SE7714670L (sv) 1978-06-25
AU519524B2 (en) 1981-12-10
JPS5379880A (en) 1978-07-14
SU827489A1 (ru) 1981-05-07
JPS6052708B2 (ja) 1985-11-20
CA1077483A (fr) 1980-05-13
ES465406A1 (es) 1978-09-16
DE2757431A1 (de) 1978-06-29
PH12700A (en) 1979-07-20
BE862213A (fr) 1978-04-14
NL7714205A (nl) 1978-06-27
CH636874A5 (de) 1983-06-30
AU3182577A (en) 1979-06-28
GB1594840A (en) 1981-08-05
SU795469A3 (ru) 1981-01-07
SE436208B (sv) 1984-11-19
FR2378779B1 (fr) 1980-08-22
US4130648A (en) 1978-12-19

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Legal Events

Date Code Title Description
ST Notification of lapse