FR2364928A1 - Procede de preparation de steroides halogenes en position 9,11, et les composes obtenus par le procede - Google Patents

Procede de preparation de steroides halogenes en position 9,11, et les composes obtenus par le procede

Info

Publication number
FR2364928A1
FR2364928A1 FR7727739A FR7727739A FR2364928A1 FR 2364928 A1 FR2364928 A1 FR 2364928A1 FR 7727739 A FR7727739 A FR 7727739A FR 7727739 A FR7727739 A FR 7727739A FR 2364928 A1 FR2364928 A1 FR 2364928A1
Authority
FR
France
Prior art keywords
preparation
compounds obtained
halogen steroids
steroids
halogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7727739A
Other languages
English (en)
Other versions
FR2364928B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of FR2364928A1 publication Critical patent/FR2364928A1/fr
Application granted granted Critical
Publication of FR2364928B1 publication Critical patent/FR2364928B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
    • C07J5/0076—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
    • C07J7/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa
    • C07J7/002—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa not substituted in position 16

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Procédé de préparation de stéroïdes halogénés en positions 9, 11, et les composés obtenus par le procédé. Ce procédé de l'invention se caractérise par le fait qu'il consiste à faire réagir un 9 alpha-chloro-11-bêta-hydroxy-stéroide avec un composé de formule F3 SX, dans laquelle X représente le groupe amino provenant d'une amine secondaire. Application à l'industrie pharmaceutique.
FR7727739A 1976-09-16 1977-09-14 Procede de preparation de steroides halogenes en position 9,11, et les composes obtenus par le procede Granted FR2364928A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
LU75809A LU75809A1 (fr) 1976-09-16 1976-09-16

Publications (2)

Publication Number Publication Date
FR2364928A1 true FR2364928A1 (fr) 1978-04-14
FR2364928B1 FR2364928B1 (fr) 1981-03-06

Family

ID=19728351

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7727739A Granted FR2364928A1 (fr) 1976-09-16 1977-09-14 Procede de preparation de steroides halogenes en position 9,11, et les composes obtenus par le procede

Country Status (13)

Country Link
JP (1) JPS5337652A (fr)
AT (1) AT356303B (fr)
AU (1) AU514425B2 (fr)
BE (1) BE858709A (fr)
CA (1) CA1105003A (fr)
DE (1) DE2741067A1 (fr)
DK (1) DK410077A (fr)
FR (1) FR2364928A1 (fr)
GB (1) GB1584826A (fr)
LU (1) LU75809A1 (fr)
NL (1) NL7710086A (fr)
SE (1) SE7710337L (fr)
ZA (1) ZA775537B (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0029151A2 (fr) * 1979-11-16 1981-05-27 STEROSYNT Ltd. 6-Alpha-fluoro-9-alpha-chloro-prednisolone-17,21-diesters, compositions pharmaceutiques les contenant et intermédiaires

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1209140B (it) * 1979-11-16 1989-07-10 Prochem Ets 6 alfa-fluoro-prednisolone 17,21-diesteri.

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0029151A2 (fr) * 1979-11-16 1981-05-27 STEROSYNT Ltd. 6-Alpha-fluoro-9-alpha-chloro-prednisolone-17,21-diesters, compositions pharmaceutiques les contenant et intermédiaires
EP0029151A3 (en) * 1979-11-16 1981-08-26 Sterosynt Ltd. 6-alpha-fluoro-9-alpha-chloro-prednisolone-17,21 diesters, pharmaceutical compositions containing them and intermediates

Also Published As

Publication number Publication date
CA1105003A (fr) 1981-07-14
ZA775537B (en) 1978-07-26
DK410077A (da) 1978-03-17
ATA663077A (de) 1979-09-15
GB1584826A (en) 1981-02-18
LU75809A1 (fr) 1978-05-12
AT356303B (de) 1980-04-25
FR2364928B1 (fr) 1981-03-06
JPS5337652A (en) 1978-04-06
DE2741067A1 (de) 1978-03-23
BE858709A (fr) 1978-03-15
AU514425B2 (en) 1981-02-12
NL7710086A (nl) 1978-03-20
SE7710337L (sv) 1978-03-17
AU2884877A (en) 1979-03-22

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Legal Events

Date Code Title Description
ST Notification of lapse