ES8104993A1 - Un procedimiento para preparar compuestos aromaticos susti- tuidos - Google Patents
Un procedimiento para preparar compuestos aromaticos susti- tuidosInfo
- Publication number
- ES8104993A1 ES8104993A1 ES491998A ES491998A ES8104993A1 ES 8104993 A1 ES8104993 A1 ES 8104993A1 ES 491998 A ES491998 A ES 491998A ES 491998 A ES491998 A ES 491998A ES 8104993 A1 ES8104993 A1 ES 8104993A1
- Authority
- ES
- Spain
- Prior art keywords
- hydrogen
- alkyl
- trifluoromethyl
- compounds
- preparing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D253/075—Two hetero atoms, in positions 3 and 5
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
- C07C281/16—Compounds containing any of the groups, e.g. aminoguanidine
- C07C281/18—Compounds containing any of the groups, e.g. aminoguanidine the other nitrogen atom being further doubly-bound to a carbon atom, e.g. guanylhydrazones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/15—Preparation of carboxylic acids or their salts, halides or anhydrides by reaction of organic compounds with carbon dioxide, e.g. Kolbe-Schmitt synthesis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
- C07C51/363—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE COMPUESTOS AROMATICOS SUSTITUIDOS, DE FORMULA (I), O UNA DE SUS SALES DE ADICION DE ACIDO, EN LA QUE R6, R7, R8, R9, R10 Y R11 PUEDEN SER VARIOS RADICALES. SE SOMETE A UNA REACCION DE CICLISACION POR METODOS CONVENCIONALES UN COMPUESTO DE FORMULA (III), EN LA QUE LOS RADICALES R6, R7, R8, R9 Y R10 SON LOS MISMOS QUE EN LA FORMULA (I), DISUELTO EN UN ALCANOL DE C1-4 Y EN PRESENCIA DE UNA BASE. A CONTINUACION, EVENTUALMENTE, SE SUSTITUYE EL GRUPO AMINO ADYACENTE AL ANILLO FENILO POR UN RADICAL R11, QUE ES EL MISMO QUE EN LA FORMULA (I). ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE ENFERMEDADES DEL SISTEMA NERVIOSO CENTRAL. *FORMULA*
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB7919257 | 1979-06-01 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES491998A0 ES491998A0 (es) | 1981-05-16 |
ES8104993A1 true ES8104993A1 (es) | 1981-05-16 |
Family
ID=10505597
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES491998A Expired ES8104993A1 (es) | 1979-06-01 | 1980-05-30 | Un procedimiento para preparar compuestos aromaticos susti- tuidos |
Country Status (30)
Country | Link |
---|---|
US (2) | US4486354A (es) |
EP (2) | EP0059987B1 (es) |
JP (2) | JPS5625169A (es) |
AR (1) | AR227521A1 (es) |
AT (1) | AT370097B (es) |
AU (2) | AU530999B2 (es) |
BG (1) | BG60427B2 (es) |
CA (1) | CA1112643A (es) |
CS (1) | CS234018B2 (es) |
CZ (1) | CZ384891A3 (es) |
DD (1) | DD151309A5 (es) |
DK (1) | DK153787C (es) |
ES (1) | ES8104993A1 (es) |
FI (1) | FI67844C (es) |
GE (1) | GEP19960470B (es) |
GR (1) | GR68380B (es) |
HU (1) | HU182086B (es) |
IE (1) | IE49823B1 (es) |
IL (1) | IL60201A (es) |
IT (1) | IT1147087B (es) |
MX (1) | MX9202962A (es) |
MY (1) | MY8500062A (es) |
NL (1) | NL950007I2 (es) |
NZ (1) | NZ193890A (es) |
PL (1) | PL124029B1 (es) |
SU (1) | SU1055331A3 (es) |
UA (1) | UA5576A1 (es) |
YU (1) | YU145680A (es) |
ZA (1) | ZA803250B (es) |
ZW (1) | ZW12980A1 (es) |
Families Citing this family (90)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0024351B1 (en) * | 1979-08-16 | 1984-10-31 | The Wellcome Foundation Limited | Solid pharmaceutical formulation containing substitued phenyl-triazines |
GB8328757D0 (en) * | 1983-10-27 | 1983-11-30 | Wellcome Found | Chemical compounds |
DE3600891A1 (de) * | 1986-01-15 | 1987-07-16 | Bayer Ag | 1,8-verbrueckte 4-chinolon-3-carbonsaeuren und diese enthaltende arzneimittel |
GB8613183D0 (en) * | 1986-05-30 | 1986-07-02 | Wellcome Found | Triazine salt |
US4972496A (en) * | 1986-07-25 | 1990-11-20 | Grid Systems Corporation | Handwritten keyboardless entry computer system |
FI895821A0 (fi) | 1988-12-07 | 1989-12-05 | Wellcome Found | Farmaceutiskt aktiva cns foereningar. |
US5136080A (en) * | 1989-12-04 | 1992-08-04 | Burroughs Wellcome Co. | Nitrile compounds |
GB9012312D0 (en) * | 1990-06-01 | 1990-07-18 | Wellcome Found | Pharmacologically active cns compounds |
GB9012311D0 (en) * | 1990-06-01 | 1990-07-18 | Wellcome Found | Pharmacologically active cns compounds |
US5629016A (en) * | 1991-01-30 | 1997-05-13 | Glaxo Wellcome Inc. | Water-dispersible tablets |
BE1004461A5 (fr) * | 1991-01-30 | 1992-11-24 | Wellcome Found | Comprimes dispersables dans l'eau. |
GB9124807D0 (en) * | 1991-11-22 | 1992-01-15 | Wellcome Found | Pharmaceutical formulations |
GB9203483D0 (en) * | 1992-02-19 | 1992-04-08 | Wellcome Found | Anti-inflammatory compounds |
EP0644763B1 (en) * | 1992-06-12 | 1997-01-22 | The Wellcome Foundation Limited | Use of 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine isethionate for the treatment and prevention of dependence, tolerance and sensitization of drugs |
GB9215908D0 (en) * | 1992-07-27 | 1992-09-09 | Wellcome Found | Water dispersible tablets |
FR2699077B1 (fr) * | 1992-12-16 | 1995-01-13 | Rhone Poulenc Rorer Sa | Application d'anticonvulsivants dans le traitement de lésions neurologiques liées à des traumatismes. |
US6133299A (en) * | 1993-02-25 | 2000-10-17 | Warner-Lambert Company | Methods for treating neurodegenerative diseases and disorders using N-(2,6-disubstituted aromatic)-N'-pyridinyl ureas and other anticonvulsant compounds |
GB9305692D0 (en) * | 1993-03-19 | 1993-05-05 | Wellcome Found | Therapeutic triazine compounds and use |
GB9305693D0 (en) * | 1993-03-19 | 1993-05-05 | Wellcome Found | Therapeutic triazine compounds and use |
US5866597A (en) * | 1993-03-19 | 1999-02-02 | Glaxo Wellcome Inc. | Use of triazine compounds for the treatment of memory and learning disorders |
US5698226A (en) * | 1993-07-13 | 1997-12-16 | Glaxo Wellcome Inc. | Water-dispersible tablets |
GB9317146D0 (en) * | 1993-08-18 | 1993-10-06 | Wellcome Found | Therapeutic combinations |
GB9424766D0 (en) * | 1994-12-07 | 1995-02-08 | Wellcome Found | Pharmaceutical composition |
GB9426448D0 (en) * | 1994-12-30 | 1995-03-01 | Wellcome Found | Process |
PT800520E (pt) * | 1994-12-30 | 2002-11-29 | Wellcome Found | Processo para a preparacao de lamotrigina |
GB9512854D0 (en) * | 1995-06-23 | 1995-08-23 | Wellcome Found | Novel formulation |
GB9518027D0 (en) * | 1995-09-05 | 1995-11-08 | Wellcome Found | Pharmacologically active compound |
FR2741879A1 (fr) * | 1995-12-05 | 1997-06-06 | Esteve Labor Dr | Derives de fluorophenyl-triazines et pyrimidines, leur preparation et leur application en tant que medicament |
US6202491B1 (en) | 1997-07-22 | 2001-03-20 | Skf Condition Monitoring, Inc. | Digital vibration coupling stud |
GB9726987D0 (en) | 1997-12-22 | 1998-02-18 | Glaxo Group Ltd | Compounds |
US6124500A (en) * | 1998-03-09 | 2000-09-26 | Rohm And Haas Company | Process for synthesizing benzoic acids |
GB9812413D0 (en) | 1998-06-10 | 1998-08-05 | Glaxo Group Ltd | Compound and its use |
PL348865A1 (en) * | 1998-12-14 | 2002-06-17 | Torrent Pharmaceuticals Ltd | An improved process for the preparation of 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine |
US20020055177A1 (en) * | 1999-03-10 | 2002-05-09 | Glaxo Wellcome Inc. | Compound and its use |
GB9907965D0 (en) * | 1999-04-09 | 1999-06-02 | Glaxo Group Ltd | Medical use |
AU4334900A (en) * | 1999-04-09 | 2000-11-14 | Euro-Celtique S.A. | Sodium channel blocker compositions and the use thereof |
WO2001049669A1 (en) * | 2000-01-03 | 2001-07-12 | Rpg Life Sciences Limited | A process for the preparation of 6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine, commonly known as lamotrigine |
IL134730A (en) * | 2000-02-25 | 2003-10-31 | Chemagis Ltd | Process for preparing substituted benzoyl cyanide amidinohydrazones |
KR20030059287A (ko) | 2000-11-30 | 2003-07-07 | 화이자 프로덕츠 인코포레이티드 | Gaba 작용제 및 알도스 리덕타제 억제제의 혼합물 |
SK6192003A3 (en) | 2000-11-30 | 2004-07-07 | Pfizer Prod Inc | Combination of GABA agonists and sorbitol dehydrogenase inhibitors |
WO2002068398A1 (en) * | 2001-02-27 | 2002-09-06 | Teva Pharmaceutical Industries Ltd. | New crystal forms of lamotrigine and processes for their preparations |
NZ531586A (en) * | 2001-09-03 | 2005-09-30 | Newron Pharm Spa | Pharmaceutical composition comprising gabapentin or an analogue thereof and an alpha-aminoamide and its analgesic use |
CA2366521C (en) | 2001-12-24 | 2007-03-06 | Brantford Chemicals Inc. | A new and efficient process for the preparation of lamotrigine and related 3,5-diamino-6-substituted-1,2,4-triazines |
AU2003217676B2 (en) | 2002-02-22 | 2009-06-11 | Takeda Pharmaceutical Company Limited | Active agent delivery systems and methods for protecting and administering active agents |
AU2003234240A1 (en) * | 2002-04-23 | 2003-11-10 | Teva Pharmaceutical Industries Ltd. | Pharmaceutical composition containing lamotrigine particles of defined morphology |
US8637512B2 (en) | 2002-07-29 | 2014-01-28 | Glaxo Group Limited | Formulations and method of treatment |
HU225667B1 (en) | 2002-09-20 | 2007-05-29 | Richter Gedeon Nyrt | Method for producing high-purity 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine |
ES2209639B1 (es) | 2002-10-31 | 2005-08-01 | Vita Cientifica, S.L. | Procedimiento para la obtencion de un compuesto farmaceuticamente activo y obtencion de su intermedio. |
AU2003217437A1 (en) * | 2003-03-17 | 2004-10-11 | Hetero Drugs Limited | Novel crystalline forms of lamotrigine |
WO2004085426A1 (en) | 2003-03-27 | 2004-10-07 | Hetero Drugs Limited | Novel crystalline forms of candesartan cilexetil |
CA2525366A1 (en) | 2003-05-16 | 2004-11-25 | Pfizer Products Inc. | Therapeutic combinations of atypical antipsychotics with gaba modulators, anticonvulsants or benzodiazapines |
WO2004103340A1 (en) * | 2003-05-20 | 2004-12-02 | Ranbaxy Laboratories Limited | Water dispersible tablets of lamotrigine |
GB2395483A (en) * | 2003-07-03 | 2004-05-26 | Jubilant Organosys Ltd | Crystalline lamotrigine and its monohydrate |
DK1691811T3 (da) | 2003-12-11 | 2014-10-20 | Sunovion Pharmaceuticals Inc | Kombination af et sedativ og en neurotransmittermodulator og fremgangsmåder til forbedring af søvnkvaliteten og behandling af depression |
CA2553291A1 (en) * | 2004-01-29 | 2005-09-09 | Pfizer Products Inc. | Combination of .gamma.-aminobutyric acid modulators and 5-ht1b receptor antagonists |
CA2567249A1 (en) * | 2004-04-19 | 2006-10-05 | Jds Pharmaceuticals, Llc | Lithium combinations, and uses related thereto |
KR101277520B1 (ko) * | 2004-09-10 | 2013-06-21 | 뉴론 파마슈티칼즈 에스. 피. 에이. | (할로벤질옥시)벤질아미노-프로판아미드를 포함하는 선택적 나트륨 및/또는 칼슘 채널 조절제로서 유용한 약제학적 조성물 |
US8378117B2 (en) * | 2005-09-23 | 2013-02-19 | Janssen Pharmaceutica N.V. | Hexahydro-cycloheptapyrazole cannabinoid modulators |
US7790718B2 (en) | 2005-09-23 | 2010-09-07 | Janssen Pharmaceutica Nv | Tetrahydro-cyclopentyl pyrazole cannabinoid modulators |
DE602006012514D1 (de) * | 2005-09-23 | 2010-04-08 | Janssen Pharmaceutica Nv | Hexahydro-cyclooctyl-pyrazol-cannabinoid-modulatoren |
US8378096B2 (en) * | 2005-09-23 | 2013-02-19 | Janssen Pharmaceutica N.V. | Hexahydro-cycloheptapyrazole cannabinoid modulators |
US7825151B2 (en) * | 2005-09-23 | 2010-11-02 | Janssen Pharmaceutica Nv | Hexahydro-cyclooctyl pyrazole cannabinoid modulators |
CA2623745A1 (en) * | 2005-09-23 | 2007-04-05 | Janssen Pharmaceutica N.V. | Hexahydro-cycloheptapyrazole cannabinoid modulators |
US20070117858A1 (en) * | 2005-11-23 | 2007-05-24 | Mingde Xia | Substituted 5-heteroaryl-1-phenyl-pyrazole cannabinoid modulators |
EP1979593B1 (en) * | 2006-02-03 | 2017-12-06 | Rolls-Royce Corporation | Gas turbine engine fuel system with fuel metering valve |
US7795294B2 (en) * | 2006-02-14 | 2010-09-14 | Janssen Pharmaceutica N.V. | Tetrahydro-2H-indazole pyrazole cannabinoid modulators |
US20070254911A1 (en) * | 2006-03-27 | 2007-11-01 | Mingde Xia | Tetrahydro-Pyrazolo[3,4-c]Pyridine Cannabinoid Modulators |
US8012957B2 (en) * | 2006-03-27 | 2011-09-06 | Janssen Pharmaceutica Nv | Tetrahydro-1H-1,2,6-triaza-azulene cannabinoid modulators |
WO2007122638A2 (en) * | 2006-04-26 | 2007-11-01 | Ratnamani Bio-Chemicals & Pharmaceuticals Pvt. Ltd. | An improved process for preparation of lamotrigine intermediates |
EP2024345B1 (en) * | 2006-05-31 | 2009-12-16 | Calaire Chimie SAS | Method for preparing lamotrigine and its intermediate 2,3-dichlorobenzoyl chloride |
GB0613836D0 (en) | 2006-07-13 | 2006-08-23 | Univ Greenwich | New medical use of triazine derivatives |
US20120142919A1 (en) | 2006-08-02 | 2012-06-07 | Medichem, S.A. | Method for synthesizing lamotrigine |
CA2659290A1 (en) * | 2006-08-14 | 2008-02-21 | Jean-Paul Roduit | A process for the preparation of lamotrigine |
WO2008090117A1 (en) | 2007-01-24 | 2008-07-31 | Glaxo Group Limited | Pharmaceutical compositions comprising 3, 5-diamin0-6- (2, 3-dichl0phenyl) -l, 2, 4-triazine or r (-) -2, 4-diamino-5- (2, 3-dichlorophenyl) -6-fluoromethyl pyrimidine and an nk1 |
US7943653B2 (en) * | 2007-08-13 | 2011-05-17 | Janssen Pharmaceutica N.V. | Substituted 5-vinylphenyl-1-phenyl-pyrazole cannabinoid modulators |
US20090076010A1 (en) * | 2007-09-13 | 2009-03-19 | Protia, Llc | Deuterium-enriched lamotrigine |
US8486927B2 (en) * | 2007-11-09 | 2013-07-16 | Thar Pharmaceuticals | Crystalline forms of lamotrigine |
GB0800741D0 (en) * | 2008-01-16 | 2008-02-20 | Univ Greenwich | Cyclic triazo and diazo sodium channel blockers |
US20100190752A1 (en) * | 2008-09-05 | 2010-07-29 | Gruenenthal Gmbh | Pharmaceutical Combination |
CN102421763B (zh) | 2009-05-13 | 2015-06-17 | 尼克塔治疗公司 | 含有寡聚体的取代的芳族三嗪化合物 |
EP2564836A1 (en) | 2009-05-20 | 2013-03-06 | Ranbaxy Laboratories Limited | Controlled release lamotrigine formulations |
GB2471713A (en) * | 2009-07-08 | 2011-01-12 | Univ Greenwich | 1,2,4-triazine derivatives and their use as sodium channel blockers |
GB2471729A (en) | 2009-07-08 | 2011-01-12 | Univ Greenwich | 1,2,4-triazine derivatives and their use as sodium channel blockers |
US20110052686A1 (en) * | 2009-09-03 | 2011-03-03 | Ranbaxy Laboratories Limited | Modified release lamotrigine tablets |
GB201111712D0 (en) | 2011-07-08 | 2011-08-24 | Gosforth Ct Holdings Pty Ltd | Pharmaceutical compositions |
WO2013183985A1 (en) | 2012-06-05 | 2013-12-12 | Erasmus University Medical Center Rotterdam | Method of treating cognitive impairment and compounds for use therein |
US10189859B2 (en) | 2013-12-21 | 2019-01-29 | Nektar Therapeutics | Derivatives of 6-(2,3-dichlorophenyl)-1,2,4-triazin-5-amine |
US10576086B2 (en) | 2015-06-12 | 2020-03-03 | University Of Greenwich | Triazine derivatives as interferon-gamma inhibitors |
CN110072521B (zh) | 2016-12-16 | 2022-11-29 | 爱杜西亚药品有限公司 | 包含t型钙通道阻断剂的药物组合 |
TWI826531B (zh) | 2018-09-21 | 2023-12-21 | 南韓商愛思開生物製藥股份有限公司 | 具有㗁二唑之化合物及包含該化合物之醫藥組合物 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB759014A (en) * | 1952-02-26 | 1956-10-10 | Wellcome Found | Improvements in triazines and their manufacture |
AT190941B (de) * | 1954-09-22 | 1957-07-25 | Chemie Linz Ag | Verfahren zur Herstellung neuer Guanylhydrazone |
US2952677A (en) * | 1956-10-01 | 1960-09-13 | Ici Ltd | Aminoguanadine compounds |
BE663481A (es) * | 1964-05-05 | |||
DE1802364C3 (de) * | 1967-10-12 | 1975-03-20 | Shell Internationale Research Maatschappij B.V., Den Haag (Niederlande) | Arzneimittel mit thymeretischer Wirkung |
GB1223491A (en) * | 1967-10-13 | 1971-02-24 | American Home Prod | Guanidines |
US3637688A (en) * | 1970-01-09 | 1972-01-25 | American Home Prod | 6-(fluoro and trifluoromethyl phenyl)-3 5-diamino - 1 2 4 - triazines and substituted - 6 - phenylalkyl-3,5-diamino-1 2 4-triazines |
EP0024351B1 (en) * | 1979-08-16 | 1984-10-31 | The Wellcome Foundation Limited | Solid pharmaceutical formulation containing substitued phenyl-triazines |
-
1980
- 1980-05-30 EP EP82102293A patent/EP0059987B1/en not_active Expired
- 1980-05-30 AT AT0289680A patent/AT370097B/de not_active IP Right Cessation
- 1980-05-30 FI FI801758A patent/FI67844C/fi not_active IP Right Cessation
- 1980-05-30 ES ES491998A patent/ES8104993A1/es not_active Expired
- 1980-05-30 EP EP80103032A patent/EP0021121B1/en not_active Expired
- 1980-05-30 CS CS803829A patent/CS234018B2/cs unknown
- 1980-05-30 PL PL1980224633A patent/PL124029B1/pl unknown
- 1980-05-30 GR GR62081A patent/GR68380B/el unknown
- 1980-05-30 IE IE1126/80A patent/IE49823B1/en not_active IP Right Cessation
- 1980-05-30 JP JP7158080A patent/JPS5625169A/ja active Granted
- 1980-05-30 AU AU58906/80A patent/AU530999B2/en not_active Expired
- 1980-05-30 IL IL60201A patent/IL60201A/xx unknown
- 1980-05-30 CA CA353,081A patent/CA1112643A/en not_active Expired
- 1980-05-30 ZW ZW129/80A patent/ZW12980A1/xx unknown
- 1980-05-30 AR AR281263A patent/AR227521A1/es active
- 1980-05-30 HU HU801364A patent/HU182086B/hu unknown
- 1980-05-30 ZA ZA00803250A patent/ZA803250B/xx unknown
- 1980-05-30 NZ NZ193890A patent/NZ193890A/en unknown
- 1980-05-30 DK DK233880A patent/DK153787C/da active
- 1980-05-30 DD DD80221474A patent/DD151309A5/de unknown
- 1980-05-30 IT IT48848/80A patent/IT1147087B/it active Protection Beyond IP Right Term
- 1980-05-31 YU YU01456/80A patent/YU145680A/xx unknown
- 1980-06-02 SU SU802932704A patent/SU1055331A3/ru active
- 1980-06-02 UA UA2932704A patent/UA5576A1/uk unknown
-
1981
- 1981-10-05 US US06/308,805 patent/US4486354A/en not_active Expired - Lifetime
-
1983
- 1983-04-28 AU AU14051/83A patent/AU566870B2/en not_active Expired
-
1984
- 1984-02-27 US US06/583,286 patent/US4602017A/en not_active Expired - Lifetime
-
1985
- 1985-06-04 JP JP12137085A patent/JPS6133163A/ja active Granted
- 1985-12-30 MY MY62/85A patent/MY8500062A/xx unknown
-
1991
- 1991-12-17 CZ CS913848A patent/CZ384891A3/cs unknown
-
1992
- 1992-06-17 MX MX9202962A patent/MX9202962A/es unknown
-
1993
- 1993-07-29 BG BG097992A patent/BG60427B2/bg unknown
-
1994
- 1994-05-16 GE GEAP19941909A patent/GEP19960470B/en unknown
-
1995
- 1995-04-28 NL NL950007C patent/NL950007I2/nl unknown
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