ES8104993A1 - Un procedimiento para preparar compuestos aromaticos susti- tuidos - Google Patents

Un procedimiento para preparar compuestos aromaticos susti- tuidos

Info

Publication number
ES8104993A1
ES8104993A1 ES491998A ES491998A ES8104993A1 ES 8104993 A1 ES8104993 A1 ES 8104993A1 ES 491998 A ES491998 A ES 491998A ES 491998 A ES491998 A ES 491998A ES 8104993 A1 ES8104993 A1 ES 8104993A1
Authority
ES
Spain
Prior art keywords
hydrogen
alkyl
trifluoromethyl
compounds
preparing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES491998A
Other languages
English (en)
Other versions
ES491998A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10505597&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES8104993(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Publication of ES491998A0 publication Critical patent/ES491998A0/es
Publication of ES8104993A1 publication Critical patent/ES8104993A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D253/075—Two hetero atoms, in positions 3 and 5
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/16—Compounds containing any of the groups, e.g. aminoguanidine
    • C07C281/18—Compounds containing any of the groups, e.g. aminoguanidine the other nitrogen atom being further doubly-bound to a carbon atom, e.g. guanylhydrazones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/15—Preparation of carboxylic acids or their salts, halides or anhydrides by reaction of organic compounds with carbon dioxide, e.g. Kolbe-Schmitt synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/363—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE COMPUESTOS AROMATICOS SUSTITUIDOS, DE FORMULA (I), O UNA DE SUS SALES DE ADICION DE ACIDO, EN LA QUE R6, R7, R8, R9, R10 Y R11 PUEDEN SER VARIOS RADICALES. SE SOMETE A UNA REACCION DE CICLISACION POR METODOS CONVENCIONALES UN COMPUESTO DE FORMULA (III), EN LA QUE LOS RADICALES R6, R7, R8, R9 Y R10 SON LOS MISMOS QUE EN LA FORMULA (I), DISUELTO EN UN ALCANOL DE C1-4 Y EN PRESENCIA DE UNA BASE. A CONTINUACION, EVENTUALMENTE, SE SUSTITUYE EL GRUPO AMINO ADYACENTE AL ANILLO FENILO POR UN RADICAL R11, QUE ES EL MISMO QUE EN LA FORMULA (I). ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE ENFERMEDADES DEL SISTEMA NERVIOSO CENTRAL. *FORMULA*
ES491998A 1979-06-01 1980-05-30 Un procedimiento para preparar compuestos aromaticos susti- tuidos Expired ES8104993A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7919257 1979-06-01

Publications (2)

Publication Number Publication Date
ES491998A0 ES491998A0 (es) 1981-05-16
ES8104993A1 true ES8104993A1 (es) 1981-05-16

Family

ID=10505597

Family Applications (1)

Application Number Title Priority Date Filing Date
ES491998A Expired ES8104993A1 (es) 1979-06-01 1980-05-30 Un procedimiento para preparar compuestos aromaticos susti- tuidos

Country Status (30)

Country Link
US (2) US4486354A (es)
EP (2) EP0059987B1 (es)
JP (2) JPS5625169A (es)
AR (1) AR227521A1 (es)
AT (1) AT370097B (es)
AU (2) AU530999B2 (es)
BG (1) BG60427B2 (es)
CA (1) CA1112643A (es)
CS (1) CS234018B2 (es)
CZ (1) CZ384891A3 (es)
DD (1) DD151309A5 (es)
DK (1) DK153787C (es)
ES (1) ES8104993A1 (es)
FI (1) FI67844C (es)
GE (1) GEP19960470B (es)
GR (1) GR68380B (es)
HU (1) HU182086B (es)
IE (1) IE49823B1 (es)
IL (1) IL60201A (es)
IT (1) IT1147087B (es)
MX (1) MX9202962A (es)
MY (1) MY8500062A (es)
NL (1) NL950007I2 (es)
NZ (1) NZ193890A (es)
PL (1) PL124029B1 (es)
SU (1) SU1055331A3 (es)
UA (1) UA5576A1 (es)
YU (1) YU145680A (es)
ZA (1) ZA803250B (es)
ZW (1) ZW12980A1 (es)

Families Citing this family (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0024351B1 (en) * 1979-08-16 1984-10-31 The Wellcome Foundation Limited Solid pharmaceutical formulation containing substitued phenyl-triazines
GB8328757D0 (en) * 1983-10-27 1983-11-30 Wellcome Found Chemical compounds
DE3600891A1 (de) * 1986-01-15 1987-07-16 Bayer Ag 1,8-verbrueckte 4-chinolon-3-carbonsaeuren und diese enthaltende arzneimittel
GB8613183D0 (en) * 1986-05-30 1986-07-02 Wellcome Found Triazine salt
US4972496A (en) * 1986-07-25 1990-11-20 Grid Systems Corporation Handwritten keyboardless entry computer system
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US5136080A (en) * 1989-12-04 1992-08-04 Burroughs Wellcome Co. Nitrile compounds
GB9012312D0 (en) * 1990-06-01 1990-07-18 Wellcome Found Pharmacologically active cns compounds
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US5629016A (en) * 1991-01-30 1997-05-13 Glaxo Wellcome Inc. Water-dispersible tablets
BE1004461A5 (fr) * 1991-01-30 1992-11-24 Wellcome Found Comprimes dispersables dans l'eau.
GB9124807D0 (en) * 1991-11-22 1992-01-15 Wellcome Found Pharmaceutical formulations
GB9203483D0 (en) * 1992-02-19 1992-04-08 Wellcome Found Anti-inflammatory compounds
EP0644763B1 (en) * 1992-06-12 1997-01-22 The Wellcome Foundation Limited Use of 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine isethionate for the treatment and prevention of dependence, tolerance and sensitization of drugs
GB9215908D0 (en) * 1992-07-27 1992-09-09 Wellcome Found Water dispersible tablets
FR2699077B1 (fr) * 1992-12-16 1995-01-13 Rhone Poulenc Rorer Sa Application d'anticonvulsivants dans le traitement de lésions neurologiques liées à des traumatismes.
US6133299A (en) * 1993-02-25 2000-10-17 Warner-Lambert Company Methods for treating neurodegenerative diseases and disorders using N-(2,6-disubstituted aromatic)-N'-pyridinyl ureas and other anticonvulsant compounds
GB9305692D0 (en) * 1993-03-19 1993-05-05 Wellcome Found Therapeutic triazine compounds and use
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US5866597A (en) * 1993-03-19 1999-02-02 Glaxo Wellcome Inc. Use of triazine compounds for the treatment of memory and learning disorders
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GB9317146D0 (en) * 1993-08-18 1993-10-06 Wellcome Found Therapeutic combinations
GB9424766D0 (en) * 1994-12-07 1995-02-08 Wellcome Found Pharmaceutical composition
GB9426448D0 (en) * 1994-12-30 1995-03-01 Wellcome Found Process
PT800520E (pt) * 1994-12-30 2002-11-29 Wellcome Found Processo para a preparacao de lamotrigina
GB9512854D0 (en) * 1995-06-23 1995-08-23 Wellcome Found Novel formulation
GB9518027D0 (en) * 1995-09-05 1995-11-08 Wellcome Found Pharmacologically active compound
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GB2471713A (en) * 2009-07-08 2011-01-12 Univ Greenwich 1,2,4-triazine derivatives and their use as sodium channel blockers
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US10576086B2 (en) 2015-06-12 2020-03-03 University Of Greenwich Triazine derivatives as interferon-gamma inhibitors
CN110072521B (zh) 2016-12-16 2022-11-29 爱杜西亚药品有限公司 包含t型钙通道阻断剂的药物组合
TWI826531B (zh) 2018-09-21 2023-12-21 南韓商愛思開生物製藥股份有限公司 具有㗁二唑之化合物及包含該化合物之醫藥組合物

Family Cites Families (8)

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Publication number Priority date Publication date Assignee Title
GB759014A (en) * 1952-02-26 1956-10-10 Wellcome Found Improvements in triazines and their manufacture
AT190941B (de) * 1954-09-22 1957-07-25 Chemie Linz Ag Verfahren zur Herstellung neuer Guanylhydrazone
US2952677A (en) * 1956-10-01 1960-09-13 Ici Ltd Aminoguanadine compounds
BE663481A (es) * 1964-05-05
DE1802364C3 (de) * 1967-10-12 1975-03-20 Shell Internationale Research Maatschappij B.V., Den Haag (Niederlande) Arzneimittel mit thymeretischer Wirkung
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Also Published As

Publication number Publication date
FI67844C (fi) 1985-06-10
DK233880A (da) 1980-12-02
GR68380B (es) 1981-12-28
EP0021121B1 (en) 1983-05-11
CS234018B2 (en) 1985-03-14
EP0059987A1 (en) 1982-09-15
JPS5625169A (en) 1981-03-10
MX9202962A (es) 1992-07-01
JPH0144706B2 (es) 1989-09-29
DK153787C (da) 1989-01-16
MY8500062A (en) 1985-12-31
ES491998A0 (es) 1981-05-16
AT370097B (de) 1983-02-25
CA1112643A (en) 1981-11-17
IL60201A0 (en) 1980-07-31
NL950007I1 (nl) 1995-06-16
PL124029B1 (en) 1982-12-31
GEP19960470B (en) 1996-08-29
SU1055331A3 (ru) 1983-11-15
IT8048848A0 (it) 1980-05-30
AR227521A1 (es) 1982-11-15
NZ193890A (en) 1984-07-06
IE801126L (en) 1980-12-01
AU530999B2 (en) 1983-08-04
JPH0144179B2 (es) 1989-09-26
IT1147087B (it) 1986-11-19
ATA289680A (de) 1982-07-15
AU566870B2 (en) 1987-11-05
HU182086B (en) 1983-12-28
FI67844B (fi) 1985-02-28
US4602017A (en) 1986-07-22
US4486354A (en) 1984-12-04
EP0059987B1 (en) 1985-08-14
JPS6133163A (ja) 1986-02-17
PL224633A1 (es) 1981-02-13
YU145680A (en) 1983-02-28
EP0021121A1 (en) 1981-01-07
BG60427B2 (bg) 1995-03-31
ZW12980A1 (en) 1982-01-06
UA5576A1 (uk) 1994-12-28
FI801758A (fi) 1980-12-02
CZ384891A3 (en) 1993-10-13
IE49823B1 (en) 1985-12-25
DK153787B (da) 1988-09-05
NL950007I2 (nl) 1997-02-03
IL60201A (en) 1984-05-31
AU5890680A (en) 1980-12-04
ZA803250B (en) 1982-01-27
DD151309A5 (de) 1981-10-14

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