BE904662A - Derive antipsychotique du benzisothiazole s-oxyde. - Google Patents
Derive antipsychotique du benzisothiazole s-oxyde.Info
- Publication number
- BE904662A BE904662A BE0/216581A BE216581A BE904662A BE 904662 A BE904662 A BE 904662A BE 0/216581 A BE0/216581 A BE 0/216581A BE 216581 A BE216581 A BE 216581A BE 904662 A BE904662 A BE 904662A
- Authority
- BE
- Belgium
- Prior art keywords
- antipsychotic
- benzisothiazole
- derivative
- oxide
- compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, ***e
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Procédé de préparation d'un composé de formule (1) ou de ses sels d'addition d'acides pharmaceutiquement acceptables, qui consiste à faire réagir un composé de formule (2) avec un mélange d'acides minéraux à une température inférieure à environ 5 degrés C et, si on le souhaite, à en former le sel pharmaceutiquement acceptable par réaction du produit final basique avec un acide organique ou minéral choisi, pour obtenir un agent antipsychotique présentant moins d'effets secondaires genants.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/726,449 US4656173A (en) | 1985-04-24 | 1985-04-24 | Antipsychotic benzisothiazole S-oxide compound |
Publications (1)
Publication Number | Publication Date |
---|---|
BE904662A true BE904662A (fr) | 1986-10-23 |
Family
ID=24918649
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BE0/216581A BE904662A (fr) | 1985-04-24 | 1986-04-23 | Derive antipsychotique du benzisothiazole s-oxyde. |
Country Status (26)
Country | Link |
---|---|
US (1) | US4656173A (fr) |
JP (1) | JPH0764842B2 (fr) |
KR (1) | KR900000372B1 (fr) |
CN (1) | CN1017528B (fr) |
AT (1) | AT394719B (fr) |
AU (1) | AU592787B2 (fr) |
BE (1) | BE904662A (fr) |
CA (1) | CA1247102A (fr) |
CH (1) | CH666034A5 (fr) |
DE (1) | DE3613739C2 (fr) |
DK (1) | DK187686A (fr) |
EG (1) | EG18002A (fr) |
ES (1) | ES8708228A1 (fr) |
FI (1) | FI84604C (fr) |
FR (1) | FR2581064B1 (fr) |
GB (1) | GB2174393B (fr) |
GR (1) | GR861063B (fr) |
HU (1) | HU195654B (fr) |
IE (1) | IE59182B1 (fr) |
IT (1) | IT1208600B (fr) |
LU (1) | LU86405A1 (fr) |
MY (1) | MY102041A (fr) |
NL (1) | NL8601043A (fr) |
PT (1) | PT82450B (fr) |
SE (1) | SE462163B (fr) |
ZA (1) | ZA861531B (fr) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4780466A (en) * | 1988-03-17 | 1988-10-25 | Hoechst-Roussel Pharmaceuticals, Inc. | Arylpiperazinylalkoxy derivatives of cyclic imides |
EP0350145A3 (fr) * | 1988-04-28 | 1990-07-04 | Yamanouchi Pharmaceutical Co. Ltd. | Derivés de Pyridylthiazolidine carboxamide et intermédiaires et leur production |
US5077295A (en) * | 1988-09-16 | 1991-12-31 | Pfizer Inc. | Antipsychoic 4-(4-(3-benzisothiazolyl)-1-piperazinyl)buytl bridged bicycle imides |
US4956368A (en) * | 1989-07-24 | 1990-09-11 | Bristol-Myers Company | Metabolites and prodrug formulations of 8-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dione |
US4968792A (en) * | 1989-09-25 | 1990-11-06 | American Home Products Corporation | Psychotropic benzisothiazole derivatives |
US5162321A (en) * | 1989-12-20 | 1992-11-10 | Adir Et Compagnie | 1-naphthyl piperazines useful as 5-HT1A receptor ligands |
JP2800953B2 (ja) * | 1990-07-06 | 1998-09-21 | 住友製薬株式会社 | 新規なイミド誘導体 |
US10154988B2 (en) | 2012-11-14 | 2018-12-18 | The Johns Hopkins University | Methods and compositions for treating schizophrenia |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE759371A (fr) * | 1969-11-24 | 1971-05-24 | Bristol Myers Co | Azaspirodecanediones heterocycliques et procedes pour leur preparation |
US3976776A (en) * | 1972-12-06 | 1976-08-24 | Mead Johnson & Company | Tranquilizer process employing N-(heteroarcyclic)piperazinylalkylazaspiroalkanediones |
CH582699A5 (fr) * | 1973-03-26 | 1976-12-15 | Sandoz Ag | |
AT342057B (de) * | 1974-04-25 | 1978-03-10 | Thomae Gmbh Dr K | Verfahren zur herstellung von neuen 3-piperazino-isochinolinen und deren salzen |
FI753625A (fr) * | 1975-01-06 | 1976-07-07 | Spofa Vereinigte Pharma Werke | |
JPS51144735A (en) * | 1975-06-06 | 1976-12-13 | Nippon Nohyaku Co Ltd | A remedy for hepatic failure |
US4411901A (en) * | 1981-12-23 | 1983-10-25 | Mead Johnson & Company | Benzisothiazole and benzisoxazole piperazine derivatives |
US4452799A (en) * | 1981-12-23 | 1984-06-05 | Mead Johnson & Company | Benzisothiazole and benzisoxazole piperazine derivatives |
US4524206A (en) * | 1983-09-12 | 1985-06-18 | Mead Johnson & Company | 1-Heteroaryl-4-(2,5-pyrrolidinedion-1-yl)alkyl)piperazine derivatives |
-
1985
- 1985-04-24 US US06/726,449 patent/US4656173A/en not_active Expired - Lifetime
-
1986
- 1986-02-21 CA CA000502439A patent/CA1247102A/fr not_active Expired
- 1986-02-28 ZA ZA861531A patent/ZA861531B/xx unknown
- 1986-04-02 KR KR1019860002515A patent/KR900000372B1/ko not_active IP Right Cessation
- 1986-04-15 AU AU56121/86A patent/AU592787B2/en not_active Ceased
- 1986-04-20 EG EG232/86A patent/EG18002A/xx active
- 1986-04-21 FI FI861668A patent/FI84604C/fi not_active IP Right Cessation
- 1986-04-22 GR GR861063A patent/GR861063B/el unknown
- 1986-04-22 FR FR8605789A patent/FR2581064B1/fr not_active Expired
- 1986-04-23 NL NL8601043A patent/NL8601043A/nl active Search and Examination
- 1986-04-23 IT IT8620187A patent/IT1208600B/it active
- 1986-04-23 LU LU86405A patent/LU86405A1/fr unknown
- 1986-04-23 IE IE108386A patent/IE59182B1/en not_active IP Right Cessation
- 1986-04-23 CN CN86102742A patent/CN1017528B/zh not_active Expired
- 1986-04-23 DK DK187686A patent/DK187686A/da not_active Application Discontinuation
- 1986-04-23 ES ES554284A patent/ES8708228A1/es not_active Expired
- 1986-04-23 PT PT82450A patent/PT82450B/pt not_active IP Right Cessation
- 1986-04-23 GB GB08609932A patent/GB2174393B/en not_active Expired
- 1986-04-23 DE DE3613739A patent/DE3613739C2/de not_active Expired - Fee Related
- 1986-04-23 SE SE8601883A patent/SE462163B/sv not_active IP Right Cessation
- 1986-04-23 CH CH1685/86A patent/CH666034A5/de not_active IP Right Cessation
- 1986-04-23 BE BE0/216581A patent/BE904662A/fr not_active IP Right Cessation
- 1986-04-24 HU HU861704A patent/HU195654B/hu not_active IP Right Cessation
- 1986-04-24 JP JP61095859A patent/JPH0764842B2/ja not_active Expired - Lifetime
- 1986-04-24 AT AT0110486A patent/AT394719B/de not_active IP Right Cessation
-
1987
- 1987-09-28 MY MYPI87002086A patent/MY102041A/en unknown
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RE | Patent lapsed |
Owner name: BRISTOL-MYERS CY Effective date: 20000430 |