FR2320302A1 - (11)-Amino-vincamine prepd. by nitration and then redn. of vincamine - is used as a cerebral vasoregulator - Google Patents

(11)-Amino-vincamine prepd. by nitration and then redn. of vincamine - is used as a cerebral vasoregulator

Info

Publication number
FR2320302A1
FR2320302A1 FR7524390A FR7524390A FR2320302A1 FR 2320302 A1 FR2320302 A1 FR 2320302A1 FR 7524390 A FR7524390 A FR 7524390A FR 7524390 A FR7524390 A FR 7524390A FR 2320302 A1 FR2320302 A1 FR 2320302A1
Authority
FR
France
Prior art keywords
vincamine
redn
nitration
prepd
vasoregulator
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7524390A
Other languages
French (fr)
Other versions
FR2320302B3 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Omnium Chimique SA
Original Assignee
Omnium Chimique SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Omnium Chimique SA filed Critical Omnium Chimique SA
Priority to FR7524390A priority Critical patent/FR2320302A1/en
Publication of FR2320302A1 publication Critical patent/FR2320302A1/en
Application granted granted Critical
Publication of FR2320302B3 publication Critical patent/FR2320302B3/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D461/00—Heterocyclic compounds containing indolo [3,2,1-d,e] pyrido [3,2,1,j] [1,5]-naphthyridine ring systems, e.g. vincamine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

11-Aminovincamine of formula (I) in dextro- and laevo-rotatory forms and the racemic mixt. are prepd. by the nitration of vincamine of formula (II) to form 11-nitro vincamine of (III) and redn. of this prod.: The nitration is effected using nitric acid in glacial acetic acid. the redn. may be effected using H2/Raney Ni, SnCl2 in HCl or Zn/HCl. In an example, 25g. (II) was nitrated with a mixt. of 100ml. glacial acetic acid and 100ml. nitric acid (d = 1.52) to give 22.4g. (III) m.pt. 196-197 degrees C. 18g (III) was dissolved in 500ml. methanol and 3g. Raney nickel added. Hydrogenation gave 13.6g. (I), m.pt.
FR7524390A 1975-08-05 1975-08-05 (11)-Amino-vincamine prepd. by nitration and then redn. of vincamine - is used as a cerebral vasoregulator Granted FR2320302A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7524390A FR2320302A1 (en) 1975-08-05 1975-08-05 (11)-Amino-vincamine prepd. by nitration and then redn. of vincamine - is used as a cerebral vasoregulator

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7524390A FR2320302A1 (en) 1975-08-05 1975-08-05 (11)-Amino-vincamine prepd. by nitration and then redn. of vincamine - is used as a cerebral vasoregulator

Publications (2)

Publication Number Publication Date
FR2320302A1 true FR2320302A1 (en) 1977-03-04
FR2320302B3 FR2320302B3 (en) 1978-03-24

Family

ID=9158774

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7524390A Granted FR2320302A1 (en) 1975-08-05 1975-08-05 (11)-Amino-vincamine prepd. by nitration and then redn. of vincamine - is used as a cerebral vasoregulator

Country Status (1)

Country Link
FR (1) FR2320302A1 (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2339618A1 (en) * 1976-01-30 1977-08-26 Omnium Chimique Sa (11)-Amino-vincamones useful as cerebral circulation regulators - prepd. from (11)-nitro-vincamines by reduction and treatment with a base
EP0170926A1 (en) * 1984-07-11 1986-02-12 Richter Gedeon Vegyeszeti Gyar R.T. Eburnanecarboxylic acid derivatives having an amino group in position 9 or 11, the amino group eventually being substituted, process for their preparation, and medicaments containing these compounds
EP0173824A1 (en) * 1984-07-11 1986-03-12 Richter Gedeon Vegyészeti Gyár R.T. Racemic or optically active 9- respectively 11-substituted apovincamine acid derivatives and process for their preparation
EP0307167A2 (en) * 1987-09-07 1989-03-15 Taisho Pharmaceutical Co. Ltd Vincaminic acid derivatives

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2339618A1 (en) * 1976-01-30 1977-08-26 Omnium Chimique Sa (11)-Amino-vincamones useful as cerebral circulation regulators - prepd. from (11)-nitro-vincamines by reduction and treatment with a base
EP0170926A1 (en) * 1984-07-11 1986-02-12 Richter Gedeon Vegyeszeti Gyar R.T. Eburnanecarboxylic acid derivatives having an amino group in position 9 or 11, the amino group eventually being substituted, process for their preparation, and medicaments containing these compounds
EP0173824A1 (en) * 1984-07-11 1986-03-12 Richter Gedeon Vegyészeti Gyár R.T. Racemic or optically active 9- respectively 11-substituted apovincamine acid derivatives and process for their preparation
EP0307167A2 (en) * 1987-09-07 1989-03-15 Taisho Pharmaceutical Co. Ltd Vincaminic acid derivatives
EP0307167A3 (en) * 1987-09-07 1990-01-24 Taisho Pharmaceutical Co. Ltd Vincaminic acid derivatives

Also Published As

Publication number Publication date
FR2320302B3 (en) 1978-03-24

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